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Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
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Articles 207 Documents
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Antibiotics in Prevention and Treatment of Multi-Drug Resistant (MDR) Organisms causing Surgical Site Infection (SSI) Saranya K. Lakshmi; Hema N. Gowda; Anuradha Kundapur
Pharmacology and Clinical Pharmacy Research Vol 5, No 3 (2020)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i3.29230

Abstract

Antibiotics play a vital role in prevention and treatment of various infections. But inappropriate antibiotic choice could lead to emergence of multi-drug resistance (MDR) among microorganisms. Since, the antibiotic susceptibility pattern of organisms could vary from place to place; forming a local prophylaxis and treatment protocol could hugely reduce this global burden. The primary objectives of the study were to observe the frequency of multi-drug resistant organisms causing Surgical Site Infections (SSIs) and to study the pattern of antibiotic usage for the prophylaxis and treatment of SSIs. A descriptive study was carried out in general surgical wards of KR hospital, Mysore for a period of 18 months (2015-2016). The relevant data was collected from the case sheets of patients who were diagnosed with SSI. Pus samples were collected, and culture-sensitivity was done. Collected data were analyzed using relevant statistical tests. A total of 263 study subjects including both males and females were enrolled in the study. Cefotaxime was the most common antibiotic used for pre-surgical prophylaxis (n=221). Out of 263 pus samples 92% were culture positive. The most common organisms causing SSI were E-coli-ESBL (n=73) and MRSA (n=44). About 95% of organisms showed multi-drug resistance. Imipenem, Gentamicin, Piperacillin-Tazobactum and Linezolid were the most common antibiotics used in the treatment of SSIs. The result of the study is alarming. Overall, there is great rise in the prevalence of MDR organisms causing SSIs. The hospital antibiotic policy should be revised in such a way to decrease the emergence of MDR microbes.
An Intensive Monitoring of Adverse Drug Reactions in Indoor Patients of Paediatric Department at Tertiary Care Teaching Hospital in Gujarat, India. Kandarp Patel; Kuntal Thacker; Neeta Kanani; Vimesh Mistry
Pharmacology and Clinical Pharmacy Research Vol 6, No 1 (2021)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v6i1.30769

Abstract

they differ from adults in pharmacokinetic and pharmacodynamics responses. ADRs reported in adults do not predict those in children. Thus, this study aimed to intensively monitor ADRs occurred in inpatients of paediatric department of tertiary care teaching hospital to assess the same in terms of incidence, causality, severity and preventability. A prospective observational single centre study was done in the paediatric department of SSG hospital, Vadodara over duration of 8 months. The ADRs were actively monitored and collected reports were analysed for ADR pattern, demographic profile, causality, severity, and preventability. A total of 66 ADRs were documented during the period of 8 months. Among these 53.03% ADRs occurred below the age of 1 year, 89.13% ADRs occurred due to antibiotics, 56.06% ADRs are of Diarrhoea and vomiting and 80.43% ADRs developed after receiving drug intravenously. As per WHO-UMC criteria, 46.96 % ADRs were of probable while 51.51% ADRs were of possible causality while as per Naranjo scale 60.61% ADRs were of probable and 39.39% ADRs were of possible category. As per severity scale 69.70% reactions were mild and 30.30 % reactions were moderate. Probably preventable ADRs were about 57.58%. ADRs occurred more among infants and antibiotics were more commonly implicated. Most of the reactions were of mild severity and were probably preventable. Certain Precautionary measures can lead to significant prevention of ADRs in paediatric patients.
Ethanolic Extract of Xestospongia Sp. Induces CD4+ and CD14 Cells Levels on Wistar Male Rat Infected with Staphylococcus aureus Adryan Fristiohady; Wahyuni Wahyuni; Muhammad H Malaka; Dewiyanti Madu; Dayatriana Muthalib; Dian Munasari; La Ode MJ Purnama; Baru Sadarun; Muhammad Ilyas; Idin Sahidin
Pharmacology and Clinical Pharmacy Research Vol 5, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i2.26986

Abstract

Immunomodulator is a substance that increases or suppresses the immune response through the certain mechanism. The marine sponge Xestospongia sp. has immunomodulatory activity by increasing phagocytic activity. In addition, the phagocytic activity is affected by CD4+ and CD14 cells levels. Thus, this study aims to investigate the effect of Xestopongia sp. extract toward CD4+ and CD14 cells level in model rat. Animals were divided into 4 groups (n=5) and treated for 7 days, as follow: Group I (Ethanolic extract of Xestospongia sp. dose of 300 mg/KgBW); Group II (Ethanolic extract of Xestospongia sp. dose of 400 mg/KgBW); Group III (Phylantus niruri extract); and Group IV (0.5% Na CMC). On day 8, animals were infected with Staphylococcus aureus intraperitoneally. And the blood was collected by cardiac puncture and assayed with ELISA kit CD4 (elabscience®) and ELISA kit CD14 (elabscience®). Ethanolic extract of Xestospongia sp. provided high levels of both CD4+ and CD14 cells (Group II) compared to baseline (Group IV)  (p<0.05). Group I provided similar activity to group III (p>0.05) and Group II provided significant activity with higher levels of CD4+ and CD14 cells compared to group III (p<0.05). In conclusion, both doses of Xestospongia sp. extract provide activity as immunomodulator by increasing CD4+ and CD14 cells levels, yet dose of 400 mg/KgBw provides the higher immunomodulatory activity.
Medication Adherence to Successful Tuberculosis Treatment Outcome among TB/HIV Patient at Prof. Dr. Sulianti Saroso Infectious Disease Hospital Yusmaniar Yusmaniar; Adin H Kurniawan
Pharmacology and Clinical Pharmacy Research Vol 5, No 3 (2020)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i3.29166

Abstract

Tuberculosis/Human Immunodeficiency Virus (TB/HIV) co-infection has poorer treatment outcome compared to non-co-infected patients. To benefit from therapy and to avoid contracting treatment-resistant strains, the individuals must adherent to medications. There is limited information regarding successful TB treatment outcomes and their associated factors. Thus, the study was designed to identify medication adherence associated with treatment outcomes among TB/HIV Patients at Prof. Dr. Sulianti Saroso Infectious Disease Hospital. This research was an observational study with retrospective approach from January 2015 to December 2017 by taking data from medical records and TB-01 form of TB/HIV patients in the outpatient clinic of the disease which would be used as a sample. Regarding compliance in treatment with first visit for 2-4 months, an approach using secondary data which were TB-01 Form, as well as HIV Care and Antiretroviral Therapy summary forms was used. The statistical analysis used was the bivariate analysis with the chi-square test as the statistical test. A total of 114 patients were included in the study. The outcome of treatment success obtained from this study had a patient cure rate of 91.30%. There is a significant relationship between medication adherence to successful tuberculosis treatment outcome with p-value= 0.012; OR= 5.684. There is a meaningful relation between medication compliance with treatment outcome. It is when on medication adherence, the treatment results can be declared cured in accordance with predetermined criteria, while when not on medication adherence, the treatment results are not declared cured.
Inventory Control of Drugs Listed in Private Health Insurance at Pharmacies in South Tangerang using ABC Analysis Andriyani R. Fahriati; Dwi S. Suryatiningrum; Tanti J. Saragih
Pharmacology and Clinical Pharmacy Research Vol 6, No 1 (2021)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v6i1.31541

Abstract

Inventory control in pharmacies must be appropriately and effectively maintained to promote continuous drug affordability and availability in the community within the healthcare delivery system. Initially, effective drug planning and procurement are essential to attain proper drug selection, quantification, and procurement based on the consumption pattern with good economic impact and clinical value. Therefore, the ABC analysis method is suggested to be implemented to optimize efficient budget and effective drug planning. This study aimed to investigate the planning and procurement process of drug listed in private health insurance using the ABC analysis method in the pharmacies X and Y. This study was non-experimental study with descriptive analysis utilizing qualitative and quantitative data. Drug enlisted in the private insurance data in 2019 were taken retrospectively. Based on the ABC analysis results, in pharmacy store X, drug listed in group A showed 83 items with the highest investment value of 86.38%, group B showed 102 items with 15.61%, and group C showed 129 items with the lowest investment value of 4.79%. Meanwhile, in pharmacy Y, drug listed in group A showed 87 items with the highest investment value of 89.62%, group B showed 100 items with 7.62%, and group C showed 134 items with the lowest investment value of 2.76%. Using the ABC analysis to manage the drug inventory system could assist pharmacy store X and Y in planning the procurement of drug listed in the private healthcare insurance effectively. Also, taking into account the values of consumption and investment are obtained efficiently.
Effects of Insulin against Aluminium Induced Neurotoxicity in Wistar Rats Amir Alam; Garima Bansal
Pharmacology and Clinical Pharmacy Research Vol 5, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i2.28096

Abstract

Aluminium toxicity is well known to cause neurotoxicity leading to Alzheimer disease with dementia. The aim of the present study is to evaluate the effects of Insulin in Aluminium induced neurotoxicity. Thirty male wistar rats randomized into three groups (group V, C, T) of ten each were used for the study after obtaining institutional animal ethics committee approval. Chronic aluminium neurotoxicity was induced in the rats and the neurobehavior was evaluated using Morris water maze test, elevated plus maze test and rotarod test using standard methodologies. Group C rats exhibited significant deviation in performance of behavioural test of the study during day 1 (Morris water maze test- 18.6±9.5, elevated plus maze test- 34.9±1.9, rotarod test- 118.6±15.2) and day 30 (Morris water maze test- 64.5±4.6, elevated plus maze test- 72.1±3.9, rotarod test- 110.7±9.3). Rats of group T showed decrease in behavioural changes induced by aluminium toxicity (P value: Morris water maze test-0.0002, elevated plus maze test- 0.0007 and rotarod test- 0.015). Insulin may play a role in neuroprotection against toxicity similar to that of aluminium induced neurotoxicity.
Effect of COVID-19 on the Treatment of Infections by Community Pharmacists in Nigeria Edidiong Orok; Success David; Chiemezie Ibegwam
Pharmacology and Clinical Pharmacy Research Vol 5, No 3 (2020)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i3.29262

Abstract

COVID-19 has had tremendous effects on different aspects of health care. Patients have been one of the most affected since the pandemic has limited their access to healthcare everywhere in the world including Nigeria. Reduced access to healthcare services in hospitals has caused an increase in the number of patient visits to the community pharmacies. This study was designed to evaluate the effect of the COVID-19 pandemic on the treatment of infections by community pharmacists. This study was a prospective cross-sectional study that was carried out among community pharmacists working in community pharmacies in Ibadan, Oyo state and Uyo, Akwa Ibom state due to the recent rise in COVID-19 cases from July until August 2020. Data was collected through a pre-tested online questionnaire which was sent to the pharmacists upon provision of consent after the purpose of the study was explained. A total of one hundred and twenty two pharmacists consented to participate in this study out of which 65 (53.3%) were female. Malaria (81, 66.4%), respiratory tract infections (40, 32.8%) and sexually transmitted infections (1, 0.8%) were identified as infections with the highest frequency by the community pharmacists, while more than 96% (118) pharmacists reported that COVID-19 has affected the way they manage or treat other infections seen in their pharmacy. This study shows that the COVID-19 pandemic has affected the way community pharmacists treat other infections in the community pharmacy setting. More studies are needed to explore the specific nature of this effect on specific infections. 
Antibacterial Activities of Parijoto (Medinilla speciosa Blume) Fruit Extracts Against Clinical Isolates of Salmonella typhi and Shigella dysenteriae Tiana Milanda; Melisa I. Barliana; Rosidah Rosidah; Arif S.W Kusuma
Pharmacology and Clinical Pharmacy Research Vol 6, No 1 (2021)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v6i1.31992

Abstract

Medinilla speciosa (M. speciosa) Blume is a plant originating from Mount Muria, Kudus District, Central Java, Indonesia. Its fruit has been used by the local community to treat mouth sores, diarrhea, inflammatory, hyperlipidemia, cancer, bacterial infection and nutrients for pregnant women. However, the antibacterial activity against Salmonella typhi (S. typhi) and Shigella dysentriae (S. dysentriae) is yet unknown. Thus, the aim of this study was to determine the antibacterial activities of M. speciosa fruit extracts against clinical strain of S. typhi and S. dysentriae. Plant determination and sample preparation were conducted. The fruits of M. speciosa were extracted by gradual maseration using n-hexane, ethyl acetate and methanol as solvents. Phytochemicals were screened by Fransworth method. Antibacterial activity was determined using agar well diffusion. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values and comparison study of antibacterial activity were determined. The results showed that all of the extracts exhibited antibacterial activities, with the greatest activity  shown by the methanol extract. This extract was more effective against S. dysenteriae  than S. typhi, as evidenced by the largest inhibition diameter and lowest MIC (25 mg/mL) and MBC (50 mg/mL) values. With regard to the results of phytochemical screening, the antibacterial activity of methanol extract could be due to the presence of alkaloids, flavonoids, polyphenols, quinones, saponins and tannins. From the comparative antibacterial activity value indicated that in order to give the same inhibition diameter with 1 ppm of chloramphenicol, 312.3 ppm methanol extract is needed. It can be conclude that M. speciosa fruit has a potential to be developed as natural antibacterial agent, especially to treat bacillary dysentery
Prescription Patterns of Antituberculosis Drugs in Treatment of Tuberculosis at a Tertiary Care Hospital in Andgra Pradesh, a Cross-Sectional Study Krishnakanth K; Chakrapani Cheekavolu; Poojala Kumar; Ravi Shankar K; Jagadeesh A
Pharmacology and Clinical Pharmacy Research Vol 5, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v5i2.29224

Abstract

The success of tuberculosis treatment is based upon the prescription pattern following Revised National Tuberculosis Control Program/National Tuberculosis Elimination Program/World Health Organization guidelines, reflecting the burden of the disease which is increasing yearly. This implicates the variations in prescriptions advised in the treatment of tuberculosis. The present study was aimed to evaluate the prescription patterns of tuberculosis treatment in a tertiary hospital at Andhra Pradesh, India. Ninety-two patients were included in the study after obtaining ethical approval and informed consent. The prescription patterns were evaluated and compared to the standard guidelines. The mean age of the patients was 38.72 and showed male preponderance. Six regimens were used during the treatment. The patients showed good recovery which concludes that following the standard prescription pattern provides a good success rate in the treatment of tuberculosis.
Antibacterial Activity of Red yeast rice Extract against Propionibacterium acnes ATCC 11827 and Methicilin-Resistant Staphylococcus aureus ATCC BAA-1683 Tiana Milanda; Ade Zuhrotun; Ulya Nabila; Vesara A. Gathera; Arif S.W Kusuma
Pharmacology and Clinical Pharmacy Research Vol 6, No 2 (2021)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v6i2.35062

Abstract

Propionibacterium acnes ATCC 11827 and Methicillin-Resistant Staphylococcus aureus ATCC BAA-1683 are bacteria that cause skin infections, namely acne vulgaris and skin and soft tissue infection/SSTI. The increase in the number of resistant bacterial strains, such as MRSA,  requires the search for alternative antibiotics, including using natural ingredients. Red yeast rice is a product of rice fermentation by Monascus purpureus, which is known to have antibacterial, antifungal, antitumor, antioxidant, anti-inflammatory, anti-cholesterol and immunomodulator. This study aims to determine the antibacterial activity of several red yeast rice extracts against these bacteria that cause skin infections. The research was carried out through the stages of collecting materials and identifying the yeast isolates, extracting of red yeast rice, phytochemical screening of red yeast rice extract, confirmation of bacterial test, preparation of bacterial test suspension, testing for bacterial resistance, testing for antibacterial activity of red yeast rice extract and determining the value of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the most active extract. The results showed that the ethyl acetate and ethanol extracts had antibacterial activity against P. acnes ATCC 11827 and MRSA ATCC BAA-1683. Both extracts contain compounds from the polyphenols, flavonoids, quinones and saponins group. Ethyl acetate extract was the most active extract with MIC values against P. acnes ATCC 1182 and MRSA ATCC BAA-1683 of 50 mg/mL and 12.5 mg/mL. The MBC values of ethyl acetate extract against these bacterial tests were 100 mg/mL and 25 mg/mL. The ethyl acetate extract is more active against MRSA ATCC BAA-1683 than against P. acnes ATCC 11827. From the results of this study it is known that red yeast rice has activity against bacteria that cause skin infections, especially against MRSA

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