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Pharmacology and Clinical Pharmacy Research

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Published by Universitas Padjadjaran

ISSN : 25277332 EISSN : 26140020 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.

Arjuna Subject : -

Articles 207 Documents

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Binding Modes of Doxorubicin Compared to Estratetrol and Tamoxifen Muchammad R. Ghozaly; Ellin Febrina; Achmad Zaenudin
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Doxorubicin, a compound isolated from Streptomyces peucetius var Caesius, is commonlyused in the treatment of breast cancer. This drug works by interacting on human nucleicacids. This work was aimed to study the binding modes of doxorubicin with estrogen receptoralpha (ERα). Estratetrol and tamoxifen were used as natural ligand and standard drug,respectively. Molecular docking simulations was performed by AutoDock v.3.05 using minimumcoordinates -34, -6, -15 (x, y, z) and the maximum coordinates -13, 13, 3 (x, y, z).Tamoxifen formed one hydrogen bond with Glu353 (Ki=3.78 μM); estratetrol binds to Glu-353, Arg394, Gly521, and His524 (Ki=0.01 μM). Doxorubicin only formed one hydrogenbond with Ser317 (Ki=N/A). In conclusion, doxorubicin could not interact appropriatelywith ERα due to its voluminioues structure which hinder its entrance to binding pocket ofthe macromolecule.Keywords: doxorubicin, estrogen receptor alpha.

Efficacy and Side Effects of Deferasirox and Deferiprone for Thalasemia Major in Children Asti Y. Rindarwati; Ajeng Diantini; Keri Lestari
Pharmacology and Clinical Pharmacy Research Vol 1, No 3
Publisher : Universitas Padjadjaran, Indonesia

Thalassemia major (TM) is an inherited disease caused by defective or absent of hemoglobin chain synthesis. Regular chelation therapy is necessary to reduce excess iron in several organs of TM patients. The most commonly used chelating agents are deferasirox and deferiprone. However, information regarding their effectiveness and side effects in Indonesian children population with TM were limited. This study was conducted to assess the effectiveness and side effects of deferasirox and deferiprone in pediatric patients with TM. This was an observational study with prospective analysis which was conducted during April-August 2015. We included pediatric patients with TM who visited a hospital in Bandung, Indonesia, using consecutive sampling method. Thirty two subjects were divided into two groups, i.e., deferasirox and deferiprone group. Review of medical records and interview were performed for each participants. Effectiveness was defined as reduction in ferritin level. Side effects were assessed using Naranjo scale. Data were analyzed using Mann-Whitney test, Wiloxon test and Chi square test. P value < 0.05 defined statistical significance. We found that deferasirox was more effective than deferiprone for the treatment of TM in pediatric patiens, with less side effects. The use of deferasirox as iron chelating agent is recommended for patients with TM.Keywords: deferasirox, deferiprone, ferritin, thalassemia major

Assessment of Risk Factors of Hepatotoxicity among Tuberculosis Patients Muhammad F. Wardhana; Tiana Milanda; Sri A. Sumiwi
Pharmacology and Clinical Pharmacy Research Vol 3, No 1
Publisher : Universitas Padjadjaran, Indonesia

Tuberculosis is a devastating disease caused by Mycobacterium tuberculosis. If left untreated or not properly treated, it could lead to progressive tissue damage and even death. Short-term chemotherapy containing isoniazid, rifampicin. and pyrazinamide were proven to be very effective in the treatment of TB. However, the concern regarding its potential hepatotoxicity might hinder the completion of treatment. Information regarding risk factor of hepatotoxicity among Indonesian tuberculosis patients were limited. This study aimed to investigate risk factors of hepatotoxicity among Indonesian tuberculosis patients. This was a case-control study with retrospective approach conducted at one of the public hospital in Lampung, Indonesia. We included 320 tuberculosis patients who were classified as case (64 patients who were diagnosed with hepatotoxicity during hospitalization) and control (256 patients). Results of multivariate logistic regression analysis showed that age was significant risk factor of hepatotoxicity (adjusted odds ratio (OR) 1.056, 95% CI 1.0121, 1.091), while longer duration of hospitalization had a 1.4 lower odds of hepatotoxicity compared to control (adjusted OR 0.757, 95% CI 0.682, 0.839) (p<0.005). The results indicated that older patients were more likely to have hepatotoxicity, while patients with shorter duration of hospitalization tend to have higher risk of hepatotoxicity. In conclusion, age was the risk factor associated with hepatotoxicity among tuberculosis patients.Keywords: tuberculosis, hepatotoxicity, age, hospitalization

Assessment of Plasma Selenium Level based on Dietary Intake among Geriatric Patients Ika M. Silviana; Nuraini Yasmin; Ronny Lesmana
Pharmacology and Clinical Pharmacy Research Vol 1, No 1
Publisher : Universitas Padjadjaran, Indonesia

Low plasma selenium level was associated with the increasing risk of death in geriatric patients, particularly those with multiple comorbidities. The sufficient level of selenium intake as an antioxidant is necessary for this population. This study aimed to investigate the plasma selenium level based on dietary intake in geriatric clinic population at Dr. Hasan Sadikin General Hospital Bandung.This study was a descriptive study using cross-sectional method. Fourteen geriatric patients were selected by consecutive sampling technique. Semiquantitative food frequency questionnaire (SQ-FFQ) was used as a tool to assess dietary intake. Plasma selenium level was measured as selenium binding protein 1 (SELENBP1) using enzyme-linked immunosorbent assay kit. Overall, mean of plasma selenium level of the subjects was 2,68 µg/L and mean of selenium intake was 62,85 µg/day. Selenium level of the subjects with sufficient selenium intake (85,7%) was 2,62 µg/L and selenium level of the subjects with deficient selenium intake (14,3%) was 3,05 µg/L. In conclusion, plasma selenium level among geriatric patients was varied and not dependent on dietary intake.Keywords: antioxidant, dietary intake, geriatric, plasma selenium level

Assessment of Plasma Selenium-Binding Protein-1 Level in Geriatric Population Annisa F. Dewi; Lazuardhi Dwipa; Ronny Lesmana
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Geriatric physiologically undergoes aging process that can cause decreasing cell functionand increasing risk of degenerative diseases caused by the accumulation of reactive oxygenspecies (ROS) in the body. Selenium (Se) is an antioxidant, which is needed for maintainingthe balance of ROS. The aim of this study was to observe the selenium-binding protein(SELENBP1) level in relation with the geriatric patients charcateristics including sex, age,body mass index (BMI), activity of daily living (ADL), instrumental activity of daily living(IADL), cognitive function, nutrition, depression, and insomnia status. The study usedcross-sectional quantitative descriptive study design on 14 geriatric patients in Geriatric OutpatientsClinics, at a hospital in Bandung. The data was obtained by interviewing the patientsand then blood samples were taken. The analysis of SELENBP1 was done using ELISA kit.The average level (SD) of SELENBP1 from all of the characteristics group was 2.68 (0.69)ng/ml. The highest SELENBP1 level was identified in female geriatric patients and followedby male and pre-obese groups. The lowest SELENBP1 level was identified in geriatric patientsaged 70-79 years.Keywords: elderly, SELENBP1, selenium.

Potential Nephrotoxicity of Lisinopril and Valsartan on Patients with Congestive Heart Failure Sarini Pani; Melisa I. Barliana; Eli Halimah; Venice Chaeriadi; Mally G. Sholih
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Lisinopril (angiotensin converting enzyme inhibitor) and valsartan (angiotensin II receptorblocker) are the first-line treatment for patients with congestive heart failure (CHF). Thesetwo drugs potentially cause side effects on renal functions. However, limited informationwas available regarding the comparison of potential nephrotoxicity of these drugs in IndonesianCHF patients. This research was aimed to compare the potential nephrotoxicitybetween lisinopril and valsartan in outpatients with CHF at a hospital in Palu, Indonesia.This was an observational study conducted during April-May 2015. Potential nephrotoxicitywere assessed by measuring serum creatinin (SCr) and blood urea nitrogen (BUN). Datawere obtained from Cardiology Unit from a hospital in Palu, Indonesia. Statistical analysiswas conducted using T-test and Mann-Whitney test. The increasing trend of SCr and BUNwere observed in lisinopril-treated patients with the mean of increase were 21% and 59%,respectively. Relatively higher increase was observed in valsartan treatment group with 47%and 51% in SCr and BUN, respectively. The analysis showed that there were significant differencesin SCr level between lisinopril and valsartan groups (p=0.001), but the oppositeresults observed in BUN parameter (p=0.697). Therefore, valsartan was potentially morenephrotoxic than lisinopril based on the increase of SCr parameter. Thus, lisinopril is recommendedfor CHF patients who are particularly at high risks of having renal impairment.Keywords: lisinopril, valsartan, nephrotoxicity, congestive heart failure

In Vitro Effectiveness of Neem Oil (Azadirachta Indica A. Juss) Shampoo as Anti Head Lice (Pediculus humanus capitis) Norisca A. Putriana; Azizul Hakim; Patihul Husni; Taofik Rusdiana
Pharmacology and Clinical Pharmacy Research Vol 4, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v4i3.25780

Head lice (Pediculus humanus capitis), a parasite causing hair problem, often occurs in society.The study aimed to evaluate in vitroeffectiveness of shampoo formulation containing neem oil as an anti head lice. An experimental method was used to examine the formulation of shampoo, irritation test, testing the effectiveness of shampoo against head lice (Pediculicidal activity), and testing the effectiveness of shampoo against nits (Ovicidal activity). The effectiveness test employed an in vitromethod where neem oil shampoo were tested directly towards head lices and nits isolated from humans, then the mortality was observed. To recognize the safety of the shampoo, skin and eye irritation tests were carried out by applying 0.5 ml on the skin and dripping 0.1 ml shampoo into New Zealand white rabbit’s eyes.Data were analyzed using Kruskal Wallis and Mann Whitney. The study results showed that the primary irritation index for 5%, 10%, 15%, and 20% neem oil shampoo were 0; 0111; 0.222; and 0.222, respectively. All of the shampoos were very mild irritation response category. Eye irritation tests showed that only the 20% neem oil shampoo gave a mild irritation response with degree of corneal opacity ≥ 1 and recovered after 7 days of observation. The 5%, 10%, 15%, and 20% neem oil shampoo were effective as an anti head lice. The 15% and 20% neem oil shampoo had anti head lice effectiveness activity as same as 1% permethrin lotion. In conclusion, the 15% neem oil shampoo was chosen as the best shampoo, its high anti head lice effect and light irritation response. Keywords: Head lice, neem oil (Azadirachta indica A. Juss), shampoo

Perinatal Propylthiouracil-Induced Hypothyroidism Impaired Motor Coordination in Adult Female Offspring Miski A. Khairinisa; Yusuke Takatsuru; Izuki Amano; Michifumi Kokubo; Asahi Haijima; Wataru Miyazaki; Noriyuki Koibuchi
Pharmacology and Clinical Pharmacy Research Vol 4, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v4i3.25264

Thyroid hormone (TH) play crucial roles in the growth and development of brain. Efficiency of TH during the perinatal period results in severe mental and physical retardation, known as cretinism in humans. Animal models have largely focused on mild and severe hypothyroidism associated with deficits in body weight, developmental delays, and cognitive deficits. Although various behavioral analyses have been reported, the effect of perinatal hypothyroidism in adult female mice has not been clarified. The aim of this study was to examine whether propylthiouracil (PTU)-induced hypothyroidism could impair motor coordination in female offspring. We used C57BL/6j mice and divided them into three groups based on the dose of PTU which was applied during perinatal period (embryonic day-14 to postnatal day-14); control, 5 ppm, and 50 ppm groups. We observed motor coordination function and additional nociceptive test in female offspring. We found that motor coordination and nociceptive threshold were affected in 50 ppm groups. We concluded that the moderate hypothyroidism could impair motor coordination in adult offspring.

Natural Antidiabetic of Tunjuk Langit (Helminthostachys zeylanica) Rhizome Extracts Fania E. Ridhasya; Hilwan Y. Teruna; Rudi Hendra; Muhammad Almurdani
Pharmacology and Clinical Pharmacy Research Vol 4, No 3
Publisher : Universitas Padjadjaran, Indonesia

The use of medicinal plants in treating diabetes mellitus is increasing in Indonesia. Plenty of plants from different regions may have anti-diabetic effect, including Helminthostachys zeylanica. This plant is commonly used as a traditional medicine to treat inflammation, cough, dysentery, and malaria in Talang Mamak tribe, Indragiri Hulu, Riau, however in China it is used to treat diabetic. Thus, we examined whether the extract of H. zeylanica originated from Riau have potential antidiabetic activity. We assessed the α-glucosidase inhibitory activity of the extract of H. zeylanica rhizome. The results showed the antidiabetic values of n-hexane, dichloromethane (DCM), ethyl acetate (EtOAc), methanol (MetOH), and ethanol (EtOH) extracts were 380.88 ± 0.09; 190.76 ± 0.22; 61.18 ± 0.59; 47.86 ± 0.06; and 60.78± 0.02, respectively. Acarbose were used as standard with antioxidant values of 19.73± 0.07. It can be concluded that the methanol extract is potential to be proposed as antidiabetic.

Anti-inflammatory Activity of the Gel Containing a Combination of Neem Leaf Extract and Shallot Extract Sara Nurmala; Moerfiah Moerfiah; Restu T. Purnama
Pharmacology and Clinical Pharmacy Research Vol 5, No 1
Publisher : Universitas Padjadjaran, Indonesia

Neem leaves (Azadirahcta indica A. Juss) and shallots (Allium cepa L) contain flavonoids that are effective as an antioxidant, antibacterial, and anti-inflammatory. The aim of this study was to determine the effective concentration and the duration of treatment of the anti-inflammatory activity of the gel containing a combination of neem leaf extract and shallot extract. These substances have a similar effect, and it is believed that these combinations may effective as an anti-inflammatory at small doses to reduce the side effects. The animals were randomly divided into 6 groups with 5 rats per group. The rats were wound-induced by incising its back (length 1.5 cm, depth 0.7 mm) and were observed for 8 days. Parameters measured were wound’s closure, color, and healing process. Statistical analysis showed that the most effective concentration as an anti-inflammatory was formula 1 (neem leaf extract 3.125%: shallots extract 4%) with the fastest healing time was 5 days. Thus, this formula is one of the effective treatment options for healing wounds.Keywords: neem leaves, shallots, anti-inflammatory, combination, gel

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Home Page

OAI Link

Editorial Team

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Reviewer

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Contact Name Widya Norma Insani, M.Sc., Apt.

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Journal Mail Official pcpreditorialteam@gmail.com

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Location Kota bandung, Jawa barat INDONESIA

Abstract

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Contact Name
Widya Norma Insani, M.Sc., Apt.

Contact Email
Widya Norma Insani, M.Sc., Apt.

Phone
-

Journal Mail Official
pcpreditorialteam@gmail.com

Editorial Address
-

Location
Kota bandung,

Jawa barat

INDONESIA