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Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
Arjuna Subject : -
Articles 207 Documents
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Effectiveness of Cognitive-behavioral Therapy for Generalized-Anxiety Disorders in Adolescents: A Systematic Review Using PICO Framework Suryanto, Rajwa Dwifauza; Gaharani, Prodio Efa; Salsabila, Salma; Finola Aziz, Calista Sasikirana; Khaerani, Fitri Azlia; Athaya, Salsabila; Setyowati, Lulu Alya; Kartadikaria, Elisya; Djamaluddin, Muhammad Ilham; Soewahju, Renata Bella Aprilana; Pitaloka, Dian Ayu Eka
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.53373

Abstract

A number of teenagers experience various levels of mental disorders, ranging from mild stress to Generalized Anxiety Disorder (GAD). According to the World Health Organization (WHO), approximately 264 million people suffer from anxiety disorders, including GAD, and this condition is a significant leading cause of suicide incidents, ranking sixth among serious mental health issues. From a societal perspective, Cognitive Behavioral Therapy (CBT) has the advantage of cost-effectiveness by minimizing the use of medications and enhancing productivity in education for adolescents receiving CBT. This study aims to conduct a systematic review of the existing literature on GAD in adolescents, using the PICO format method and formulating relevant research questions (RQ). Based on research that has been done, CBT has a relevant effect on some cases of GAD experienced by adolescents, although in some conditions CBT needs to be combined with antidepressants.
Identification of Drug Related Problems (DRPs) Based on Drug and Dosage Selection in Type 2 Diabetes Mellitus Patients Wijaya, Dhani; Rahmadanita, Fathia Faza; Atmaja, Ria Ramadhani Dwi; Syarifuddin, Sadli; Mutiah, Roihatul; Habibah, Atiqoh Nur; Nafisah, Fika Sayyidatun
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.61653

Abstract

Pharmacological therapy for type 2 diabetes mellitus involves more than one type of drug, this increases the potential for Drug Associated Problems (DRPs) in terms of selecting the type and dose of the drug. This study aimed to determine the treatment profile and identify the occurrence of DRPs based on drug selection and dosage in patients with type 2 diabetes mellitus. This descriptive observational study was conducted in October 2022 in the medical record room of one general hospital in Batu, East Java. The study sample was obtained by total sampling using 36 medical records of inpatients with type 2 diabetes mellitus without complications. Identification of DRPs based on The Pharmaceutical Care Network Europe (PCNE) V.9.1 guidelines. The results showed that glimepiride (6.45%), insulin (16.13%), a combination of metformin and glimepiride (3.23%), a combination of metformin and insulin (3.23%), and basal-bolus insulin (67.74%) were antidiabetic drugs used by patients. Based on the drug selection, 17 patients were identified as having DRPs where the use of drugs without indication (38.89%) was the most common case. Meanwhile, DRPs based on dose selection were found in 6 patients with 13.89% of cases being too high a drug dose. Based on this study, it can be concluded that there are cases of DRPs based on drug selection and dosage in patients with type 2 diabetes mellitus so improved pharmaceutical services are needed to address this to improve patient safety.
Phytochemical and Nutritional Composition of Vernonia Amygdalina: Antioxidant, Antidiabetic Efficacy, and Hematological Benefits Adewuyi, Hassan Abdulsalam
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.59067

Abstract

Vernonia amygdalina, a traditionally used medicinal plant, has been purported to possess health-promoting properties.The aim of this study is to investigate the phytochemical and nutritional composition of V. amygdalina, evaluate its antioxidant and antidiabetic efficacy, and assess its hematological benefits. Phytochemical screening, proximate analysis, antioxidant assays (DPPH, ABTS), antidiabetic evaluations in streptozotocin-induced diabetic rats, and hematological assessments were conducted according to standard protocol. V. amygdalina exhibited a rich phytochemical profile, comprising flavonoids, phenolic acids, and terpenoids, alongside significant antioxidant activity (IC50 = 12.5 μg/mL) and complete source of protein. Proximate analysis revealed high protein (21.1%) and fiber (15.6%) content. Antidiabetic evaluations demonstrated significant reductions in blood glucose levels (p < 0.01). Hematological assessments showed significant improvements in hemoglobin (14.1 ± 0.6 g/dL), packed cell volume (42.9 ± 1.8%), red blood cell count (7.1 ± 0.3 x 10^12/L), and differential WBC count, including reduced monocyte (6.3 ± 0.9%) and eosinophil (2.6 ± 0.6%) percentages, and increased lymphocyte (34.4 ± 2.4%) percentage. This study provides comprehensive evidence for the phytochemical, nutritional, and pharmacological value of V. amygdalina, underscoring its potential as a functional food and phytomedicine for oxidative stress and diabetes management, as well as a natural adjunct for improving hematological parameters. 
Effectiveness of Pharmacist-Led Intervention for Hepatitis C Patients - A Systematic Review Surya, Geraldo; Angelica, Angelica; Amalia, Zerra Rizki; Nisrina, Diflaa Kayla; Insani, Widya Norma
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.64176

Abstract

Background: Pharmacist-led interventions, encompassing patient education, adherence monitoring, and personalized care, have emerged as a critical strategy to optimize treatment outcomes in Hepatitis C (HCV) management, particularly in improving Sustained Virologic Response (SVR) and mitigating drug-related challenges.Objective: This review assesses the impact of pharmacist-led interventions on key HCV patient outcomes, including SVR rates, medication adherence, and the management of Adverse Drug Reactions (ADRs) and Drug-Drug Interactions (DDIs).Methods: A systematic search was conducted on PubMed database for studies published between January 2000 and December 2024, following PRISMA guidelines. The search included Randomized Controlled Trials (RCTs), cohort, and retrospective studies. An initial search identified 192 records, from which 12 studies were included in the review. Result: In hepatitis C management, pharmacists intervened in many ways including direct close monitoring, patient education, and individualized care which led to enhanced clinical outcomes and improved patient engagement. Most included studies, both RCTs and Observational studies showcased high SVR rates. Some studies that demonstrated lower SVR rates or did not differ significantly from the control group were due to more complex patient demographics.  Recorded improvements also included medication adherence, patient engagement, and effective management of ADRs and DDIs. Conclusion: The findings indicate that pharmacist-led interventions demonstrated predominantly positive impacts on clinical outcomes. However, the evidence is limited by variations in study design and shortage of RCTs. Further research with standardized protocols is recommended to better define the role of pharmacists in HCV care.
Antioxidant Properties Of N-Hexane Extract From Tobacco Leaves (Nicotiana tabacum L.) Using 2,2-Diphenyl-1-Picrylhydrazil (DPPH) Method Patricia, Vinda Maharani; Az-zahra, Dhea Khairunnisa; Fakih, Taufik Muhammad; Suarantika, Farendina
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.59372

Abstract

Tobacco (Nicotiana tabacum L.) is a commercial plant that often used for making cigarettes. In 2012, the government issued regulations for the diversification of tobacco products besides cigarettes. Some of these diversified tobacco products include organic pesticides, anesthetics, cosmetic ingredients, and biochar as an alternative to coal. Therefore, in order to further to diversification of tobacco product, this study aimed to determine the antioxidant activity from n-hexane extract from leaves using the Soxhlet extraction method. Antioxidant activity was assessed by the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, while the total phenolic content was determined using the Folin-Ciocalteu method that allowed quantification of phenolic compounds in the extract, which possesses the role of antioxidant. The IC50 value obtained from the antioxidant activity assay of the n-hexane extract of tobacco leaves was 426.042 μg/mL, classified as very weak. Meanwhile, the total phenolic content was 51.93 mg GAE/g. These results suggest that the high total phenol content may have other potential activities that can be tested, such as antibacterial activity.
Efficacy of Angiotensin Receptor Blockers (Valsartan, Candesartan, Losartan) in Lowering Blood Pressure: A Systematic Review Maharani, Shafa Shaomi; Destiani, Dika Pramita
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.59629

Abstract

Hypertension is a significant health issue that significantly increases the risk of cardiovascular disease. Angiotensin II receptor blockers (ARBs) are commonly used in Indonesia to treat hypertension, yet comprehensive comparative efficacy data within this drug class remain limited. This review seeks to evaluate the blood pressure-lowering efficacy of three particular angiotensin receptor blockers (ARBs)—Valsartan, Candesartan, and Losartan—in individuals diagnosed with hypertension. This systematic review identified randomized controlled trials (RCT) obtained from PubMed and Google Scholar using several keyword combinations. Among 20 RCTs with 6.425 patients treated with three ARBs, all included studies demonstrated significant blood pressure reductions. The mean reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP) were the greatest for Candesartan (-18.69/-10.25 mmHg), followed by Losartan (-14.80/-7.8 mmHg), and Valsartan (-8.94/-7.58 mmHg). Candesartan achieved the largest reduction, decreasing baseline systolic blood pressure (SBP)/diastolic blood pressure (DBP) by 38.16/18.95 mmHg over 12 weeks. In contrast, Valsartan showed the smallest reduction, with SBP decreasing by 0.81/0.04 mmHg after 66 months. It can also be linked to the pharmacokinetic properties of the drugs, where Valsartan has a higher bioavailability, and Losartan has a lower bioavailability compared to the other ARBs. It can be concluded that ARBs, including Valsartan, Candesartan, and Losartan, are generally effective in reducing blood pressure in hypertensive patients, with Candesartan showing the greatest efficacy. Future research should involve direct comparative trials of Valsartan, Candesartan, and Losartan, along with studies on their molecular mechanisms, to increase effective hypertension treatments.
Comprehensive In Silico Analysis Of Bioactive Compounds From Pyrrosia piloselloides Leaves As Xanthine Oxidase Inhibitors Sinuhaji, Masira Sony Crespo; Havid, Husnul; Ysrafil, Ysrafil; Alexandra, Francisca Diana
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.60233

Abstract

This study aimed to evaluate the potential of bioactive compounds from Pyrrosia piloselloides leaves as xanthine oxidase (XO) inhibitors through an in silico approach. Methods included molecular docking and molecular dynamics simulations to identify the binding affinity of test compounds to XO. Among 59 screened compounds, 3 compounds (2,6,10,14,18,22-Tetracosahexaene, 6-Hydroxymethaqualone, and β-Sitosterol acetate) exhibited the lowest binding energy in comparison to the control, Allopurinol, with key residue contributions from GLU 802, ARG 880, and THR 1010. Molecular dynamics simulations confirmed the interaction stability, with β-Sitosterol acetate showing the lowest total binding free energy (-46.23 ± 0.66 kcal/mol). ADMET predictions revealed promising pharmacokinetic profiles for these compounds. This study highlights Pyrrosia piloselloides as a promising source of novel XO inhibitors, with further validation required through in vitro and in vivo experiments.

Page 21 of 21 | Total Record : 207

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