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JSFK (Jurnal Sains Farmasi & Klinis)
Published by Universitas Andalas
ISSN : 24077062     EISSN : 24425435     DOI : 10.25077
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.
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Articles 533 Documents
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Nanotechnology-Based Formulations of Propolis Bioactives for Modern Natural Product Therapy: A Narrative Literature Review: A Narrative Literature Review Yandi Syukri; Najwah Saffanah Alivuelsa; Hannie Fitriani; Hendra Budiman
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 02 (2026): J Sains Farm Klin 13(2), August 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.02.137-151.2026

Abstract

Propolis contains phenolic acids, flavonoids, and other bioactive metabolites with antimicrobial, anti-inflammatory, antioxidant, wound-healing, and anticancer activities. However, their therapeutic application is limited by poor aqueous solubility, physicochemical instability, and low bioavailability. This narrative review summarizes recent advances in nanotechnology-based formulations developed to improve the delivery of propolis extracts and identified bioactive compounds. A structured search of Scopus, ScienceDirect, and PubMed identified studies published between 2022 and 2026, with the final search completed on 31 July 2026. Of 333 records retrieved, 25 studies met the eligibility criteria. Reported nanocarriers included nanoemulsions, polymeric and chitosan nanoparticles, lipid nanoparticles, niosomes, nanovesicles, micelles, dendrimers, protein- and starch-based nanoparticles, metal–organic frameworks, and injectable hydrogels, with particle sizes ranging from 8.87 to 488.28 nm. These systems generally enhanced solubility, bioaccessibility, controlled release, and biological efficacy in antimicrobial, wound-healing, anticancer, anti-inflammatory, periodontal, and cardiovascular models. Nevertheless, evidence remains preclinical and methodologically heterogeneous. Future studies should emphasize standardized chemical and nanocarrier characterization, pharmacokinetics, long-term safety, and clinical validation. Unlike previous reviews, this study systematically links identified propolis bioactives with specific nanocarriers, providing a framework for the rational development of clinically translatable propolis nanomedicines.
Questionnaire for Assessing Knowledge and Self-Reported Antipsychotic Dispensing Practices Among Indonesian Pharmacists: A Rasch Analysis of Validity Evidence Reina Melani; Lukman Hakim; Genialita Fadhilla; Muhammad Jayyid Zidan; Renanda Nabila Putri; Ikhwan Yuda Kusuma
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 02 (2026): J Sains Farm Klin 13(2), August 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.02.152-167.2026

Abstract

Inappropriate dispensing of antipsychotic medications may cause preventable medication-related harm, yet validated instruments for assessing pharmacists’ knowledge and dispensing practices remain limited in Indonesia. This study evaluated the Rasch measurement properties of a questionnaire developed for Indonesian pharmacists. A cross-sectional survey was conducted among 642 pharmacists recruited through convenience sampling using professional pharmacy networks and online communication platforms. Participants completed a 22-item instrument comprising 12 dichotomous knowledge items and 10 five-category practice items. 22-item instrument comprising 12 dichotomous knowledge items and 10 five-category self-reported practice items. The two domains were analysed separately using the Rasch model, assessing person and item fit, unidimensionality based on principal component analysis of standardized residuals (with a first-contrast eigenvalue <2.0), reliability, separation, item-person targeting, and sex-related differential item functioning. Item fit was evaluated using Infit and Outfit mean-square (MNSQ) statistics, with values between 0.5 and 1.5 considered acceptable. Mean person and item infit and outfit mean-square values were close to 1.00 in both domains. Person reliability was 0.78 for knowledge and 0.86 for practice, item reliability was 1.00 in both domains, and Cronbach’s alpha values were 0.76 and 0.87, respectively. The Rasch measures explained 60.5% of the variance in knowledge and 69.5% in practice. Wright maps showed satisfactory central targeting, and no visually apparent moderate-to-large sex-related differential item functioning was identified. Overall, the instrument demonstrated satisfactory initial Rasch-based validity and reliability, although further validation in geographically balanced samples and comparison with observed dispensing behaviour are warranted.
Cost-Effectiveness of Anthracycline, Cyclophosphamide-Taxane (AC-T) Chemotherapy Based on Diagnostic Delay Status: A Payer Perspective Fitri Handayani; Almahdy Almahdy; Yelly Oktavia Sari; Najmiatul Fitria
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 02 (2026): J Sains Farm Klin 13(2), August 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.02.168-182.2026

Abstract

Diagnostic delay in breast cancer accelerates disease progression and escalates healthcare expenditures under the National Health Insurance (Jaminan Kesehatan Nasional/JKN) program. This study aimed to evaluate the cost-effectiveness of 8-cycle anthracycline, cyclophosphamide-taxane (AC-T) chemotherapy regimen based on diagnostic delay status  from the perspective of the Social Security Agency for Health (BPJS Kesehatan). A retrospective cohort study  was conducted on 49 breast cancer patients at RSUP Dr. M. Djamil Padang, stratified into neoadjuvant (n = 23) and adjuvant (n = 26) arms, evaluating prospective INA-CBGs claim tariffs and serum CA 15-3 kinetics as a surrogate response biomarker. In the neoadjuvant arm, the non-delay group achieved significant within-group biomarker reduction (p = 0.007; net change: 4.69 vs. 0.31 μ/mL, between-group p = 0.231) and saved IDR 10,125,271 per patient (ICER: -IDR 2,311,706/μ/mL, dominant).  In the adjuvant arm, diagnostic delay was associated with post-mastectomy biomarker elevation (-17.25 μ/mL), whereas non-delay saved IDR 10,396,936 per patient (ICER: -IDR 563,520/μ/mL, dominant). Probabilistic sensitivity analysis (10,000 iterations) confirmed 100% stability in Quadrant II of the Cost-Effectiveness Plane across both arms. Prompt diagnosis demonstrates economic dominance by curbing public reimbursement expenditures alongside favorable surrogate biomarker trajectories, supporting the macroeconomic value of strengthening early detection policies.

Page 54 of 54 | Total Record : 533

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