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JSFK (Jurnal Sains Farmasi & Klinis)
Published by Universitas Andalas
ISSN : 24077062     EISSN : 24425435     DOI : 10.25077
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.
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Articles 533 Documents
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Potentially Inappropriate Medications (PIMs) in Elderly Hypertensive Inpatients using 2023 AGS Beers Criteria: A Cross-Sectional Study : Prevalence and predictors of PIM exposure among elderly inpatients Humaira Issa; Retnosari Andrajati; Nadia Farhanah Syafhan; Muhammad Adil Khan
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.38-46.2026

Abstract

Polypharmacy and complex pharmacotherapy are common in older adults with hypertension and increase the risk of potentially inappropriate medications (PIMs). This study aimed to determine the prevalence, pattern, and predictors of PIM exposure among elderly hypertensive inpatients at Universitas Indonesia Hospital (RSUI) using the American Geriatrics Society 2023 updated AGS Beers Criteria®. A retrospective cross-sectional study was conducted using de-identified electronic medical records. From 1,265 admissions screened in 2023-2024, 200 hypertensive inpatients aged 65 years or older were included. Inpatient prescriptions were evaluated using the 2023 AGS Beers Criteria and classified by Beers categories. Logistic regression was used to identify predictors of PIM exposure. The mean age was 72.1 ± 6.5 years, and 55.0% were female; polypharmacy (≥5 medications) occurred in 85.5%. Overall, 83.0% received at least one Beers-listed medicine, most commonly Category 3 (“use with caution”) PIMs (72.5%), followed by Category 1 (“avoid”) (26.0%) and Category 4 (23.0%). Diuretics (furosemide, hydrochlorothiazide) and clonidine were frequent PIM-related medications. Polypharmacy was the only significant independent predictor of PIM exposure. These findings support systematic medication review and deprescribing-focused interventions during hospitalization.
Optimization of Fermentation Condition for Hydrolytic Enzyme Production by Endophytic Bacteria from Kleinhovia hospita L. Armini Syamsidi; Ni Gusti Ayu Puja Erawati; Angelika Brigita Ali; Indriati; Aurelia Amarilis; Wa Ode Sitti Musnina
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.47-60.2026

Abstract

Kleinhovia hospita L. is a tropical Indonesian medicinal plant that hosts endophytic bacteria capable of producing hydrolytic enzyme proteins through fermentation. Enzyme production is influenced by fermentation pH and temperature, which affect enzymatic reactions, microbial growth, and enzyme synthesis. This study evaluated the activity of hydrolytic enzymes produced by endophytic bacteria isolated from K. hospita L. and examined were the effects of fermentation pH and temperature at pH 5, 7, and 10 and temperatures of 28, 34, and 40 °C. Enzyme activity was analyzed using the well diffusion method, and enzyme protein content was measured using the biuret method with BSA as a standard. The highest protein concentrations were observed at pH 5 in isolate KHD1 (507.5 mg/mL), pH 7 in isolate KHD2 (560 mg/mL), and pH 10 in isolate KHB1 (607.5 mg/mL). All isolates showed amylase activity, with the highest clear zone diameter recorded in isolate KHD2 (12.79 ± 0.24 mm). Pectinase and esterase activities were highest in isolates KHD1 and KHB1, respectively, while isolate KHA1 exhibited the highest lipase, cellulase, and protease activities. Fermentation pH and temperature significantly affected hydrolytic enzyme protein activity, indicating that endophytic bacteria from K. hospita L. are promising sources of hydrolytic enzymes.
Computational Screening of Functional Monomers for Esculetin Recognition Using a Semiempirical Tight-Binding Approach Dia Indah Azhari; Akmal Djamaan; Aiyi Asnawi; Purnawan Pontana Putra
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.61-69.2026

Abstract

Esculetin is a bioactive coumarin derivative with reported antioxidant, anti-inflammatory, and anticancer activities. Despite its pharmacological relevance, achieving selective molecular recognition of esculetin in complex systems remains challenging. Computational screening of functional monomers offers a rational strategy to identify candidates capable of forming stable noncovalent interactions with the target molecule. In this study, 21 monomers were evaluated using a semiempirical extended tight-binding (xTB) approach. Initial screening was performed through automated interaction site screening (aISS) to estimate interaction energies. The aISS results identified 4-vinylbenzeneboronic acid as having the most favorable interaction energy (-312.87 kcal/mol), followed by 2-Acrylamido-2-methyl-1-propanesulfonic acid (-25.34 kcal/mol), p-vinylbenzoic acid (-24.71 kcal/mol), trans-3-(3-pyridyl)acrylic acid (-23.04 kcal/mol), and 9-vinylcarbazole (-22.17 kcal/mol). To evaluate dynamic stability, selected complexes were subjected to molecular dynamics simulations. The results showed that 2-Acrylamido-2-methyl-1-propanesulfonic acid exhibited the lowest average energy (-76.301 kcal/mol), followed by p-vinylbenzoic acid (-70.03 kcal/mol) and 4-vinylbenzeneboronic acid (-69.70 kcal/mol). Metadynamics simulations further confirmed this trend, with total energy (Etot) values of -76.23 kcal/mol, -69.96 kcal/mol, and -69.64 kcal/mol for the same monomers, respectively. The consistency between molecular dynamics and metadynamics analyses indicates that 2-Acrylamido-2-methyl-1-propanesulfonic acid forms the most energetically stable complex with esculetin under simulated conditions. This study provides a computational basis for selecting functional monomers for esculetin recognition systems and supports further experimental validation.
A Novel Postbiotic Patch Formulation Using Pediococcus acidilactici BK01 for Anti-Acne Applications Lidia Armayeni; Rini Agustin; Sri Melia; Adhitya Jessica
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.70-83.2026

Abstract

Acne is an inflammatory skin disorder often associated with infection by Cutibacterium acnes. Postbiotics in the form of cell-free supernatant (CFS) from Pediococcus acidilactici BK01 contain lactic acid, bacteriocins, and hydrogen peroxide, which exhibit potential antibacterial activity. This study aimed to formulate P. acidilactici BK01 CFS into a topical patch and evaluate its activity against C. acnes. Antibacterial activity and minimum inhibitory concentration (MIC) were determined using the well-diffusion method. The MIC (6.25%) was used to formulate patches via solvent-casting with HPMC K4M or PVA (2–4%) as polymers and glycerin, propylene glycol, or PEG 400 (0.2–0.6%) as plasticizers. The selected formulation was evaluated for antibacterial activity and physical characteristics. A combination of 4% PVA and 0.6% glycerin produced the best base and was used to prepare patches containing 6.25–75% CFS. The 65% CFS patch showed the highest inhibition against C. acnes ATCC 11827 (12.03 ± 0.373 mm), categorized as strong. The patch demonstrated acceptable organoleptic properties, thickness, folding endurance, pH, moisture content, and tensile strength. These findings indicate that the 65% CFS patch has potential as a topical anti-acne preparation.
Analysis of Porcine Gelatin in Hard Capsule Shells by Using A Combination of FTIR and Principal Component Analysis Methods Zilhadia; Mabrurotul Mustafidah; Herdini; Chairul Amin Muhammad
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.84-89.2026

Abstract

This study aims to conduct a halal analysis of hard capsule shells by using a combination of Fourier Transform Infrared (FTIR) and Principal Component Analysis (PCA) methods. The study was conducted by extracting gelatin from commercial hard capsule shells containing drugs and then measuring their absorbance by using FTIR. As a comparison, gelatin extracted from a simulated hard capsule shell was used. The FTIR spectrum data was analyzed by using PCA. The results of the analysis showed that the FTIR spectra of bovine and porcine gelatin were very similar, but PCA could classify the differences. The absorbance (appearing as a spectrum peak), which plays a significant role in the classification of bovine and porcine gelatin, was at wavenumbers 1455 cm-1 and 1409 cm-1. The PCA analysis showed that samples A and D had properties similar to porcine gelatin, sample C had properties similar to hard capsule shells made from porcine gelatin, sample B had properties similar to bovine gelatin, and sample E had properties similar to hard capsule shells from bovine gelatin. These results indicate that bovine gelatin and porcine gelatin in simulated hard capsule shells can be distinguished based on the FTIR spectrum combined with PCA. Commercial hard capsule shells can be classified based on their similar properties to bovine and porcine gelatin. However, this research could not confirm the exact source of the gelatin.
Rapid Release ODF Loaded with Ketoprofen– Tromethamine Multicomponent Crystals: Formulation and Evaluation Indah Syahrani; Adhitya Jessica; Erizal Zaini
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.90-100.2026

Abstract

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) with low solubility and limited bioavailability. To enhance its solubility, ketoprofen was modified into a multicomponent crystal with tromethamine using the solvent evaporation method. The ketoprofen–tromethamine multicomponent crystal was then formulated into an orally dissolving film (ODF) to produce a dosage form that rapidly disintegrates in the oral cavity. The ODF was prepared by the solvent casting method, with variations in HPMC K4M as the film-forming polymer and PEG 400, propylene glycol, and glycerin as plasticizers. The formulations were evaluated based on organoleptic properties, thickness, pH, folding endurance, moisture content, swelling index, disintegration time, and dissolution profile. The optimal formulation was identified in F07, which consisted of 2% HPMC K4M and 30% PEG 400, resulting in a film with the best physical and mechanical properties and a disintegration time of 37.21 ± 1.93 seconds. These findings indicate that the ketoprofen–tromethamine multicomponent crystal ODF improves dissolution performance and meets the criteria for fast-disintegrating dosage forms, suggesting its potential as an effective alternative for patients with swallowing difficulties.
Nanoemulgel Based Delivery of Pometia pinnata Leaf Extract as a Potent Antioxidant Larysa Fernenda; Kony Putriani; Asiska Permata Dewi; Elsa Nurita; Bintang Indragiri; Yandi Syukri
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 02 (2026): J Sains Farm Klin 13(2), August 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.02.101-107.2026

Abstract

This study aimed to formulate and evaluate a nanoemulgel containing ethanol extract of Pometia pinnata leaf as a topical antioxidant preparation. The extract was obtained through maceration using 96% ethanol, then formulated into a nanoemulsion and incorporated into a gel base containing Carbopol 940 at concentrations of 0.5%, 1%, and 2%. The evaluations included organoleptic test, homogeneity, pH, spreadability, viscosity, physical stability, and antioxidant activity, using the DPPH method with IC₅₀ as the parameter. The results showed that all formulations met acceptable physical criteria.  The pH values ranged from 4.86 to 5.49, while the spreadability ranged from 4.81 to 5.95 cm. The best formulation was the nanoemulgel containing 2% Carbopol, which showed an IC₅₀ value of 88.78 ppm, indicating strong antioxidant activity. These findings suggest that the Pometia pinnata ethanolic leaf extract nanoemulgel has promising potential as a topical antioxidant formulation for preventing premature skin aging.
Effects of Extra Virgin Olive Oil and Virgin Coconut Oil Combination on Hematologic Profiles in a Rat Model of Preeclampsia Elsa Badriyya; Mutiara Venni; Rahmanisa Dwi Putri; Almahdy A
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 02 (2026): J Sains Farm Klin 13(2), August 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.02.108-117.2026

Abstract

Preeclampsia is a hypertensive disorder of pregnancy marked by systemic inflammation, oxidative stress, and endothelial dysfunction. Extra-virgin olive oil (EVOO) and Virgin Coconut Oil (VCO) are natural antioxidants with potential therapeutic benefits. This study aims to determine the effect of EVOO, VCO, and their combination on blood pressure and hematologic profiles in a preeclampsia-induced rat model using N-nitro-L-arginine methyl ester (L-NAME). A total of 25 pregnant Wistar rats were divided into five groups: negative control (PBS), positive control (L-Name 75 mg/kgBW), EVOO (4.5 mL/kg BW/day), VCO (4.45 mL/kg BW/day), and EVOO+VCO (2.25 mL each/ kg BW/day). The treatment was given orally from gestational day 1, and L-NAME was injected intraperitoneally from day 9 to 18 of gestation. The data were statistically analyzed using one-way ANOVA. Results showed that the EVOO+VCO group reduced systolic and diastolic blood pressure more than the positive control and single-treatment groups (p<0.001). Hematological parameters also differed significantly (p<0.001): hemoglobin (12.34 ± 0.67 g/dL), erythrocyte count (6.29 ± 0.52 × 10⁶/μL), and platelet count (1310.80 ± 67.33 × 10³/μL) increased, whereas leukocyte count decreased (8.06 ± 0.37 × 10³/μL). Erythrocyte indices also improved. Overall, combined EVOO and VCO showed greater protective effects than either treatment alone, suggesting potential benefit for blood pressure control and hematological disturbances associated with preeclampsia.
Appropriateness of Bronchodilator Therapy and Its Association with Exacerbation and Hospitalization among Asthma Outpatients: A GINA 2024-Based Assesment Asniar Pascayantri; Wahyuni; Nita Trinovitasari; Rachma Malina; Muhamad Andriawan; Andi Asrianty
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 02 (2026): J Sains Farm Klin 13(2), August 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.02.118-127.2026

Abstract

Bronchodilator use and inadequate therapy escalation may increase the risk of asthma exacerbations and hospitalization. This study evaluated treatment-related factors and its association with exacerbation and hospitalization among asthma outpatients. A retrospective cross-sectional study was conducted using medical records of asthma outpatients at RSUD Kota Kendari over a 1-year observation period (January–December 2024). A total of 94 eligible patients were included. Treatment-related factors comprising ICS–LABA therapy, inhalation route appropriateness, dosing appropriateness, therapy escalation with add-on LAMA, and SABA overuse were analyzed using bivariate analysis. ICS-LABA was associated with the lower risk of exacerbation (OR = 0.276; 95% CI: 0.104–0.735) and hospitalization (OR = 0.201; 95% CI: 0.072–0.559). Correct dosing was associated with lower risks of exacerbation (OR = 0.142; 95% CI: 0.052–0.390) and hospitalization (OR = 0.116; 95% CI: 0.039–0.343). Inhalation therapy showed a strong protective effect against exacerbation (OR = 0.078; 95% CI: 0.022–0.282) and hospitalization (OR = 0.059; 95% CI: 0.016–0.218). Lack of therapy escalation with add-on LAMA markedly increased the risk of exacerbation (OR = 17.889; 95% CI: 3.898–82.091) and hospitalization (OR = 14.000; 95% CI: 3.040–64.473). SABA overuse was strongly associated with higher likelihood of exacerbation (OR 10.833; 95% CI:2.987-39.288) and hospitalization (OR=14.167; 95% CI: 3.815-52.605). Asthma outcomes were mainly influenced by treatment-related factors. Optimizing inhaled controller therapy and applying stepwise treatment escalation according to GINA are essential to lower the risk of exacerbations and hospitalization.
The The Role of Pharmacists in Pharmaceutical Services and Care for Menopausal Women: A Narrative Review Nur Irhamni Sabrina; Lydia Septa Desiyana; Azizah Vonna; Okpri Meila; Tedy Kurniawan Bakri; Meutia Faradilla
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 02 (2026): J Sains Farm Klin 13(2), August 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.02.128-136.2026

Abstract

Menopause is an anticipated physiological change in women marked by the end of the menstrual cycle, The complexity of its symptoms requires comprehensive and multidisciplinary interventions, including support from pharmacists. This article aims to review the pharmacist’s function in pharmaceutical care for menopausal women. The analysis was conducted narratively, highlighting key themes related to pharmacists' understanding of hormone replacement therapy (HRT) and non-pharmacological interventions, the types of pharmaceutical services provided, and challenges in practice implementation. Based on literatures obtained, it is indicated that pharmacists play a crucial function in education, counseling, therapy monitoring, and promoting a healthy lifestyle for menopausal women. Pharmacist involvement has been shown to improve patient knowledge, therapy adherence, treatment efficacy, and the prevention of long-term complications such as diabetes, osteoporosis, and cardiovascular disease. However, challenges such as limited knowledge, lack of training, limited consultation privacy, and low patient awareness of the pharmacist's role remain. In conclusion, strengthening the role of pharmacists in pharmaceutical care for menopausal women is crucial for improving patients' quality of life, and further research is needed to develop more innovative and sustainable intervention models.

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