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JSFK (Jurnal Sains Farmasi & Klinis)
Published by Universitas Andalas
ISSN : 24077062     EISSN : 24425435     DOI : 10.25077
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.
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Articles 509 Documents
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Metabolomic and Cytotoxicity Profiles of Ethanol Extract of Peronema canescens Jack on Human Non-small Lung Cancer Cell A549 Anjayani, Nuri; Amalia, Senya Putri; Sukmarini, Linda; Tamhid, Hady Anshory; Primahana, Gian; Triastuti, Asih
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.7-14.2025

Abstract

Cancer has a high prevalence and mortality in the world. Cancer treatment is still hampered by high levels of side effects, drug resistance and the lack of affordable prices for anticancer drugs. It is necessary to develop new anticancer drugs to help overcome this problem. One of the plants that has the potential to be developed as an anticancer drug is Sungkai (Peronema canescens Jack). This study aims to determine the cytotoxic activity of sungkai leaf and identify its metabolomic profile. The sungkai leaves were macerated for 24 hours with 96% ethanol. Metabolomic profiles were analyzed with Ultra High-Performance Liquid Chromatography-High Resolution Mass Spectrometry (UHPLC-HRMS). Chemical structure identification was performed by MS-DIAL and MS-FINDER platforms. The ethanol extract of sungkai leaves was analyzed for its cytotoxic activity using the MTT test on A549 lung cancer cells and its selectivity on normal HDFa fibroblast cells. The ethanol extract of sungkai showed IC50 105,21 µg/mL on A549 cells and no cytotoxic activity against normal HDFa cells. Based on the metabolomic analysis, 7 furano terpenoid compounds were detected in the ethanol extract, namely peronemin A2; A3; B1; B2; B3: C1; and D1 along with other compounds. In conclusion, the ethanol extract of P. canescens leaves has cytotoxic and selective activity against A549 lung cancer cells, and potential to be further developed as an anticancer drug candidate. Peronemins and other substances like flavonoids and polyphenols may be linked to the cytotoxic properties of sungkai leaves
A Comprehensive Review of Solid Self Nano Emulsifying Drug Delivery System (S-SNEDDS) Technology to Enhance Nanoemulsion Stability Yandi Syukri; Syafira Tri Nurmala Sari; Arba Pramundita Ramadani
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.15-28.2025

Abstract

Patients and practitioners prefer oral medication administration for systemic or local treatment due to its convenience and pleasurable experience. Nevertheless, numerous oral pharmaceutical formulations encounter various delivery challenges as a result of the hostile conditions of the gastrointestinal tract and a multitude of physiological barriers, including gastrointestinal architectural traits, biochemical variables, and physiological factors. Nanoparticle technology is often employed to surmount these challenges. Nanoemulsions, a form of nanotechnology, have been shown to improve the bioavailability and solubility of active pharmaceutical ingredients. However, despite these advantages, they often encounter adjustment challenges related to physical and chemical stability, necessitating the development of advanced delivery systems to ensure their therapeutic efficacy. Furthermore, liquid dosage forms may present several limitations for oral administration, such as inadequate masking of unpleasant tastes in the absence of flavoring agents or sweeteners, as well as difficulties in achieving accurate doses. Another potential method to enhance the stability of the drugs is the Solid Self Nano Emulsifying Drug Delivery System (S-SNEDDS). This lipid-based drug delivery device utilizes a particular porosity carrier and a Liquid SNEDDS compaction process. The S-SNEDDS formulation is a potential method of delivering medications for active substances not soluble in water, sensitive to light, or unstable in liquid form. It also exhibits benefits such as excellent stability, straightforward scalability, consistent content distribution, precise dosage accuracy, and improved patient adherence. Encapsulation of hydrophobic pharmaceuticals protects against the aqueous environment, impeding hydrolysis and enhancing the drug's stability when exposed to moisture. Another mechanism of S-SNEDDS is the controlled release mechanism, which can also enhance the drug's stability in terms of its chemical composition and therapeutic effectiveness. Therefore, S-SNEDDS have the potential to provide a viable approach to improving the stability of nanoemulsions.
Cost-Effectiveness of Oseltamivir and Favipiravir in Covid-19 Patients: a Cost-Effectiveness Analysis Study in a Hospital Yusransyah, Yusransyah; S.farm, Baha Udin
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.29-35.2025

Abstract

The COVID-19 pandemic poses not only a threat to health but also to the global economy, including healthcare costs. Although there is no specific drug for COVID-19 patients, there are antiviral drugs such as oseltamivir and favipiravir that can be used to treat COVID-19. The purpose of this study was to determine the most cost-effective antiviral therapy between oseltamivir and favipiravir for COVID-19 patients in one of the hospitals in Banten province. The pharmacoeconomic method used in this study was cost-effectiveness analysis by calculating the Average Cost-Effectiveness Ratio (ACER) and Incremental Cost-Effectiveness Ratio (ICER). The results of this study showed that the ACER value of the favipiravir group (IDR  364,010 (n = 7)) was lower than the oseltamivir group (IDR 431,744 (n = 7)), with an ICER value of IDR  60,605. Based on the results of the Mann-Whitney test, there was no significant difference between the costs of the favipiravir and oseltamivir groups (p value 0.940). The sensitivity test showed that the cost of medical consumables was the cost that had the greatest impact on cost-effectiveness. Based on the calculation results, it can be concluded that the favipiravir group is more cost-effective than the oseltamivir group.
Determination of Total Phenolic Content and Antioxidant Activity of Epigallocatechin Gallate Rich Fraction from Tea Leaves (Camellia sinensis L.) Amelia, Puteri; Citraningsih, Kinanti; Dewi, Asri Kusuma; Anggia, Vivi; Anggraeni, Yuni
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.36-40.2025

Abstract

The tea plant, Camellia sinensis L., is a well-known natural product with significant health advantages. The main catechin found in green tea leaves is epigallocatechin gallate (EGCG), which has potent antioxidant properties. EGCG is a common active ingredient in products from the medical and cosmetics industries. This study examines the antioxidant properties and total phenolic content (TPC) of an EGCG-rich fraction (ERF) that is extracted from green tea leaves. TPC was quantified using the Folin-Ciocalteu method, with absorbance measured via UV-VIS spectrophotometry at 760.5 nm. Antioxidant activity was assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, with absorbance recorded at 516 nm. The findings indicated that the TPC of ERF was 437.18 mg GAE/g ± 5.54, while the IC50 value for antioxidant activity was 4.47 mg/L, This value was lower than that of the positive control, Vitamin C, which exhibited an IC₅₀ of 5.07 mg/L. These results suggest that ERF could be developed into a natural ingredient for cosmetics and dietary supplements.
Nanoemulsion Formulation and Antibacterial Activity of Nagasari (Mesua ferrea L.) Leaf Extract Suhesti, Tuti Sri; Prasasti, Eka; Arifa Aldi, Nisa
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.41-49.2025

Abstract

Nagasari (Mesua ferrea L.) has antibacterial activity. Its active compounds are difficult to absorb. Nanoemulsions can enhance the absorption and solubility of these compounds. This study aims to determine the physical stability of a Nagasari extract nanoemulsion, as evaluated by its antibacterial activity. The nanoemulsion was prepared using VCO (1%) as the oil phase, Tween 80 (16%) as the surfactant, and PEG 400 as the cosurfactant, with variations of 1% (FI), 3% (FII), and 5% (FIII). The nanoemulsions were evaluated for their physical properties, solubility, organoleptic properties, pH, emulsion type, transmission percentage, particle size, polydispersity index, zeta potential, and stability. The most effective nanoemulsion was tested against B. subtilis. The results show that FI was stable during freeze-thaw testing. Its pH was 6.2 ± 0.15. FI was found to be an o/w emulsion-type with the following characteristics: transmission (94.23 ± 1.18%), polydispersity index (0.345 ± 0.051), particle size (103.07 nm), and zeta potential (-6.47 ± 2.20 mV). The stability and physical characteristics of the nanoemulsion are affected by variations in the concentration of PEG 400 as a co-surfactant. Antibacterial activity testing of the nanoemulsions resulted in an inhibition zone measurement of 19.15 mm against B. subtilis
Advancing Ticagrelor Bioavailability: A Comprehensive Review of Solubility Enhancement Techniques Shidik, Muhammad Luthfi; Tania Miranda Sarlie; Rachmat Mauludin; Saleh Wikarsa; Yuda Prasetya Nugraha
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.50-62.2025

Abstract

Ticagrelor (TICA) inhibits platelet activity by reversibly binding to the P₂Y₁₂  receptor, it is classified as a BCS class IV drug with low solubility and permeability. BCS Class IV drugs have a major challenge due to their reduced rate of dissolution, which leads to poor bioavailability. The absolute bioavailability of TICA after oral administration is ~36%. Various techniques, including particle size reduction, solid dispersion, lipid-based formulation, co-crystals, and polymeric micelles can increase solubility. This article discusses the methodology used to increase the solubility of ticagrelor, thereby emphasizing the research that has been conducted and documented. The increased bioavailability of ticagrelor is apparent when formulated as a solid dispersion (SD), self- microemulsifying drug delivery system (SMEDDS), self-nanoemulsifying drug delivery system (SNEDDS), nanostructured lipid carriers (NLC), suspensions, and co-crystals. Among these approaches, co-crystals and solid dispersions are highly recommended for improving the solubility of ticagrelor. This review provides insights into formulation strategies for improving ticagrelor solubility, guiding future research on its bioavailability and efficacy
Chronic Toxicity Study of Ethanol Extract from Voacanga foetida (Blume) Rolfe Leaves on Liver Biochemical and Histopathological Parameters in Male White Rats (Rattus norvegicus) susanty, adriani; Lifiani, Rilialita; Kurniasih, Aminah
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.63-71.2025

Abstract

This study aimed to evaluate the chronic toxicity of the ethanol extract of Voacanga foetida (Blume) Rolfe leaves onliver biochemical and histopathological parameters in male white rats (Rattus norvegicus). The animals were orally administeredthe extract daily for six months and divided into four groups: a control group and three treatment groups receiving doses of70, 140, and 210 mg/kg body weight (BW), respectively. Biochemical analyses included serum levels of albumin, total bilirubin, SGOT, SGPT, and triglycerides. Liver histopathological changes were observed both macroscopically and microscopically. The results showed that ethanol extract administration at all tested doses did not cause significant changes (p>0.05) in albumin, total bilirubin, SGOT, or triglyceride levels compared to the control. However, SGPT levels were significantly elevated (p<0.05) in the 140 and 210 mg/kg BW groups. Macroscopic examination revealed no alterations in liver color or texture across all groups. Microscopic observations indicated no structural damage to the central vein in the liver (p>0.05). In conclusion, subchronic oral administration of ethanol extract from V. foetida leaves up to 210 mg/kg BW for six months did not produce significant toxic effects on liver function or morphology in male rats
A Quantitative Study Assessment of Public Knowledge Regarding Self-Medication with Ibuprofen In Marang Kayu District: A Quantitative Study Sentat, Triswanto; Nurjannah, Ika; Jubaidah, Siti; Wijaya, Heri; Helmidanora, Rusdiati
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.72-80.2025

Abstract

Self-medication is an approach widely used by the public to treat mild pain symptom by using over-the-counter medications without a prescription from physician. One of the medications that can be used for self-medication is Ibuprofen. Ibuprofen is a drug that can be used for self-medication; however, its use should be under the supervision and guidance of healthcare professionals. This study aims to determine the level of public knowledge regarding the self-medication use of ibuprofen in Marang Kayu District. This research uses a quantitative design with a descriptive approach. Data were collected through questionnaires distributed to 369 respondents selected using purposive sampling. The questionnaire included questions about knowledge aspects regarding ibuprofen and self-medication patterns. The study results showed that the level of public knowledge in Marang Kayu District about Ibuprofen for self-medication was 14.5% (49 respondents) with a high level of knowledge, 31.3% (106 respondents) with a moderate level of knowledge, and the majority, 54.3% (184 respondents), with a low level of knowledge. The results underscore the urgent need for targeted health education programs to improve public awareness and promote safe self-medication practices. Enhancing community knowledge is essential to minimize the risks associated with improper ibuprofen use and to encourage responsible drug consumption
Pembentukan dan karakterisasi kristal cair aceklofenak untuk sistem penghantaran transdermal Mutiara Zulkarnaini; Zaini, Erizal; Agustin, Rini
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.81-91.2025

Abstract

Aceclofenac is a phenylacetic acid derivative classified as a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain caused by inflammation. It has potential for topical application through a transdermal delivery system. One promising approach is the use of liquid crystals as carriers in transdermal dosage forms. This study aims to develop a simple liquid crystal cream formulation for aceclofenac, using glyceryl monostearate as a mesogen and Pluronic as a stabilizer. The aceclofenac liquid crystal cream was characterized using Polarized Light Microscopy (PLM), Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), and Differential Scanning Calorimetry (DSC). Evaluations included drug release, permeation, viscosity, flow properties, zeta potential, and freeze-thaw stability. The optimal formulation consisted of oil: glyceryl monostearate–Pluronic P123: water in a 5:15:80% ratio. PLM results showed birefringence and a lamellar phase texture. FTIR analysis confirmed no new chemical bonds, while DSC indicated a reduced melting point and increased enthalpy of fusion. The release and permeation of aceclofenac after 6 hours were 27.849 ± 0.5479 µg/cm² and 21.093 ± 0.5761 µg/cm², respectively—higher than non-liquid crystal preparations. The cream exhibited thixotropic flow behavior, a zeta potential of -50.8 mV, and remained stable after six freeze-thaw cycles. In coclusion, Aceclofenac can be formulated into a liquid crystal cream with glyceryl monostearate as a mesogen, showing a birefringent lamellar phase that enhances its release and permeation
Formulation of Nanoemulsion Gel Cayenne Pepper (Capsicum frutescens) Extract as an Anti-inflammatory in Gout Arthritis Pain Salsabila, Amilia; Jonisa, Rahma Aprilya; Jannah, Yasmin Raudhatul; Yuningzia, Vannesha; Sari, Aulia Desvita; Lucida, Henny
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 2 (2025): J Sains Farm Klin 12(2), August 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.2.92-101.2025

Abstract

Cayenne pepper fruit extract has anti-inflammatory effects and could be a natural remedy of arthritis gout pain. The research aims to find the optimal formula for cayenne pepper extract nanoemulsion gel to improve its permeation capability and assess its effect on inflammation in mice induced by 1.5% carrageenan. Extraction using the maceration method followed by standardizing the extract. The optimal nanoemulsion formula is determined by constructing a pseudo-ternary diagram of the nanoemulsion base. The optimal formula obtained was 80% aquadest, 2% VCO, 18% SMIX (surfactant and cosurfactant). The cayenne pepper extract nanoemulsion is integrated with a gel base followed by evaluation. The extract nanoemulsion has been proven to form globules with a size of 54.4 nm, zeta potential of -23.6 mV, and polydispersity index of 0.403. Exudate volume and TNF-α levels were measured using the air pouch method to assess for anti-inflammatory activity. In comparison to other treatment groups, rats treated with chili pepper extract nanoemulsion gel had the lowest average exudate volume, with a statistically significant difference (DNMRT; P <0.05), according to the results of an ANOVA test combined with Duncan's post-hoc test. Meanwhile, the test for TNF-α levels did not show any significant differences

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