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JSFK (Jurnal Sains Farmasi & Klinis)
Published by Universitas Andalas
ISSN : 24077062     EISSN : 24425435     DOI : 10.25077
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.
Arjuna Subject : -
Articles 515 Documents
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Analisis Biaya Hemodialisis pada Penyakit Ginjal Kronis: Peran Karakteristik Pasien di Rumah Sakit Regional Indonesia Fauziah, Fauziah; Kusuma, Ikhwan Yuda; Aisya Putri, Bella; Indah Kurniasih, Khamdiyah; Agung Nugroho, Gamaliel; Nurkholis, Fiqih
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.192-198.2025

Abstract

Haemodialysis (HD) is the primary treatment for end-stage renal disease in Indonesia and heavily strains the national health insurance. This study examined how patient characteristics influence the direct medical costs of CKD patients receiving HD at Dr. R. Goeteng Taroenadibrata Regional General Hospital. A retrospective cross-sectional analysis was conducted using secondary data from medical, pharmacy, and financial records between July and December 2023. The study included 85 patients who met the inclusion criteria. Statistical analyses were performed using IBM SPSS Statistics, and cost differences across patient characteristics were analysed using nonparametric tests. The total cost over six months reached IDR 2.64 billion, averaging IDR 654,758 per HD visit. While no significant cost differences were observed across patient characteristics such as age, gender, comorbidities, or HD frequency (p > 0.05 for all), descriptive data indicated higher average costs in older patients, in patients receiving HD weekly, and in patients with CKD due to non-hypertensive etiologies. These findings suggest that standard reimbursement rates may overlook variations in resource utilization, highlighting observed cost variations that suggest the need for more tailored health financing approaches. Broader, multicenter studies are recommended to improve resource allocation in CKD management.
Formulation Development of a Peel-Off Mask using Red Tilapia Fish (Oreochromis niloticus) Scale Gelatin as a Gelling Agent Nursal, Fith Khaira; Febianti, Febianti; Hariyanti, Hariyanti
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.199-205.2025

Abstract

Gelling agents are essential components in peel-off mask bases, with gelatin being a commonly used material. RedNile tilapia (Oreochromis niloticus) scales, a by-product of the fishery, have potential as a halal gelatin source. This study aimed to compare the characteristics of gelatin derived from red Nile tilapia scales (NTSG) with commercial gelatin (CG) as a gelling agent in peel off mask bases through their physical evaluation. Gelatin extraction and characterization were conducted, followed by the formulation of peel-off masks with gelatin concentrations of 6%, 8%, and 10%. NTSG characteristics met the Indonesian National Standard (ISN) and GMIA based on organoleptic properties, pH, ash content, moisture content, and gel strength. Gel physical characterisation revealed pH values of 5.7–5.9, a viscosity of 3500–6500 cP, a spreadability of 5–7 cm, an adhesion time of more than 4 seconds, and a drying time of 15–30 minutes. The results indicate that red Nile tilapia scales can produce gelatin suitable as a gelling agent on peel-off masks.
Impact of self-care training on prediabetes prevention among UIN Jakarta employees: The Role of Public Health Pharmacy in Education and Monitoring Siregar, Barita Juliano; A, Almahdy; Almasdy, Dedy; A, Syamsudin; Betha, Ofa Suzanti; Rohaedi, Edi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.206-216.2025

Abstract

Prediabetes is a preclinical condition with a high risk of progressing to type 2 diabetes. This study evaluated an eight-week self-care training program among UIN Jakarta employees, facilitated by Public Health Pharmacy and integrating Avicenna’s classical health principles with WhatsApp-based digital education. A quasi-experimental pre–post design without a control group was applied to 39 participants meeting prediabetes criteria. Clinical parameters assessed included random blood glucose (RBG), systolic blood pressure (SBP), body mass index (BMI), and waist circumference (WC), along with self-care practices using the Indonesian version of the Diabetes Self-Management Questionnaire (DSMQ). Data were analyzed using Wilcoxon signed-rank test and Cohen’s dz effect size. Significant improvements were observed in SBP (dz = -0.530), BMI (dz = -0.253), WC (dz = -0.320), and DSMQ score (dz = +0.793), while RBG showed no significant change. These findings support a culturally relevant, cost-effective model for workplace-based prediabetes prevention. In line with American Diabetes Association (ADA) 2025 Standards of Care, the approach emphasizes person-centered Diabetes Self-Management Education and Support (DSMES) and team-based support; European Society of Cardiology (ESC) 2024 guidelines align the observed SBP reduction with recommended targets after lifestyle intervention. Future programs should extend duration and adopt hybrid delivery for optimal glycemic control.
Self-Nanoemulsifying Drug Delivery System (SNEDDS): Challenges and Opportunities in Enhancing Drug Solubility Sabillah, Farhad Aulan; Fitriani, Hannie; Zubair, Muhammad Sulaiman; Syukri, Yandi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.217-225.2025

Abstract

For oral medications, especially those in BCS Classes II and IV, poor aqueous solubility continues to be a significant formulation challenge. This problem restricts dosage consistency, therapeutic efficacy, and bioavailability. A promising method for improving the solubility and absorption of lipophilic drug compounds is the Self-Nanoemulsifying Drug Delivery System (SNEDDS). With ramifications for the pharmaceutical and medical domains, this narrative review attempts to investigate the synthesis, characterization, difficulties, and possible uses of SNEDDS in improving drug solubility. According to the standards of scientific merit, accessibility, and relevance, a total of 25 articles released within the previous five years were included. When SNEDDS meet gastrointestinal fluids, they spontaneously form nanoemulsions, which improves drug solubility. Oil, surfactant, and co-surfactant make up this system, which is optimized according to zeta potential (±30 mV), polydispersity index (<0.3), and particle size (<200 nm). Numerous studies have shown how well it works to enhance the pharmacokinetics and solubility of medications like thymoquinone, rosuvastatin, and curcumin. However, issues with excipient safety, formulation scalability, and long-term stability still exist. SNEDDS offers a versatile and efficient method for enhancing oral drug delivery, especially for nutraceuticals and health supplements. To fully realize its therapeutic and industrial potential, more research involving clinical validation, regulatory harmonization, and quality-by-design approaches is required.
Activity and Characterization of ZnO Nanoparticles from Ethanol Extract of Plantago major L. as Antibacterial against Propionibacterium acnes Sudartayasa, I Kadek; Anwar, Risyandi; Rakhmawatie, Maya Dian
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.226-235.2025

Abstract

Acne infections are common in tropical regions such as Indonesia and are mainly caused by Propionibacterium acnes. Long-term use of antibiotics for acne treatment may lead to bacterial resistance, highlighting the need for safer natural antibacterial alternatives. Ethanol extract of broadleaf (Plantago major L.) has been reported to exhibit antibacterial activity, which can be enhanced through the application of nanotechnology in the form of zinc oxide nanoparticles (ZnO-NPs). Therefore, this study aims to synthesize and evaluate the antibacterial activity of ZnO-NPs derived from ethanol extract of broadleaf against P. acnes. The broadleaf extract was obtained through maceration with 96% ethanol, and ZnO-NPs were prepared by a precipitation method using zinc nitrate and zinc acetate precursors. The disc diffusion test results showed that 20 mg of ZnO-NPs acetate from broadleaf extract had strong antibacterial activity, with an inhibition zone of 18.11 ± 0.10 mm. The minimum inhibitory concentration of ZnO-NPs acetate from broadleaf extract is 0.078 mg/mL. The morphological characterization of ZnO-NPs acetate from broadleaf extract using Scanning Electron Microscopy-Energy Dispersive X-Ray (SEM-EDX) show a uniform granular particle shape with a size range of 200-228 nm. Based on the research results, the ZnO-NPs acetate from ethanolic extract of broadleaf has the potential to be an effective topical antibacterial alternative for treating acne infections. Based on these findings, ZnO-NPs synthesized from ethanol extract of broadleaf are expected to enhance antibacterial effectiveness and have potential as a safer and more effective topical antibacterial alternative for acne treatment

Page 52 of 52 | Total Record : 515

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