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JSFK (Jurnal Sains Farmasi & Klinis)
Published by Universitas Andalas
ISSN : 24077062     EISSN : 24425435     DOI : 10.25077
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.
Arjuna Subject : -
Articles 526 Documents
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Analisis Biaya Hemodialisis pada Penyakit Ginjal Kronis: Peran Karakteristik Pasien di Rumah Sakit Regional Indonesia Fauziah Fauziah; Ikhwan Yuda Kusuma; Bella Aisya Putri; Khamdiyah Indah Kurniasih; Gamaliel Agung Nugroho; Fiqih Nurkholis
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.192-198.2025

Abstract

Haemodialysis (HD) is the primary treatment for end-stage renal disease in Indonesia and heavily strains the national health insurance. This study examined how patient characteristics influence the direct medical costs of CKD patients receiving HD at Dr. R. Goeteng Taroenadibrata Regional General Hospital. A retrospective cross-sectional analysis was conducted using secondary data from medical, pharmacy, and financial records between July and December 2023. The study included 85 patients who met the inclusion criteria. Statistical analyses were performed using IBM SPSS Statistics, and cost differences across patient characteristics were analysed using nonparametric tests. The total cost over six months reached IDR 2.64 billion, averaging IDR 654,758 per HD visit. While no significant cost differences were observed across patient characteristics such as age, gender, comorbidities, or HD frequency (p > 0.05 for all), descriptive data indicated higher average costs in older patients, in patients receiving HD weekly, and in patients with CKD due to non-hypertensive etiologies. These findings suggest that standard reimbursement rates may overlook variations in resource utilization, highlighting observed cost variations that suggest the need for more tailored health financing approaches. Broader, multicenter studies are recommended to improve resource allocation in CKD management.
Formulation Development of a Peel-Off Mask using Red Tilapia Fish (Oreochromis niloticus) Scale Gelatin as a Gelling Agent Febianti Febianti; Fith Khaira Nursal; Hariyanti Hariyanti
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.199-205.2025

Abstract

Gelling agents are essential components in peel-off mask bases, with gelatin being a commonly used material. RedNile tilapia (Oreochromis niloticus) scales, a by-product of the fishery, have potential as a halal gelatin source. This study aimed to compare the characteristics of gelatin derived from red Nile tilapia scales (NTSG) with commercial gelatin (CG) as a gelling agent in peel off mask bases through their physical evaluation. Gelatin extraction and characterization were conducted, followed by the formulation of peel-off masks with gelatin concentrations of 6%, 8%, and 10%. NTSG characteristics met the Indonesian National Standard (ISN) and GMIA based on organoleptic properties, pH, ash content, moisture content, and gel strength. Gel physical characterisation revealed pH values of 5.7–5.9, a viscosity of 3500–6500 cP, a spreadability of 5–7 cm, an adhesion time of more than 4 seconds, and a drying time of 15–30 minutes. The results indicate that red Nile tilapia scales can produce gelatin suitable as a gelling agent on peel-off masks.
Impact of self-care training on prediabetes prevention among UIN Jakarta employees: The Role of Public Health Pharmacy in Education and Monitoring Barita Juliano Siregar; Almahdy A; Dedy Almasdy; Syamsudin A; Ofa Suzanti Betha; Edi Rohaedi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.206-216.2025

Abstract

Prediabetes is a preclinical condition with a high risk of progressing to type 2 diabetes. This study evaluated an eight-week self-care training program among UIN Jakarta employees, facilitated by Public Health Pharmacy and integrating Avicenna’s classical health principles with WhatsApp-based digital education. A quasi-experimental pre–post design without a control group was applied to 39 participants meeting prediabetes criteria. Clinical parameters assessed included random blood glucose (RBG), systolic blood pressure (SBP), body mass index (BMI), and waist circumference (WC), along with self-care practices using the Indonesian version of the Diabetes Self-Management Questionnaire (DSMQ). Data were analyzed using Wilcoxon signed-rank test and Cohen’s dz effect size. Significant improvements were observed in SBP (dz = -0.530), BMI (dz = -0.253), WC (dz = -0.320), and DSMQ score (dz = +0.793), while RBG showed no significant change. These findings support a culturally relevant, cost-effective model for workplace-based prediabetes prevention. In line with American Diabetes Association (ADA) 2025 Standards of Care, the approach emphasizes person-centered Diabetes Self-Management Education and Support (DSMES) and team-based support; European Society of Cardiology (ESC) 2024 guidelines align the observed SBP reduction with recommended targets after lifestyle intervention. Future programs should extend duration and adopt hybrid delivery for optimal glycemic control.
Self-Nanoemulsifying Drug Delivery System (SNEDDS): Challenges and Opportunities in Enhancing Drug Solubility Farhad Aulan Sabillah; Hannie Fitriani; Muhammad Sulaiman Zubair; Yandi Syukri
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.217-225.2025

Abstract

For oral medications, especially those in BCS Classes II and IV, poor aqueous solubility continues to be a significant formulation challenge. This problem restricts dosage consistency, therapeutic efficacy, and bioavailability. A promising method for improving the solubility and absorption of lipophilic drug compounds is the Self-Nanoemulsifying Drug Delivery System (SNEDDS). With ramifications for the pharmaceutical and medical domains, this narrative review attempts to investigate the synthesis, characterization, difficulties, and possible uses of SNEDDS in improving drug solubility. According to the standards of scientific merit, accessibility, and relevance, a total of 25 articles released within the previous five years were included. When SNEDDS meet gastrointestinal fluids, they spontaneously form nanoemulsions, which improves drug solubility. Oil, surfactant, and co-surfactant make up this system, which is optimized according to zeta potential (±30 mV), polydispersity index (<0.3), and particle size (<200 nm). Numerous studies have shown how well it works to enhance the pharmacokinetics and solubility of medications like thymoquinone, rosuvastatin, and curcumin. However, issues with excipient safety, formulation scalability, and long-term stability still exist. SNEDDS offers a versatile and efficient method for enhancing oral drug delivery, especially for nutraceuticals and health supplements. To fully realize its therapeutic and industrial potential, more research involving clinical validation, regulatory harmonization, and quality-by-design approaches is required.
Activity and Characterization of ZnO Nanoparticles from Ethanol Extract of Plantago major L. as Antibacterial against Propionibacterium acnes I Kadek Sudartayasa; Risyandi Anwar; Maya Dian Rakhmawatie
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.226-235.2025

Abstract

Acne infections are common in tropical regions such as Indonesia and are mainly caused by Propionibacterium acnes. Long-term use of antibiotics for acne treatment may lead to bacterial resistance, highlighting the need for safer natural antibacterial alternatives. Ethanol extract of broadleaf (Plantago major L.) has been reported to exhibit antibacterial activity, which can be enhanced through the application of nanotechnology in the form of zinc oxide nanoparticles (ZnO-NPs). Therefore, this study aims to synthesize and evaluate the antibacterial activity of ZnO-NPs derived from ethanol extract of broadleaf against P. acnes. The broadleaf extract was obtained through maceration with 96% ethanol, and ZnO-NPs were prepared by a precipitation method using zinc nitrate and zinc acetate precursors. The disc diffusion test results showed that 20 mg of ZnO-NPs acetate from broadleaf extract had strong antibacterial activity, with an inhibition zone of 18.11 ± 0.10 mm. The minimum inhibitory concentration of ZnO-NPs acetate from broadleaf extract is 0.078 mg/mL. The morphological characterization of ZnO-NPs acetate from broadleaf extract using Scanning Electron Microscopy-Energy Dispersive X-Ray (SEM-EDX) show a uniform granular particle shape with a size range of 200-228 nm. Based on the research results, the ZnO-NPs acetate from ethanolic extract of broadleaf has the potential to be an effective topical antibacterial alternative for treating acne infections. Based on these findings, ZnO-NPs synthesized from ethanol extract of broadleaf are expected to enhance antibacterial effectiveness and have potential as a safer and more effective topical antibacterial alternative for acne treatment
Cytotoxic Potential of Uncaria cordata (Lour) Merr. Ethyl Acetate Subfraction on T47D Breast Cancer Cells Noveri Rahmawati; Enda Mora; Reyvia Rahma Ningsih Ningsih; Nurbaiti Nurbaiti
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.1-7.2026

Abstract

Uncaria cordata is a plant that grows in Indonesia and is known locally as Akar kaik-kaik. The local communities have traditionally used it to treat cancer. A Preliminary study has shown that potential secondary metabolites in the plant extract exhibit cytotoxic activity. This study aims to determine the cytotoxic activity of subfractions obtained from ethyl acetate extracts of U. cordata leaves on T47D breast cancer cells. The dried leaves were extracted using ethyl acetate and then fractionated using vacuum liquid chromatography (VLC). The extracts and fractions were determined for their cytotoxic activity using the Brine Shrimp Lethality Test (BSLT) and MTT test. BSLT assay showed the results of the cytotoxic activity fraction (F3-F14) have an LC50 value of 24.0; 67.1; 98.8; 161.5; 102.6; 119.8; 18.3; 16.8; 43.1; 186.1; 54.3 and 29.9 µg/ml. The MTT assay revealed that the IC50 of the fractions F9, F10, and F14 were 15.81, 15.12, and 17.43 µg/mL, respectively. The three fractions exhibited a strong cytotoxic effect on T47D breast cancer cells. Therefore, it can be concluded that the three fractions, F9, F10, and F14, have a substantial cytotoxic effect on T47D breast cancer cells.
Antibacterial Activity of Defatted Ethanolic Extract of Cordyline fruticosa (L.) A.Chev Leaves Against Respiratory Pathogen Vera Nurviana; Eka Indriyani; Ira Rahmiyani
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.8-14.2026

Abstract

Introduction: Red hanjuang (Cordyline fruticosa L.) leaves have traditionally been used to treat respiratory tract infections, including productive cough caused by Staphylococcus aureus. The increasing prevalence of antibiotic resistance highlights the need for natural antibacterial agents. Objective: This study aimed to evaluate the antibacterial activity of the 70% ethanol extract of red hanjuang leaves against S. aureus. Methods: Leaves were dried, powdered, and extracted through maceration with 70% ethanol after defatting with n-hexane. Physicochemical and phytochemical analyses were performed. Antibacterial activity was assessed via the well diffusion method, measuring inhibition zones and determination of the Minimum Inhibitory Concentration (MIC). Data were analyzed with SPSS (p < 0.05). Results: The simplicia met quality standards. Phytochemical screening revealed flavonoids, polyphenols, tannins, and saponins. All extract concentrations (5%, 20%, 35%, 50%) inhibited bacterial growth, with the largest inhibition zone at 50% (16.45 mm). Amoxicillin (positive control) produced 12.826 mm, while DMSO showed no inhibition. The MIC was 0.7% with an inhibition zone of 1.83 mm. Statistical analysis confirmed significant differences among concentrations. Conclusion: The 70% ethanol extract of red hanjuang leaves demonstrated strong antibacterial activity against S. aureus, supporting its potential as a natural therapeutic option for respiratory tract infections
Crystal Engineering of Ibuprofen and Caffeine by Cocrystal Formation Using Solvent Evaporation and Slurry Methods Mikhania Christiningtyas Eryani; Yudi Wicaksono; Budipratiwi Wisudyaningsih; Kuni Barikah; Hery Febrianto
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.15-20.2026

Abstract

Ibuprofen is a pharmaceutical active compound used to treat mild to moderate pain and fever. However, ibuprofen has low solubility in water. One method to increase solubility is cocrystal formation. The ibuprofen cocrystal was prepared in this study using caffeine as a coformer at a 1:1 molar ratio via solvent evaporation and slurry methods. The results of the XRD and thermal analysis of the sample indicate that a new solid phase is formed in the specific sa mple, which is different from both of its constituent components. Morphologically, the resulting cocrystals show a change in shape from their constituent compounds as well as a change in size. The solubility test results show that cocrystal formation is able to increase the solubility of ibuprofen. The conclusion of this study is that ibuprofen cocrystals can be formed with the coformer caffeine at a molar ratio of 1:1 using the slurry method and solvent evaporation.
Essential oils from Homalomena aff. pendula (Blume) Bakh F. and Its Antioxidant Activities Rifaldi Harfiyantama; Nurainas Nurainas; Deddi Prima Putra; Nova Syafni
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.21-27.2026

Abstract

Homalomena is a genus from the family Aracaceae that is characterized by scent. Most Homalomena species from Indonesia have limited information on the chemical components of their essential oils, including those found in West Sumatra Province. The species of Homalomena aff. pendula (Blume) Bakh. F. is found in large amounts in Padang city, and it has the potential to explore its profile of essential oil substances in its leaves, petioles, and rhizomes. In this research, the antioxidant activity of the essential oils was screened using three methods: DPPH, ABTS, and FRAP. The essential oils are extracted through hydro-distillation, and their components are analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). The results show that the three major components in the leaves and petioles were β-bisabolene, α-selinene, and α-bergamotene with different percentages. The rhizomes had the same higher component as β-bisabolene, followed by trans-caryophyllene and α-bergamotene. The antioxidant activity, as measured by DPPH and ABTS, showed an IC50 greater than 200 μg/mL. That result is also supported by the FRAP value of leaves, petioles, and rhizomes, 0.165±0.0081;  0.168±0.0019;  0.191±0.0003 µmol Fe(II)/mg sample and 0.013±0.0006; 0.014±0.0001; 0.015±0.0001 µmol trolox/mg sample, respectively. Although the essential oils from H. aff. pendula do not exhibit antioxidant activity, the primary compound, β-bisabolene, has been shown to possess other potential activities.
Enhancement of Solubility, Dissolution, and Anti-Inflammatory Activity of Aceclofenac via Multicomponent Crystal Formation with Tromethamine Hendrizal Usman; Salman Umar; Yufri Aldi; Muhammad Nasrul Siregar; Erizal Zaini
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.28-37.2026

Abstract

Aceclofenac (ACE) is a non-steroidal anti-inflammatory drug (NSAID) widely used for osteoarthritis and rheumatoid arthritis, yet its therapeutic performance is limited by poor aqueous solubility as a Biopharmaceutics Classification System (BCS) Class II drug. This study aimed to enhance the physicochemical and pharmacological properties of ACE by forming a multicomponent crystal (MC) with tromethamine (TRIS). The MC was produced via solvent-dropped grinding in a 1:1 molar ratio and characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FTIR). DSC and PXRD results indicated the formation of a eutectic system with reduced crystallinity, while FTIR showed intermolecular hydrogen bonding, evidenced by the broad OH stretching band near 3000 cm⁻¹, without new covalent bond formation. Solubility increased 35.8-fold relative to pure ACE, and dissolution testing showed a markedly improved dissolution efficiency (DE₆₀) of 75.33 ± 1.57% compared with 49.10 ± 0.54% for ACE alone. In vivo anti-inflammatory assessment using a carrageenan-induced granuloma pouch model further demonstrated superior pharmacological activity of the MC, significantly reducing exudate volume (0.56 mL) and TNF-α levels (25.26 pg/mL) versus pure ACE (0.82 mL and 29.70 pg/mL). Overall, the ACE–TRIS multicomponent crystal effectively enhances solubility, dissolution, and anti-inflammatory efficacy, offering a promising approach for improving ACE’s therapeutic performance.

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