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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Arjuna Subject : -
Articles 364 Documents
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Occupational Asthma in Hospital Healthcare Worker Rahmad Budianto; Tri Wahju Astuti
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.126

Abstract

Occupational asthma is defined as an adult onset of asthma triggered by specific exposures or combinations from the workplace. Occupational asthma is classified into a sensitizer-induced occupational asthma or allergic occupational asthma caused by exposure or sensitization by a causative agents induced by immunological reactions; and irritant-induced occupational asthma or non-allergic occupational asthma caused by agents that are irritative to the airway. Occupational asthma can occur in health workers at hospitals. In the hospital there are various exposure of agents, medicines, and health equipments which can induce the asthma symptoms for health workers. The diagnosis of occupational asthma established by history taking, physical examination, supporting examination (spirometry, bronchial hyper-responsiveness test, exhaled nitric oxide, and immunological tests), and biomarker test. Management of occupational asthma includes principle management by avoiding exposure, pharmacological therapy, and immunotherapy. Precautions taken by primary, secondary (medical surveilance) and tertiary prevention (prevention of disability through worker’s compensation system).
The Compability Level of Tuberculin Skin Test and T-SPOT.TB, Sensitivity and Spesifisity of T-SPOT.TB in Detecting Latent Tuberculosis in Hemodialysis Patients Astuti Setyawati; Reviono Reviono; Wachid Putranto
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.159

Abstract

Background: Controling Latent Tuberculosis Infection (LTBI) is important for the End TB Strategy program. The prevalence of LTBI and reactivation to active tuberculosis are increased in immunodeficiency conditions, such on hemodialialysis patients. Laten tuberculosis can be diagnosted by Tuberculin Skin Test (TST) and immunoglobulin release assay (IGRA). This diagnostic study aimed to determine the agreement level of TST and T-SPOT.TB, accurancy of T-SPOT.TB, and the correlation between T cluster of differentiation 4 (CD4+) cell counts with TST and T-SPOT.TB. Methods: This is a cross sectional study design was performed in hemodialysis patients of Dr. Moewardi Surakarta Hospital in May 2018. The study subject had TST and T-SPOT.TB examinations by using 2 Tuberkulin Unit (TU) of intradermal purified protein derivate (PPD) RT 23 (Biofarma, Bandung) and venous blood ELISPOT analysis, respectively. Statistical analysis used windows SPSS 21. Results: There were 30 study subjects. The prevalence of LTBI was 23.3%. The agreement level of TST and T-SPOT.TB was substantial (K=0.667;P<0.001). The sensitivity and specificity of T-SPOT.TB were 66.7% and 95.8%, respectively. There were no significant correlation of CD4+ T cell counts with TST (R=0,253;P=0,177), T-SPOT.TB ESAT-6SFUs (R=-0.169;P=0.317), T-SPOT.TB CFP-10 SFUs (R=0.006;P=0.975), and the highest value of T-SPOT.TB ESAT-6/CFP-10 SFUs, (R=-0.070;P=0.741). Conclusion: The prevalence of LTBI is high in hemodialysis patients, thus early detection is necessary. TST examination is recommended for LTBI diagnostic tool in hemodialysis patients because of its practical use, inexpensive, and does not require skilled personnel.
The Effect of Thymoquinone on Interleukin-8 Levels, %FEV1 and CAT Scores in Chronic Obstructive Pulmonary Disease Levana Kasumadewi; Suradi Suradi; Ana Rima Setijadi
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.145

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a characterized by respiratory symptoms and persistent airway obstruction due to alveoli and/or airway abnormalities caused by continuous exposure to harmful particles or gases. Airway inflammation plays an important role in the pathogenesis of COPD. Nigella sativa, known as habbatusauda, contains thymoquinone, which has an anti-inflammatory effect. Airway inflamation improvement was measured based on decreased plasma IL-8 level, maintain the optimization of %FEV1 value and clinical improvement based on the decreased CAT score. Methods: The pretest and posttest experimental clinical trial was carried out in 40 patients with stable COPD in the pulmonology outpatient clinics of Dr. Moewardi Surakarta and dr. Soehadi Prijonegoro Sragen Hospital from 29 June to 3 August 2019. Subjects were grouped into treatment group (n=20) receiving standard therapy along with thymoquinone oil capsules 500 mg/day and placebo group (n=20) receiving standard therapy only for 30 days. Results: The study revealed statistically insignificant decreases of IL-8 level (P=0.052) and %FEV1 value (P=0.943) in the treatment group, while CAT score showed significant decreases in the treatment group (P=0.0005). Conclusion: Thymoquinone administration reduce inflammation as it can lower IL-8 level and improves the clinical condition of patients with stable COPD based on a decrease in CAT score.
Pleura Fluid Leukocyte Levels Test in Establish of Pleura Tuberculosis Effusion in Exudative Pleural Effusion Patients at H. Adam Malik General Hospital Medan in 2018 Selvy Wulandari; Fajrinur Syahrani; Ade Rahmaini; Putri Chairani Eyanoer
Jurnal Respirologi Indonesia Vol 41, No 3 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i3.182

Abstract

Background: Tuberculous pleural effusion is an accumulation of fluid in the pleural cavity produced by Mycobacterium tuberculosis (MTB). The gold standard of TB pleural effusion diagnosis is to obtain TB bacilli in pleural fluid or pleural tissue. However, this is often constrained due to the low identification level of these bacilli and the slow growth of MTB cultures. This study aimed to assess the pleural fluid leukocyte level in establishing a diagnosis of pleural effusion caused by TB. Methods: This was a diagnostic study conducted on 111 patients with pleural effusion, caused by TB, malignancy or non-TB infections that were assigned by supporting examinations obtained from medical records, which then assessed for pleural fluid leukocytes. Statistical analysis was performed using Kruskal Wallis Test and Receiver Operating Characteristic (ROC) curve to attain the cut-off point of pleural fluid leukocyte level. Results: Pleural fluid leukocyte levels in TB cases were significantly different when compared to pleural effusion caused by malignancy and non-TB infections (P<0.001). Pleural fluid leukocyte level ≥1100 cell/mm3 was a cut-off diagnostic test for tuberculous pleural effusion with a sensitivity of 77% and specificity of 60.3%. Conclusion: Pleural fluid leukocyte level ≥1100 cell/mm3 could assist in diagnosing tuberculous pleural effusion.
The Role of Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), and D-Dimer in Predicting the Outcome of Confirmed COVID-19 patients Fathiyah Isbaniah; Tomu Juliani; Triya Damayanti; Dewi Yenita; Faisal Yunus; Budhi Antariksa; Wahyu Aniwidyaningsih; Sita Laksmi Andarini; Diah Handayani
Jurnal Respirologi Indonesia Vol 41, No 4 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i4.215

Abstract

Background: Cytokine storm or hyperinflammation condition in COVID-19 patients could result in fatal outcomes. Inflammation could also result in coagulation disorders. The Neutrophil-Lymphocyte Ratio (NLR) and Platelet-lymphocyte ratio (PLR) have been known as inflammation markers in several diseases. D-dimer value can be used to assess a patient's coagulation status. Further study on thromboinflammation biomarkers in COVID-19 patients is needed. Therefore, we conducted a study to assess the association between NLR, PLR, and d-dimer on the clinical outcome of confirmed COVID-19 patients at Persahabatan Central Hospital.Methods: Observational cohort retrospective analysis was conducted on 214 medical records of confirmed COVID-19 patients who meet the inclusion criteria in Persahabatan Central Hospital from March to July 2020.Results: The mean patient’s age in this study is 54.35 years, dominated by male patients (60.7%). Most of the patients had normal nutritional status (54.7%). The proportion of patients with comorbidities is 65.4%. The most common comorbid is hypertension, followed by diabetes mellitus. 76.1% of patients have severe-critically ill disease, followed by moderate (20.1%) and mild disease (3.7%) The length of hospitalization median were 12 days. Sixty patients (28%) have died during hospitalization. The median of initial value of NLR, PLR, and d-dimer is 5.75 (0.68–81.5), 243.5 (44.7–1607), and 1140 (190–141300) respectively. We found significant associations between NLR (p = 0.000), PLR (p=0.013) and d-dimer (p = 0.032) on clinical outcome. Conclusion: Initial value of NLR, PLR, and D-dimer of confirmed COVID-19 patients at Persahabatan Central Hospital were associated with clinical outcome. 
Outcomes Prediction Using qSOFA, SpO2 / FiO2 and Procalcitonin of Pneumonia Sepsis Patients In Lung Ward at Dr. M.Djamil Padang Hospital Irawan, Eka; Medison, Irvan; Khairsyaf, Oea; Anggraini, Fenty
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.268

Abstract

Background: Sepsis is a systemic inflammatory response to severe infections, sepsis is a major cause of morbidity and mortality. This study aims to determine the outcome prediction using qSOFA, SpO2/FiO2 Rasio and Procalcitonin in sepsis pneumonia patients in Lung ward of Dr. M DJamil Padang Hospital. Methods: Cohort study design with correlative analytics for 43 pneumonia sepsis patiens in Lung ward at Dr. M. Djamil Padang Hospital from September 2019 until to Februari 2020. Samples were taken by consecutive sampling method. Results: There were a significant relationship between qSOFA score with procalcitonin (p value = 0.006). There were no significant relationship between SpO2/FiO2 Rasio with procalcitonin (p value = 0.128). There were a significant relationship between qSOFA scores with patient outcomes (p value = 0.036), there were no significant relationship between procalcitonin with patient outcomes (p value = 0.205), and there were a significant relationship betweenSpO2/FiO2 Rasio with patient outcomes (p value = 0.019). Conclusion: qSOFA and SpO2 / FiO2 Rasio can predict the outcomes of patients with sepsis pneumonia 
Gender Disparities in Their Effects on Characteristics and Prognostics of Lung Cancer Patients in Pulmonary Ward of Dr. M Djamil Hospital, Padang Sabrina Ermayanti; Afriani Afriani; Sari Nikmawati; Russilawati Russilawati; Irvan Medison; Suyastri Suyastri
Jurnal Respirologi Indonesia Vol 41, No 4 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i4.216

Abstract

Background: Lung cancer incidence in female tends to increase in many countries. Various studies have reported the characteristics of lung cancer in female are different from male. The purpose of this study was to determine the effect of gender on characteristics of lung cancer at Dr. M Djamil Hospital, Padang.Methods: A retrospective analytic study of lung cancer patients treated in the Pulmonary Ward of Dr. M. Djamil Hospital Padang from January 1, 2004 to December 31, 2017, with recognized cancer cell types. Data were grouped according to gender.Results: This study found that 451 lung cancer patients, male-dominant 77.8%. Female were younger than male (52.97 ± 12.79 years vs. 57.81 ± 11.23 years; p = 0.00). Most of male (94.5%) were smokers and former smokers, while 93.9% of female were non-smokers (p = 0.00). Most female were having prior history of tuberculosis (TB) (21.2% vs 11.0%; p = 0.008) and also prior history of other organs cancer (10.1% vs 3.4%; p = 0.007) than in male. Squamous cells were highest in males (41.1%), while females had adenocarcinoma (55.0%); with p = 0.008. Advanced stage in female more than male (91.8% vs 82.7%; p = 0.027). The mean life expectancy of female was longer than male, respectively 8.74 ± 1.56 and 7.29 ± 0.64 months; (p = 0.95).  Conclusion: There are differences in the epidemiology of lung cancer between male and female in Dr. M. Djamil Hospital Padang in the form of age, cell type and staging. Non-smokers, a previous history of TB and a history of cancer in other organs were more dominant in female.
Safety of Favipiravir for Treatment of COVID-19: Latest Systematic Review Rizki Oktarini; Anna Rozaliyani; Ratika Rahmasari; Muhammad Alkaff; Rani Sauriasari
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.243

Abstract

Background: Adverse event studies of favipiravir use in treating COVID-19 have been ongoing since it was established as a treatment option. A better understanding of the side effects of favipiravir from recent studies is important in developing and assessing the recognition of effective treatments for COVID-19. Method: This was a systematic review based on studies and case reports on favipiravir monotherapy in COVID-19. Access to the included studies was gained via PubMed, SCOPUS, Science Direct, SpringerLink, and MedRxiv. Results: Twelve studies consisting of eight studies and four case reports were reviewed. The most common side effects were diarrhea, elevated liver enzyme levels, and hyperuricemia. None of which were significantly different from the comparison. Currently, various adverse event were reported in case reports such as drug fever,acute generalized exanthematous pustulosis (AGEP), and transient increase in viral load. The side effects would mostly be subsided after the treatment was discontinued.Conclusion: The use of favipiravir to treat COVID-19 caused dose-related side effects such as diarrhea, changes in liver enzymes, and increased level of uric acid. There were no serious side effectscompared to other antiviral drugs. To improve the efficacy and safety of COVID-19 therapy, it is important to prepare an incidence report of antiviral adverse events in special populations such as children, pregnant women, and  patients with organ dysfunction.
Role of Interventional Radiology in the Management of Massive Hemoptysis Prijo Sidipratomo; Gabriela Enneria Sibarani
Jurnal Respirologi Indonesia Vol 41, No 4 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i4.220

Abstract

Massive hemoptysis is one of the emergencies in respiratory system, representing hemorrhage of the bronchial or pulmonary vascular system into the respiratory tract. Massive hemoptysis is a life-threatening condition due to high risk of asphyxia it may induce. Bronchial artery embolization (BAE) is an interventional radiology procedure dedicated in the emergency management of massive hemoptysis. BAE is known for its great success rate and low risk of complications. Proper catheterization technique, recognition of bronchial artery variant anatomy and appropriate selection of embolic material agent proves essential in determining the success of this procedure. As a minimally invasive procedure, BAE is highly recommended to be used in cases of massive hemoptysis.
Concordance of TST and QFT-Plus, Sensitivity and Specificity of TST and QFT-Plus in Detection of LTBI in MDR TB Contact Rullyano Hardian; Reviono Reviono; Harsini Kusumo; Yusup Subagio Sutanto
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.282

Abstract

Background: Tuberculosis (TB) is an infectious disease and the main cause of world health problems. Not all individuals infected with Mycobacterium tuberculosis (Mtb) develop active TB. Latent tuberculosis infection (LTBI) is a state of persistent immune response to stimulation of the Mtb antigen with no evidence of clinically manifest active TB. Closed contact and household contact with MDR TB patients increases the risk of MDR TB transmission. There is no gold-standard test for LTBI. Tuberculin Skin Test (TST) and Quantiferon Gold Plus (QFT-Plus) examinations are used for LTBI diagnosis.Methods: A cross-sectional diagnostic test of 32 MDR TB contacts, consisting of 16 household contacts and 16 close contacts, was conducted in April 2020 at Dr. Moewardi Surakarta Hospital.Results: Positive TST results among MDR TB contacts were 18.8%, while QFT-Plus positive was 25%. The concordance level of TST and QFT-Plus was nearly perfect (κ=0.818, p<0.001). The sensitivity and specificity of QFT-Plus with household contacts as the gold standard were 37.5% and 87.5%, respectively. The sensitivity and specificity of TST with household contacts as the gold standard were 25% and 87.5%, respectively.Conclusion: The concordance level of TST and QFT-Plus in the detection of LTBI in MDR TB contacts was very good. The TST can be used in place of QFT-Plus although QFT-Plus has better sensitivity. Both tests are useful for confirming TB infections. Both of these tests are not diagnostic, however they can be used to screen for LTBI in MDR TB contacts. 

Page 15 of 37 | Total Record : 364

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