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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Respirologi Indonesia Jurnal Abdi Insani Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Mandala Pengabdian Masyarakat Indonesian Journal of Health Science
Ratika Rahmasari
Fakultas Farmasi Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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The Efficacy of Remdesivir in Reducing SARS-CoV-2 Viral Load and Its Safety on COVID-19 Patients: A Systematic Review Afifah Fauziyyah; Ratika Rahmasari; Rani Sauriasari
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.211

Abstract

Background: This study aimed to examine the effectiveness of Remdesivir in reducing Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) viral load and its safety for antiviral therapy in Coronavirus disease 2019 (COVID-19) treatment.Methods: This systematic review used data sources from the PubMed, ProQuest, SpringerLink, and ClinicalTrial.gov databases for relevant observational and interventional studies during August 2020 to August 2021. Studies evaluating Remdesivir in adults hospitalized for COVID-19 were included in this review. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines.Results This review found 9 studies that were relevant to the study objectives. In total, 1,088 patients participated as subjects. Three studies demonstrated the effect of remdesivir in reducing SARS-CoV-2 viral load in upper and lower respiratory tract specimens. Six studies demonstrated that remdesivir was safe for use in a variety of baseline conditions (patients on hemodialysis and patients receiving kidney transplantation), had no significant hepatotoxicity, did not increase the risk of acute kidney injury, and did not increase eGFR or systemic symptoms in patients taking remdesivir.Conclusion: Remdesivir has been shown to reduce SARS-CoV-2 viral load and was safe for use as antiviral therapy in the treatment of COVID-19, but an assessment of randomized controlled trial for the effect of Remdesivir on viral load reduction was not available yet.
Safety of Favipiravir for Treatment of COVID-19: Latest Systematic Review Rizki Oktarini; Anna Rozaliyani; Ratika Rahmasari; Muhammad Alkaff; Rani Sauriasari
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.243

Abstract

Background: Adverse event studies of favipiravir use in treating COVID-19 have been ongoing since it was established as a treatment option. A better understanding of the side effects of favipiravir from recent studies is important in developing and assessing the recognition of effective treatments for COVID-19. Method: This was a systematic review based on studies and case reports on favipiravir monotherapy in COVID-19. Access to the included studies was gained via PubMed, SCOPUS, Science Direct, SpringerLink, and MedRxiv. Results: Twelve studies consisting of eight studies and four case reports were reviewed. The most common side effects were diarrhea, elevated liver enzyme levels, and hyperuricemia. None of which were significantly different from the comparison. Currently, various adverse event were reported in case reports such as drug fever,acute generalized exanthematous pustulosis (AGEP), and transient increase in viral load. The side effects would mostly be subsided after the treatment was discontinued.Conclusion: The use of favipiravir to treat COVID-19 caused dose-related side effects such as diarrhea, changes in liver enzymes, and increased level of uric acid. There were no serious side effectscompared to other antiviral drugs. To improve the efficacy and safety of COVID-19 therapy, it is important to prepare an incidence report of antiviral adverse events in special populations such as children, pregnant women, and  patients with organ dysfunction.
Supramolekul Oligomer (Struktur Multimer Sitokrom c (Cyt c)) Wahyu Fitriana; Ratika Rahmasari
SAINSTECH FARMA Vol 12 No 2 (2019): Sainstech Farma Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.213 KB) | DOI: 10.37277/sfj.v12i2.453

Abstract

Kimia supramolekul saat ini sedang berkembang pesat pada berbagai fungsi sistematik. Protein memainkan peranan penting pada organisme hidup, mencakup 50% bobot sel kering. Protein heme bertanggung jawab pada banyak aktivitas biologis esensial. Domain swapping menjadi salah satu mekanisme terbentuknya struktur multimer. Sitokrom c (Cyt c), suatu protein transfer elektron, dapat mengalami domain swapping membentuk struktur dimer, trimer, dan kuarterner yang memiliki kemampuan oksidasi dan apoptosis yang lebih tinggi dibandingkan monomer. Metionin80 menstabilkan monomer Cytc dengan koordinasinya terhadap heme. Namun, disosiasi Met80 dari heme, tidak berpengaruh pada terbentuknya struktur multimer. Struktur multimer Cyt c akan tetap terbentuk tanpa disosiasi Met80.
Herpes Simplex Virus Tipe 1: Prevalensi, Infeksi dan Penemuan Obat Baru Marina Ika Irianti; Wahyu Fitriana; Ayun Erwina Arifianti; Ratika Rahmasari
SAINSTECH FARMA Vol 13 No 1 (2020): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.692 KB) | DOI: 10.37277/sfj.v13i1.519

Abstract

Herpes Simplex Virus Tipe 1 (HSV-1) merupakan salah satu virus herpes yang dapat menyebabkan infeksi seumur hidup pada manusia. Struktur dan kandungan protein pada herpes simplex virus, serta pengunaan berulang obat anti-HSV merupakan faktor yang terlibat dalam kemunculan resistensi. Produk bahan alam yang bervariasi dapat menjadi sumber potensial dalam penemuan obat baru. Pencarian obat baru sebagai alternatif dari obat anti-herpes yang sudah ada, terutama dari produk bahan alam, merupakan hal penting yang harus dilakukan.
Empowering the Baduy Tribe Through Training in Processing Local Spices into Ready-to-Use Kitchen Seasonings Berna Elya; Roshamur Cahyan Forestrania; Ratika Rahmasari; Retnosari Andrajati; Syamsu Nur; Vitri Agustiarni
Jurnal Mandala Pengabdian Masyarakat Vol. 7 No. 1 (2026): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v7i1.820

Abstract

Suku Badui merupakan masyarakat badui luar dan badui dalam yang menetap di Desa Kanekes, Banten, dengan mata pencaharian utama sebagai petani. Masyarakat Suku Badui memiliki rempah-rempah yang melimpah seperti jahe, cabe, kunyit dan daun jeruk dari hasil kebun, tetapi nilai jualnya rendah karena hanya dijual sebagai bahan mentah. Permasalahan yang dihadapi yaitu keterbatasan pengetahuan tentang teknik pengolahan rempah menjadi bumbu dapur siap pakai yang higienis, praktis, dan tahan lama, serta keterbatasan akses pasar. Pengabdian masyarakat ini bertujuan untuk mengatasi masalah tersebut melalui pelatihan dan pendampingan pembuatan bumbu dapur siap pakai. Metode yang digunakan meliputi sosialisasi, pelatihan teknis (pemilihan bahan baku, pengeringan, formulasi bumbu dasar, dan pengemasan). Hasil PkM menunjukkan peningkatan signifikan pada pengetahuan dan keterampilan mitra dalam memproduksi berbagai varian bumbu dasar berkualitas. Peningkatan pengetahuan dapat dilihat dari nilai pretest dan postest dari 71,3 menjadi 82,85. Pelatihan dan pendampingan ini dapat menciptakan unit usaha baru yang dikelola mandiri oleh Suku Badui . Upaya ini akan berkontribusi pada diversifikasi pendapatan, penguatan ketahanan ekonomi lokal, dan pelestarian kearifan lokal dalam pemanfaatan rempah-rempah.
Drug Repurposing for Monkeypox: An Alternative Strategy for Emergency Response Luthfi Harbulcholizi; Jekmal Malau; Ihsan Alfiandri; Iqbal Zulkifli; Ratika Rahmasari
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 3 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i3.96215

Abstract

The global monkeypox (MPOX) outbreak, which has resulted in more than 100,000 confirmed cases across over 120 countries, underscores the urgent need for effective therapeutic strategies. MPOX, caused by a virus belonging to the Orthopoxvirus genus, poses significant clinical and public health challenges, particularly in regions with limited healthcare capacity. Although the World Health Organization declared MPOX a Public Health Emergency of International Concern in 2022, no specific antiviral treatment has yet been formally approved. While vaccination remains essential for long-term prevention, its impact is constrained by limited availability and unequal global distribution. Consequently, drug repurposing has emerged as a practical, rapid, and cost-efficient strategy to address immediate therapeutic demands during active outbreaks. This narrative review evaluates key repurposed antiviral agents including tecovirimat, brincidofovir, and cidofovir were originally developed for other Orthopoxvirus infections. A structured literature search using PubMed, ScienceDirect, and Google Scholar (2014–2024) identified studies providing clinically relevant evidence regarding their therapeutic roles in MPOX. Tecovirimat demonstrated consistent potential to improve viral clearance, shorten symptom duration, and reduce severe manifestations. Brincidofovir exhibited a more favorable safety profile, albeit with limited clinical data, whereas cidofovir showed antiviral activity but remains restricted by its nephrotoxicity. Collectively, current evidence suggests that drug repurposing offers a timely and resource-efficient option for managing MPOX and mitigating disease burden while vaccine accessibility continues to vary globally. When integrated with targeted public health interventions, repurposed drugs may serve as a crucial interim strategy to reduce transmission and enhance outbreak response capacity.
PELATIHAN DAN PENDAMPINGAN PEMBUATAN JAMU KESEHATAN PADA SUKU BADUY DI DESA KENEKES LEUWIDEMAR BANTEN Berna Elya; Roshamur Cahyan Forestrania; Ratika Rahmasari; Retnosari Andrajati; Syamsu Nur; Vitri Agustiarni
Jurnal Abdi Insani Vol 13 No 4 (2026): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v13i4.3725

Abstract

Suku Baduy, yang mendiami Desa Kenekes, Leuwidemar, Banten, memiliki kekayaan tradisi lokal yang salah satunya tercermin dalam pemanfaatan tanaman obat tradisional. Namun, pengetahuan dan teknik pengolahan produk jamu kesehatan tradisional ini masih terbatas. Kegiatan pengabdian masyarakat ini bertujuan untuk memberdayakan Suku Baduy dalam memanfaatkan potensi sumber daya alam lokal suku Baduy melalui pelatihan dan pendampingan yang berfokus pada teknik pembuatan jamu kesehatan yang higienis dan bervariasi. Jamu kesehatan yang dilakukan pelatihan yaitu jamu koneng ayu dan jamu kadeudeuh ti lembur. Metode kegiatan yang dilaksanakan meliputi tiga tahapan yaitu persiapan yang meliputi perizina, penyiapan materi, alat dan bahan, jamu koneng ayu meliputi kunyit, lada kering, asam jawa, gula aren dan air sedangkan kadeudeuh ti lembur menggunakan sereh, jahe emprit, kencur, cengkeh secang, gula aren dan air. Tahap pemberian materi meliputi pentingnya kebersihan, pemilihan bahan baku berkualitas, dan teknik pengolahan yang benar. Praktik langsung, di mana peserta didampingi secara intensif dalam proses pembuatan dan formulasi jamu. Evaluasi kegiatan untuk memastikan keberhasilan program dilihat dari proses diskusi dan nilai pretest dan postest. Hasil yang dicapai menunjukkan adanya peningkatan signifikan dilihat dari nilai pretest 70 dan nilai postest 80. Keberhasilan program ini meliputi sanitasi dan SOP sederhana dalam pembuatan jamu. Masyarakat Baduy mampu menghasilkan produk jamu kesehatan yang lebih terstandar dan dikemas tanpa meninggalkan nilai-nilai tradisi. Pelatihan ini juga berkontribusi pada upaya pelestarian kearifan lokal dalam meracik jamu.
Analysis of adverse drug reactions in remdesivir therapy using the Naranjo Algorithm Afifah Fauziyyah; Rani Sauriasari; Ratika Rahmasari; Hindun Wilda Risni; Puji Astuti
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.2049

Abstract

Research on the safety of remdesivir in Indonesian subjects for COVID-19 therapy is still limited and has yielded different results. None of these studies have used the Naranjo algorithm to analyze the causality of remdesivir safety. This study aimed to evaluate the safety of remdesivir in patients with severe COVID-19. Data were collected using medical records of patients with severe COVID-19 at Cengkareng Regional Hospital, Indonesia. The study was conducted retrospectively with a cohort study design. Subjects consisted of the remdesivir group (n=80) and the non-remdesivir group (n=80). Adverse drug reactions (ADRs) were observed, and causality analysis of ADRs was performed using the Naranjo algorithm. The study found 10 ADRs experienced by patients during treatment. ADRs were more common in the remdesivir group than in the non-remdesivir group (58.8% vs 53.8%; p=0.633). Significant events with a high proportion in the remdesivir group were increased ALT (p=0.037) and lymphopenia (p=0.01). Hepatotoxic reactions associated with remdesivir use were associated with P-glycoprotein (P-gp) inhibitor interactions. Decreased lymphocyte counts were closely related to the clinical condition of the study subjects, namely patients with severe COVID-19, and this condition was associated with a poor prognosis. Increased blood triglycerides, lymphopenia, and decreased estimated glomerular filtration rate (eGFR) were categorized as probable. Meanwhile, nausea, melena, QT interval prolongation, increased ALT, increased AST, hyperuricemia, and neutrophilia were categorized as quite possible. The results of this study can be concluded that remdesivir causes liver dysfunction manifested by increased ALT values ​​and decreased lymphocyte counts, which worsen the condition of patients with severe COVID-19.
Resistensi Flukonazol pada Candida glabrata: Mekanisme Molekuler Mutasi Gen ERG11 Astri Arri Febrianti; Robiatul Adawiyah; Ratika Rahmasari
Jurnal Ilmu Kedokteran Vol 20, No 1 (2026): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v20i1.2026.30-38

Abstract

Candida glabrata is one of the leading causes of non-albicans Candida infections with an increasing prevalence worldwide. This species is associated with high mortality rates and a marked tendency to develop resistance to antifungal agents, particularly azoles such as fluconazole. A comprehensive understanding of its biological characteristics, pathogenic mechanisms, and resistance patterns is essential for improving diagnosis and therapeutic strategies. The genetic factor that plays an important role in this resistance mechanism is the ERG11 gene, which encodes the lanosterol 14-α-demethylase enzyme, the main target of fluconazole in the ergosterol biosynthesis pathway. This review was conducted based on an analysis of recent literature focusing on the biology, epidemiology, pathogenesis, antifungal resistance mechanisms, susceptibility testing methods, and molecular identification of Candida glabrata. Special emphasis was given to the role of the ERG11 gene in fluconazole resistance and the application of molecular tools such as ITS and D1/D2 rDNA sequencing for species-level identification. The findings indicate that Candida glabrata exhibits several virulence factors, including adhesins, biofilm formation, cell wall modifications, and iron acquisition strategies. Antifungal resistance is mediated through mutations in the ERG11 gene, overexpression of efflux pumps (CgCDR1, CgCDR2, CgSNQ2), alterations in sterol biosynthesis pathways, and mitochondrial dysfunction (petite mutants). Susceptibility testing methods following CLSI/EUCAST standards, as well as automated systems such as VITEK 2, have shown reliable and rapid results. Candida glabrata is an emerging pathogen with rising prevalence and complex antifungal resistance mechanisms. Accurate species identification and molecular analysis of the ERG11 gene are crucial for understanding local resistance patterns and supporting the development of more effective therapeutic strategies.
Co-Authors Afifah Fauziyyah Anna Rozaliyani Astri Arri Febrianti Ayun Erwina Arifianti Berna Elya Fauziyyah, Afifah Forestrania, Roshamur Cahyan Hindun Wilda Risni Ihsan Alfiandri Iqbal Zulkifli Jekmal Malau Luthfi Harbulcholizi Marina Ika Irianti Muhammad Alkaff Puji Astuti Rani Sauriasari, Rani Retnosari Andrajati Retnosari Andrajati Rizki Oktarini Robiatul Adawiyah Syamsu Nur Syamsu Nur Vitri Agustiarni Vitri Agustiarni Wahyu Fitriana