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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Arjuna Subject : -
Articles 364 Documents
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Covid-19 Patient Condition at Early Pandemic in Jakarta Andika Chandra Putra; Wiwien Heru Wiyono; Mohammad Fahmi Alatas; Aulya Fairuz; Fransiska Fransiska; Bettia Bermawi; Ratna Moniqa; Hendra Koncoro; Laurentius Aswin Pramono; Maria Edith Sulistio; Ramzi Ramzi; Robert Sinto; Rachmat Hamonangan; C. Krismini Dwi Irianti; JB Endrotomo Sumargono
Jurnal Respirologi Indonesia Vol 41, No 3 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i3.193

Abstract

Background: COVID-19 is a disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) that has become a pandemic. It became apparent that COVID-19 transmitting from person to person. The clinical manifestations and characteristics of COVID-19 encompassing from asymptomatic infection until severe pneumonia and death. This study aimed to describe and compare the characteristics between COVID-19 suspected patients and confirmed patients at an early pandemic in Jakarta, Indonesia. Methods: A cross-sectional design was used in this study. Data were collected from March to April 2020 using the electronic health record reporting database, initial laboratory tests, and RT-PCR for SARS-CoV-2 results. There were 58 subjects: 43 COVID-19 confirmed patients and 15 COVID-19 suspected patients. Results: Male was found predominantly in COVID-19 confirmed patients than female. The mean age of confirmed patients was 49,6 years old. Nearly half of the confirmed patients had comorbidities namely hypertension and diabetes mellitus. Fever and cough were the most common presenting symptoms, and they were also found in suspected patients. Confirmed patients tended to have lymphopenia and neutrophilia. Pulmonary infiltrate was the most common feature in both confirmed and suspected patients. Conclusion: There were no significant differences found between COVID-19 confirmed and suspected cases regarding demographic characteristics, comorbidities, presenting symptoms, physical examination results, laboratory tests, and chest x-ray results. COVID-19 confirmed patients had a history of exposure to COVID-19 confirmed patients.
Coronary Artery Calsification on Chest CT Scan as Coronary Heart Disease Predictor in Lung Cancer Patients Luths Maharina; Yusup Subagio Sutanto; Widiastuti Widiastuti; Sulistyani Kusumaningrum; Adam Prabata; Hari Wujoso
Jurnal Respirologi Indonesia Vol 41, No 2 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i2.173

Abstract

Background: Lung cancer is widely known has strong association with cardiovascular diseases, including coronary heart disease. Smoking as the main risk factor for lung cancer and coronary artery disease is strongly hypothesized as reason behind this association. Our study aimed to predict ability of coronary artery calcification based on chest CT in prevalence of coronary heart disease in patients with lung cancer. Method: This study had cross-sectional design with consecutive sampling method. Subjects in this study were adults (>18 years old) with lung cancer based on histopathological examination. Result: Forty subjects with lung cancer who undergone chest CT was selected as samples in this study. After calculated with other factors, patients with lung cancer who also had coronary artery calcification lesions in Chest CT had 73 times higher risk to develop coronary heart disease (OR=72.63%;95% CI=3.81-1386.21;P=0.004). In addition, lung cancer subjects who are current and ex-smoker had 46 times higher risk to develop coronary heart disease (OR=45.75;95% Cl=1.14-1987.62;P=0.043). Based on those findings, coronary artery calcification has 86.7% sensitivity, 80.0% specificity, 72.2% PPV and 90.9% NPV for predicting coronary heart disease in lung cancer patients. Conclusion: Coronary artery calcification based on chest CT can be utilized as coronary heart disease predictor in lung cancer patients, especially who are current and ex-smoker. Extensive studies, is needed for strengthen this finding in near future.
The Comparison Between Risk Factors of Invasive Candidiasis and 1,3-β-D-Glucan in Septic Pneumonia Dwi Rosa Eka Agustina; Ungky Agus Setyawan; Teguh Rahayu Sartono
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.132

Abstract

Background: Invasive candidiasis (IC) occurs in immunocompromised and immunocompetent patients. It represents the 4th bloodstream infection in the ICU. Selection of patient characteristics based on risk factors in the 1,3-β-D-Glucan (BDG) examination provided a learning value in IC screening. The aim of this study was to assess the comparison of risk factors for IC and BDG levels using a cut off value of ≥80 pg/dl. Method: this cross-sectional study was conducted in 40 patients with septic pneumonia in ICU who had the risk factors of IC (multifocal colonization, broad-spectrum antibiotics, long term use of corticosteroids, and lymphocyte status) at Saiful Anwar Malang General Hospital. Results: There were 40 patients with risk factors of IC had positive BDG, but only 1 patient (2,5%) had candidemia and 14 patients (35%) had Candida sp from sputum culture. Comparison of BDG levels between group which used broad-spectrum antibiotics and those that did not wassignificant (P=0.020). Rank Spearman linear regression of the lymphocyte
Effect of Andrographolide on The Expression of TNF-α and Pulmonary Tuberculosis in Rats Granulomas are Infected With Mycobacterium tuberculosis Y. Slamet Nugroho; Reviono Reviono; Suradi Suradi; Diding Heri Prasetyo
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.161

Abstract

Background. Andrographolide as an anti-inflammatory inhibit activation of NF-κβ, the production of TNF-α, IL-12, pressing the release inducibele nitic oxide synthase (iNOS), inhibiting the release of COX-2 in human fibroblast cells and also prevents the production of oxygen radicals. TNF- α stimulates the migration of immune cells to get to the site of infection, contribute to the formation of granulomas, and can control the disease progresificity. Methods. The study aims to analyze the effect of andrographolide on the expression of TNF-α and tuberculosis granuloma in mice infected with CFA. Laboratory tests in the laboratory of histology and pathology anatomy medical faculty of UNS. Samples are 30 individuals’ mice, consist of 10 rats as control, 10 rats injected with CFA, and 10 rats injected with CFA+ andrographolide. Histopathology and immunohistochemistry of lung tissue granuloma examinated in the laboratory of pathology anatomy medical faculty of UNS. Results. The study design was purely experimental or (true experiment, with randomized post test only control group design). Andrographolide lowering the average expression of TNF-α compared to the CFA group, based on the description of the variable expression of TNF-α. The results of the analysis of three different variations or the average using Kruskal Wallis test showed that there are differences in the average number 3 granuloma with P=0.003. It means different average number of granulomas in the control group, CFA and CFA+ Andrographolide completely different convincingly. Compared with the average number of granulomas in the control group, the group CFA has a tendency average number of granuloma higher (increased), then the average number of granuloma in group CFA + Andrographolide has an average lower than the group CFA or mean average granuloma amount can be reduced by giving Andrographolide paniculata extract. Conclusion. Andrographolide 14.8% paniculata extract shown to decrease the expression of TNF-α induction of pulmonary tuberculosis in mice the CFA. Andrographolide 14.8% paniculata extract shown to reduce the number of lung granuloma in mice induced tuberculosis CFA. There is a positive correlation between the expression of strong TNF-α by the number of granulomas in the lungs in mice induced tuberculosis CFA. (J Respir Indo 2018; 38(2): 75-82)
Correlation of Ceramic Dust Content in Workplace with Lung Function in Ceramics Industry Workers of X Company, Mabar, Medan Endy Todo Sirait; Amira Permatasari Tarigan; Nuryunita Nainggolan; Putri Chairani Eyanoer
Jurnal Respirologi Indonesia Vol 41, No 3 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i3.187

Abstract

Background: Workers in the ceramics industry are often exposed to silica content which is unwittingly inhaled and deposited in the lungs. Macrophages will release Interleukin 8 (IL-8), a chemoattractant that causes neutrophil recruitment to the alveoli and releases proteolytic enzymes that damage the lung parenchyma and cause a decrease in lung function. This study aimed to determine whether dust level correlate with IL-8 serum in ceramic industry workers. Method: This research is an analytic study with a cross-sectional design conducted in March–June 2019 in the X Ceramic Industry in Mabar, Medan. Personal Dust Sampler was used to measure dust level of the study subjects at work sites. Lung function was measured by spirometry. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) software. Results: A total of 35 male workers were divided into 3 working sections, 11 (31.4%) in the pre-compression section, 13 (37.1%) in the compression section and 11 (31.4%) in the sintering section. Dust levels at each working section were 24.8, 29.2, and 6.11, respectively. The lung function examination showed restrictive impairment in 21 subjects (60%). Statistical analysis showed that the higher the level of dust in the workplace, the lower the value of Forced Expiratory Volume 1 (FEV1) and Forced Vital Capacity (FVC) values, although this correlation was not statistically significant (r = -0.03 and -0.22 respectively; p> 0.05). Conclusion: There was no significant relationship between workplace dust levels and lung function in ceramic workers.
The Depiction of Lung Function and Fractional-Exhaled Nitric Oxide (FeNO) among Asthmatic Outpatients: A Preliminary Study Mulkan Azhary; Ratnawati Ratnawati; Budhi Antariksa
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.152

Abstract

Background: Asthma is a heterogeneous disease manifested by airway inflammation and wheezing, dyspnea, breathlessness and cough which are varied in intensity and time accompanied with variably restricted expiratory airflow. Asthma patients experienced decreased lung function that occured during asthma attack accompanied by increased levels of fractional-exhaled nitric oxide (FeNO) caused by the pathophysiological process of asthma and the resulting ventilation problems. The study aimed to reveal the depiction of lung function using spirometry dan FeNO level among asthmatic outpatients. Methods: This was a cross sectional study involving 13 uncontrolled-moderate persistent asthmatic outpatients at Asthma Clinic of Persahabatan General Hospital during October 2019 – March2020. The involved respondents had to undergo the spirometry test and the measurement of FeNO level. Results: The uncontrolled-moderate persistent asthmatic patients were dominated by female with mean age of 48.38+12.494 years old. The mean predicted FEV1 was 70.38+20.230% of whom 61.54% patients showed moderate obstruction. The mean FEV1/FVC ratio was 72.85+12.681% of whom 53.85% patients showed obstruction inFEV1/FVC ratio. The mean FeNO level was 29.62+9.152 ppb of whom 76.92% patients had FeNO level ranging 25-50 ppb. Conclusion: The moderate persistent asthmatic patients showed a decreased lung function with reduction of FEV1, obstructive FEV1/FVC ratio as well as increasing FeNO level.
Correlation of Hemostatic Parameter with Lung Tumor Marker in Non-Small Cell Lung Cancer Patient with Chemotherapy Ganda M. Leonard Samosir; Parluhutan Siagian; Putri Chairani Eyanoer
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.137

Abstract

Backgrounds: There is a subclinical activation of coagulation and fibrinolysis system in patient with lung cancer. Alterations in hemostatic system are seen frequently in lung cancer correlated with the prognosis of disease. In oncology practice, the use of tumor markers may be helpful in the diagnosis and pathologic classification of tumors. Tumor marker may reflect both, stage of the disease and prognosis. Aim of this research is to asses the correlation of this parameters in patient non-small cell lung cancer with chemotherapy. Methods: This research is an analytic observational with a cross sectional design. The research was conducted at RSUP Haji Adam Malik, Medan from January 1, 2015 to May 31, 2016. Blood test examination was performed to measure the hemostatic parameter (PT, INR, APTT, TT, D-dimer) and serum tumor marker (CEA, Cifra21-1, NSE) of 41 non-small cell lung cancer patients before first cycle of chemotherapy and after fourth or sixth cycles of chemotherapy. Results: The study comprised 41 patients of non-small cell lung cancer (31 adenocarcinoma, 10 squamous cell carcinoma), There were 35 men (85,4%) and 3 women (14,6%) with mean age of 56,7 years. For all patients, we give a platinum based therapy as first line chemotherapy (gemsitabine and carboplatin regimen in 27 patients, paclitaxel and carboplatin in 10 patients, vinorelbine and carboplatin in 4 patients). There is no significant difference of hemostatic parameter and serum tumors marker values before chemotherapy againts after chemotherapy values. And there is a weak negative correlation of hemostatic parameter againts serum tumor marker on non-small cell lung cancer patients with chemotherapy. Conclusion: There is a weak negative correlation of hemostatic parameter againts serum tumor marker in non-small cell lung cancer patients with chemotherapy. (J Respir Indo 2018; 38(1): 33-38)
The Comparison of TGF-β Levels in Post Pulmonary Tuberculosis Patients with and Without Smoking History in Haji Adam Malik General Hospital Medan Shilvanna Litania; Amira P. Tarigan; Fajrinur Syarani
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.110

Abstract

Backgrounds: Pulmonary tuberculosis (TB) and smoking related disease such as chronic obstructive of lung disease (COPD) are major health problem around the world, particularly in developing countries such as Indonesia. Chronic airway obstruction as impact of TB may results during or after completion of TB treatment. Transforming growth factor beta (TGF-β) is a cytokine which contributes to fibro genesis in post-TB treatment. The aim of this study was to compare the TGF-β in post-TB patients with and without smoking history. Methods: This was an analytic study with cross sectional design, conducted from October 2016 to February 2017 in RSUP H. Adam Malik Medan. All subjects had recovered from TB, confirmed by clinical, radiological and bacteriological examination. Smoking history of the subjects was assessed using Brinkman Index. The TGF-β measurement was performed using venous blood sample processed through Enzyme Link Immunosorbent Assay (ELISA) by means of TGF-β kit. Results: This study included post-pulmonary TB patients, of which 26 subjects were smokers and 25 were non-smokers, consisted of 31 males and 20 females. The mean TGF-β level of all samples was 6690.5±4913.4 mg/ml. The mean TGF-β level in smokers was 6621.5±4856.7 mg/ml, while in non-smokers 6762.2±5071 mg/ml. Statistical analysis using Mann-Whitney test revealed that there were no significant differences of TGF-β level in smokers and non-smokers among post-pulmonary TB patients (P=0.618). Conclusions: There were no significant differences of TGF-β level in smokers and non-smokers among post-pulmonary TB patients. (J Respir Indo. 2020; 40(3): 139-43)
The Effect of Alumunium Dust Exposure on Lung Function Disorders Rinto Mangitua Hutapea; Novrikasari Novrikasari; Mona Lestari; Anita Camelia; Desheila Andarini; Rizka Faliria Nandini
Jurnal Respirologi Indonesia Vol 41, No 2 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i2.178

Abstract

Background: Industrial development continues to increase every year. CV X is a company in the manufacture of cauldrons and prickles which produce aluminum dust contaminants. Workers who work more than eight hours and lack of air exchange can affect lung function. This study aims to analyze the effect of aluminum dust exposure on lung function disorders in workers at CV X. Methods: This type of research was quantitative study with cross-sectional design. Sampling using simple random sampling technique according to inclusion and exclusion criteria with 40 respondents. Data analysis by using univariate and bivariate analysis with Chi-Square and Kolmogorov-Smirnov tests. Results: The results showed that there was no effect of aluminum dust exposure on lung function disorders (p = 0.166). However, there are 65% of workers who have lung function disorders, consists of 42.5% obstructive workers, 22.5% restrictive workers, and none of which have impaired combined lung function, while 35% of workers is normal. The majority of aluminum dust levels in the work environment are above the Threshold Value (5 mg/m3) of 72.5%. Conclusion: It is known that workers who experience obstruction problems of 51.7% are workers that exposed to aluminum dust above TLV (5 mg/m3) and there are 24.1% of workers experiencing restriction disorders exposed to aluminum dust above TLV. To prevent workers from experiencing lung function disorders due to exposure to aluminum dust, it is necessary to control efforts in the form of additional ventilation to reduce dust levels in the work environment.
CCL2 and CCR2 Expression in Broncoalveolar Lavage Fluid of Cynomolgus Macaque Model Of Asthma Sela S Mariya; Fitriya N Dewi; Villiandra Villiandra; Yasmina A Pramastri; Diah Iskandriati; Eric Hayes; Joko Pamungkas; R.P Agus Lelana; Ligaya I Tumbelaka; Dondin Sajuthi
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.166

Abstract

Background: Animal models are essential for the development and improvement of novel and effective methods for diagnostic and treatment of human diseases. Cynomolgus monkeys have been used as animal model in asthma studies wherein they exhibited different responses to allergen exposure in the airway; some were low responders while others were high responder. CCL2 is a potent chemotactic factor for monocytes and the gene expression was high in animal model of asthma. The aim of this study was to evaluate CCL2 and CCR2 expression between the low and high responders. Methods: Realtime PCR technique was used to evaluate CCL2 and CCR2 gene expression in bronchoalveolar lavage samples. The subject of this study was asthmatic cynomolgus monkeys, consisted of 4 low responders and 4 high responders. This study was held in Biotechnology Laboratory of Primate Research Center LPPM IPB on October 2016- January 2017. Results: CCL2 and CCR2 expression in low responders were higher than those in high responders at 24hours post airway challenge. Conclusion: CCL2 may potentially be developed as target for therapy or a genetic marker for asthma responsiveness in individuals. (J Respir Indo 2018; 38(2): 115-22)

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