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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Arjuna Subject : -
Articles 364 Documents
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The Effects of Anthocyanins in Purple Sweet Potato Extract to the Level MDA and NO Sputum Asymptomatic Smokers Ni Luh Putu Eka Arisanti; Helmia Hasan
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.160

Abstract

Backgrounds: Cigarette consist of 4000 chemical substances which can induce oxidative stress. In lungs, oxidative stress can cause lipid peroxidation, which produce MDA that leads to DNA damage, gene mutations, and loss of repair. Cigarette can also reduce the activity of endogenous Nitric Oxide (NO). Decrease of physiologic NO can cause dysfunction of the endothelium, pulmonary vasoconstriction, bronchospasm, mucous hypersecretion, reduction of mucociliary clearance, and airway remodeling. This damage can be prevented by antioxidant. The content of antosianin in purple cassava (purple sweet potato) is a potent antioxidant that can prevent oxidative stress. The aim of this study is to find out the effects of antosianin administration on MDA and NO sputum level in asymptomatic smoker. Methods: This study is an experimental study with randomized controlled trial pre–post test controlled group design, that performed on outpatient clinic of dr. Soetomo hospital. Results: The result of this study shows that MDA level in treatment group were significantly decrease P=0.0001 between pre (336,90 ng/ml) and post treatment (165,30 ng/ml) compare with control group that shows the opposite effect. In the control group, there was an increase of MDA level both before (416,00 ng/ml) and after placebo was given (476,00 ng/ml). The NO level in treatment group increase but it is not statistically significant between pre (40,80 ng/ml) and post treatment (78,30 ng/ml). The increase of NO level also occured in control group but it is not statistically significant between before (66,67 ng/ml) and after placebo was given (72,00 ng/ml), with the increment was higher in treatment group (6,66 ng/ml) compare with control group (0.53 ng/ml). Conclusions: The MDA sputum level were significantly decrease after the administration of antosianin extract from purple sweet potato in asymptomatic smoker. There were no significant increment of sputum NO level after the given of antosianin extract from purple sweet potato in asymptomatic smoker. (J Respir Indo 2018; 38(2): 64-74)
Profile of Adenosine Deaminase (ADA) Level in Active Pulmonary Tuberculosis Patients Sheila Gerhana Darmayanti; Soedarsono Soedarsono
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.149

Abstract

Background: Pulmonary tuberculosis (TB) has a risk of increasing the transmission of infection and death may occur if diagnosis is delayed due to limited testing. Faster, more accurate, inexpensive new methods with easy-to-obtain samples, such as serum levels of Adenosine deaminase (ADA), need to be applied. This study aims to compare serum ADA levels in new cases of pulmonary TB patients and in healthy individuals, and to examine the potential of serum ADA to diagnose pulmonary TB. Methods: This study was an observational analytic study conducted at the Outpatient Clinic of TB/TB-MDR-DOTS, Dr. Soetomo Hospital, Surabaya, Indonesia, from August to December 2019. The subjects were new cases of pulmonary TB patients and healthy individuals. Serum ADA levels were analyzed using the enzymatic colorimetric method, using Erba XL 600. Results: A total of 60 patients were divided into 34 new cases of pulmonary TB patients and 26 healthy individuals. Serum ADA levels in new cases of pulmonary TB patients were significantly higher compared to those in healthy individuals (P<0.001). The cut-off value of serum ADA levels was 11.4 U/L with a sensitivity of 85.3% and specificity of 84.6%. Conclusion: ADA serum levels are increased in patients with new cases of pulmonary TB. ADA serum can be used to assist the diagnosis of tuberculosis.
Correlation Between Leukocyte Differential Counts with The Severity and Outcome of Coronavirus Disease 2019 (COVID-19) Patients In Jember Angga Mardro Raharjo; Eprila Darma Sari; Diana Chusna Mufida
Jurnal Respirologi Indonesia Vol 41, No 3 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i3.186

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is an acute respiratory disease caused by new strain of RNA viruses named Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Hematological changes, especially leukocyte differential counts, presumed to be a predictor of the severity and outcome of COVID-19 patients. This study aimed to analyze the correlation between leukocyte differential counts with the severity and outcome of COVID-19 patients. Methods: This study was conducted using a cross-sectional analytic observational method, through secondary data analysis of COVID-19 patients who were tested positive by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) and hospitalized between April–November 2020 at Citra Husada Jember, Kaliwates Jember, and Jember Klinik Hospital. Results: From 267 patients, there were 139 female patients (52.1%) and 128 male patients (47.9%). There was a positive correlation on leukocytes, neutrophil, and neutrophil-lymphocyte ratio (NLR) with the severity and outcome of the patients, and negative correlation on eosinophils, lymphocytes, and monocytes (P 0.05) Conclusion: Leukocyte differential counts examination could be a predictor of the severity and outcome of COVID-19 patients, especially neutrophils, lymphocytes, and NLR.
The Role of Pedometer Based Walking Exercise To Quadriceps Muscle, Quality of Life, Benefit, and Cost in Stable COPD Patient Jatu Aviani; Suradi Suradi; Ana Rima
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.117

Abstract

Backgrounds: Quadriceps muscle dysfunction in chronic obstructive pulmonary disease (COPD) is caused by systemic or local inflammation, hypoxia, hypercapnia, corticosteroid use, nutritional depletion, anabolic/catabolic hormone imbalances, oxidative stress, genetic susceptibility, and decreased daily activity. Decreased quadriceps muscle strength reduces exercise capacity, physical activity, increases shortness of breath, and decreases quality of life. Exercise trainng of walking increases the quadriceps muscle strength and overcomes deconditioning. The purpose of this study was to analyze effect of pedometer-based exercise on quadriceps muscle strength, quality of life, benefits, and cost on patients with stable COPD. Methods: A clinical study with quasi-experimental pre-post test control group design using consecutive sampling was performed in patients with stable COPD at Dr. Moewardi Hospital from September to November 2018. Subjects were divided into intervention group which were given pedometer based walking exercise for six weeks and control group with standard rehabilitation. Quadriceps muscle strength, SGRQ score, LCADL score, and cost effectiveness were measured before and after exercise. Results: Twenty-seven of stable COPD patients were included in this study. The intervention groups showed increased quadriceps muscle strength (2,58+0,49), decreased SGRQ scores (23,39+6,60), decreased LCDAL scores (-5,69+2,18), and cost effectiveness compared to control group (P
Proportion of Allergic Rhinitis in Asthma Patient and Their Correlation with Asthma Control Fersia Iranita Liza; Wiwien Heru Wiyono; Deasi Anggraini; Erlang Samoedro; Triya Damayanti
Jurnal Respirologi Indonesia Vol 41, No 2 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i2.177

Abstract

Background: Upper and lower airway diseases have strong interaction, particularly between asthma and AR. SPT and nasal endoscopy are not always used as tools for diagnosing AR. This study aimed to determine proportion of AR in asthma patients and the correlation with asthma control. Methods: This was a cross sectional study in 185 adult patients with asthma. Nasal endoscopy was used to objectively obtain data on the anatomical condition of nose and paranasal sinus orifices. Allergic rhinitis severity was classified according to the ARIA system. The ACT questionnaire was used to assess asthma control and allergic reactions were measured using SPT with 12 allergens. Results: A total of 54 asthma patients (29.2%) had AR. The most common allergens were house dust mite (38.8%), house dust (37.3%), and human skin flakes (32.8%). The results of nasal endoscopy showed that there were septum deviation (56.6%), pale concha (50.9%), edematous concha (22.6%), hypertrophic concha (18.9%), sinusitis and polyp (16.9%, respectively). The results of ACT questionnaire showed a score of ≤19 (uncontrolled asthma) found in 45.9% asthmatic patients, partially control in 47% patients and controlled asthma in 7% patients. Based on AR severity, it was obtained those with mild intermittent (46.3%), mild persistent (46,3%) and moderate-severe persistent AR (7.4%). There was a significant correlation between AR and asthma control (P=0,045). Conclusions: AR is a common comorbid in asthmatic patients. Precipitating allergens could be detected by SPT in asthmatic patients with AR. Avoiding exposure to precipitating allergens could prevent exacerbation in asthmatic patients with AR.
Effect of Vitamin C to The Plasma Level of Interleukin-6, Plasma MDA and Length of Hospitalization of COPD Exacerbation Patient Fadlia Yulistiana; Suradi Suradi; Reviono Reviono
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.136

Abstract

Background: Exacerbation is an acute condition characterized by worsening of symptoms that require a change in therapy. Increased inflammation of the airways and lungs during exacerbations causes an increase in plasma IL-6 and MDA levels and causes most patients needed treatment at the hospital. Vitamin C is an antioxidant vitamin that has anti-inflammatory and antioxidant effects so that it can be added to COPD exacerbations therapy. This study aims to determine the effect of vitamin C on plasma IL-6, plasma MDA levels and length of hospitalization of acute exacerbation of COPD patients. Methods: This research is an experimental study with pre-test and post-test design. Subjects consisted of 33 patients with exacerbation of COPD were treated at the Soehadi Pridjonegoro Hospital Sragen in October-November 2015 which were selected by purposive sampling. Subjects were divided into two groups, the treatment group (n=16) received vitamin C therapy 1x1000 mg/day and the control group (n=17) received 5 mL of NaCl 0.9%. Levels of IL-6 plasma and plasma MDA was measured on admission and at discharge criteria are met. Length of hospitalization is calculated based on the number of days’ patients in hospital. Results: There was no statistically significant difference to decreased of IL-6 plasma level (P=0.379), MDA plasma level (P=0.27) and length of hospitalization (P=0.24) between treatment and control group. Conclucions: The addition of vitamin C 1x1000 mg/day during hospitalization is not helpful to decreased in levels of plasma IL-6, plasma MDA and length of hospitalization in this study. (J Respir Indo 2018; 38(1): 24-32)
Affect Decreasing Lung Function in Laundry Installation Worker At Rumah Sakit Umum Pusat H. Adam Malik, Medan Wina Elizabeth Octaria Saragih; Nuryunita Nainggolan; Amira Permatasari Tarigan
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.165

Abstract

Background: Data from International Labor Organization (ILO) at 2005 shows that there are 250 million case of diseases that related to occupation which can also cause 300.000 death in the world with annual incidence rate of work related lung disease around 1:1000 worker. Laundry worker was included as group that has risk of having occupational pneumoconiosis. Method: This is a descriptive study using total sampling with sample number 24 patient, this study was done in Laundry Installation of Rumah Sakit Umum Pusat Haji Adam Malik Medan on November 2016. Examination was done by using questionnaire, physical examination, daily PEF (before and after working) for 14 days, spirometry, total room dust, total room bacterial colonization. Factors (age, sex, working duration, smoking history, p.2,5 dust exposure, bacterial exposure, safety equipment usage, and nutritional status) that had potential of affecting the decreasing lung function was assessed. Result: From PEF examination, we found mean variability 3.1%. from all worker, there are 9 workers that had decreasing lung function ≥3, 1%. From examination result of 9 sample, decreasing lung function mostly caused by smoking (55%) and p.2,5 dust exposure (66%) Conclusion: Smoking and p.2,5 dust exposure is the most common factors that affected decreasing lung function in laundry worker. (J Respir Indo 2018; 38(2): 109-14)
Asthma in Pregnancy: Mechanism and Clinical Implication Triya Damayanti; Sri Pudyastuti
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.125

Abstract

Asthma in pregnancy can influence clinical status of an asthma patient. Study showed that one third of asthma patients were worsening, one third stable and one third improving. During pregnancy, lung function, ventilation pattern and gas diffusion are influenced by biochemistry (hormonal) and mechanic. Mechanism in pregnancy with asthma including hypoxia, inflammation, corticosteroids therapy, history of exacerbation, smoking mother and changes in placenta function. Hormonal status during pregnancy is different with non-pregnancy woman which hormonal level changes through the pregnancy time. Those changes can influence lung function in pregnancy. Treatment of asthma in pregnancy is giving optimal asthma therapy, therefore it can improve asthma control, also the quality of life of a mother and her fetus during pregnancy.
Coal Workers' Pneumoconiosis at PT. A Sawahlunto and The Influencing Factors Ulfahimayati Ulfahimayati; Deddy Herman; Masrul Basyar; Fenty Anggrainyi
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.157

Abstract

Background: Coal workers’s pneumoconiosis (black lung disease) is an interstitial lung disease caused by chronic inhalation of coal dust. The incidence of coal workers’s pneumoconiosis increased globally from the 1990s to the 2000s by 3.2%. Indonesia is the country which has many coal mining, but national prevalence of coal workers pneumoconiosis was not discovered. PT. A is one of mining companies in Sawahlunto. The aims of this study was to determine the incidence of coal workers’ pneumoconiosis at PT. A Sawahlunto and it’s influencing factors. Methods: This study is an analytic study with cross sectional design, conducted from November 2019 to April 2020. There were 90 coal miners participated in this study. All subjects were performed chest X-ray examination with ILO standard to asses the incidence of pneumoconiosis. Spirometr examination, dust level measurement with portable low volume air sampler, interview, and validated questionnare were performed to evaluate it’s influencing factors. Statistical analysis used Chi-square test and double logistic regression test. Results: This study found 12 workers (13.3%) had pneumoconiosis. From the statistical test results obtained age >50 years (P=0.035), duration of exposure (P=0.040), mask usage (P=0.029), restrictive lung function (P=0.004), and the mixed abnormality lung function (P=0.006) is associated with pneumoconiosis. The most dominant factor was mask usage (P=0.049) with OR=5.026 Conclusion: The most dominant factor that influence coal workers’ pneumoconiosis was mask usage. Others related factors were age, duration of exposure and abnormality lung function.
Effect of Lower Extremity Exercise on The Borg Scale in Chronic Obstructive Pulmonary Disease Ghamal Arif Hanafiah; Amira P Tarigan; Pandiaman Pandia; Putri C Eyanoer
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.141

Abstract

COPD patients tend to experience complaints shortness of breath, limb muscle fatigue and distress in an effort in activities that result in a decrease in quality of life and inhibit daily activities. This situation will eventually cause the patients to experience fatigue faster and fall into a deconditioning state. The Borg scale is a way to measure the intensity level of physical activity using a ratio scale size. This study aimed to assess the effect of lower limb endurance training on the Borg Scale of COPD patients. A quasi-experimental study conducted on 20 patients with COPD group C and D which underwent lower extremity resistance training. The Borg scale was assessed before and after training, with statistical analysis performed by the Mann Whitney-Test. There was an effect on lower extremity resistance training on the Borg Scale of COPD patients in the form of a significant decrease in the Borg Scale value where in the effort parameters. Before training, the Borg Scale score of COPD patients was 9 and 15, decreased to 1 and 13 after training. While tired feet, before training was 5 which decreases to 3 after training and shortness of breath, before training is 7 which decreases to 4 after training. There is a significant improvement in the value of the Borg Scale of COPD patients after undergoing a lower limb endurance training program. There were no significant Borg scale differences between Group C and Group D after undergoing a lower limb endurance training program.

Page 13 of 37 | Total Record : 364

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