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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Arjuna Subject : -
Articles 364 Documents
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The Effect of Pursed Lips Breathing Exercises and Diafragma Breathing on Spirometry and Modified Medical Research Council Scale on Stable Chronic Obstruction Lung Disease Ida Muna Junita; Mulyadi Mulyadi; Teuku Zulfikar; Nurrahmah Yusuf
Jurnal Respirologi Indonesia Vol 41, No 2 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i2.174

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease characterized by limited airflow and a chronic inflammatory response to the airways, where shortness of breath is the main complaint in COPD patients. Pursed lips breathing (PLB) and diaphragmatic breathing exercises are useful techniques to improve ventilation by increasing the Forced Expiratory Volume 1 (FEV1) value and decreasing the degree of shortness of breath. This study aims to determine the effect of pursed lips breathing and diaphragmatic breathing exercises on the improvement of lung function and the degree of shortness of breath in stable COPD patients. Methods: This is an experimental study with pre-test and post-test control group methods of 60 stable COPD patients at the RSUDZA Pulmonology Clinic from November 2019 to February 2020. The sample was taken by systematic random sampling, divided into 2 groups, namely the intervention group who received training. PLB and diaphragmatic breathing exercises for 4 weeks coupled with indacaterol bronchodilator therapy. The control group only received indacaterol therapy. Changes in lung function were assessed by spirometry, namely FEV1 and Forced Vital Capacity (FVC) values and changes in the degree of shortness of breath using the mMRC scale. Statistical analysis used was t-test and Wilcoxon test, which were performed to assess differences between groups, the value of significance (P<0.05). Results: There was a significant effect on FEV1 (P=0.0005) and FVC (P=0.014) in the intervention group compared to the control group. There was a significant effect on improving the degree of shortness of breath using the mMRC scale in the intervention group compared to the control group (P=0,0005). Conclusion: The administration of PLB and diaphragmatic breathing exercises significantly increased FEV1, FVC and improved the degree of shortness of breath. It is suggested that this exercise can be used as an adjunct therapy in COPD patients.
Correlation Between Pleural Fluid GenXpert® and Histopathology Finding of Pleural Biopsy in Tuberculous Pleural Effusion Sheilla Matheos; Isnin Anang Marhana; Anny Setijo Rahaju
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.133

Abstract

Backgrounds: Tuberculosis pleural effusion is the most common extrapulmonary TB after lymphadenitis TB, but a definite diagnosis is still a challenge. Pleural biopsy has historically been the gold standard procedure for the diagnosis of pleural tuberculosis. GenXpert® is a computerize test based in nucleic acid amplification tahat automatically detect MTB and rifampicin resistance. This study aimed to prove the correlation between pleural fluid GenXpert® and histopathological findings of pleural biopsy in patients with pleural tuberculosis. Methods: This study used an observational analytic design with a cross-sectional design conducted in Dr. Soetomo Hospital, Surabaya in March-June 2017. Statistic analysis was using chi square test and contingensi coofisient. The pleural GenXpert® was tested in 23 patients with pleural effusion and their biopsy speciments underwent histopathological analysis. Results: Histopathological findings of pleural biopsy was positive in 4 subjects and pleural fluid GenXpert® resulted positive in 6 subjects. There was significant correlation between pleural fluid GenXpert® and histopathological findings of specimen pleural biopsy in patients with pleural tuberculosis (P=0.040) with moderate strenght (P=0.014). Sensitivity and specificity of pleural fluid GenXpert® were 75.0% dan 84.2% respectively. Conclusions: There was significant correlation between pleural fluid GenXpert® and histopathological findings of pleural biopsy in patients with pleural tuberculosis. (J Respir Indo 2018; 38(1): 1-6)
The Test of DLCO Is A Valuable Predictor for Prognostic Determination of Patients with Chronic Obstructive Pulmonary Disease Dina Okfina Ria; Suradi Suradi; Jatu Aphridasari; Reviono Reviono; Dono Indarto
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.162

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is characterized by permanent and progressive air way obstruction. In terms of morbidity, this disease is the first highest pulmonary disease in the world. DLCO is used for measurement of gas transfer from alveoli to blood capillary and Hb level is one of the main factors affecting the gas transfer. The aim of this study was to examine prognosis of patients with stable COPD using lung function, DLCO and Hb tets. Methods: Consecutive sampling was used to recruit 33 outward patients who suffered stable COPD and visited the Lung Clinic at Public Hospital dr. Moewardi Surakarta. Classification of COPD was determined using GOLD 2016. Airway and lung functions were examined using spirometry and single breath DLCO. Hb level was measured using cyamethemoglobin method. All collected data were analyzed using student t test and p value was set up P
Proportion of Mutation of Epidermal Growth Factor Receptor (EGFR) Genes from Tissue Biopsy and Liquid Biopsy ctDNA in Lung Adenocarcinoma Hendra Taufik; Noni Novisari Soeroso; Setia Putra Tarigan; Erna Mutiara
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.118

Abstract

Backgrounds: In recent years, circulating tumor DNA (ctDNA) has emerged as a specific and sensitive blood-based biomarker to detect EGFR mutations. This study aims to determine the diagnostic accuracy of ctDNA in detecting EGFR gene mutations in adenocarcinoma lung cancer. Methods: This study was a cross-sectional study with the subjects were adenocarcinoma lung cancer patients from histopathology or cytology examination and examined EGFR mutations from plasma tissue biopsy and ctDNA specimens from April 2018 to February 2019 in several hospitals in the Medan City. Results: There were 100 data have been collected, with male were 71 subjects and female were 29 subjects. Found 20 mutations, single mutations of tissue biopsy were 19 cases, del exon 19 were 12 cases, mutation in exon 21 (L858R) were 6 cases, mutation exon 21 (L861Q) was 1 case, del exon 19 and 21 (L861Q double mutations) was 1 case. From plasma ctDNA examination EGFR mutations were found 15 cases, del exon 19 were 12 cases and del exon 21 (L858R) were 3 cases. Conclusions: The highest proportion of EGFR mutations by sex were women from tissue biopsy or ctDNA, the most often frequency of EGFR mutations from tissue biopsy and ctDNA in single mutations and exons19. (J Respir Indo. 2020; 40(3): 150-5)
Pediatric Hemoptysis Hana Khairina Putri Faisal; Faisal Yunus; Nastiti Rahajoe
Jurnal Respirologi Indonesia Vol 41, No 3 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i3.189

Abstract

Hemoptysis or expectoration of blood is one of the respiratory symptoms in children, hemoptysis is hard to detect because it is often swallowed. The common causes of hemoptysis in adults include bronchiectasis, tuberculosis, pulmonary mycosis, and lung cancer. On the other hand, hemoptysis in children is often caused by tracheobronchitis, pneumonia, bronchiectasis in cystic fibrosis, and foreign body aspiration. Bleeding of the pulmonary artery or bronchial artery is the cause of hemoptysis. Upper airway examination is important to rule out epistaxis as the cause of hemoptysis. The primary objectives of hemoptysis management are asphyxia management, bleeding cessation, and treatment of the underlying disease. When all other treatments fail to stop the bleeding, surgery is recommended.
Clinical Characteristics of COVID-19 Patients in Dr. Saiful Anwar Hospital, Malang Magdalena Magdalena; Yani Jane Sugiri; Rezki Tantular; Aditya Listyoko
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.150

Abstract

Background: Coronavirus Disease (COVID-19) emerge as a new global health crisis. COVID-19 has a wide range of clinical feature, from mild cough to severe respiratory failure. This study aims to learn more about clinical feature of COVID-19. Methods: This cross sectional analytic descriptive study includes all COVID-19 patients that yield positive result through GeneXpert-SARS-CoV-2 or Polymerase Chain Reaction (PCR). All data was taken from inpatient form March 12th –June 30th 2020. Results: There were 103 patients with 58 men and 45 women. Patients with male sex tend to experience severe pneumonia than women. It was also found that patients exposed to cigarette smoke tended to experience severe pneumonia symptoms. Patients with more than 1 comorbid tend to develop severe pneumonia symptoms. The dominant clinical symptoms in the patient were cough (84.5%), fever / history of fever (70.9%), and shortness of breath (67.9%). Hematological parameters that correlate with the degree of severity are leucocytes, thrombocyts, lymphocytes, neutrophils, CRP, LDH, creatinine, procalcitonin, SGOT, and SOFA Score. The most common radiological picture obtained was bilateral infiltrate (78.2%). The most common complication was sepsis (38.9%). The mortality rate for COVID-19 patients treated at RSSA tends to be high (26.2%). Discussion: clinical characteristics such as gender, smoking history, comorbides, clinical symptoms (fever, shortness of breath and cough), laboratory (leukocytes, % lymphocytes, % neutrophils and neutrophil counts, CRP, LDH, procalcitonin, creatinine, SGOT, and SOFA scores) has a significant effect on the severity of Covid infection 19 Conclusion: The clinical characteristics of COVID-19 patients affects the severity of the disease.
Effect of Low Dose Azithromycin Towards The Long Period of Clinical Improvement, Level of IL-8 And Sputum Neutrophil of Pneumonia Patients Leonardo H. Simandjuntak; Reviono Reviono; Harsini Harsini
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.138

Abstract

Backgrounds: Pneumonia is an acute inflammation of the lung parenchyma caused by microorganisms. Inflammation is an immune response that occurs when bacterial infection. The immune response that occurs will induce alveolar macrophages secrete IL-8 which mediates the movement of neutrophils into the alveolar to release reactive oxygen species (ROS) and protease. Low-dose azithromycin has anti-inflammatory effects that are used on a chronic inflammatory disease of the lung, so its use in pneumonia interesting to do. This study aimed to determine the effect of low-dose azithromycin towards the long period of clinical improvement, level of IL-8 and sputum neutrophil of pneumonia patients. Methode: This research is an experimental study with pretest and post-test design. Subjects were patients with pneumonia who were treated at the Hospital Dr. Moewardi Surakarta in July - August 2016. Samples were taken by consecutive sampling as many as 30 patients. treatment group (n = 15) received additional therapy of azithromycin 250 mg / day and the control group (n = 15) received additional placebo. Result: Supplementation of low-dose azithromycin was significantly reduced levels of IL-8 (reduction = -90.31 ± 89.30; P=0.002) and sputum neutrophil (reduction = -35.73 ± 25.25; P=0.0001) in pneumonia patients. There is a statistically significant difference (P=0.0001) of the long period of clinical improvement between treatment groups (3.87 + 0.64 days) and control (5,60+ 0.91 days). Conclusion: Supplementation 250 mg/day of azithromycin during hospitalization led to decreased levels of IL-8 serum, sputum neutrophil, and affect the long period of clinical improvement in pneumonia patients. (J Respir Indo 2018; 38(1): 39-47)
Immunosenescence and the Susceptibility of the Elderly to Coronavirus Disease 2019 (COVID-19) Widya Wasityastuti; Andika Dhamarjati; Siswanto Siswanto
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.115

Abstract

A new disease caused by a newly-found coronavirus, known as Coronavirus Disease 2019 (COVID-19), has been declared as a pandemic by World Health Organization (WHO). This new disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outbreak started in late December of 2019 and it did not take a long time until it spread to more than 200 countries in the world with over 4 million confirmed cases to date. The number keeps skyrocketing as day passes, followed by the increasing number of fatalities. Among all of the infected patients, elderly is one of the vulnerable populations. Studies reported that the risk of infection is doubled in older people. This infection-susceptible characteristic may be due to the weak immune system, therefore they lack the capabilities to fight the infection. The deterioration of immune system in elderly is known as immunosenescence. The aim of this literature review is to understand the effect of immunosenescence in the immunopathogenesis and susceptibility of elderly who are exposed to COVID-19 infection. (J Respir Indo. 2020; 40(3): 182-91)
Effect of Asthma Gymnastic on Blood Nitric Oxide, Mood, Energy Expenditure and Sex Quality Ita Juliastuti; Suradi Suradi; Debree Septiawan
Jurnal Respirologi Indonesia Vol 41, No 2 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i2.179

Abstract

Background: Sex is a basic function in human life. Exercise stimulates formation of blood nitric oxide (NO) as a potent vasodilator in all organs of the body including the genitals. Exercise prevents and improves depression and anxiety, but the link between exercise and sexual function has received less attention. Asthma gymnastic is an exercise in pulmonary rehabilitation that everyone can practice it. The effect of asthma gymnastic in sexology has never been studied yet. Methods: The pretest and posttest experimental clinical trials were carried out on 40 people aged 40-60 years old in Surakarta on 21st July 2019 until 27th October 2019. The intervention group (n=20) were treated with asthma gymnastics once a week for 12 weeks while the control group (n=20) didn’t exercise regularly. The aims of this study are to assess the effect of asthma gymnastic on blood nitric oxide, mood based on the Beck Depression Inventory (BDI) questionnaire, energy expenditure (physical and sexual activity) and sex quality based on the Arizona Sexual Experiences Scale (ASEX) questionnaire. Results: Asthma gymnastic had a significant positive effect on blood NO (B=0.426;P<0.003), physical activity (B=0.664;P<0.001) and sexual activity (B=0.336;P=0.026). Asthma gymnastic had a significant negative effect on the BDI score (B=-0.664;P<0.001). Asthma gymnastic did not have a direct effect on sex quality (B=-0.071;P=0.756). BDI score had a positive effect on sex quality (B=0.464;P=0.009). NO blood levels had no effect on sex quality (B=0.018;P=0.904). Conclusion: Asthma gymnastic had no direct effect on sex quality, but it increased blood NO, energy expenditure and improved mood. Asthma gymnastic would have significant effect on improving sex quality if supported by good mood.
Breath Failure in Obesity Wirya Sastra Amran; Putri Suci; Nina Aspiah; Menaldi Rasmin; Prasenohadi Prasenohadi; Agus Dwi Susanto
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.167

Abstract

Based on calculations of over one million people in the world weighing excessively or known as obesity with body mass index (IMT) 25 kg / m2 or more. Obesity is the cause of morbidity, as is the case in the population of the United States an estimated 400,000 deaths caused due to obesity. Obesity especially abdominal obesity is a significant risk factor for cardiovascular diseases, type 2 diabetes, rheumatoid arthritis and cancer. The relationship between obesity and chronic respiratory illness began to increase and began to be recognized. The World Health Organization (WHO) predicts about 10% of the global population will be obese by 2015. (J Respir Indo 2018; 38(2): 123-33)

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