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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Arjuna Subject : -
Articles 364 Documents
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Differences of Interleukin-6 Serum Levels in Lung Cancer Patients and Healthy Individuals in Medan Dumasari Siagian; Noni Novisari Soeroso; Bintang Yinke Magdalena Sinaga; Putri C Eyanoer
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.155

Abstract

Background: Interleukin-6 (IL-6) is a pro-inflammatory cytokines involved in the development of lung cancer. However, the association of IL-6 in lung cancer patients remains uncertain. The aim of this study was to analyze the difference of IL-6 serum levels in lung cancer patients and healthy individuals in Medan. Methods: This was a case-control study that included 42 lung cancer patients (case) and 42 healthy individuals (control) which was held in Haji Adam Malik General Hospital Medan. The examinations of IL-6 serum levels were conducted for all subjects using ELISA method. Differences of IL-6 serum levels in lung cancer patients and healthy individuals were analyzed using Spearman Correlation test. Results: The mean serum IL-6 levels in lung cancer patients was 45.99 pg/ml while in healthy individuals was 6.24 pg/ml. There was a significant difference of serum IL-6 levels in the lung cancer group compared to healthy individuals (P=0.0005;r=0.854). Conclusion: There was a statistically significant difference of IL-6 serum levels between lung cancer patients and healthy individuals.
Preliminary Study: Increased Profile of PAI-1 in Lung Cancer Patients Receiving Chemotherapy Ria Siska Myrnasari; Triwahju Astuti; Suryanti Dwi Pratiwi
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.139

Abstract

Background: Lung cancer has the highest mortality rate in the world. Lung cancer management requires biomarkers to evaluate the chemotherapy response. Levels of Plasminogen Activator Inhibitor-1 (PAI-1) in malignancy >14 ng/ml shows poor prognosis. Increased levels of PAI-1 are associated with stage, metastasis, and prognosis of lung cancer. The chemotherapy is thought to decrease PAI-1 levels. The aim this study is analyze the profile of PAI-1 levels before and after 3rd and 6th chemotherapy cycle and their changes by type of lung cancer and Response Evaluation Criteria in Solid Tumors (RECIST). Methods: This research was conducted from December 2016 to December 2017 at RSSA Malang. The study design was a cohort of 18 lung cancer patients. PAI-1 levels were measured by ELISA in 18 lung cancer stage III or IV patients before (PAI-1(1)) and after 3rd chemotherapy cycle (PAI-1(2)), and 9 patients after 6th chemotherapy cycle (PAI-1(3)). Average PAI-1 levels are presented in tables and graphs. Result: PAI-1(1) 2,151±0,564 ng/ml, PAI-1(2) 1,951±0,534 ng/ml, and PAI-1(3) 1,647±0,495 ng/ml. PAI-1 levels in non-small cell lung carcinoma (NSCLC) were 1.658±0.562 ng/ml and small cell lung carcinoma (SCLC) were 1.609±0.244 ng/ml. Levels of PAI-1(2) in partial response 1.784 ± 0.363 ng/ml, stable disease 1.980 ± 0.304 ng/ml, and progressive disease 2.020±0.635 ng/ml. Levels of PAI-1(3) in the partial response 1.427 ± 0.324 ng/ml and in progressive disease 2.085±0.532 ng/ml. Conclusions: PAI-1 levels in patients with stage III and IV lung cancer after chemotherapy were lower than before chemotherapy, and showed changes corresponding to the response according to RECIST. PAI-1 levels in NSCLC are higher than SCLC. (J Respir Indo 2018; 38(1): 48-56)
Type 2 Diabetes Mellitus And Hemoptisis Risk Factor In Lung Tuberculosis : A Case Control Study Widhy Yudistira Nalapraya; Jaka Pradipta; Muhammad Ikhsan Mokoagow; Erlina Burhan
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.111

Abstract

Background: Diabetes mellitus (DM) is a risk factor for tuberculosis (TB) morbidity and mortality. Increasing cases of type 2 DM in the world increases the risk of developing TB. The frequency of DM in TB patients was reported to be around 10-15% and the prevalence of this infectious disease was 2-5 times higher in diabetic patients compared to non-diabetics. Hemoptysis is a respiratory symptom which can be life threatening. Tuberculosis and bronchiectasis are the two most common ethology of hemoptysis, while TB with DM are the cause of recurrent hemoptysis. Methods: This was case control study which used the medical records data of diabetic patients infected with TB who experienced hemoptysis and no hemoptysis, treated at Fatmawati General Hospital during 2017. Sampling method was total sampling. Results: There were 12 hemoptysis patients with DM comorbidity and 31 patients without DM comorbidity. As many as 58% of patients with DM had new cases of pulmonary TB and 42% had history of treatment completion. The correlation between hemoptysis of TB patients with DM compared to without DM obtained a relative risk of 1.535 (95% CI=0.677-2.618) Conclusion: The proportion of hemoptysis in TB patients with DM comorbidity was 10.3%. Diabetes Mellitus was a risk factor for hemoptysis 1.535 times higher compared to TB patients without DM but statistically not significant. (J Respir Indo. 2020; 40(3): 144-9)
The Correlation Between Air Pollution Exposure Duration and Occurence of Emphysema Based on Chest CT Scan in Public Transportation Drivers Yopi Simargi; Jessica Seprianto; Bryany Titi Santi
Jurnal Respirologi Indonesia Vol 41, No 2 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i2.180

Abstract

Background: Emphysema is included in chronic obstructive pulmonary disease (COPD) whose prevalence tends to increase in Indonesia. Air pollution is one of risk factor for emphysema. Public transportation drivers are one of the most vulnerable occupation exposed to air pollution. This study aimed to determine the correlation between air pollution exposure duration and occurence of emphysema in public transportation drivers. Methods: This was an analytic observational study using a cross-sectional approach. Samples of this study (n=32) were public transportation drivers in North Jakarta. Data were collected during August – October 2019 at Atma Jaya Hospital, North Jakarta. The study datawere secondary data obtained through interviews and chest CT scan. Data analysis was performed using Fisher’s exact method. Results: The prevalence of emphysema was 46,9% with 9 respondents (60%) had mixed type emphysema and 13 respondents (87,7%) had mild degrees. The prevalence of public transportation drivers exposed to air pollution for more than or equal to 8 hours a day was 87,5%. There was a significant correlation between air pollution exposure duration and occurence of emphysema (P=0,038). Conclusion: There was a statistically significant correlation between air pollution exposure duration and occurence of emphysema. As many as 11 respondents (39,3%) exposed to air pollution for more than or equal to 8 hours a day exposure were found to have emphysema. However, all respondents in this study were smokers, which was also a risk factor for emphysema and could be considered as severe air pollution.
The Successful Management of COVID-19 Patient with Severe ARDS Using Standard Therapy Dian Indriani Hidayat; Sofyan Budi Raharjo
Jurnal Respirologi Indonesia Vol 41, No 2 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i2.170

Abstract

The clinical manifestations of COVID-19 are very diverse. Young patients generally develops mild infection, whereas in older age with various comorbidities, the mortality rate increases. Since SARS-CoV-2 virus is still relatively new, a variety of treatments to manage COVID-19 patients are sought with various treatment effects. Currently there are many antiviral regimens and other drugs as treatment options for COVID-19, but there has been no specific therapy approved by U.S. Food and Drug Administration (FDA). This case report described the incidence of severe-critical ARDS in young patients without comorbids, as well as the comparison of successful management of COVID-19 patients with critical manifestations of severe ARDS using standard therapy. This case study compared the clinical and therapeutic similarities and differences in two patients who have successfully recovered from COVID-19 using standard therapy. Both patients were young male with no comorbids. The therapies administered were antivirus, anticoagulant, antibiotic, ventilator, steroid and symptomatic therapy corresponding to clinical condition development. Early case detections, ventilator use with high PEEP strategy, negative liquid balance, symptomatic management and sepsis prevention were factors that support the success of therapy.
The Correlation of Body Mass Index with Sputum Conversion Time in MDR-TB Patients Undergoing Treatment with Short Term Regimen at H. Adam Malik Medan General Hospital Diana Santy; Parluhutan Siagian; Bintang Yinke Magdalena Sinaga; Putri C Eyanoer
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.130

Abstract

Background: It was estimated about 10.4 million incidence of TB cases worldwide, of which 580,000 were MDR TB cases in 2015, however, only 125,000 were successfully found and treated. The World Health Organization (WHO) issued a recommendation of 9-11 month Short Term Regimen (STR) guideline that could provide satisfactory results in terms of successfull outcome, easier to control and also low-cost. The study aimed to analyze the correlation between Body Mass Index (BMI) and sputum conversion time in MDR TB patients undergoing treatment with STR and to determine the final treatment outcome using STR at H. Adam Malik Medan General Hospital, North Sumatra, Indonesia. Methods: This was a case series study of a total 76 MDR TB patients undergoing treatment using STR. Samples were obtained from medical record of the pulmonary isolation ward and MDR TB clinic at H. Adam Malik Medan General Hospital. Data were analyzed descriptively to identify the trend in sputum conversion from nine months of treatment. Results: The number of patients with normal BMI was 51.3% higher than those of low, very low and high BMI. The time to sputum conversion occured in the second month of treatment. All groups of BMI categories experienced conversions and normal BMI was higher in number. At the end of the treatment evaluation, the cure rate was 44.8%, the drop out was 28.9%, the regimen change was15.8%, died 9.2%, and moved 1.3%. Conclusion: There was a significant correlation between BMI and sputum conversion time in MDR TB patients. Good nutritional status was a predictor of treatment success.
The Role of Bronchoscopic Cryoablation in Management of Central Airway Obstruction Dicky Soehardiman; Rahma Ayu Indahati; Mia Elhidsi
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.154

Abstract

Central airway obstruction is one of respiratory emergency manifested as dyspnea, stridor and obstructive pneumonia. Most of central airway obstruction cases were treated with resection and surgery. Bronchoscopy is an initial modality to diagnose, stabilize the airway obstruction and evaluate for palliative treatment. Cryoablation is an evolving therapeutic bronchoscopic methods. Through rapid freeze–thaw cycles, cryoablation causes cell death and tissue necrosis or tissue adherence that can be used via the flexible or rigid bronchoscope. Cryoablation can safely restore airway patency and improve symptoms in patients with central airways obstruction from exophytic tumours. It is also used in the treatment of granulation tissue and benign strictures. Clinical studies showed improvement of dyspnea, cough, and hemoptysis with non-significant complications.
Problems of Chronic Obstructive Pulmonary Disease (COPD) Among Workers Agus Dwi Susanto
Jurnal Respirologi Indonesia Vol 41, No 1 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i1.148

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases. Occupational exposure as a one of important risk factor that contribute for COPD on nonsmoker patients. Several studies at population consistent showed that COPD correlated with hazards exposure at work place. COPD among workers can decrease quality of life, increase of work impairment, work disability and hospitalitation also increase of abstinentia from work and decrease of work productivity. Prevention were major action to prevent incident and morbidity of COPD among workers. Prevention programs including primary, secondary and tertiary prevention.
Correlation Between Type 2 Diabetes Mellitus and Pulmonary Tuberculosis at Atma Jaya Hospital Mario Steffanus; Anastasia Pratiwi Fodianto; Jessica Novia Hadiyanto
Jurnal Respirologi Indonesia Vol 41, No 3 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i3.184

Abstract

Background: Diabetes Mellitus (DM) is considered one of the factors that increase the risk of pulmonary tuberculosis (TB). Tuberculosis in Indonesia is severe and ranked second in the world after India. Previous studies suggested that DM increased the risk of developing pulmonary TB by 2–5 times. This study was conducted to determine the effect of type 2 DM on the incidence of pulmonary TB at Atma Jaya Hospital. Methods: This was a case-control study conducted at Atma Jaya Hospital from December 2016 to April 2017 using medical records. Data were further processed by pairing gender and age between case and control groups. A total of 121 samples were obtained and tested using McNemar paired correlation non-parametric analysis. Results: The incidence of pulmonary TB was higher in men than women with a ratio of 2.1:1 and within the productive age range of 27–46 years. The percentage of type 2 DM in pulmonary TB cases was 70% (35 samples) compared to 30% (15 samples) without DM with a total of 50 samples in the case group. The percentage of type 2 DM in the control group without pulmonary TB was 46.5% (33 samples) compared to 53.5% (38 samples) without DM with a total of 71 samples in the control group. Based on the statistical analysis, the P=0.013 and the OR (odds ratio) was 2.20. Conclusion: There was a significant correlation between type 2 DM and the incidence of pulmonary TB in Atma Jaya Hospital with the risk of pulmonary TB 2.20 times higher than those without type 2 DM.
Profil and Evaluation of Resistant Tuberculosis Drug’s Side Effect in Diabetes and Non Diabetes Mellitus Patient at RSUD Arifin Achmad Dani Rosdiana; Dewi Anggraini; Indra Yovi; Marlina Tasril
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.119

Abstract

Backgrounds: Diabetes mellitus (DM) increases the risk of reactivation of tuberculosis included multi-resistant drug tuberculosis (MDR-TB). This situation is threatening Riau province due to the high prevalence of DM. Since 2014 Arifin Achmad Hospital as a referral hospital of MDR-TB management. It’s treatment especially in DM patients, requires an evaluation of both outcome and side effects. This evaluation needs to be compared with non-DM MDR TB patients. The aim of this study was to evaluate and analyse patient’s characteristic, conversion of smear or culture, drugs side effect and treatment outcome. Methods: This is a cross sectional retrospective study in RSUD Arifin Achmad Pekanbaru on April-October 2018. Sample of this study were all patients from 2014 – 2017. This study was divided into 2 groups, namely the DM and non-DM groups, then analysed the differences between the two groups Results: There were 113 MDR TB patients had its treatment, which 61% of the patients were male. Baseline data show 26.5% of MDR TB patients have comorbid DM. The most common side effects were nausea and vomiting (100%) in all subjects. In the MDR TB DM group, we found included: well controlled plasma glucose level was 33.3%, severe side effects was16.7%, conversion in the second month 40% and cured or complete treatment was 30%. Conclusions: As many as 26,5% of MDR TB patients had DM comorbidity. There were no differences in the percentage of drugs side effects, smear conversion in the second month and treatment outcome between MDR TB DM and MDR TB non-DM group. (J Respir Indo. 2020; 40(3): 156-62)

Page 11 of 37 | Total Record : 364

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