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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 12 Documents

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Search results for , issue "Vol 12, No 2 (2017)" : 12 Documents clear

Time-Kill Assay of 4-Hydroxypanduratin A Isolated from Kaempferia Pandurata Against Foodborne Pathogens Soerya Dewi Marliyana; Didin Mujahidin; Yana M Syah; Yaya Rukayadi
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Time–kill assay was performed for 4-hydroxypanduratin A that was isolated from Kaempferia pandurata rizhome against four important foodborne pathogens, namely Bacillus cereus ATCC 21772, Bacillu subtilis ATCC 6633, Staphylococcus aureus ATCC 29737, and Proteus mirabilis ATCC 21100. The methods have been investigated in term of Minimum Inhibitory Concentration (MIC) and killing time curve using methods of Clinical and Laboratory Standards Institute (CLSI) guidelines. The results showed that 4-hydroxypanduratin A rapid acting in killing bacteria as follow: B. cereus : 1×MIC for 4 h, P. mirabilis: 4×MIC for 0.5 h, meanwhile B. subtilis and S. aureus were 1×MIC for 2 h. In conclusion, 4-hydroxypanduratin A showed strong antimicrobial activity against four important foodborne pathogens.

Effect of Natural Fe2O3 Doping on Performance of Lithium Phospate Ceramic Glass as Secondary Battery Cathode Mukhtar Effendi; Dina Rahmawati; Wahyu Tri Cahyanto; Wahyu Widanarto
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Natural Fe2O3 doped lithium phosphate Ceramic-glass was made by glass route method at 900 oC with the composition of 5Li2CO3:15ZnO : x Fe2O3: (80 – x) P2O5 where x = 0; 0.5; 1.5 (in mol percent). Thermal stability of sample was studied through determination of glass temperature Tg and crystal temperature Tc. XRD pattern and LCR meter measurement were carried out to determine phase, structure and ionic conductivity of the ceramic-glass samples. LiFePO4 was formed at 1.5% addition of Fe2O3. Ionic conductivity rise up by the increasing Fe2O3 concentration. The highest electric conductivity is 8,42 x 10-4 S/cm which was obtained at 1.5% addition of Fe2O3

Silica Content and Structure from Corncob Ash with Various Acid Treatment (HCl, HBr, and Citric Acid) Gladys Ayu Paramita Kusumah Wardhani; Nurlela Nurlela; Mia Azizah
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

In this study, a simple method to obtain silica from corncob ash has been investigated using a nonthermal and thermal method. The Nonthermal method was done by various acid treatment with HCl, HBr and citric acid at room temperature. Thermal method was performed for HCl-leached, HBr-leached, and citric acid-leached corncob in the furnace at 750 ºC for 5 hours. Corncob ash was characterized by Energy Dispersive X-ray fluorescence spectroscopy (EDXRF), Fourier transforms infrared spectroscopy (FTIR), X-Ray diffraction (XRD), and Scanning electron microscope-electron dispersive X-ray (SEM-EDX). In this study silica content increase after acid treatment (leaching) and combustion at high temperatures. The result established that silica is most obtained with HCl treatment that is equal to 79,95% with lower metallic oxide impurity content. The FTIR spectra with different intensity shows silanol group at 1636 – 1641 cm-1, whereas siloxane group at 1037 – 1106 cm-1, 616–797 cm-1, and 459–469 cm-1. X-Ray diffractogram shows silica transition pf amorphous (2θ = 21 - 25º) to quartz crystalline (2θ = 26.66º) phase. The surface morphology of silica that characterized with SEM-EDX shows amorphous and crystalline silica corresponds to XRD result. The high intensity spectra of Si and O in EDX shows the presence of silica in corncob ash.

Modification of Screen Printed Carbon Electrode (SPCE) with Fe3O4 for the Determination of Nitrite (NO2-) in Squarewave Voltammetry Erica Marista Rosida; Ani Mulyasuryani; Rachmat Triandi Tjahjanto
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Nitrite is one of the food preservatives that the government permits, but on the use of over limits can cause endanger health, so it is necessary to control the content of nitrite in the food. Modification of electrodes on a screen printed carbon electrode (SPCE) with Fe3O4 has been successfully done for determination of nitrite. Modification of the electrode has been done by electrodeposition with cyclic voltammetry. Electrodeposition successfully performed with an electrolyte solution of FeCl3 in ethanol. Selection of the optimum drying temperature modified electrode obtained based on the respond of the solution of nitrite in Britton Robinson buffer pH 8. The result of the modification electrode used for the determination of nitrite with squarewave voltammetry method. Reaction between Fe3+ with nitrite a basis for determining nitric indirectly measured so that the peak current is the peak current of Fe3+ of about 0,55 V vs Ag/AgCl. The results showed nitrite measurements with this method has a detection limit of 1.3 x 10-8 M.

Biochemical Properties of Mercuric Reductase from Local Isolate of Bacillus sp for Bioremediation Agent Purkan Purkan; Yuliana Firdausi Nuzulla; Sofijan Hadi; Endang Triwahyu Prasetyawati
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Mercuric reductase is the important enzyme which catalyzes a reduction of a toxic Hg2+ to non-toxic Hg0. The enzyme which has been potentially used as mercury bioremediation agent is produced by mercury resistant bacteria. These research aims are to determinate the resistance level of a local Bacillus sp to HgCl2 in media, to determine the mercuric reductase activity from the bacteria, and to determine the biochemical properties of the mercuric reductase. The Bacillus sp was grown in the Nutrient Broth media with various of 0; 20; 40; 60; 120; and 160 µM HgCl2 to know the response of the bacteria against mercury, The cell growth of Bacillus sp was measured by optical density (OD) method of at λ 600 nm. The mercuric reductase activity was assayed in the solution of MRA (Mercury Reductase Assay), then the oxidized NADPH was observed by the spectrophotometry method at λ340 nm. The result showed that the Bacillus sp has been resistant to media containing mercury at 120 µM, but the microbial growth was decreased by 50% in media containing mercury 80 µM. The Bacillus sp could produce highly the mercuric reductase enzyme at 16 hours of growth time with enzyme activity as 0.574 Unit/µg. The mercuric reductase from the bacteria has an optimum activity at pH 6 and temperature 37 °C

A Cytotoxic Rocaglate Compound from The Stembark of Aglaia argentea (Meliaceae) Ace Tatang Hidayat; Kindi Farabi; Desi Harneti; Nurlelasari Nurlelasari; Rani Maharani; Tri Mayanti; Unang Supratman; Yoshihito Shiono
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

The Aglaia genus belong to Meliceae family is unique plant species because the presence of rocaglate and rocaglamide which is so far isolated only from Aglaia genus, indicate that type of this compound as a chemical marker for the genus of Aglaia. This type of compound known to have strong activity, such as insecticide and cytotoxic. This study describe the isolation, structure elucidation, and cytotoxic activity of an isolated rocaglate compound. Dried stembark of A. argentea extracted with methanol and partition between n-hexane, ethyl acetate, and n-butanol, respectively The extracts were tested against P-388 murine leukemia cells and the ethyl acetat showed strongest activity with IC50 value of 15.5 mg/mL. The ethyl acetate then was separated and purified with chromatography technique to obtain isolated compound 1. The chemical structure of isolated compounds were elucidated by spectroscopic methods including one and two-dimensional NMR as well as high-resolution mass spectrometric analysis and identified as a methyl rocaglate. Compound 1 showed strong cytotoxic activity with an IC50 value of < 0.1 μg/mL.

The Effect of pH and Aging Time on the Synthesis of TiO2 – Chitosan Nanocomposites as Photocatalyst by Sol-Gel Method at Room Temperature Imelda Fajriati; M Mudasir; Endang Tri Wahyuni
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

The synthesis of TiO2–chitosan nanocomposite photocatalyst using Titanium(IV)-Isopropoxide (TTIP) as precursors and chitosan as host material has been conducted. The synthesis was carried out using sol-gel method at room temperature and aging to grow crystal seeds and generate nanoparticles. The success of forming nano-sized anatase phase TiO2 nanocrystal was strongly influenced by the sol pH system during hydrolysis and the aging time. The effect of sol pH system and aging time to the crystallinity level and particle size were examined using X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM) and Diffuse Reflectance UV-Spectroscopy (DR-UV). The results showed that TiO2 produced in acidic pHs (pH 2-4) tended to have higher crystallinity level than that produced in weakly alkaline (pH > 6), which prone to be amorphous. The longer aging time (> 14 days) also tended to produce the amorphous phase. Furthermore, chitosan as a host material had a notable influence in determining the crystallinity level and particle size of TiO2 in TiO2–chitosan nanocomposite.

Degradation of Paracetamol by Photolysis Using C-N-codoped TiO2 Vanny Yulia Safitri; Adlis Santoni; Diana Vanda Wellia; Khoiriah Khoiriah; Safni Safni
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Paracetamol is generally used as analgesic and antipyretic drugs. Contamination paracetamol in the environment can occur because of waste material disposal from production site and immediate disposal of household that cause water pollution. Paracetamol is degraded by photolysis method under irradiation 10 watt UV-light (λ=365 nm), visible-light (Philips LED 13 watt 1400 lux) and solar-light with and without addition C-N-codoped TiO2catalyst. The solution is analyzed by UV-Vis spectrophotometer at λ 200-400 nm. Optimum weight of C-N-codoped TiO2 catalyst obtained is 20 mg under UV-light photolysis. Paracetamol 4 mg/L is degraded 45.48% after 120 minutes under UV-light irradiation without catalyst, and increases to be 69.31% by using 20 mg catalyst. While degradation percentage of paracetamol is 16.96 % without catalyst, the percentage increases to be 34.29% after using 20 mg catalyst for 120 minutes photolysis under visible-light. Degradation of paracetamol by solar light achieves only 12.27% in absance of catalyst for 120 minutes irradiation, but it increases significantly until 70.39% in presence of 20 mg catalyst.

Potential of Lactobacillus casei Shirota Strain Probiotic Toward Total Cholesterol Levels and Sod Activity in Rat with High Cholesterol Diet Kiswanti Surya Utami; Aulanni'am Aulanni’am; Chanif Mahdi
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

Probiotic of Lactobacillus casei Shirota strain is lactic acid bacteria that have benefits to enhance immunity system, as an antioxidant and has the ability to decrease the cholesterol level. The aim of this study was to determine the potential of Lactobacillus casei Shirota strain probiotic toward total cholesterol decreasing and SOD activity increasing in rats’ aorta with a high-cholesterol diet. This study used 25 male rats of Rattus novergicus Wistar strain that will be divided into 5 groups. The 1st group as the negative control, and the 2nd group as positive control. The positive control group was induced by high-cholesterol diet contained quail egg yolk, pure cholesterol, cholic acid and waste oil that were given for 3 weeks. The 3rd, 4th and 5th group were treated by probiotic Lactobacillus casei Shirota strain with variation dose of 3.6 x 107, 7.3 x 107 and 10.9 x 107 cells/kg bodyweight/day. The results showed that probiotic of Lactobacillus casei Shirota strain therapy dose of 10.9 x 107 cells/kg bodyweight/day can decrease the total blood cholesterol of rats’ serum that were given with high-cholesterol diet of about 32.0%. In addition, the probiotic of Lactobacillus casei Shirota strain therapy also increase the activity of SOD about 50.70%.

Evaluation of Free Radical Scavenging Activity in Ethanolic Extract from Promising Accessions of Curcuma aeruginosa RoxB. Waras Nurcholis; Nurul Khumaida; Muhamad Syukur; Maria Bintang
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

This study evaluated the free radical scavenging activity in ethanolic extracts from 20 accessions of Curcuma aeruginosa. The radical scavenging activity of the extract accessions was investigated with 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. IC50 values for DPPH radical scavenging activity ranged from 89.81 to 505.65 µg mL-1. Based on IC50 values, twenty accessions of C. aeruginosa can be divided into three groups: strong (two accessions); moderate (seventeen accessions); and low (one accession) of DPPH scavenger. Sukoharjo (SH) and Muara Bungo (MB) showed promising accessions for antioxidant potential, thus these accessions important to selection for future breeding program in pharmaceutical products.

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Amin Fatoni

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Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Home Page

OAI Link

Editorial Team

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Reviewer

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Contact Name Amin Fatoni

Contact Email aminfatoni@unsoed.ac.id

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Journal Mail Official j.molekul@gmail.com

Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

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Abstract

Abstract

Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA