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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 13 Documents

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Search results for , issue "Vol 14, No 2 (2019)" : 13 Documents clear

Toxicity test of desorbed chromium from polluted soil around tannery industry in Yogyakarta-Indonesia by using Brassica juncea and Helianthus annuus L. Suherman Suherman; Wina Akmarina; Wulandari Sutiawan; Nurul Hidayat Aprilita; Mudasir Mudasir; Kinichi Morita
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Indonesia’s target to be a new industrial country makes a wide chance in the developing of many industrial sectors. The main problem is the disruption of environmental balance due to poorly managed liquid waste released by the industry. Heavy metal such as chromium (Cr) is the typical pollutant generated from tannery industry in Indonesia. Toxicity test of desorbed chromium ions from polluted soil around tannery industry in Yogyakarta-Indonesia by using Brassica junceaand Helianthus annuus L.has been carried out. In this research, soil samples were dividedinto four sample points based on the distances from the waste water point sources. Metal content and some physico-chemical properties including ash content, total organic carbon, and cation exchange capacity were determined in this study. Furthermore, the chromium ions adsorption and desorption from polluted soils were investigated and measured by atomic adsorption spectrophotometry (AAS). Thus, ecotoxicity testsof soil eluates from desorption experiments wereperformed with Brassica junceaand Helianthus annuus L.The resultsshowed that sample III had the highestCr content at916mgkg–1.The adsorption isotherm of Cr ions into soils followed Langmuir isotherm with the highest maximum adsorption capacity value at 14.286 mg kg-1in the sample point IV (unpolluted soil). The optimum desorption of chromium occurred at pH 3. Toxicity test showed that Cr ions had toxic effect to Brassica junceaand Helianthus annuus L.

No Acute Toxicity Tests of Purwoceng (Pimpinella pruatjan Molk.) Ethanolic Extract on Male Albino Rat by Determined Hepatorenal Function Test and Histopathology Fitranto Arjadi; Dhadhang Wahyu Kurniawan; Yudhi Wibowo; Wahyu Siswandari; Lantip Rujito
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Pimpinella pruatjan Molkis a local indegineuos plant speciescommonly used aphrodisiac.This studywas performed to analyze the effect of acute administration of purwoceng (Pimpinella pruatjan Molk.) roots ethanol extract to liver and kidney histological damagein rats. The study used an experimental approachusing post test only with control group design. Rats were randomly divided into five groups; 3 rats in each group. Group A as a control group received aquadest, group B, C, D, and E were given purwoceng roots ethanol extract dose of 5 mg/kgBW, 50 mg/kgBW, 300 mg/kgBW, and 2000 mg/kgBW respectively.Liver histological damage was assessed by a modification of the Roenigk score, whereaskidney damage was by the semiquantitative scoring of proximal tubular necrosis. UV test was used to quantify the AST and ALT levels, the measurement of blood urea levels was using the Urease-GLDH method, and Jaffe methodwas used to access the creatinine levels.Kruskal-Wallis test showed that liver and kidney histologicalparameterswere not significantly affected, as well as theblood urea and creatinine levels (p>0.05).Meanwhile,ALT level wasonly parameters which showed the significant test (p <0.05)among groups. Study concluded that the liver and kidney histological appearance, AST, blood urea, and creatinine levels in the male albino rat were not significantly affected by acute administration of Purwoceng roots in various dosesbut the ALT level was significantly affected

Quantitative Structure-Property Relationship Analysis Against Critical Micelle Concentration of Sulfonate-Based Surfactant Based on Semiempirical Zindo/1 Calculation Ponco Iswanto; Eva Vaulina Yulistia Delsy; Ely Setiawan; Fiandy Aminullah Putra
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Development of anionic surfactant compound isvery important because the anionic surfactant class iswidely used in people's lives. For instance,anionic surfactantsare used as food additives and detergents. The novelcompound of sulfonate-basedsurfactantor proposed compound has predictedthe CriticalMicelle Concentration(CMC) value of experiment. Quantitative Structure-Property Relationship (QSPR)analysisbased on semiempiricalZINDO/1 calculationwas conducted to obtain QSPR equation. Theoretical predictorsor independent variable which have an influence on the value of CMC are used to construct QSPR equation. The theoretical predictors areclassified intopredictor of electronic properties, solubility and steric. A total of 108experimentalCMCbelongs to sulfonate-basedsurfactant are calculated their theoretical predictors and analyzed by multiple linear regression. The QSPR equationwhich is obtainedfromthis study contains theimportant theoretical predictors.They are solubility properties, molecular weight, molecular size and net charge of carbon atomin thepolar partof sulfonate-based surfactant. This QSPR equation couldbe used to predict the CMC value of the novelsulfonate-based surfactant.

Frontmatter (Front Cover, Editorial Team, Preface and Table of Contents) Amin Fatoni
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

No Abstract

Caryophyllene-Type Sesquiterpenoids from the Stembark of Aglalia harmsiana and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells Hersa Milawati; Desi Harneti; Rani Maharani; Nurlelasari Nurlelasari; Ace Tatang Hidayat; Mohamad Nurul Azmi; Yoshihito Shiono; Unang Supratman
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Sesquiterpenoid is a class of terpenoid compounds that have the most abundant diversity of structures and biological activitiesthat can be found in natural resources. Tropical plants are main source of sesquiterpenoid compounds such as Aglaiagenus belong to Meliaceae family. A. harmsianais a species from Aglaiathat only has few previous researchs. Therefore, the purpose of this study was to isolate and determine the structure of sesquiterpenoid compounds from stem barkA. harmsianaalong withtheir cytotoxic activity against MCF-7 breast cancer cells. The isolation process begins by extracting powder from A. harmsianastembark using n-hexane, ethyl acetate and methanol. All extracts were evaluated for their cytotoxic activity against MCF-7 breast cancer cells, and n-hexane extractsshowed significant cytotoxic activitywith IC50values of 117.86 µg/mL. Therefore, n-hexane extracts were further separated and purified by various chromatographic techniquesto obtain compounds 1and 2. Compounds 1and 2were elucidated their chemical structures by spectroscopic methods includingIR, NMR, and MS as well as bycomparison of data with literatures and identified ascaryophyllene-typesesquiterpenoids, β-caryophylleneoxide (1) and senecrassidiol (2). Compounds 1and 2were submitted for cytotoxic eveluation on MCF-7 breast cancer cells and as a result, β-caryophyllene oxide (1) showed the stronger activity compared to senecrassidiol (2). These finding indicatedthat the cytotoxic activity of caryophyllene-typesesquiterpenoid areinfluenced by the presence of double bonds and configuration of methyl groups.

Optimization of Total Flavonoids Extraction and Α-Glucosidase Inhibitory Activity from Plectranthus amboinicus (Lour.) Spreng. Leaves using the Simplex-Centroid Design Kunto Wibisono; Syarifah Iis Aisyah; Sri Suhesti; Waras Nurcholis
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

The leaves of Plectranthus amboinicus (Lour.) Spreng. (Lamiaceae) is a perennial plant that contained flavonoids compounds with have antidiabetic properties. The aim of the work was to select the best solvent for extraction of the flavonoid compounds from torbangun leaves. A statistical simplex-centroid mixture design for the water, ethanol, and hexane solvents has been used to the extraction of extract yield, flavonoids content, and inhibitory α-glucosidase activity of torbangun leaves. The ethanol-water extracts showed the highest extract yield with value of 15.92%. The ethanol-hexane extracts presented the highest total flavonoids content, 96.30 mg QE/g, followed by hexane extract (82.91 mg QE/g). The ethanol extract recorded higher inhibitory of α-glucosidase activity, with value of 25.53%, followed by hexane extract (25.21%), and ethanol-water extract (23.02%). The weak correlation between the α-glucosidase inhibition and total flavonoids content showed that flavonoids contribute non-significantly to the α-glucosidase activity.

Backmatter (Instruction for author and back cover) Amin Fatoni
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

No Abstract

Xylose and Arabinose Fermentation to Produce Ethanol by Isolated Yeasts from Durian (Durio zibethinus L.) Fruit Hermansyah Hermansyah; Fachrijal Fachrijal; Miksusanti Miksusanti; Fatma Fatma; Getari Kasmiarti; Almunadi T Panagan
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Xylose and arabinose are pentosesugars that present in hemicellulose, part of lignocellulose biomass.These pentose sugars can be fermented by yeast into ethanol.The aim of this research was to utilize yeast isolated from durian fruit (DuriozibethinusL.) in fermentation of xylose and arabinose to produce bioethanol.Phenotypic test of isolates was conducted by growingthe isolates in various agar media, i.e.YPD (Yeast Peptone Dextrose), YPA (Yeast Peptone Arabinose), and YPX (Yeast Peptone Xylose) containing dextrose, arabinose, xylose, respectively, assole carbon source to see cell growth. The yeast isolates were further identified using API AOC 20C kit method. Yeast isolates were applied for fermentation of glucose, arabinose, and xylosein incubated cultures. Ethanol production in the fermentation was analyzed bygaschromatography. Yeast isolates were identified as Kodamaea ohmeri, Candida famata, Candida guilliermondii, and Crytococcuc laurentii. Based on gas chromatography data, it was found that ethanol produced in the fermentation for three days, the highest ethanol content on xylose substrate was fermented by Candida famata-Awhich is0.021% (v/v) ethanol resulted from initial concentration of 5% xylose (w/v). While on arabinose substrate, the highest ethanol content was fermented by Crytococcus laurentii-Bwhich is 0.0034% (v/v) ethanol resulted from initial concentration of 5% arabinose (w/v).

The bioactive contents and antioxidant activity of honey bee nest extract of Apis dorsata Binghami from the North Sulawesi Mokosuli Yermia Semuel; Eva Sherly Nonke Kaunang; Jacklin Stella Manopo
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Apis dorsata Binghami is a Sulawesi endemic honey bee. Apis dorsata Binghami cannot be bred, so it still lives wildlyin the forests of Sulawesi. However, Apis dorsata Binghami produces more honey, compared to all honey bee species. Furthermore, the diversity of plants as a source of nectar, pollen and plant resin, which is used in the formation of nests and honey is more, than all types of honey bees in the world. Ethnomedically, the Minahasa community has long used honeynest for degenerative diseases such as hyperlipidemia and cancer. Nevertheless, there have been no research reports on bioactive content and bioactivity of Apis dorsataBinghami nest extract. This research wasaimed to determinethe bioactive content of honey bee nest and to obtain the inhibitory concentration 50 (IC50) antioxidant activity of honey bee nest extractofApis dorsata Binghami. Honey bee nest was obtained directly from the forest of Minahasa peninsula, North Sulawesi, Indonesia. Extraction of fresh honey bee nest was conductedusingmaceration method. Bioactive content analysis was carried out by the Harborne method, followed by analysis using UV Vis spectrophotometer and High performance liquid chromatography. IC50antioxidant activity of honey bee nest extract was obtained using DPPH free radical reduction method. The results showed that Apis dorsata Binghami honey bee nest extract containedalkaloids, flavonoids, saponins, tannins, steroids and triterpenoids. Identified flavonoids displayed the highest phytochemical content. Based on the results of HPLC and UV Vis spectrophotometer analysis, there were 20 flavonoid derivatives found in honey bee nest samples in Minahasa. Ethanol extract and n-hexane extract showed high free radical reduction activity compared to vitamin C as a control treatment. However, ethanol extract produced the highest DPPH free radical reduction activity.

Synthesis and Characterization of TiO2-CaO and TiO2-CaO-Fe2O3 Photocatalyst for Removal of Catechol Tahya, Candra Yulius; Irawati, Wahyu; Karnelasatri, Karnelasatri; Purba, Friska Juliana
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

TiO2-CaO and TiO2-CaO-Fe2O3 photocatalysts have been synthesized through the surfactant-assisted sol-gel method. The catalysts were characterized using XRD, FTIR, SEM-ED Sand BET surface area. XRD pattern showed the formation of anatase TiO2 crystal phase both in TiO2-CaO and TiO2-CaO-Fe2O3. The TiO2-CaO has higher crystallinity than TiO2-CaO-Fe2O3. Based on the peak refinement using Rietveld, there are two peaks identified as Fe2O3 hematite in the sample TiO2-CaO-Fe2O3. BET surface area analysis showed that the average pore size of TiO2-CaO and TiO2-CaO-Fe2O3 catalysts are 8.04 and 8.41 nm respectively, indicating both catalysts are mesoporous.FTIR spectra show that the vibration of Ti-O, Ca-O, and Ca-TiO2 were observed in both catalysts. SEM images confirm that both catalysts are porous material. The catechol removal using TiO2-CaO and TiO2-CaO-Fe2O3 improved with the increase of catalyst concentration. After 360 minutes of UV radiation, the removal of catechol using TiO2-CaO-Fe2O3 reached 46.0%, 48.3%, and 69.2%, while when using TiO2-CaO, it reached 22.1%, 36.8%, and 57.0% for 0.1 g, 0.15 g, and 0.2 g of catalysts, respectively. The photocatalytic activity of TiO2-CaO-Fe2O3 is not so strong compared to TiO2-CaO catalyst but the catechol adsorption property of TiO2-CaO-Fe2O3 is higher than that of TiO2-CaO catalyst.

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Amin Fatoni

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Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Home Page

OAI Link

Editorial Team

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Reviewer

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Contact Name Amin Fatoni

Contact Email aminfatoni@unsoed.ac.id

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Journal Mail Official j.molekul@gmail.com

Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

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Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA