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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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Comparison of Cr/C and Cr2O3/Z Catalysts on Hydrocracking of Bio Oil from Pyrolysis of Palm Empty Fruit Bunches Zainal Fanani; Hasanuddin hasanuddin; Addy Rachmat; Muhammad Said
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Bio-oil derived from palm empty fruit bunch is not suitable for fuel purpose due to high acidity and low heating. Cr2O3/Zeolite and Cr/C catalysts was developed to upgrade bio-oil through hydrocracking. The catalyst prepared via impregnation method followed by oxidation-reduction. Ammonia and pyridine adsorption used to evaluate acidity as well as crystallinity assessment by using XRD. Hydrocracking reaction conducted in hydrogen gas flow rates 0.5-3.0 L/min, the surface area of Cr/C catalyst found out 1,497.07-1,652.58 m2/g, whilst the temperatures 450 to 700 ℃ and the catalyst weights between 0.5 to 2.5 g. Acidity calculated from ammonia and pyridine adsorption shows Cr2O3/Zeolite has higher value compare to pristine Zeolite. XRD pattern shows Cr2O3/Zeolite has high crystallinity as indicated by sharp and pointed diffraction peaks. The optimum condition of hydrocracking confirmed by lower density of liquid product. The variables obtained by a separate experiments shows that H2 gas flow rate best at 2.5 L/min, temperature of hydrocracking 500 ℃ for Cr2O3/Zeolite and 600oC for Cr/C whereas weight of Cr2O3/Zeolite catalyst is 1.5 g. The Cr/C catalyst that gave low density product possess 1,554.48 m2/g surface area. GCMS data shows increase on the number of straight chain compounds within the hydrocracking product.

Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium Hernayanti Hernayanti; Sri Lestari; Saryono Saryono; Puji Lestari
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Cadmium is a toxic heavy metal. The present of cadmium caused inflammation in liver. This study aims to know the anti inflammatory of Centella asiatica extract on rat induced by cadmium. This research was an experimental study using post test only control group design. Twenty four rats divided into six groups with four replications, i.e group of healthy control (C1), negative control induced by CdSO4 with dosage 56 mg/kg for 14 days and treatment (C3-C6) with dosage of 100, 200 ,300 and 400 mg/kg of C. asiatica. The blood Cd, GST, GSH, TNF- α and COx2 were measured after a 21 days administration of C. asiatica. The data were analyzed by ANOVA test followed by Duncan test with a significance level of 5%. The result showed that administrating C.asiatica can neutralized cadmium, improve inflammation in liver.The conclusion of our research that C.asiatica extract can decrease Cd level, TNF-α and COx2 levels and increase GST and GSH level in rat induced by cadmium. A 200 mg/kg was the effective dosage to reduce Cd, TNF-α and COx2 levels and increase GST and GSH levels. Key words : anti inflammatory, Cd, Centella asiatica, GST, COX2

Backmatter (Instruction for author and back cover) Amin Fatoni
Molekul Vol 15, No 1 (2020)
Publisher : Universitas Jenderal Soedirman

Backmatter (Instruction for author and back cover)

Synthesis and Anticancer Activity of 2’-hydroxy-2-bromo-4,5-dimetoxychalcone Against Breast Cancer (MCF-7) Cell Line Retno Aliyatul Fikroh; Sabirin Matsjeh; Chairil Anwar
Molekul Vol 15, No 1 (2020)
Publisher : Universitas Jenderal Soedirman

Breast cancer is one of cancer causes of death in woman. Chemotherapy is one cancer treatment give toxic effects on normal cells. Alternative of cancer treatment by using flavonoid derivative have potent anticancer to reduce side effects of cancer. Chalcone is family of flavonoid that have biological activity. Chalcone derivatives have potential compound as anticancer agent. Chalcone with the presence halogen, metoxy group in ring B is know to inhibit cancer cells. The aims of this research were to synthesize chalcone derivate with bromo, methoxy, and hyroxy group in ring chalcone and to determine the anticancer activity of chalcone derivative. The chalcone derivative was synthesized from 2-hydroxyacetophenone with 2-bromo-4,5-dimethoxybenzaldehyde by Claisen-Schmidt reaction. In vitro cytotoxicity against breast cancer cell was tested by MTT assay method. The compound of 2’-hydroxy-2-bromo-4,5-dimethoxychalcone was yield in 78% as yellow solid. The IC50 of 2’-hydroxy-2-bromo-4,5-dimethoxychalcone was 42,19 µg/mL as a moderate activity to inhibiting breast cancer cell line. Cytotoxity of docorubicin againts breast cancer cell line more active than 2’-hydroxy-2-bromo-4,5-dimethoxychalcone with IC50 10,61 µg/mL. Doxorubicin as drug standar had better anticancer activity than 2’-hydroxy-2-bromo-4,5-dimethoxychalcone. Based on the IC50 value, the compound 2’-hydroxy-2-bromo-4,5-dimethoxychalcone has a moderate activity towards breast cancer cell lines. This study can recommend as candidate for anticancer againts breast cancer cell lines.

KARAKTERISTIK ADSORPSI TEMBAGA (II) PADA HUMIN DALAM MEDIUM AIR TAWAR Roy Andreas; Narsito Narsito; Sri Noegrohati
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

Although humic substances consist mosly of humin (65%), however its characteristic in Cu(II) odsorption is not yet clearly revealed. In this work, humin was isolated from peat soil of west Kalimantan, purified and then interacted with Cu(II). The purity of isolated humin was determined by its ash content. The funtional group in this purified humin was characterized qualitatively by FTIR and quantitatively by titration. Study on the solubility of Cu(II) in freshwater was carried out at pH from 2-12 in the presence and without purified humin. To obtain adsorption kinetic parameters of Cu(II) on humin in freshwater, study based on Langmuir-Hinshelwood was carried out, while for its thermodinamics parameters, a study based on Langmuir and Freundlich were employed.The ash content of purified humin was 1,58 % (w/w), it showed that the humin was in pure condition. The active fungtional group identified humin were –COOH (1700 cm-1) 115 cmol/kg and –OH fenolic (3421,5 cm-1) 562 cmol/kg. At 2<pH<5 was in Cu(II) and [Cu(H2O)4]2+ which soluble in water, at 6<pH<7 part of the soluble Cu(II) precipitated as Cu(OH)2 while at pH>7 all of Cu(II) was precipitated as Cu(OH)2. The rate constant for Cu(II) in freshwater medium were 2,7 x 10-3 S-1 and 0,6 x 10-3 S-1. The obtained curve fitting of langmuir and freundlich adsorption showed that Langmuir model fit better than Freundlich, indicated that the adsorption reaction are of monolayer. The adsorption capacities of Cu(II) on humin in freshwater was 3,033 x 10-4 mol/g

PENURUNAN KADAR AMONIA, NITRIT, DAN NITRAT LIMBAH CAIR INDUSTRI TAHU MENGGUNAKAN ARANG AKTIF DARI AMPAS KOPI Irmanto Irmanto; Suyata Suyata
Molekul Vol 4, No 2 (2009)
Publisher : Universitas Jenderal Soedirman

The tofu industry is one of food industry which the product of organic waste to environment pollution. One of alternative methode which used to overcome tofu industrial waste water pollution is adsorption methode using activated carbon from coffee waste. The aim of this researched is to know about the activated carbon from coffee waste quality which observe of rendemen, water content, ash content, and iodium adsorption, to know optimum contact of time and pH of coffee waste to decrease ammonia, nitrite and nitrate contents in tofu industry waste water and to know decrease percentage of ammonia, nitrite and nitrate contents in tofu industrial waste water using activated carbon from coffee waste. The activated carbon made by soaking of coffee waste in HCl 0.1 M solution for 2 days. The activated carbon coaled in muffle furnace at temperature 350°C. The activated carbon analyzed consist of rendemen, water content, ash content, and iodium adsorption. Optimum contact of time and pH of coffee waste determined in order to get optimum adsorption ammonia, nitrite and nitrate in tofu industrial waste water. Contact time variation are 1, 10, 30, 45, 60, 90, 120 minutes and pH variation are 4, 5, 6, 7, 8, 9, 10. The result showed that the activated carbon from coffee waste fulfill the criteria SNI number 06-3730-1995. The activated carbon from coffee waste could be used to decrease the ammonia, nitrite, and nitrate contents in tofu industrial waste water at the optimum contact of time of 30 minutes and pH 7. Decreasing percentage of ammonia, nitrite and nitrate contents in tofu industrial waste water are 64,69% , 52,35% and 86,40% respectively

PENURUNAN KADAR ZAT WARNA RODAMIN B MENGGUNAKAN HUMIN HASIL ISOLASI DARI TANAH HUTAN DAMAR BATURRADEN Tien Setyaningtyas; Roy Andreas
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

Humin was isolated from the Baturraden resin forest and purified use mixture of HCl:HF. Purified humin is characterised such as identify of functional group of humin, stipulating of water content, stipulating of dust content, obstetrical stipulating of total acidity content, carboxylic and OH phenolic functional group. The adsorption of rodamin by humin measured by UV-Visible spectrophotometer at maximum wavelength of rodamin B liquid, optimum pH and optimum contact time to determine absorbtion capacities and isotherm adsorption pattern .Humin that isolated from Baturraden resin forest have characteristic such as water content 16.6199 %; dust content 9.2050 %; total acidity content 475 cmol / Kg; carboxylic rate 200 cmol/Kg, and OH phenolic rate 275 cmol/Kg. Maximum wavelength of rodamin B is 554 nm and optimum contact time of adsorption rodamin B by humin is 180 minute with optimum pH 4. Adsorption rodamin B by humin follows the pattern of Langmuir isotherm adsorptionwith the value of R2 is 0.9801 and absorption capacities is 39,5257 mg/g.

KONSTRUKSI MUTAN PROTEIN FOSFATASE ptc2D Saccharomyces cerevisiae DENGAN METODE PENGGANTIAN GEN TARGET DENGAN POLYMERASE CHAIN REACTION (PCR) Hermansyah Hermansyah
Molekul Vol 6, No 1 (2011)
Publisher : Universitas Jenderal Soedirman

Yeast Saccharomyces cerevisiae is an excellent model to studi genes function of eukarotic cells such as study of gene encoding protein phosphatase PTC2. Novel phenotypic caused by mutated gene is an important step to study function of gene. In this study constructed mutant of PTC2 gene encoding protein phosphatase. Method that used in this construction was replacement of target gene (PTC2) with auxotroph marker Candida albicans HIS3 by Polymer Chain Reaction (PCR) or called by PCR-mediated disruption. Mutant colonies which grew in selective medium SC without histidine were confirmed by PCR amplification. By using 1% Agarose gel electrophoresis the result showed that size of ptc2D::CgHIS3 transformant was 3.52 kb while wild type strain was 2.9 kb, indicated thatptc2D::CgHIS3 has integrated on chromosome V replacing PTC2 wild type.

DESIGN OF LOW CYTOTOXICITY DIARYLANILINE DERIVATIVES BASED ON QSAR RESULTS: AN APPLICATION OF ARTIFICIAL NEURAL NETWORK MODELLING Ihsanul Arief; Ria Armunanto; Bambang Setiaji; Muhammad Fachrie
Molekul Vol 11, No 2 (2016)
Publisher : Universitas Jenderal Soedirman

Study on cytotoxicity of diarylaniline derivatives by using quantitative structure-activity relationship (QSAR) has been done. The structures and cytotoxicities of diarylaniline derivatives were obtained from the literature. Calculation of molecular and electronic parameters was conducted using Austin Model 1 (AM1), Parameterized Model 3 (PM3), Hartree-Fock (HF), and density functional theory (DFT) methods. Artificial neural networks (ANN) analysis used to produce the best equation with configuration of input data-hidden node-output data = 5-8-1, value of r2 = 0.913; PRESS = 0.069. The best equation used to design and predict new diarylaniline derivatives. The result shows that compound N1-(4′-Cyanophenyl)-5-(4″-cyanovinyl-2″,6″-dimethyl-phenoxy)-4-dimethylether benzene-1,2-diamine) is the best-proposed compound with cytotoxicity value (CC50) of 93.037 μM.

Two Phenolic Compounds from Chloroform Fraction of Syzygium Polycephalum MIQ. Stem Bark (Myrtaceae) Tukiran Tukiran; Andika Pramudya Wardhana; Nurul Hidajati; Kuniyoshi Shimizu
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Syzygium polycephalum (Kupa) is a plant of the Myrtaceae family which is one of the endemic plants in Indonesia, commonly called as Gowok. The chemical components of the plant have not been reported so far. This study is intended to know the molecular structures of isolated compounds of chloroform fraction from S. polycephalum stem bark.The steam bark of the plant is dried, powdered and macerated with methanol to yield methanolic extract. The methanolic extract was then conducted to fractionation using hexane and chloroform to obtain hexane and chloroform fractions. The chloroform fraction was further subjected to separation using column chromatography to obtain pure isolates and followed by measuring of their spectroscopic evidences. The isolation of chloroform fraction had led to the findings of two pure isolates. Their structures of isolates were elucidated by extensive spectroscopic methods and by comparison with the literature data to gain two phenolic compounds that are gallic acid and 3,4,3’-tri-O-methylellagic acid.

Page 30 of 34 | Total Record : 331

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Home Page

OAI Link

Editorial Team

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Contact Name Amin Fatoni

Contact Email aminfatoni@unsoed.ac.id

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Journal Mail Official j.molekul@gmail.com

Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

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Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA