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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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Subchronic Toxicity of Methanol Extract From Erythrina Variegata (Leguminosae) Leaves on Male Wistar Rats (Rattus Norvegicus) Tati Herlina; Madihah Madihah; Deden Deni; Suseno Amien
Molekul Vol 12, No 1 (2017)
Publisher : Universitas Jenderal Soedirman

Erythrina variegata is a herbal plant commonly used in Indonesia traditional medicine for treatment malaria disease. Acute toxicity test results showed that the methanol extract of E. variegata leaves categorized as practically nontoxic. In this study, we investigated sub chronic toxicity of the extract on male Wistar rats and the procedure based on guidelines of OECD 408 (1998) and EPA OPPTS 870.3100 (1998) for 90 constitutive days. The rats are classified into four dose groups were 0 (control), 250, 500, and 1000 mg/kg body weight with each group consist of five test animals. The results do not show toxic signs either behavior or body weight changed. Hematological analysis and clinical blood chemistry revealed slightly changes but were within the normal limits, except for BUN and SGPT values. Histopathological examination showed an increased damage of liver and kidney cells in form hydropic degeneration, fatty degeneration, as well as necrosis along with increased of extract doses that significantly different with control (p<0.05). However, the damage is reversible and was assumed had not has relations with the treatment. Thus, orally administration of E. variegata extract by dosage 250, 500, and 1000 mg/kg BW did not cause subchronic toxicity on male Wistar rats.

ANALISIS SENYAWA KIMIA DALAM EKSTRAK KLOROFOM BUNGA KAMBOJA (Plumeria alba) DENGAN GC-MS Santi Nur Handayani; Kapti Riyani
Molekul Vol 3, No 2 (2008)
Publisher : Universitas Jenderal Soedirman

lumeria alba is called frangipani is one of Apocynaceae family’s plant. Frangipani is potentially used as traditional medicine, for example as an antiinflamation drugs. It has not been yet done an extensive reasearch on the chemical compound content of frangipani. The reasearch was conducted to investigate some chemical constituents by using Gas Chromatography-Mass Spectrometer (GC-MS). Extraction of chemical compound of frangipani has been conducted by soxhletasi using n-hexane as solvent followed by chloroform and ethyl acetate. Then chloroform extract was identified by GC-MS. The result showed that extract of chloroform contained : palmitic acid, clionasterol, fucosterol, fagarasterol and methyl commate B respectively.

Sub-chronic hepatotoxicity test of Plantago mayor L. extract Eman Sutrisna; Setia Wati; Farissa Utami; Rahayu Nurmalia Fauziah; Dara AisyahRahayu Abdurrachman; Ika Murti Harini; Thianti Silviningrum
Molekul Vol 14, No 1 (2019)
Publisher : Universitas Jenderal Soedirman

The aim of this study was to examine hepatotoxicity of Plantago mayor L. extract on rat by using effective dosage. By experimental study and post test only with control group design. 15 rats (Rattus norvegicus) were divided in to 3 group. Group A as a natural control was given aquades. Group B and C were given extract of Plantago major L. 50mg, and 100mg/200g BW rat/day per oral. Liver function was determined with measurement of Aspartate aminotransferase (AST) level, Alanine aminotransferase (ALT), total bilirubin, and histopathological feature of liver. Blood sampling and Liver organ were taken after 28 days of intervention. The average of AST levels, ALT and total bilirubin among groups A, B and C were AST levels (145.40±52.92, 129.00±34.89, and 115.60±13.24 U/l), ALT (76.40±18.87, 83.20±18.71, and 61.00±8.45 U/l) and total bilirubin (0.56±0.03, 0.77±0.22, and 0.58±0.08 mg/dL). Statistical analysis showed that there were not significantly differences of AST levels (p=0,63; CI95%), ALT (p=0,47; CI95%) and total bilirubin (p=0,0,09; CI95%) between the groups. In histopathological features, the average Scheuer score between groups A, B and C is 1.79 ± 0.74, 3.30 ± 0.66 and 2.84 ± 0.77. There is a significant difference in Scheuer scores between the groups (p=0,005; CI95%) that show that there is a difference in the effect of giving extract of Plantago major L. to hepatocyte cells leading to a piecemeal necrosis. This study can be concluded that in effective dosage, Plantago major L. extract able to induce hepatocytes injury although it cannot cause liver disfunction yet.

SINTESIS NATRIUM PENTAGAMAVUNONAT DAN UJI STABILITASNYA MENGGUNAKAN SPEKTROFOTOMETER UV-Visible Ely Setiawan; Trisnowati Trisnowati; Dadan Hermawan
Molekul Vol 1, No 1 (2006)
Publisher : Universitas Jenderal Soedirman

A research on the synthesis of sodium pentagamavunonat (Na-PGV-0) and its stability test using UV-Visible spectrophotometer were carried out. The synthesis of Na-PGV-0 carried out by reacting PGV-0 in tetrahydrofuran solvent refluxed with sodium ethoxide in mol comparison (1:2) for two hours. Structure elucidation by spectroscopic methods using UV-Visible, IR, 1H-NMR, 13C-NMR and stability test in water using UV-Visible spectrophotometer. The reaction yields 107,21 % (% w/w) products. A products was soluble in water and methanol. Structure elucidation results indicated that the formed compound where the OH phenolic of pentagamavunon-0 was replaced by sodium ions. Stability test shows that decreasing of sodium

KARAKTERISTIK FILM TIPIS TiO2 DOPING NIOBIUM Bilalodin Bilalodin; Mukhtar Effendi
Molekul Vol 5, No 1 (2010)
Publisher : Universitas Jenderal Soedirman

Niobium (Nb) doped Titanium dioxide (TiO2) thin films have been successfully grown using spin coating method. Characterizations of thin films was carried out using EDAX (Energy Dispersion Analysis for X-Ray), XRD (X-Ray Diffaction) and SEM (Scanning Electron Microscope) to determine the microstructure of thin films. Determination microstructure, particularly of crystal structure was examined using ICDD data, whereas porosity calculation was done using the toolbox application on Matlab 6.1 software. EDAX, XRD and SEM characterization show that the thin films grown well at the Si substrates with the (002) field orientation is dominant and the thin film has the rutile structure. The TiO2 : Nb thin films product have granules round, uniform grain size and porosity value of about 41%.

Synthesis, Antiproliferative Activity and Molecular Docking Studies of 1,3,5-Triaryl Pyrazole Compound as Estrogen α Receptor Inhibitor Targeting MCF-7 Cells Line Noval Herfindo; Riska Prasetiawati; Daniel Sialagan; Neni Frimayanti; Adel Zamri
Molekul Vol 15, No 1 (2020)
Publisher : Universitas Jenderal Soedirman

This research has been successfully synthesized three compounds of 1,3,5-triaryl pyrazole derivatives by two steps reaction. Firstly, pyrazoline (4a-c) compound was obtained by one-pot reaction of aromatic ketones, aldehyde and hydrazine in basic condition. Then, pyrazole (5a-c) compound was obtained by oxidative aromatization of compound 4 in the presense of acetic acid. Chemical structure of predicted molecules was confirmed by FTIR, NMR and HRMS spectroscopy data analysis. Antiproliferative activity of compound 5a-c were evaluated by in vitro assay against MCF-7 cells line and molecular docking simulation against ERα (PDB ID: 3ERT) using MOE 2019. Biological evaluation result showed that pyrazole compounds had weak antiproliferative activity against MCF-7 cells with IC50 were > 1000 µM, whereas the docking studies agrees the result.

PENENTUAN KEASAMAN ZEOLIT MENGGUNAKAN METODE GRAVIMETRI, TITRASI DAN FTIR Dwi Kartika; Mardiyah Kurniasih
Molekul Vol 2, No 2 (2007)
Publisher : Universitas Jenderal Soedirman

Determination of natural zeolite and activated natural zeolite acidity using gravimetric, titration and FTIR methods had been carried out. The result of gravimetric method show that the acidity of the natural zeolite and activated natural zeolite was 2,350 and 5,628 mol/gram, respectively. The titration method can be obtained that the acidity degree of the natural zeolite and activated natural zeolite was 12,333 and 12,067, respectively. The result showed that the activation of the natural zeolite sample by HCl caused dealumination.

EFEKTIVITAS ECENG GONDOK (Echhornia crassipes) DALAM PENYERAPAN KADMIUM (Cd) PADA LEACHATE TPA GUNUNG TUGEL Sri Lestari; Slamet Santoso; Sulastri Anggorowati
Molekul Vol 6, No 1 (2011)
Publisher : Universitas Jenderal Soedirman

Leachate is liquid of result organic garbage that contain substance is dissolved and suspension as decomposition by microorganism. Leachate contain material organic with high level and many formed at landfill with open dumping system. Material organic in leachate can be reduced by phytoremediation with water hyacinth (Echhorniacrassipes). The aim of research are know large closure of water hyacinth, long residence time and the best interaction to reduce the levels of material organic in leachate. Method of research was designed experimental based on Completely Randomized Design (CRD) with Factorial Design. The first factor are closing large percentage of water hyacinth (0%, 25%, 50%, 75% and 100%) and the second factor are long residence time (4 days, 5 days and 6 days). Result of research showed that is closing large of 75% is the best treatment to reducing level of Cd that is 29,279%. and long residence time of 6 days is the best treatment to reducing level of Cd that is 27,211%. Interaction closing large of 75% and long residence time of 6 days is the best treatment to reducing level of Cd that is 39,770%

DEGRADASI ZAT WARNA AZO TARTRAZIN PADA LIMBAH CAIR MIE DENGAN METODE AOPs (Advanced Oxidation Processes) Tien Setyaningtyas; Dian Windy Dwiasi
Molekul Vol 7, No 2 (2012)
Publisher : Universitas Jenderal Soedirman

Penggunaan metode untuk mendegradasi zat warna dari limbah industri dengan proses AOPs (Advanced Oxidation Processes) atau proses oksidasi lanjut saat ini banyak dikembangkan terutama untuk limbah cair zat warna yang sulit terdegradasi. Salah satu industri makanan yang menggunakan bahan aditif zat warna pada proses produksinya adalah industri mie yaitu menggunakan zat warna tartrazin. Dampak negatif perkembangan industri mie adalah timbulnya pencemaran lingkungan dari limbah cair industri mie yang masih mengandung zat warna tartrazin. Penurunan kadar zat warna tartrazin dalam limbah cair mie dapat diupayakan dengan cara mendegradasi zat warna tartrazin melalui metode AOPs.Proses AOPs untuk mendegradasi tartrazin dalam limbah cair mie pada penelitan ini menggunakan kombinasi H2O2dengan sinar matahari sebagai sumber sinar UV (H2O2/UV-Vis). Paramaeter yang dilakukan antara lain variasi konsentrasi H2O2 yaitu 0,01 M ; 0,02 M dan 0,03 M dengan variasi waktu kontak 0; 0,5 ; 1 ; 1,5 ; 2 ; 2,5 ; 3 ; 3,5 ; 4 jam. Pengaruh pH terhadap degradasi tartrazin dengan variasi 2, 5, 7, 9 dan 12.Hasil yang diperoleh bahwa degradasi tartrazin tidak dipengaruhi oleh konsentrasi H2O2 tetapi konsentrasi H2O2mempengaruhi waktu kesetimbangan. Waktu kesetimbangan paling cepat dicapai 30 menit pada konsentrasi H2O20,03 M, sedangkan untuk H2O2 0,01M dan 0,02 M waktu kesetimbangan tercapai pada 2,5 jam dengan penurunan tartrazin sebesar 45%. Proses AOPs pada degradasi tartrazin dipengaruhi oleh harga pH. Pada pH rendah penurunan tartrazin semakin besar. Pernurunan tartrazin paling besar pada pH 2 yaitu sebesar 65%.

Frontmatter (Front Cover, Editorial Team, Preface and Table of Contents) Amin Fatoni
Molekul Vol 15, No 1 (2020)
Publisher : Universitas Jenderal Soedirman

Frontmatter (Front Cover, Editorial Team, Preface and Table of Contents)

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Home Page

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Contact Name Amin Fatoni

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Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA