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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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The Effect of Iron Ion to the Removal of Nickel Ion From Electroplating Wastewater Using Double Chamber Electrodeposition Cell (DCEC) Reactor Djaenudin Djaenudin; Dani Permana
Molekul Vol 12, No 1 (2017)
Publisher : Universitas Jenderal Soedirman

Modern society demands industrial technology advances to produce products that have high durability and long utilization lives. Materials made from ferrous metal become a solution to meet these industry needs. Ferrous metal is corrosive and it requires more care to support the performance. Electroplating or metal coating applied to iron or nickel solves this problem. In the production process, the usage of nickel is only 30%-40% and the remaining 60-70% is wasted through effluent. Nickel is a toxic heavy metal that can cause cancer. The purpose of this study is to evaluate the effect of iron concentration on nickel metal removal in electroplating wastewater using an insulated electrolytic reactor double chamber electrodeposition cell (DCEC). The result of this study shows that any ratio variation of iron concentration to nickel gives varying impacts on nickel removal efficiency, electric current efficiency, and specific energy. On the fourth variation, the iron ratio of 1.29% removed 83.1% nickel (the highest removal efficiency) at the cost of 20.687 kWh / kg specific energy. The number is extremely high for energy needs. On the other hand, the variation of iron ratio of 1.73% consumpting only 15.067 kWh / kg, the lowest specific energy needs, resulted in the lowest removal efficiency of 63.6%.

Cytotoxicity, Antiproliferative and Apoptotic Effect of n-Hexane Fraction of Lime Parasite (Dendrophtoe pentandra) Subandrate Subandrate; Masayu Farah Diba; Salni Salni; Triwani Triwani; Sri Nita
Molekul Vol 14, No 1 (2019)
Publisher : Universitas Jenderal Soedirman

Breast cancer is one of the biggest causes of death in women in the world. Lime parasite (Dendrophtoe pentandra (L.) Miq.), a folk remedy used by Indonesian people, is believed to be efficacious as anticancer drug. This research aims to know the activity of n-hexane fractions of lime parasite in inhibiting the proliferation and apoptosis of T47D cells in vitro. Cytotoxic test with MTT method assay from n-hexane fractions used a multilevel concentration. Antiproliferative test was carried out by the method of MTT assay and cell doubling time was calculated at the time of duplication. Apoptotic test was done with concentration of 1 IC50and ½ IC50which was analyzed by flow cytometry. The results reveals that fractions of lime parasite have cytotoxic activity with concentration of IC50is included in moderatecytotoxic level. The result of the doubling time of the optimum fraction of n-hexane is in 31 hours with the concentration of ¼IC50. Results for the flow cytometry shows the fraction of n-hexane does not induce apoptosis in cells of T47D. Those results show that the active fraction of lime parasite has cytotoxic activity which is able to inhibit proliferation, but does not induce apoptosis of T47D cell.

Enhancing Remazol Yellow FG Decolorination by Adsorption and Photoelectrocatalytic Degradation Sayekti Wahyuningsih; Puji Estiningsih; Velina Anjani; Liya N.M.Z. Saputri; Candra Purnawan; Edi Pramono
Molekul Vol 12, No 2 (2017)
Publisher : Universitas Jenderal Soedirman

The combination of adsorption and photoelectrocatalytic degradation system for Remazol Yellow FG decolorization has been studied. The adsorption of Remazol Yellow FG was carried out using alumina and silica, which was activated using H2SO4 1 M and NaOH 1 M. The adsorption results at optimum pH were then used for photoelectrocatalytic process. Photoelectrocatalytic degradation cell was built by electrode Ti/TiO2 as a cathode and Ti/TiO2-PbO as an anode. Material characterizations were performed by UV-Vis Spectrophotometers, X-Ray Diffraction (XRD), and Fourier Transform Infra-Red (FTIR). Activation of the adsorbent can increase Remazol Yellow FG adsorption on alumina base and silica acid that were reached 99.500% and 81.631%, respectively. The optimum condition of Remazol Yellow FG 6 adsorption by alumina acid was at pH 3, alumina base were at pH 4 and pH 5, and silica base were at pH 6 and pH 10. Degradation of Remazol Yellow FG using TiO2-PbO electrode was 72.756% at potential cells of 7.5 Volts for 10 minutes. The combination of adsorption and photoelectrocatalytic degradation can decrease the concentration of Remazol Yellow FG achieved 99.705%

Identification of Secondary Metabolites Compounds and Antibacterial Activities on The Extract of Soursop Leaf Dian Riana Ningsih; Zusfahair Zusfahair; Dwi Kartika
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

Treatment of bacterial infectious diseases using semi-synthetic antibiotics can lead to resistance, so as to overcome it necessary to search for natural ingredients from plant extracts that has potential as an antibacterial, one of which is the leaf extract of soursop (Annona muricata L.). This study aims to determine the antibacterial activity of soursop leaf against E. coli and identify groups most active chemical compounds from the extracts. Soursop leaves extracted by maceration using n-hexane, chloroform and methanol. The extracts were tested for antibacterial activity using the diffusion method. Extract with the highest activity determined the minimum inhibitory concentrations grow (MIC) and tested the content of secondary metabolites with phytochemical test, subsequently identified using IR spectrophotometer. Soursop leaves with extraction solvent n-hexane, chloroform and methanol to produce n-hexane extract (E1), the chloroform extract (E2), and the methanol extract (E3) with a yield respectively 0.82%; 5.21%; 8.2% and produce antibacterial activity with consecutive inhibition zone of 3.52 mm; 8.34 mm; 3.00 mm. MIC of soursop leaf chloroform extract of the E. coli bacteria that is at a concentration of 1 ppm with inhibition zone of 3.23 mm. Based on the test results phytochemical soursop leaf chloroform extract showed the presence of compounds alkaloids, steroids, saponins and tannins. IR spectrophotometer identification results showed that the chloroform extract of the leaves of the soursop has functional groups OH, aliphatic C-H, C = O, C = C aromatic, CH3, C-O ether and C-H outside the field.

ESTIMASI HUBUNGAN KUANTITATIF STRUKTUR-AKTIVITAS (HKSA) MENGGUNAKAN ARTIFICIAL NEURAL NETWORKS (ANN) Supriyanto Supriyanto
Molekul Vol 4, No 1 (2009)
Publisher : Universitas Jenderal Soedirman

The Quantitative structure-Activity Relationship (QSAR) study has been performed on pattern of structure-molecule relationship. Artificial Neural Network (ANN) model used to estimate pattern of enzyme activity structure-molecule and atomic location in three-dimension for compound of flavonoid as the predictors. Value of determination coefficient used to compare between actual value and value of estimating by ANN models based on enzyme’s wavelength, so resulting cross validating is obtained. We use Quasy-Newton algorithm with Broyden-Fletcher-Goldfarb-Shanno (BFGS) procedure.

The Interaction of Air Pollutant Molecules with Germanene and Silicene: a Density Functional Theory Study Muhammad Rifqi Al Fauzan; Wijayanti Dwi Astuti; Ghorby Al Fauzan; Sholihun Sholihun
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

We investigate the adsorption of atmospheric pollutants on germanene and silicene using density functional theory (DFT) calculations. In this study, we use carbon monoxide (CO) and nitric oxide (NO) as the pollutant molecules. Electronic properties of germanene and silicene are explored to obtain a good understanding in the adsorption process. Our calculation results show both germanene and silicene provide an identical mechanism of adsorption. Germanene and silicene adsorb CO and NO spontaneously with physisorption and chemisorption types for CO and NO molecules, respectively. We also conduct the Mulliken charges calculations to evaluate the transformation of atomic charges due to the adsorption process. From Mulliken charge calculation results we can confirm the existence of charge transfer between the adsorbent materials and the pollutant molecules. This phenomenon lies behind the occurrence of the adsorption process.

KAJIAN FRAKSI METANOL DARI EKSTRAK METILEN DIKLORIDA KULIT KAYU BATANG PELAWAN (Tristania whitiana Griff.) SEBAGAI ANTIBAKTERI Purwantiningsih Sugita
Molekul Vol 2, No 1 (2007)
Publisher : Universitas Jenderal Soedirman

Antibacterial compound from methanol fraction of methylene dichloride extract of pelawan bark had been studied. Pelawan bark was extracted using ethanol 95% and CH2Cl2-water (1:1), respectively. Extract of CH2Cl2 was partitioned using hexane-methanol 90% (1:1). Afterwards, methanol fraction was analyzed by thin layer chromatography methods to find the best eluent for column chromatography. The best eluent came from mixture of acetone-chloroform-methanol (0,6:4:0,4). The fractionation yielded 16 fractions with the first (M1) and the third (M5) fractions became the one spotted fractions. M1 and M5 fractions were examined for their antibacterial activity using paper diffusion methods by determining minimum inhibitory concentration value. M1 fraction showed greater activity than M5 fraction with minimum inhibitory concentration value of 2,7857 mg/mL. The result of phytochemistry test showed that both fractions contain terpenoid.

THE CHEMICAL CHARACTERISTICS AND ANTIOXIDANT ACTIVITY OF STARCH FROM SAGO BARUK PITH (Arenga microcarpha) Lidya Irma Momuat; Edi Suryanto; Sri Sudewi
Molekul Vol 11, No 2 (2016)
Publisher : Universitas Jenderal Soedirman

Sago Baruk (Arenga microcarpha) is one of endemic crop type of Archipelago of Sangihe Talaud, North Sulawesi and potential as source bioactivities including antioxidant. The objectives of this research were to determine the chemical characteristics and antioxidant activity of starch sago baruk which was sequentially extracted with water and filtrate. The sago trunks pith was sequentially extracted with water and filtrate at room temparature for 1 hour. After that, starch of sago baruk were analyzed for their chemical composition (moisture, fat, protein, ash crude fiber and charbohydrate) and total phenolic and tannin condensed content. Antioxidant activity of each sago flour were evaluated in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and total antioxidant capacity. After that, the starch was characterized by IR spectroscopic technique. The sequential extraction result indicated percentage yield of starch I and starch II were 41.39% and 38.21%. The chemical characteristics of starch I revealed that percentage protein, ash, crude fibre and fat were below 1% than starch II especially protein and fiber crude. The starch I had highest total phenolic and tannin condensed content than starch II and starch K. The starch I also showed the highest free radical scavenging activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical than starch II and starch K. The result also showed that starch I has strongest total antioxidant capacity than starch II and starch K at all concentration level. Antioxidant activity of three starch increased with the increase in concentration of the samples. The three starch showed of hidroxy (OH), carbonyl (C=O), ether (C-O) and aliphatic group (C-C). It is concluded that starch sago baruk especially the starch I are very rich in antioxidant substituens.

PENURUNAN KADAR SIANIDA DALAM LIMBAH CAIR TAPIOKA MENGGUNAKAN FOTOKATALIS TiO2 Kapti Riyani; Tien Setyaningtyas
Molekul Vol 5, No 1 (2010)
Publisher : Universitas Jenderal Soedirman

Cyanide compound is one of the organic material contained in wastewater of tapioca production, which is a highly toxic substance for life. According to the results of physical and chemical properties of liquid waste samples of tapioca starch in the deposition process in the industry taken from Pancasan Village, Ajibarang, Banyumas, cyanide concentration in the effluent was 3.8 mg/L while the maximum level of cyanide allowed in industrial wastewater are 0.5 mg/L. Therefore, a method to reduce the concentration of cyanide is needed. One of the method is using of TiO2 catalyst. This study was aimed to determine the effect of the pH and UV irradiation time on photocatalytic activity of TiO2 to reduce the levels of cyanide on tapioca wastewater from PT. HARUM BUNGA, Purbalingga.This study uses a thin layer of TiO2 photocatalyst prepared by suspension of TiO2 coating on the glass plate that was dried at 120ºC and conducted with variations of pH that were 2, 5, 7, 8, 9, 10, and 13 in the wastewater to determine the optimum pH, continued by time variation of UV radiation for 1, 2, 4, 6, 8, 10, and 12 hours. The results showed that the largest percentage decrease in the concentration of cyanide occurs at pH 9 that is equal to 88.6361% and the largest percentage decrease in the concentration of cyanide by irradiation with UV light occurs after 10 hours irradiation, up to 93.7929%.

Validation Method of Flame-AAS with Microwave Digestion for Mineral Analysis in Carbohydrate-Rich Samples Imas Solihat; Didah Nur Faridah; Nancy Dewi Yuliana
Molekul Vol 13, No 2 (2018)
Publisher : Universitas Jenderal Soedirman

One of the effective methods for mineral destruction is by using microwave digestion. However, some parameters in the microwave manual book are different with AOAC method such as the volume of acid, temperature, and the length of destruction time (Δt). Thus, a validation for mineral analysis method of Fe, Zn, and Cu by using microwave digestion method is required. In this study, carbohydrate-rich samples such as rice and canned pineapple were being used for the validation of mineral analysis method of Fe, Zn, and Cu using microwave digestion. The parameters of this research include LOD, LOQ, LDM, linearity, precision, accuracy, and reproducibility. The accuracy result for Fe, Zn, and Cu mineral was found in the range of 75-120% with good precision value (% RSD <% 2/3RSD Horwitz). Based on the results, accuracy for mineral Fe, Zn and Cu found in the range of 75-120% with good precision value (% RSD <% 2/3RSD Horwitz). The regression curves of the Fe, Zn, and Cu minerals gave the value of R2> 0.990. For LDM values in the rice samples consecutively for Fe, Zn, and Cu minerals were 0,06; 0,07; 0,04 mg/L, while for the canned pineapple were 0,07;0,10;0,01 mg/L, respectively. The results of a modified method for minerals Fe, Zn and Cu analysis in carbohydrate-rich samples was not significantly different from AOAC (2012). Thus the method was acceptable to be used in laboratory analysis.

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Home Page

OAI Link

Editorial Team

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Contact Name Amin Fatoni

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Journal Mail Official j.molekul@gmail.com

Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

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Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA