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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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Antibacterial Activity of Essential Oil from Rosemytle Leaves (Rhodomyrtus tomentosa (Ait.) Hassk) Salni Salni; Hanifa Marisa
Molekul Vol 15, No 3 (2020)
Publisher : Universitas Jenderal Soedirman

Rosemytle leaves (Rhodomyrtus tomentosa (Ait.) Hassk) have been used by society to treat various diseases related to bacterial infections, such as dysentery and typhoid fever caused by Shigella dysenteriae and Salmonella typhi, respectively. This study aimed to evaluate the antibacterial activity of essential oils from rosemytle leaves against both bacterias. Extraction was performed with a macerating device using n-hexane, ethyl acetate, and ethanol extracts, sequentially. This study used the agar diffusion method to test the antibacterial activity applied to the essential oils with concentrations of 1000, 500, 250, 125, 62.5, and 31.25 μg/mL. The antibacterial test results showed that n-hexane and ethyl acetate extracts were active against both bacterias while ethanol extract was not. Then, isolates N1 and E1 were produced respectively from n-hexane extract and ethyl acetate extract. The MIC values of both N1 and E1 for S. dysenteriae, and S. typhi were the same, namely 125 μg/mL. Isolate N1 was an essential oil containing menthol (59.60%), caryophyllene (25.77%), and cubenol (14.63%) while isolate E1 was an essential oil containing (73.93%), pentanone (8.30%), alpha calacorene (7.58%), and calacorene (3.78%). Rosemytle leaves have the potential to be developed as a drug to treat dysentery and typhoid fever.

Carboxymethyl Glucomannan from Amorphophallus oncophyllus as an Alternative Heavy Metal Removal from Wastewater: Adsorption of Cadmium and Zinc Hikmat Hikmat; Renta Resdiana; Aprilia Nur Tasfiyati
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

Carboxymethyl glucomannan (CMGM) was successfully synthesized through the reaction of glucomannan from Amorphophallus oncophyllus and monochloroacetic acid, using NaOH as a catalyst. Two types of glucomannan were used in this study, low viscosity glucomannan (LGM) and high viscosity glucomannan (HGM). The produced CMGM were differentiated into LCMGM (synthesized from LGM) and HCMGM (synthesized from HGM). The CMGM structure was characterized by FTIR, and the degree of substitution (DS) was determined using back titration method. The DS value were 0.484 and 0.412 for LCMGM and HCMGM, respectively. Both CMGMs were then evaluated for its adsorption capacity towards Zn and Cd at the optimum pH of 6, with 60 minutes adsorption time for each sample. The maximum adsorption capacity of Zn was 13.61 mg/g and 13.04 mg/g for LCMGM and HCMGM, respectively. While for Cd, the maximum adsorption capacity of LCMGM and HCMGM was 17.70 mg/g and 15.90 mg/g. The adsorption capacity of the sample follows the Langmuir isotherm adsorption. In conclusion, CMGM from A. oncophyllus has demonstrated its potential as a reusable adsorbent for efficient removal of Cd and Zn.

The HMG-CoA Reductase Inhibitor Activities of Soy Protein Hydrolysates from Papain Hydrolysis Sandra Hermanto; Aldi Octavio; Azrifitria Azrifitria; Susi Kusumaningrum
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

The search for an HMG-CoA reductase inhibitor agent as a safe and inexpensive alternative treatment for hypercholesterolemia has been carried out using soy protein hydrolysates as one of the bioactive peptide sources. This study was conducted to explore the potency of soy protein hydrolysates as an anti hypercholesterolemia agent by an in vitro assay, through the inhibition capacity of the HMG-CoA (3-hydroxy-3-methyl glutaryl-coenzyme A) reductase enzyme as a key component of cholesterol biosynthesis. Sample preparation started with soy protein isolation through acid precipitation and separated by centrifugation. The samples were analyzed the proximate content and hydrolyzed by papain enzyme at concentration 0.2% (w/v), for 0-6 hours and at 37, 50, and 55 oC. The protein hydrolysates were subsequently evaluated for hydrolysis degree (% DH), hydrolysates profile with SDS-PAGE (Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis), and anti-cholesterol assay through HMG-CoA reductase inhibition tests. The sample with the highest inhibition activity was fractionated using gel filtration chromatography (Sephadex G-10) and the molecular weight of fractions was characterized by LCMS QTOF (Liquid Chromatography-Mass Spectrometry Quadrupole Time-of-Flight) for molecular weight determination. The results indicated the optimum hydrolysis conditions of soy protein isolates were obtained at 3 hours incubation, at 50 °C with DH 33.39% and the inhibition value was 95.65% (protein concentration 39.21 μg / mL). LCMS data showed the molecular weight of fractionated peptides were 1514 and 2029 Da. We assumed that both peptides have the same affinity as previous peptides in inhibiting HMG-CoA reductase.

Removal of Pb(II) using Hydroxyapatite from Golden Snail Shell (Pomacea canaliculata L.) Modified with Silica Poedji Loekitowati Hariani; Fahma Riyanti; Fatma Fatma; Addy Rachmat; Aldi Herbanu
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

The composites of hydroxyapatite and SiO2 were successfully synthesized. The hydroxyapatite was prepared from golden snail shells (Pomacea canaliculata L). The hydroxyapatite and hydroxyapatite-SiO2 composites were characterized using XRD, FTIR, SEM-EDS. Furthermore, hydroxyapatite and hydroxyapatite-SiO2 composites were used to remove Pb(II) from aqueous solution. Various adsorption parameters such as pH of the solution, contact time, and initial Pb(II) concentration were used to study the adsorption process. The optimum pH of the solution for removal of Pb(II) by hydroxyapatite and hydroxyapatite-SiO2 composite at pH 6 and contact time at 60 minutes. Both adsorbents follow the Langmuir isotherm. The maximum adsorption capacity of the hydroxyapatite-SiO2 composite is greater compare to hydroxyapatite, respectively 135.14 and 123.46 mg/g. The pseudo-second order kinetic model had a correlation coefficient (R2) greater than the pseudo-first order so pseudo-second order kinetic is better to describe adsorption kinetics

Four Flavan-3-ol Compounds From The Stembark of Chisocheton balansae C.DC. (MELIACEAE) Unang Supratman; Mohamad Fajar; Supriatno Salam; Rani Maharani; Desi Harneti; Nur;lelasari Nurlelasari; Dewa Gede Katja; Agus Safari; Mohamad Nurul Azmi
Molekul Vol 16, No 1 (2021)
Publisher : Universitas Jenderal Soedirman

Chisocheton balansae C.DC., is one of the Meliaceae family plants which is the endemic plants from Soputan Mountain, North Sulawesi, Indonesia. This study was aimed to determine the chemical structure of flavan-3-ol compounds from ethyl acetate extract of C. balansae C.DC stembark. Dried powder of C. balansae C.DC stem bark was extracted consecutively with n-hexane, ethyl acetate, and methanol solvents. Four flavan-3-ol compounds, named catechin (1), epicatechin (2), epigallocatechin-3-O-gallate (3), and epicatechin-3-O-gallate (4) were successfully isolated from ethyl acetate extract. The chemical structure of these isolates was determined by spectroscopic methods (1H-NMR, 13C-NMR, DEPT, and 2D-NMR) and comparison with previous reported spectral data. These compounds are first time reported from this plant.

Phosphorous fractionation distribution in surface sediments of the Jobokuto Bay Lilik Maslukah; Anindya Wirasatriya; Muh Yusuf; Resy Sekar Sari; Ummu Salma; Muhammad Zainuri
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

Phosphorus (P) is an essential nutrient that can limit primary productivity in waters. Phosphorus has significant impact on the biogeochemical cycle in marine ecosystems. Surface sediments play an important role in the nutrient dynamics. Riverine input is sources of P to the ocean and sediment plays an important role as a source or sink of P in the coloumn of water. Phosphorous (P) availability is regarded as the most important factor for determining the water quality in coastal waters. However, not all of the P fractions can be released from the sediment. This study was conducted to identify the distribution of phosphorus (P) fractionation in the sediment surface of Jobokuto Bay. Samples were collected from ten locations. Percentage of sedimentary parameters such as sand, silt, clay, and organic carbon were analyzed to find out their relation with various P fractions. The sediment found was mostly sand at the station near to the coast and mud (silt and clay) at offshore stations. The results showed that Ca-P dominant (56.03%) and percentages of Fe-P, OP, and Ads-P were 23.43, 17.41, and 3.2% respectively. Terrestrial inputs and biological deposits cause Ca-P dominant. The bioavailability of P fractions were ranged from 34.45 to 56.1% of the total P (TP) content. The high concentrations of the Ads-P was found in the mud fraction and located at offshore stations. The order of abundance of the major forms of P in the surface sediments of Jobokuto bay is as follows: Ca-P > Fe-P > OP > Ads-P

Reverse Docking, Molecular Docking, Absorption, Distribution, and Toxicity Prediction of Artemisinin as an Anti-diabetic Candidate Ruswanto Ruswanto; Richa Mardianingrum; Siswandono Siswandono; Dini Kesuma
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Aldose reductase is an enzyme that catalyzes one of the steps in the sorbitol (polyol) pathway that is responsible for fructose formation from glucose. In diabetes, aldose reductase activity increases as the glucose concentration increases. The purpose of this research was to identify and develop the use of artemisinin as an anti-diabetic candidate through in silico studies, including reverse docking, receptor analysis, molecular docking, drug scan, absorption, and distributions and toxicity prediction of artemisinin. Based on the results, we conclude that artemisinin can be used as an anti-diabetic candidate through inhibition of aldose reductase

Photocatalytic removal of Cu (II) in an aquatic solution using TiO2-Chitosan Nanocomposites imelda Fajriati; Mudasir Mudasir; Endang Tri Wahyuni
Molekul Vol 15, No 3 (2020)
Publisher : Universitas Jenderal Soedirman

Photocatalytic removal of Cu(II) in aquatic solutions using TiO2-chitosan nanocomposite had been studied. The photocatalytic process was carried out using a batch system in a closed reactor equipped with a UV lamp. The results show that the percentage of photocatalytic removal of Cu(II) by TiO2 – chitosan nanocomposite was higher than that TiO2 bulk catalyzing. Under solution containing 20 mg/L of Cu(II), pH 7, three hours of contact time, and employing 20 mg TiO2-chitosan nanocomposite, the Cu(II) removal was successfully done up to 94.55%. The maximum adsorption capacity and the highest kinetic constants were obtained under nanocomposite with the highest amount of chitosan (TiO2-chit 0.13) and nanocomposite containing the highest amount of TiO2 (TiO2-chit 1.3), respectively. The method offers high reusability up to three times with percentage more than 50% of Cu(II) removal. Keyword: Photocatalytic, Cu(II) removal, TiO2-chitosan nanocomposite

Synthesis, Characterization, Antioxidant Activity, and Toxicity Properties of Tripolyphosphate Crosslinked Chitosan Tien Setyaningtyas; Kapti riyani; Mardiyah Kurniasih; Purwati Purwati; Siti Masruroh
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Chitosan is biopolymer obtained from chitin deacetylation reaction. Chitin is a constituent of shrimps’ outer shell. Chitosan modification using crosslinker agent could increase the active groups and stabilize the physical character. One of non-toxic crosslink agents was tripolyphosphate. This study aimed at synthesizing tripolyphosphate crosslinked chitosan (TPP-Cs) to test the antioxidant and toxicity. Synthesizing tripolyphosphate chitosan was conducted using ionic gelation method. The antioxidant activity test was studied from DPPH radicals scavenging and the ability to inhibit linoleic acid oxidation. The toxicity test was using BSLT (Brine Shrimp Lethality Test) method and Artemia salina leach nauplii. The study showed that TPP-Cs could be synthesized from pink shrimp and showed antioxidant activity. The activity was due to amino and hydroxyl groups. The BSLT method showed that TPP-Cs had the potential to be applied for antibacterial, antivirus, or anticancer products.

Antibacterial Activities and Toxicity of Streptosporangium sp. SM1P Risa Nofiani; Rizky Rizky; Ridho Brilliantoro
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

This study aims to explore the anti-bacterial and toxicity activities from a rare actinobacterium isolated from mangrove, Mempawah District, West Kalimantan. The mangrove mud sample from Mempawah district was inoculated on ISP4 agar using a pour plate method. After 4 days of incubation, a colony of suspected actinobacterium was appeared, then isolated and coded as SM1P. SM1P was characterized based on morphological and biochemical traits and identified as a genus of Streptroporangium then called Streptroporangium sp. SM1P. Streptroporangium sp. SM1P was carried out anti-bacterial assay on both ISP1 agar and ISP4 agar media using the cross-streak method for the solid-state fermentation. The result showed that Streptroporangium sp. SM1P could inhibit Streptococcus sp. and Salmonella typhi on ISP1 agar and treptococcus sp., Escherichia coli, Vibrio cholerae, Staphylococcus aureus and Salmonella typhi on ISP4 agar. Streptroporangium sp. SM1P was cultivated on ISP1 broth and extracted using ethyl acetate, then evaporated to obtain crude extract. The crude extract was used for anti-bacterial assay (well-diffusion method for liquid-state fermentation) and toxicity assay (brine shrimp lethality test). The crude extract was active against 2 of the test bacteria (Streptococcus sp. and E. coli). The best medium and state fermentation for anti-bacterial assay were ISP4 agar with the condition of solid-state fermentation. The extract SM1P prepared on ISP1 broth showed toxic activity based on LC50 (106.094 µg/mL). Therefore, Streptroporangium sp. SM1P have a potential source to explore secondary metabolites having anti-bacterial and toxicity activities.

Page 28 of 34 | Total Record : 331

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Contact Name Amin Fatoni

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Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Abstract

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Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA