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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
Arjuna Subject : -
Articles 14 Documents
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Search results for , issue "Vol 6, No 1 (2012)" : 14 Documents clear
PENGEMBANGAN POTENSI RHODOMYRTONE SEBAGAI BAHAN AKTIF SEDIAAN TOPIKAL Fahmi, Rizal; Rullah, Kamal; Rahmat, Rosita Dewi; Lucida, Henny; Manjang, Yunazar; Hj. Lajisc, Nordin; Dachriyanus, .
Jurnal Farmasi Indonesia Vol 6, No 1 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v6i1.93

Abstract

Rhodomyrtone, an antibacterial constituent was isolated from the active fraction of theleaves extract of Karamuntiang, Rhodomyrtus tomentosa (Aiton) Hassk. In this presentstudy, the topical cream formula of rhodomyrtone 2% in vanishing cream was evaluated byin vitro and in vivo preclinical test. The in vitro test was peformed against Staphylococcusaureus ATTC 6538 and Staphylococcus epidermidis ATTC 12228 by using disk agardiffusion method, while the in vivo test was evaluated on the surface of skin infection area ofthe rabbit caused by Staphylococcus aureus. Both these tests were guided bychloromphenicol 2% cream as a comparison. The topical cream of rhodomyrtone 2% invanishing cream showed diameters of inhibition zones of 15 mm and 26 mm towardStaphylococcus aureus and Staphylococcus epidermidis respectively. These diffusions werelower than inhibition zones of chloromphenicol 2% cream which has 30 mm and 32 mm forthe same bacterias in the same condition. The in vivo test showed that rhodomyrtone 2%topical cream can reduced that skin infection and did not caused irritation on the testedrabbits.ABSTRAKRhodomyrtone adalah suatu konstituen antibakteri fraksi aktif ekstrak daun karamuntiang,Rhodomyrtus tomentosa (Ait) Hassk. Pada penelitian ini telah dilakukan uji preklinisterhadap krim sediaan topikal Rhodomyrtone 2% dalam vanishing cream. Uji preklinissecara in vitro menggunakan media agar dan Staphylococcus aureus ATTC 6538 danStaphylococcus epidermidis 12228 sebagai bakteri uji, sedangkan secara in-vivo dilakukanterhadap kulit pada kelinci yang di infeksi dengan Staphylococcus aureus. Kedua uji inimenggunakan krim kloromfenikol 2% sebagai pembanding. Krim sediaan topikalrhodomyrtone 2% dengan basis vanishing cream memberikan diameter hambatan berturutturut15 mm dan 26 mm terhadap Staphylococcus aureus dan Staphylococcus epidermidis.Difusi ini lebih rendah dibanding sediaan krim kloromfenikol 2% yang memberikan diameterhambatan 30 mm dan 32 mm, masing-masing untuk Staphylococcus aureus danStaphylococcus epidermidis pada kondisi yang sama. Selanjutnya uji secara in vivomenunjukkan bahwa krim sediaan topikal rhodomyrtone 2% dapat mengurangi infeksi kulitdan tidak menimbulkan iritasi pada kelinci percobaan.
OPTIMASI DAN VALIDASI METODE ANALISIS ASAM NIKOTINAT SERTA STABILITAS INOSITOL HEKSANIKOTINAT Harahap, Yahdiana; Suryadi, Herman; Wardatun, Sri
Jurnal Farmasi Indonesia Vol 6, No 1 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v6i1.94

Abstract

Nicotinic acid is a therapeutic agent for treatment atherosclerosis. Inositol hexanicotinate isan agent that can be hydrolyzed with release nicotinic acid. The low level of free nicotinicacid from inositol hexanicotinate in blood, itâ??s the reason why it needs method analysis withhigh sensitive and selective. The aims of this research were to optimize and validationmethod analysis nicotinic acid and stability study of inositol hexanicotinate by highperformance liquid chromatography. The method was optimated with variation compositionmobile phase, variation flow rate and optimation process exctraction. Condition analysiswere optimum with use a Kromasil column (250 mm x 4,6 mm) RP, mobile phase mixeddipotassium hydrogen phosphate and potassium dihydrogen phosphate 10 mM containingtetrabuthylammonium bromide 5 mM pH 7 with acetonitril (100:9), flow rate 0,8 ml/minute,with internal standard coffein in 263 nm wave lenght. The standard curve was linear over aconcentration range 124,84 to 5000 ng/ml of nicotinic acid in plasma. The HPLC method wasvalidated with accuracy -6,8779 to 3,09 %, precision 0,3 to 3,71 % and recovery 93,12 -103,09 %. The results of a stability study indicated that inositol hexanicotinate was unstablein plasma samples, but was stable in 0,6 M perchloric acid for to 24 hour at 40C. ABSTRAKAsam nikotinat merupakan obat yang dapat digunakan untuk ateroskerosis dan inositolheksanikotinat merupakan senyawa yang dapat terhidrolisis melepaskan asam nikotinat.Penelitian ini bertujuan untuk optimasi dan validasi metode analisis asam nikotinat, sertamenentukan stabilitas inositol heksanikotinat menggunakan kromatografi cair kinerja tinggi.Kondisi analisis yang optimum diperoleh dengan menggunakan kolom Kromasil (250 mm x4,6 mm) RP, fase gerak campuran kalium dihidrogen fosfat dan dikalium hidrogen fosfat 10mM yang mengandung tetrabutilammonium bromida 5 mM pH 7 dengan asetonitril (100:9),kecepatan alir 0,8 ml/menit, dengan baku dalam kafein, yang dideteksi pada panjanggelombang 263 nm. Kurva kalibrasi linier dari 124,84 sampai 5000 ng/ml. Hasil validasimetode menunjukkan akurasi -6,87 hingga 3,09 %, presisi 0,3 hingga 3,71 % dan perolehankembali 93,12 hingga 103,09%. Hasil uji stabilitas menunjukkan bahwa inositolheksanikotinat tidak stabil dalam plasma tetapi stabil dalam asam perklorat 0,6 M padapenyimpanan 40C selama 24 jam.
OPTIMASI ASAM OLEAT, PROPILEN GLIKOL DAN IONTOFORESIS TERHADAP TRANSPOR TRANSDERMAL PROPRANOLOL HCL Hendriati, Lucia; Nugroho, Akhmad Kharis
Jurnal Farmasi Indonesia Vol 6, No 1 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v6i1.95

Abstract

The purposes of this study were to evaluate the influences of oleic acid, propylene glycol andiontophoretic on the transport of propranolol HCl and to know optimum formula. Eightconditions were prepared according to 23 factorial design emplyoing oleic acid, propyleneglycol, and iontophoretic. Enhancement effect on transport of propranolol HCl wasinvestigated across hairless rat skin. The study was carried out by using vertical diffusioncell. Transport of propranolol HCl across membrane was determinedspectrophotometrically. Data were analysed based on compartment modeling to determinetransport kinetics and then the optimum formula was proposed. The transport kinetics ofpropranolol HCl followed first order. Oleic acid and propylene glycol increased the potentialof the drug to difuse (AD) but had no effect on drug release rate from donor compartement tomembrane (Ka) and from membrane to acceptor compartment (KR). Iontophoretic increasedKa and decreased KR. Based on values of Ka, AD, KR, optimum formula containing oleicacid, propylene glycol and iontophoretic which have the percentage and current density of4,8%, 20% and 0,11 mA/cm2, respectively.ABSTRAKPenelitian ini bertujuan mengetahui pengaruh asam oleat, propilen glikol dan iontoforesisterhadap parameter transpor transdermal propranolol HCl dan mengetahui komposisiformula optimum. Delapan formula disusun berdasarkan desain faktorial 23 denganmenggunakan pemacu transpor asam oleat, propilen glikol dan iontoforesis. Pengujianpenetrasi dilakukan secara in vitro menggunakan sel difusi. Kulit tikus sebagai membranmengalami praperlakuan dengan asam oleat dan propilen glikol, diikuti dengan iontoforesis.Jumlah propranolol HCl yang tertranspor ditetapkan dengan metode spektrofotometri.Analisis data menggunakan modeling berbasis kompartemen dilanjutkan dengan pemilihanformula optimal. Transpor propranolol HCl dijelaskan melalui model tiga kompartemen.Asam oleat dan propilen glikol meningkatkan potensi obat tertranspor (AD), namun tidakmempengaruhi kecepatan absorbsi dari kompartemen donor ke kulit (Ka) maupunkecepatan pelepasan dari kulit ke kompartemen reseptor (KR). Arus iontoforesismeningkatkan harga Ka dan menurunkan KR. Berdasarkan harga parameter Ka, AD dan KR,komposisi formula optimum adalah asam oleat 4,8%, propilen glikol 20% dan iontoforesis0,11% mA/cm2.
PERBANDINGAN PENGGUNAAN OBAT ANTARA PASIEN PNEUMONIA RAWAT INAP DI RUMAH SAKIT Rais, Yulia; Trisna, Yulia; Andrajati, Retnosari
Jurnal Farmasi Indonesia Vol 6, No 1 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v6i1.96

Abstract

Pneumonia is the third major disease suffered by inpatient class III in RSUPN Dr. CiptoMangunkusumo Jakarta, among other are patient of Jamkesmas, Askessos and Gakin.Treatment expense for patient Jamkesmas based on the tariff packet of INA-DRG.Thepurposes of this study were to compare of drug use by ATC/DDD methode and comparedthe portion of the cost for drugs and health supplies to INA-DRG Tariff, among the thirdpatient group. Design of this study was cross sectional. Data were collected retrospectivelyfrom medical record and prescriptions for inpatient of pneumonia with Jamkesmas,Askessos, and Gakin Program at Cipto Mangunkusumo Hospital Jakarta, over period ofMarch 2008 â?? March 2009. The result of this study showed that quantity of drug use atJamkesmas, Askessos and Gakin successively were differed, successively 391,500;380,211; and 741,895 DDD/hbd. Generic name in DU90% at Jamkesmas, Askessos andGakin were also significantly differed, i.e. 22 (31%), 19 (24%), 37 items (40%). There wasalso a significant difference among the three health insurances in regards with the portion ofthe cost for drugs and health supplies to INA-DRG Tariff.ABSTRAKPneumonia adalah penyakit ketiga terbanyak yang diderita oleh pasien di ruang rawat inapkelas III di RSUPN Dr. Cipto Mangunkusumo Jakarta, diantaranya adalah pasienJamkesmas, Askessos dan Gakin. Biaya perawatan bagi pasien Jamkesmas dilakukanberdasarkan Tarif paket INA-DRG. Penelitian bertujuan untuk membandingkan penggunaanobat dengan Metode ATC/DDD dan membandingkan persentase biaya obat dan alatkesehatan terhadap Tarif INA-DRG antara ketiga kelompok pasien. Penelitian dilakukandengan rancangan studi potong lintang. Data diambil secara retrospektif dari rekam medikdan resep dokter untuk pasien pneumonia program Jamkesmas, Askessos dan Gakin,periode Maret 2008 â?? Maret 2009. Hasil penelitian menunjukkan kuantitas penggunaan obatpada pasien Jamkesmas, Askessos dan Gakin berbeda bermakna, berturut-turut adalah391,500; 380,211; 741,895 DDD/shr. Obat dengan nama generik dalam segmen DU90%pada pasien Jamkesmas, Askessos dan Gakin berturut-turut juga brbeda bermakna,berturut-turut 22 item (31%), 19 item (24%), 37 item (40%). Juga terdapat terdapatperbedaan yang bermakna dalam persentase biaya obat dan alat kesehatan terhadap TarifINA-DRG antara ketiga kelompok yang dibandingkan.

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