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Oto Rhino Laryngologica Indonesiana
Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia
ISSN : 02163667     EISSN : 25983970     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.
Arjuna Subject : -
Articles 493 Documents
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Hasil BERA & TEOAE dengan kadar HbA1c pada pasien Diabetes Melitus tipe-2 Novi Primadewi; Hadi Sudrajad; Eka Prasetya
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.243 KB) | DOI: 10.32637/orli.v49i1.279

Abstract

Latar belakang: Neuropati adalah salah satu komplikasi yang paling sering dari Diabetes Melitus(DM) tipe 2. Disamping neuropati perifer dan otonom, pasien dengan DM tipe 2 juga dapat menderitagangguan pendengaran tipe sensorineural hearing loss (SNHL) pada frekuensi tinggi. Pada studi inihubungan HbA1c dengan hasil pemeriksaan brainstem evoked response audiometry (BERA) dan transient evoked otoacoustic emissions (TEOAE) digunakan untuk mendeteksi neuropati akustik dan sentral pada pasien DM tipe 2. Tujuan: Untuk mengetahui hubungan kadar HbA1c pada DM tipe 2 dengan masa laten gelombang BERA dan respon TEOAE. Metode: Desain penelitian cross sectional study, dilakukan dari Maret 2018 hingga jumlah sample terpenuhi. Penelitian dimulai dengan mengidentifikasi pasien DM tipe 2 dengan profil kadar HbA1c, kemudian dilanjutkan dengan pemeriksaan TEOAE dan BERA. Hasil: Dari hasil pemeriksaan BERA terdapat hubungan signifikan antara HbA1c dengan masa laten gelombang BERA di intensitas 70 dB dan 80 dB kecuali latensi antar-puncak I-V, tetapi tidak berhubungan signifikan pada intensitas 90 dB. Didapatkan pada pemeriksaan TEOAE di telinga kanan kadar HbA1c berhubungan dengan hasil pemeriksaan TEOAE kategori refer rata-rata 8,67+1,14%, sedangkan pasien dengan hasil pemeriksaan TEOAE kategori pass rata-rata 7,73+0,95%. Hasil uji t test didapatkan nilai p=0,021 (p<0,05). TEOAE di telinga kiri kategori refer rata-rata 8,82+1,09%, sedangkan pasien dengan hasil pemeriksaan TEOAE kategori pass rata-rata 7,66+0,88%. Hasil uji t test didapatkan nilai p=0,003 (p<0,05). Kesimpulan: Terdapat hubungan yang signifikan secara statistik antara kadar HbA1c dengan hasil pemeriksaan gelombang BERA dan TEOAE. Background: Neuropathy is complication of type 2 diabetes mellitus (DM). Besides peripheraland autonomic neuropathy, patients with type 2 DM may also have sensorineural hearing loss at highfrequency. In this study the association of HbA1c level with the results of BERA and TEOAE tests was used to detect acoustic and central neuropathy in type 2 DM patients. Objective: To find out the relationship of HbA1c level in type 2 DM with BERA and TEOAE. Method: Research design cross sectional study, conducted from March 2018 until the number of samples fulfilled. The study began by identifying patients with type 2 DM with the HbA1c profile, followed by TEOAE and BERA examinations. Result: There was a significant relationship between HbA1c and the latent period of waves at the intensity of 70 dB and 80 dB except on the interpeak I-V latency, but not significantly related to the 90 dB intensity. Results of TEOAE test in the right ear: the average levels of HbA1c with refer category results on TEOAE test was 8.67+1.14 %, whereas patients with pass category results on TEOAE was 7.73+0.95 %. The result of t test value was p=0.021 (p<0.05). TEOAE on the left ear: average refer category 8.82+1.09%, whereas patients with TEOAE examination results in the mean pass category 7.66+0.88%. The result of t test value was p=0.003 (p<0.05). Conclusion: There was a statistical significant relationship between HbA1clevel and BERA and TEOAE.
Hubungan kadar CA 125 dengan karakteristik klinis Diffuse Large B cell Lymphoma Agung Dinasti Permana; Igor Hutabarat; Thaufiq Boesoirie; Bethy S. Hernowo; Rovina Ruslami
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (293.742 KB) | DOI: 10.32637/orli.v49i1.287

Abstract

Latar belakang: Kadar serum CA 125 telah diketahui mengalami peningkatan pada kasus limfoma non Hodgkin. Kegunaannya dalam menentukan prognosis, tingkat keparahan penyakit, dan follow up pasca terapi limfoma non Hodgkin telah banyak diteliti dan masih didapatkan hasil yang bervariasi. Saat ini belum diketahui mengenai kadar serum CA 125 pada kasus diffuse large B cell lymphoma (DLBCL) yang bermanifestasi di regio kepala dan leher. Tujuan: Mengetahui hubungan kadar serum CA 125 dengan karakteristik klinis pada kasus DLBCL regio kepala dan leher. Metode: Penelitian ini merupakan penelitian potong lintang yang melibatkan 31 subjek penelitian dengan diagnosis DLBCL regio kepala dan leher. Dilakukan pencatatan karakteristik klinis dan penentuan kadar serum CA 125 dengan pemeriksaan Immunoasai dan kemudian dilakukan analisis statistik untuk menentukan hubungan antar variabel. Hasil: Didapatkan peningkatan kadar serum CA 125 pada stadium lanjut dengan p<0,001. Analisis statistik terhadap kadar serum CA 125 dan Kadar Lactic Dehydrogenase (LDH) menunjukkan hubungan yang signifikan (p=0,018) demikian juga hubungannya dengan skorEastern Cooperative Oncology Group (ECOG) dengan nilai p=0,001. Pada penelitian ini tidak terdapat hubungan yang bermakna antara kadar serum CA 125 dengan skor Prognostic International Index (IPI). Kesimpulan: Kadar serum CA 125 berhubungan bermakna dengan stadium klinis, kadar LDH dan Skor ECOG pada DLBCL yang bermanifestasi di regio kepala dan leher. Dengan demikian CA 125 dapat digunakan sebagai marker untuk memprediksi prognosis dan mendekati stadium lanjut kasus limfoma non Hodgkin. Background: Serum CA 125 level has been known to increase in Non-Hodgkin Lymphoma cases.Many studies had elaborately researched the prognosis, disease severity and the follow up of Non Hodgkin Lymphoma cases using CA 125, yet the results had been varied. Up to now, serum CA 125 levels in cases of diffuse large B cell lymphoma (DLBCL) which manifest in the head and neck region, is still unclear. Purpose: To find out the correlation of serum CA 125 levels with clinical manifestations of DLBCL cases in the head and neck region. Method: A cross-sectional study involving 31 subjects diagnosed with DLBCL in the head and neck region. The clinical manifestations were recorded and serum CA 125 levels were obtained by Immunoassay examination. Statistical analysis was performed to determine the correlation between variables. Results: An increase in serum CA 125 levels at an advanced stage with p <0.001. The statistical result of CA 125 serum levels and LDH levels showed a significant correlation (p=0.018), as well as its significant correlation with the Eastern Cooperative Oncology Group (ECOG) score, with p=0.001. In this study there was no significant correlation between CA 125 serum levels and Prognostic International Index (IPI) scores. Conclusion: Serum CA 125 levels were significantly correlated with clinical stage, LDH level and ECOG score of DLBCL which manifested in the head and neck region. Therefore, CA 125 might be used as a marker to predict prognosis and to detect advanced disease in Non-Hodgkin Lymphoma cases.
The correlation between plasma reactive oxygen species and hearing threshold levels in presbycusis patients Purnami, Nyilo; Nuraini, Anita; Surarso, Bakti
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.38 KB) | DOI: 10.32637/orli.v49i1.291

Abstract

Background: Presbycusis is a hearing loss due to the degeneration process in elderly people of 65 years old and beyond, characterized by a decrease in hearing sensitivity in both ears. Reactive oxygen species (ROS) are assumed to have an important role in the pathogenesis of presbycusis. Purpose: To find out the correlation between ROS levels in plasma and hearing threshold levels in presbycusis patients. Method: The design was cross sectional and conducted at the Outpatient Clinic of Neurotology Division, Geriatric Clinic, Clinical Pathology Installation, and Central Installation of Biomaterials Network Bank of Dr. Soetomo Hospital. Samples were taken by consecutive sampling for audiometric examination and measurement of ROS levels in plasma. Results: Fifty samples were collected, ROS levels in plasma were found with mean (SD) of 2.46 ng/ml (0.84). The mean hearing threshold level was 47.70 dB (12.42). The Pearson statistical test revealed a significant correlation between ROS levels in plasma and hearing threshold levels, with p=0.003 (p<0.05), and the correlation coefficient (r) 0.41. Conclusion: There was a correlation between ROS in plasma and hearing threshold levels in presbycusis patients, with a significant moderate-positive correlation pattern. It indicated that the higher the ROS levels in plasma, the higher the hearing threshold levels in presbycusis patients. Latar belakang: Presbikusis adalah gangguan pendengaran akibat proses degenerasi yang dijumpai pada usia 65 tahun atau lebih, ditandai oleh penurunan kepekaan pendengaran pada kedua telinga. Reactive oxygen species (ROS) diduga mempunyai peran penting pada patogenesis  presbikusis. Tujuan: Untuk mengetahui hubungan antara kadar ROS dalam plasma dengan nilai ambang dengar pada penderita presbikusis. Metode: Penelitian ini adalah cross sectional, dilakukan di Unit Rawat Jalan (URJ) THT-KL Divisi Neurotologi, URJ Geriatri, Instalasi Patologi Klinik, dan Instalasi Pusat Biomaterial Bank Jaringan RSUD Dr. Soetomo. Sampel diambil secara consecutive sampling. Diperoleh 50 sampel untuk dilakukan pemeriksaan audiometri dan pengukuran kadar ROS dalam plasma. Hasil: Kadar ROS dalam plasma didapatkan hasil rerata (SD) 2,46 ng/ml (0,84). Nilai ambang dengar didapatkan hasil rerata (SD) 47,70 dB (12,42). Hasil uji statistik dengan korelasi Pearson terhadap kadar ROS dalam plasma dan nilai ambang dengar didapatkan hasil koefisien korelasi (r) sebesar 0,41 dan p=0,003 (p<0,05). Kesimpulan: Terdapat hubungan antara kadar ROS dalam plasma dengan nilai ambang dengar pada penderita presbikusis dengan pola hubungan bersifat positif-sedang yang signifikan, yang berarti semakin tinggi kadar ROS dalam plasma, semakin tinggi nilai ambang dengar.
Tatalaksana karsinoma sel skuamosa kanalis akustikus eksternus Ratna Dwi Restuti; Iman Pradana Maryadi; Rangga Rayendra Saleh
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1107.78 KB) | DOI: 10.32637/orli.v49i1.289

Abstract

Latar belakang: Keganasan pada kanalis akustikus eksternus (KAE) merupakan kasus yang jarang terjadi, kurang dari 0,2 % dari seluruh keganasan pada regio kepala dan leher. Secara histologis, karsinoma sel skuamosa merupakan jenis karsinoma terbanyak, terjadi pada 80% kasus. Karsinoma sel skuamosa KAE masih menjadi tantangan bagi praktisi medis dalam mendiagnosis dan menatalaksana. Tujuan: Hingga saat ini, belum ada algoritma yang spesifik dalam menatalaksana kasus ini, sehingga membutuhkan pengetahuan yang mendalam mengenai anatomi dan teknik pembedahan, serta ditunjang dengan adanya tim multidisiplin dalam menangani kasus keganasan KAE. Laporan kasus: Tulisan ini melaporkan 4 kasus pasien karsinoma sel skuamosa KAE yang menjalani bermacam modalitas tatalaksana dengan keluaran yang bervariasi. Metode: Telaah literatur berbasis bukti mengenai tatalaksana karsinoma sel skuamosa KAE melalui database Cochrane dan Pubmed Medline. Berdasarkan kriteria inklusi dan ekslusi didapatkan satu jurnal yang relevan dengan kasus yang dilaporkan. Hasil: Karsinoma sel skuamosa liang telinga terutama ditatalaksana dengan terapi pembedahan. Modalitas tambahan yang dapat diberikan adalah kemoterapi dan radioterapi. Terapi pembedahan seringkali meninggalkan defek yang besar sehingga memerlukan tindakan rekonstruksi. Kesimpulan: Tatalaksana karsinoma sel skuamosa KAE seringkali membutuhkan pendekatan multidisiplin dan kompleks terutama pada kasus stadium lanjut. Angka harapan hidup yang lebih baik akan dicapai dengan mendiagnosis dan menatalaksana kasus ini secara dini. Background: Cancer of the external auditory canal (EAC) is a rare tumor, representing less than 0.2% of all head and neck cancers. Histologically, squamous cell carcinoma comprises more than 80% of cases. Squamous cell carcinoma (SCC) of the EAC is still a therapeutic challenge for medical specialists in its diagnosis and management. Purpose: Up to date, there is no specific treatment guidelines available due to SCC low incidence. The attending physician must have asubstantial knowledge of literatures as well as anatomy and surgical techniques, supported by an appropriate cancer center with adequate multidisciplinary team to offer the best therapy in accordance with the needs of the cancer clinical stages. Cases: This paper reports 4 cases of squamous cell carcinoma of the EAC which underwent various treatment modalities, and yielded also various outcomes. Method: Evidence based literature study about squamous cell carcinoma of EAC was performed through Cochrane and Pubmed Medline database. Based on inclusion and exclusion criteria, one study was found relevant to these cases. Results: The particular choice of SCC management of EAC is surgery, yet SCC of the EAC requires additional modalities such as chemotherapy and radiotherapy. Surgery often leaves a large defect which requires a reconstructive procedure. Conclusion: Cancer of EAC management requires a multidisciplinary approach, especially it is more complex in the advanced stage of SCC. An early stage diagnosis and prompt management will lead to a better survival rate. 
ABR profile in children with congenital rubella syndrome at Hasan Sadikin General Hospital Wijana Wijana; Alfira Ulfa
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (380.427 KB) | DOI: 10.32637/orli.v49i1.292

Abstract

Background: Congenital Rubella Syndrome (CRS) refer to a condition of variable birth defects, such as hearing impairment, congenital heart defects, cataract or congenital glaucoma, and others. In Indonesia, the incidence rate of rubella infection in 2015 was 3.2 per 100.000 live birth and increasing to 5.6 per 100.000 live birth in 2017. Rubella vaccination can decrease the incidence of CRS, however it has not been implemented in many developing country. Hearing impairment is the most common clinical manifestation among CRS cases. Purpose: This study was performed to know the hearing profile on CRS from January until December 2018, at Hasan Sadikin Hospital. Methods: A retrospective descriptive study design was conducted. Data was obtained from medical records and Auditory Brainstem Response (ABR) results, between January until December 2018, at Dr. Hasan Sadikin General Hospital, Bandung. Results: There were 60 CRS patients, 53 of them (88%) had hearing loss. Profound Sensorineural Hearing Loss (SNHL) in 27 patients (45%), severe SNHL in 18 patients (30%), 3 of them were unilateral, moderate unilateral SNHL in 3 patients (5%), mild SNHL in 5 patients (8%) consisted of 2 unilateral SNHL and 3 bilateral SNHL. Normal hearing in 7 patients (12%). Conclusion: Eighty eight percent of CRS patients had hearing loss, 75% with bilateral SNHL. Follow-up and management for these patients required multidisciplinary approach such as paediatrics, ophthalmologic, physical medicine and rehabilitation, and parental support. Latar belakang: Sindrom Rubella Kongenital (SRK) mengacu pada berbagai kondisi cacat lahir, seperti gangguan pendengaran, cacat jantung kongenital, katarak atau glaukoma kongenital, dan lain-lain. Di Indonesia, tingkat kejadian infeksi rubella pada tahun 2015 adalah 3,2 per 100,000 kelahiran hidup dan meningkat menjadi 5,6 per 100,000 kelahiran hidup pada tahun 2017. Vaksinasi rubella dapat mengurangi kejadian SRK, namun belum diterapkan di banyak negara berkembang. Gangguan pendengaran adalah manifestasi klinis paling umum di antara kasus SRK. Tujuan: Penelitian ini dilakukan untuk mengetahui profil pendengaran pada SRK, dari Januari sampai dengan Desember 2018, di Rumah Sakit Hasan Sadikin. Metode: Penelitian ini adalah deskriptif retrospektif. Data diperoleh dari rekam medis dan hasil Auditory Brainstem Response (ABR) antara Januari hingga Desember 2018 di Rumah Sakit Umum Dr. Hasan Sadikin, Bandung. Hasil: Didapatkan 60 pasien SRK, 53 pasien (88%) mengalami gangguan pendengaran. Gangguan pendengaran sensorineural (GPSN) sangat berat terdapat pada 27 pasien (45%), GPSN berat pada 18 pasien (30%), 3 di antaranya adalah GPSN unilateral. GPSN unilateral sedang pada 3 pasien (5%), GPSN ringan pada 5 pasien (8%) terdiri dari 2 gangguan pendengaran unilateral dan 3 GPSN bilateral. Pendengaran normal pada 7 pasien (12%). Kesimpulan: Delapan puluh delapan persen pasien SRK mengalami gangguan pendengaran, 75% dengan GPSN bilateral. Tindak lanjut dan penatalaksanaan untuk pasien ini memerlukan pendekatan multidisiplin: spesialis THT, spesialis anak, spesialis mata, spesialis kedokteran fisik dan rehabilitasi, serta dukungan orang tua.
Surgical management of preauricular based on plastic-reconstructive algorithm Dini Widiarni Widodo; Hemastia Manuhara Harba&#039;i
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1054.359 KB) | DOI: 10.32637/orli.v49i1.271

Abstract

Background: Preauricular fistula is a congenital malformation of the six auditory hillocks during the development of auricle, when an imperfect fusion of the first arch tuberculum to other tuberculums occurred and generated a tract. It is characterized by a nodule or a dent located adjacent to the external ear. An infection will create a swollen area in front of ear auricles with pain and suppuration. Fistula extirpation should be carried out after the acute infection subsides. Purpose: To evaluate surgery techniques with the lowest complication and recurrence rate. Case report: Reporting 4 surgical cases of prearicular fistula treated by Plastic-Reconstructive ENT Head and Neck surgery, among 26 cases of preauricular fistula diagnosed between 2015 to 2017 in Cipto Mangunkusumo General Hospital. Methods: Searching literature through Pubmed, Wiley, Proquest and Google Schoolar with keywords of “Preauricular fistula AND surgical treatment”. Further selection through clinical questions. Results: One journal presented a systematic review on the surgical outcome of preauricular sinus excision techniques. Reporting 4 cases treated by plastic-reconstructive surgery based on the systematic review above mentioned. Conclusion: The supra auricular approach could be recommended as a good technique for preauricular fistula, in particular for the infected and/or the recurrent cases. Latar belakang: Fistel preaurikula adalah suatu kelainan malformasi kongenital, dimana tuberkulum arkus brakialis pertama tidak menyatu dengan tuberkulum lainnya, sehingga terbentuk sebuah traktus (saluran). Fistel preaurikula ditandai oleh adanya nodul atau cekungan yang tampak di dekat telinga luar. Bila terjadi infeksi biasanya menyebabkan daerah di depan daun telinga bengkak dan nyeri, serta bernanah. Ekstirpasi fistel sebaiknya dilakukan setelah infeksi akut mereda. Tujuan: Mengevaluasi teknik bedah dengan tingkat komplikasi dan kekambuhan terendah. Laporan kasus: Dilaporkan 4 kasus fistel preaurikula yang ditatalaksana oleh bedah THT-KL plastik-rekonstruksi, dari sejumlah 26 kasus yang datang berobat di RSUPN Cipto Mangunkusumo, antara Januari 2015 dan April 2017. Metode: Penelitian literatur melalui Pubmed, Wiley, Proquest, dan Google Schoolar dengan kata kunci “Preauricular fistula AND surgery treatment”. Seleksi literatur lebih lanjut melalui pertanyaan klinis. Hasil: Didapati 1 jurnal yang menyajikan hasil operasi dari teknik bedah eksisi sinus preaurikular secara systematic review. Dilaporkan 4 kasus yang ditatalaksana dengan bedah plastik-rekonstruksi berdasarkan systematic review tersebut di atas. Kesimpulan: Pendekatan supra aurikula dapat direkomendasikan sebagai teknik bedah yang baik untuk penatalaksanaan fistel preaurikular, khususnya yang terinfeksi dan/atau berulang.
Anthropometric study of nasal index of Bali Aga population Agus Rudi Asthuta; I Putu Yupindra Pradiptha
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.727 KB) | DOI: 10.32637/orli.v49i1.273

Abstract

Background: Anthropometry is the measurement of human and more inclined to focus on the dimensions of the human body. Nasal indexes can be used to help determine personal identity, especially race, ethnic and gender differences. Purpose: The general objective of this study was to find out the results of nasal index anthropometric studies on Bali Aga populations in Tenganan. Methods: In this study, 20 samples (4 male and 16 female) within age group of 17-30 years old of Bali Aga population in Tenganan Village were measured strictly on Frankfort’s plane with the help of a sliding caliper. Results: The results of nasal anthropometry measurements obtained an average width of the nose of 38.790 mm, the average nose length of 45.490 mm and nasal index measurements obtained an average of 85.6416. Conclusion: Nasal index can be used to help determine personal identity, especially race, ethnic and gender differences. The result of nasal index in Bali Aga population in Tenganan Village is the Platyrrhine nose (wide nose). Latar belakang: Antropometri adalah pengukuran manusia dan lebih cenderung terfokus pada dimensi tubuh manusia. Nasal indeks dapat digunakan untuk membantu menentukan identitas personal, terutama perbedaan ras, etnis, dan jenis kelamin. Tujuan: Tujuan umum penelitian ini adalah untuk mengetahui hasil studi antropometri nasal index pada populasi Bali Aga di Tenganan. Metode: Studi ini melibatkan, 20 sampel (4 laki-laki dan 16 perempuan) dari penduduk Bali Aga Desa Tenganan yang diukur pada Frankfort’s plane dengan bantuan jangka sorong. Hasil: Pada hasil pengukuran antropometri hidung didapatkan rata-rata lebar hidung sebesar 38.790, rata-rata panjang hidung sebesar 45.490 serta pengukuran nasal index didapatkan rata-rata 85.6416. Kesimpulan: Nasal indeks dapat digunakan untuk membantu menentukan identitas personal, terutama perbedaan ras, etnis, dan jenis kelamin. Hasil nasal index pada populasi bali aga di Desa Tenganan adalah jenis hidung Platyrrhine (hidung lebar).
Prosedur penatalaksanaan celah bibir inkomplit bilateral dan rinoplasti primer dengan modifikasi mulliken Al Hafiz; Debby Apri Grecwin
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.752 KB) | DOI: 10.32637/orli.v49i1.280

Abstract

Latar belakang: Celah bibir dengan atau tanpa celah lelangit merupakan abnormalitas perkembangan kraniofasial yang paling sering terjadi. Kelainan ini bisa unilateral atau bilateral, dan mungkin disertai dengan anomali kongenital lain. Celah bibir bilateral berpotensi mengubah struktur dan bentuk wajah serta menyebabkan gangguan dalam perkembangan makan, bicara, gigi geligi, dan kosmetik. Celah bibir selalu disertai dengan deformitas hidung, termasuk pada kasus celah bibir inkomplit. Mulliken adalah pionir yang melakukan perbaikan celah bibir bilateral dan rinoplasti primer dalam satu tahap operasi. Tujuan: Mengetahui keberhasilan operasi celah bibir inkomplit bilateral dan rinoplasti primer dengan teknik modifikasi Mulliken. Laporan kasus: Dilaporkan satu kasus celah bibir inkomplit bilateral pada anak laki-laki usia 7 bulan yang ditatalaksana dengan teknik modifikasi Mulliken. Metode: Telaah literatur berbasis bukti mengenai perbaikan celah bibir inkomplit bilateral dan rinoplasti primer dengan teknik modifikasi Mulliken melalui database Cochrane library, Pubmed Medline, dan hand searching. Hasil: Pertumbuhan nasal tip projection, nasal width, columellar length, upper lip height, cutaneous lip height, dan vermilion-mucosal height mendekati nilai normal. Kesimpulan: Prosedur celah bibir inkomplit bilateral disertai rinoplasti primer dengan teknik modifikasi Mulliken memberikan hasil yang baik. Introduction: Cleft lip with or without cleft palate is the most common disorder of craniofacial development. This disorder could be occurred unilaterally or bilaterally, and sometimes were also accompanied by other type of congenital disorders. Bilateral cleft lip potentially could change the face structure and shape, causing interference in eating, speech, dental development, and aesthetics. Cleft lip always occurred with nasal deformity, even in incomplete cleft lip. Mulliken is a pioneer in performing a repair in bilateral cleft lip and primary rhinoplasty altogether at the same time. Purpose: To find out the result of surgery procedure in bilateral incomplete cleft lip and primary rhinoplasty using Mulliken modification technique. Case report: A bilateral incomplete cleft lip case in a 7 months old boy and managed by Mulliken modification technique. Method: Evidence based literature study of bilateral incomplete cleft lip and primary rhinoplasty with Mulliken modification technique through Cochrane library, Pubmed Medline, and hand searching. Result: The growth of nasal tip projection, nasal width, collumellar length, upper lip height, cutaneus lip height, and vermilion mucous height were close to normal size. Conclusion: Procedure of bilateral incomplete cleft lip and primary rhinoplasty repair using Mulliken modification technique delivered a good outcome.
Korelasi ekspresi LMP-1 dengan ekspresi E-chaderin dan MMP-9 pada mekanisme metastasis penderita KNF WHO tipe 3 Adrian Benediktus; Soehartono Soehartono; Hendradi Surjotomo
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.186 KB) | DOI: 10.32637/orli.v49i1.263

Abstract

Latar belakang: Karsinoma nasofaring (KNF) adalah karsinoma sel skuamosa yang berasal dari epitel nasofaring. Salah satu etiologi KNF adalah infeksi Epstein-Barr virus (EBV). Pada biopsi jaringan KNF sering ditemukan genom EBV. Latent membran protein-1 (LMP-1) merupakan antigen dari EBV diekspresikan pada 65% KNF. Efek LMP-1 pada signaling salah satunya adalah memodulasi E-cadherin dan matrix metalloproteinase 9 (MMP-9) yang berperan pada proses metastasis. Metastasis adalah suatu proses yang kompleks dimana sel-sel kanker meninggalkan lokasi primer dan bermigrasi ke jaringan lain dalam tubuh. E-cadherin berfungsi sebagai mediator utama yang berperan terhadap adhesi sel-sel pada jaringan epitel, sedangkan MMP-9 menyebabkan rusaknya integritas dari matriks ekstraseluler yang merupakan barrier, sehingga memungkinkan sel tumor menginvasi jaringan sekitarnya. Tujuan: Untuk mengetahui korelasi ekspresi LMP-1 dengan ekspresi E-cadherin dan MMP-9 pada penderita KNF WHO tipe 3. Metode: Penelitian observasional analitik dengan desain potong lintang yang melibatkan 11 penderita KNF WHO tipe 3. Pemeriksaan ekspresi LMP-1, MMP-9, dan E-cadherin menggunakan metode pewarnaan imunohistokimia, dan hasilnya dihitung dengan menggunakan software ImmunoRatio. Hasil: Analisis statistik ekspresi LMP-1 dan E-cadherin menunjukkan korelasi negatif yang signifikan (p=0,000) dengan koefisien korelasi r= -0,940 (terdapat korelasi yang sangat kuat). Analisis korelasi ekspresi LMP-1 dan MMP-9 menunjukkan korelasi positif yang signifikan (p=0,000) dengan koefisien korelasi r=0,881 (terdapat korelasi yang sangat kuat). Kesimpulan: Semakin tinggi ekspresi LMP-1, maka ekspresi E-cadherin pada jaringan nasofaring penderita KNF WHO tipe 3 semakin menurun. Semakin tinggi ekspresi LMP-1 maka ekspresi MMP-9 pada jaringan nasofaring penderita KNF WHO tipe 3 semakin meningkat. Background: Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma derived from nasopharynx epithel cells. Epstein-Barr virus (EBV) is one of the risk factor of NPC. EBV can often be found in NPC tissue biopsy. Latent membran protein 1 (LMP-1) is an antigen from EBV which is expressed in 65% of NPC. The effect of LMP-1 includes modifying E-cadherin and matrix metalloproteinase 9 (MMP-9) which important in metastasis. Metastasis is a complex series of steps in which cancer cells leave the original tumor site and migrate to other tissues. E-cadherin is a main mediator in adhesion between cells. Decreased of E-cadherin makes tumor cells tend to migrate to other tissues of the body. MMP-9 involved in degradation of collagen IV in basement membranes and extracellular matrix facilitating invasion, metastasis, growth, and angiogenesis. Purpose: To determine the correlation between LMP-1 with E-cadherin and MMP-9 in WHO type 3 nasopharygeal carcinoma. Method: Observational analytic study with cross sectional design involving 11 NPC patients. The expression of LMP-1, E-cadherin, and MMP-9 using immunohistochemistry staining, and the results were calculated with ImmunoRatio software. Result: Statistical analysis showed significant negative correlation between LMP-1 dan E-cadherin (p=0.000) with r= -0.940 (very strong correlation). Statistical analysis showed significant positive correlation between LMP-1 dan MMP-9 (p=0.000) with r= 0.881 (very strong correlation). Conclusion: There was a significant negative correlation between LMP-1 dan E-cadherin in tissue from type 3 NPC patient. There was a significant positive correlation between LMP-1 dan MMP- 9 in tissue from type 3 NPC patient.
Prevalensi biofilm bakteri aerob pada usapan tonsil dengan metode tube pada penderita tonsilitis kronis Ade Asyari; Aci Mayang Sari; Embun Dini; Novialdi Novialdi; Fachzi Fitri; Erly Indrama; Hafni Bachtiar
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.276 KB) | DOI: 10.32637/orli.v49i1.274

Abstract

Latar belakang: Tonsilitis kronis merupakan salah satu bentuk infeksi yang paling banyak terdapat pada anak-anak maupun dewasa. Kegagalan terapi antibiotika dalam mengeradikasi bakteri penyebab tonsilitis kronis ini masih menjadi perdebatan dan dihubungkan dengan keberadaan biofilm pada tonsil. Biofilm memiliki peran dalam infeksi kronis dan rekurensi dari tonsilitis kronis. Tujuan: Mengetahui gambaran biofilm bakteri aerob pada usapan tonsil dengan metode tube pada penderita tonsilitis kronis. Metode: Penelitian ini merupakan penelitian deskriptif yang dilakukan terhadap 96 responden. Setiap sampel dilakukan pemeriksaan swab tonsil dan kultur bakteri aerob kemudian dilanjutkan pemeriksaan biofilm dengan metode tube menggunakan crystal violet (0,1%) dan dibandingkan dengan kontrol. Data dianalisis secara statistik menggunakan komputer serta disajikan dalam bentuk tabel. Hasil: Terdapat 64,7% dari total bakteri pada usapan tonsil mengandung biofilm. Kesimpulan: Lebih dari separuh sampel terdapat biofilm bakteri aerob pada usapan tonsil dengan metode tube pada penderita tonsilitis kronis. Background: Chronic tonsillitis is one of the most common infections in children and adults. Failure of antibiotic therapy in eradicating the bacteria that cause chronic tonsillitis is still being debated and is associated with the presence of biofilm on the tonsils. Biofilms play a role in chronic infections and recurrence of chronic tonsillitis. Purpose: To determine aerobic bacterial biofilm on tonsil swabs with tube method in patients with chronic tonsillitis. Methods: This was a descriptive study conducted on 96 respondents. Each sample underwent tonsillar swab and aerobic bacterial culture, followed by examination of the biofilm with tube method using crystal violet (0.1%) and compared with controls. Data were analyzed statistically using computer program, and presented in a tabular form. Results: There were 64.7% of total bacteria in tonsil swabs containing biofilm. Conclusion: More than half of the whole samples contained aerobic bacterial biofilms on tonsil swabs with tube method in patients with chronic tonsillitis.

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