cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Dini Widiarni Widodo
Contact Email
journalorli@gmail.com
Phone
-
Journal Mail Official
journalorli@gmail.com
Editorial Address
-
Location
Unknown,
Unknown
INDONESIA
Oto Rhino Laryngologica Indonesiana
Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia
ISSN : 02163667     EISSN : 25983970     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.
Arjuna Subject : -
Articles 493 Documents
 16   17   18   19   20 
Hubungan kadar RANTES sekret hidung dengan skor gejala total penderita rinitis alergi Eva Susanti; Dwi Reno Pawarti; Soeprijadi Soeprijadi
Oto Rhino Laryngologica Indonesiana Vol 46, No 2 (2016): Volume 46, No. 2 July - December 2016
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (359.652 KB) | DOI: 10.32637/orli.v46i2.158

Abstract

Latar belakang: Rinitis alergi (RA) adalah penyakit inflamasi mukosa hidung yang diperantarai oleh imunoglobulin E (IgE) akibat pajanan alergen. Salah satu tanda penting proses alergi adalah infiltrasi sel-sel inflamasi, utamanya eosinofil ke jaringan, dan melepaskan berbagai protein dasar yang dapat merusak epitel mukosa hidung. Proses tersebut sangat dipengaruhi oleh peran regulated upon activation normal T cell expressed and secreted (RANTES). Pengukuran beratnya gejala RA dilakukan secara subyektif dengan menghitung skor gejala total (SGT), serta obyektif melalui kadar RANTES sekret hidung. Tujuan: Penelitian ini bertujuan untuk membuktikan hubungan antara kadar RANTES sekret hidung dengan SGT pada penderita RA. Metode: Penelitian dilaksanakan pada bulan Juli-Desember 2015 di Unit Rawat Jalan Telinga Hidung Tenggorok - Bedah Kepala Leher Divisi Alergi Imunologi dan Instalasi Patologi Klinik Rumah Sakit Dr. Soetomo Surabaya. Jenis penelitian ini adalah analitik observasional dengan menggunakan rancang bangun cross sectional. Pengambilan sampel dilakukan secara consecutive sampling dan didapatkan sampel sebanyak 49. Kadar RANTES sekret hidung diukur dengan metode ELISA. Skor gejala total diperoleh dari penjumlahan keseluruhan gejala, baik gejala hidung maupun gejala di luar hidung. Uji korelasi yang digunakan adalah uji Pearson. Hasil: Rerata dan standar deviasi (SD) kadar RANTES pada penelitian ini adalah 17,68 pg/ml (8,24) dan rerata (SD) SGT adalah 11,37 (3,15 pg/ml). Diagram scatter plot menunjukkan bahwa data terdistribusi normal. Hasil tes korelasi Pearson kadar RANTES sekret hidung dan SGT pada penderita RA didapatkan koefisien korelasi (r) sebesar 0,426 dan p=0,002. Kesimpulan: Terdapat hubungan positif dengan korelasi sedang antara kadar RANTES sekret hidung dan SGT pada penderita RA. Kata kunci: Rinitis alergi, RANTES, skor gejala total ABSTRACT Background: Allergic rhinitis (AR) is an inflammatory disease of nasal mucosa which is mediated by Imunoglobulin E (IgE) as a response to an allergic exposure. One important sign of an allergic process is the infiltration of inflammatory cells particullary eosinophils into the mucosal tissue, which release a variety of basic proteins that may damage the nasal mucosal epithelium. The process of migration and infiltration of inflammatory cells was strongly influenced by the role of regulated upon activation normal T cell expressed and secreted (RANTES). Evaluation of AR can be done by calculating total symptoms score (TSS) and RANTES levels in nasal secretion. Purpose: This study aimed to prove the relation between the levels of RANTES nasal secretion and TSS in AR patients. Methods: Research was conducted at Allergy–Immunology Division of Otorhinolaryngology–Head and Neck Surgery (ORL-HNS) Outpatient Department of Dr. Soetomo Hospital, Surabaya in July to December 2015. Samples were taken by consecutive sampling and obtained 49 samples. Levels of RANTES in nasal secretion were measured by ELISA method. Total symptoms scores were obtained by accumulating all the symptoms, either nasal symptoms or non nasal symptoms. This study used correlation of Pearson as the statistical analytic test. Results: Mean (SD) RANTES of this study was 17.68 pg/ml (8.24) and mean (SD) of TSS was 11.37 pg/ml (3.15). Scatter plot diagram showed that data were distributed normally. The results of Pearson test showed that there were significant correlation between the levels of RANTES nasal secretion and TSS in AR patients with correlation coefficient (r)=0.426 and p=0.002. Conclusion: There was a positive relationship with moderate correlation between the levels of RANTES nasal secretion and TSS in allergic rhinitis patients.Keywords: Allergic rhinitis, RANTES, total symptom scores
Penatalaksanaan fraktur simfisis mandibula dengan dua perpendicular mini-plates Mirta Hediyati Reksodiputro; Noval Aldino
Oto Rhino Laryngologica Indonesiana Vol 47, No 2 (2017): Volume 47, No. 2 July - December 2017
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (637.091 KB) | DOI: 10.32637/orli.v47i2.228

Abstract

Latar belakang: Fraktur mandibula merupakan salah satu fraktur daerah wajah yang paling sering terjadi. Penatalaksanaan kasus fraktur mandibula membutuhkan pemahaman secara komperehensif meliputi faktor anatomi, biomekanik, dan oklusi. Ketiga faktor tersebut bertujuan untuk mengembalikan fungsi mandibula yang sangat bergantung pada posisi anatomis fragmen tulang, dengan morbiditas seminimal mungkin. Plate and screw telah digunakan selama beberapa dekade terakhir untuk memfasilitasi stabilitas fragmen tulang di daerah maksilofasial, dan sampai saat ini merupakan teknik yang paling sering digunakan. Tujuan: Memahami prinsip penatalaksanaan kasus fraktur simfisis mandibula menggunakan 2 perpendicular mini-plates. Kasus: Dilaporkan laki-laki, berusia 24 tahun dengan fraktur multipel wajah (fraktur komplit simfisis mandibula, fraktur sagital palatum, dan fraktur rima orbita inferior) akibat kecelakaan lalu lintas. Metode: Pencarian literatur dilakukan melalui Cochrane, Pubmed, ClinicalKey, dan Wiley dalam kurun waktu 5 tahun terakhir. Berdasarkan kriteria inklusi dan eksklusi, didapatkan satu artikel yang telah dilakukan critical appraisal. Hasil: Dari 25 pasien dengan fraktur mandibula, semua pasien dilakukan tindakan open reduction diikuti dengan penggunakan fiksasi 2 mini-plates. Penatalaksanaan yang dilakukan untuk fraktur mandibula pada kasus ini adalah open reduction internal fixation (ORIF) menggunakan 2 perpendicular mini-plates, dan pemasangan intermaxillary fixation (IMF), serta maxillo-mandibular fixation (MMF) untuk menjaga stabilitas tulang, guna mendukung proses osifikasi pada fraktur palatum. Kesimpulan: Penggunaan dua buah plate and screw pada simfisis mandibula, dengan kombinasi MMF dan IMF selama 4 minggu berhasil memberikan hasil oklusi yang baik dengan komplikasi seminimal mungkin. Kata kunci: Fraktur mandibula, ORIF, MMF, IMF, perpendicular mini-plates ABSTRACT Background: Mandible fracture is one of the most common fractures in facial region. Management of mandible fractures a comprehensive knowledge about anatomical, biomechanic and occlusion factors. These factors are essential to normalize the mandible function with minimal morbidity, and it very much depends on its bone fragments anatomical position. Plate and screw have been used for decades to facilitate the stability of bone fragments in maxillofacial region, and nowadays is still frequently used technique. Objective: Understanding the principal management of mandibular symphysis fracture using two perpendicular mini-plates. Case: A 24 year-old male presented with multiple facial fractures due to traffic accident (mandibular symphysis complete fracture, sagital palatum fracture and inferior orbital rim fracture). Method: Literature study was conducted through Cochrane, Pubmed, ClinicalKey, and Wiley within last 5 years. An article has been retrieved based on the critical appraisal that was subjected to exclusion and inclusion criteria. Results: Among 25 patients with mandibular fractures, surgical procedures were performed through open reduction and internal fixation with the use of 2 mini-plates. Open reduction internal fixation (ORIF) using 2 perpendicular mini-plates was performed, followed by installation of intermaxillary fixation (IMF), and maxillo-mandibular fixation (MMF), to maintain bones stability that was needed to support ossification process of sagital palatal fracture. Conclusion: Management of mandibular fracture using two perpendicular mini-plates upon mandibular symphysis, by combining MMF and IMF for 4 weeks, was successful to obtain a good occlusion with a minimal complication. Keywords: Mandible fractures, ORIF, MMF, IMF, 2 perpendicular mini-plates
Aritenoidektomi intralaring pada paralisis abduktor bilateral Sutji Pratiwi Rahardjo
Oto Rhino Laryngologica Indonesiana Vol 40, No 2 (2010): Volume 40, No. 2 July - December 2010
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v40i2.10

Abstract

Background: Bilateral abductor paralysis is a condition caused by recurrent laryngeal nerve injuryso that the abductor muscles innervated by the nerve are paralyzed and narrowing the rima glottis. Thiscondition is very rare, but could be fatal from asphyxia. Clinical features included dyspnoea, inspiratorystridor and hoarseness. The diagnosis is based on anamnesis, physical examinations, indirect anddirect laryngoscopy, neurology, serology examinations, and radiological imaging. Purpose: To showthat bilateral abductor paralysis needs a management which provides good airway passage withoutphonation dysfunction. Case:  A patient complained of dyspnea since three month after undergoingstrumectomy and thyroid ablation in 2006. Flexible endoscopy revealed bilateral abductor paralysis.Case management: The patient underwent tracheostomy with right arytenoidectomy and right posteriorintralaryngeal cordectomy by microlaryngeal surgery approach. Conclusion: Optimal treatment willprovide adequate function of the airway and restore the function of voice.  Key words: bilateral abductor paralysis, recurrens laryngeal nerve, arytenoidectomy. Abstrak : Latar belakang: Paralisis abduktor bilateral adalah keadaan yang ditimbulkan oleh cedera nervuslaringis rekuren, sehingga otot-otot abduktor yang dipersarafinya tidak dapat berkontraksi dan rimaglotis menyempit. Kelainan ini jarang dijumpai, namun dapat menimbulkan akibat yang fatal berupaasfiksia. Gejala yang sering timbul pada paralisis abduktor bilateral adalah keluhan sesak napas disertaidengan stridor inspiratoir dan suara serak. Diagnosis paralisis abduktor bilateral ini dapat ditegakkandengan anamnesis, pemeriksaan fisik, laringoskopi indirek maupun laringoskopi direk, pemeriksaanneurologi, serologi, dan pemeriksaan radiologi. Tujuan: Untuk mempresentasikan penatalaksanaanyang baik pada paralisis abduktor bilateral untuk mendapatkan jalan napas yang baik dan juga tidakterlalu mengganggu fungsi bicara. Kasus: Pasien datang dengan keluhan sesak napas sejak tiga bulansetelah dilakukan operasi strumektomi dan ablasi tiroid pada tahun 2006. Pada pemeriksaan endoskopifleksibel didapatkan hasil paralisis abduktor bilateral. Penatalaksanaan: Dilakukan trakeostomi danaritenoidektomi dekstra dan kordektomi posterior dekstra intralaring dengan pendekatan bedah laringmikroskopik. Kesimpulan: Dengan penatalaksanaan yang baik didapatkan hasil fungsi pernapasanadekuat dan fungsi bicara cukup baik.Kata kunci: paralisis abduktor bilateral, saraf laringeal rekuren, aritenoidektomi.
Gangguan transpor ion pada polip hidung Wardani, Retno Sulistyo; Mangunkusumo, Endang
Oto Rhino Laryngologica Indonesiana Vol 41, No 2 (2011): Volume 41, No. 2 July - December 2011
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (422.28 KB) | DOI: 10.32637/orli.v41i2.43

Abstract

Background: Nasal polyps is an inflammation process effecting in epithelial natrium hiperabsorptionand decreased of chloride ion secretion. Purpose: To find out the role of nasal seroprotein in increasingthe hydraulic effect and improving cellular integrity in balancing the natrium hyperasborption in nasalpolyps patients following protocol treatment of endoscopic simple polypectomy and 6 weeks intranasalglucocorticoid. Method: Twenty-nine patients with naive bilateral nasal polyps were undergone protocoltreatment of endoscopic simple polypectomy followed by 6 weeks intranasal glucocorticoid. There were16 responder subjects and 13 non-responder subjects. Increased expresions of statherin (STATH) and prolactin-induced-protein (PIP) were obtained by microarray examination on the best five responder of paired samples pre and post treatment, and validated by real-time RT-PCR for 22 pairs samples (44nasal polyps tissue). Result: Increasing expression (foldchange) of STATH and PIP based on microarray were 115.33 (FDR 8.81) dan 26.45 (FDR 12.20) and the validation by real-time RT PCR demonstratedthe foldchange expression of 186.59 (95% CI 6.22–1024.97) in STATH expression and 17.64 (95% CI3.37–32.75) in PIP expression. Responder group showed higher transcription activity in gen STATH300.42 (95% CI 1.34–1257.32) compared to non-responder group of 72.76 (CI 95% 21.81–1285.91),while PIP in responder group showed 19.56 (CI 95% 1.75–130.70) and in non-responder group of 15.71(CI 95% 3.84–29.79). Conclusion: Gene expression comparison analysis by microarray, real-time RTPCR from the result of this study showed that STATH and PIP had a function for the improvement innasal polyps treatment protocol. Keywords: epithelial ion transport, nasal polyps, prolactin-induced-protein, statherin Abstrak :  Latar belakang: Polip hidung adalah proses inflamasi yang mengakibatkan terjadinya hiperabsorpsiion natrium dan berkurangnya sekresi ion klorida. Tujuan:  Untuk mengetahui peran nasal seroproteinyang meningkatkan efek hidraulik dan memperbaiki integritas sel untuk mengatasi hiperabsorpsi ionnatrium, akan dilakukan penelitian pada pasien polip hidung sebelum dan sesudah protokol pengobatandengan polipektomi sederhana endoskopik dan glukokortikoid intranasal selama enam minggu. Dua puluh sembilan pasien polip hidung bilateral yang dapat dievaluasi, dikelompokkan berdasarkankriteria klinis menjadi 16 subjek responder dan 13 subjek non-responder. Peningkatan ekspresi statherin(STATH) dan prolactin-induced-protein (PIP) diperoleh melalui pemeriksaan microarray pada 5 sampeldengan respons terapi terbaik. Selanjutnya 22 pasang sampel (44 jaringan) menjalani pemeriksaauntuk mengetahui ekspresi gen STATH dan PIP pada tingkat mRNA dengan pemeriksaan real-time RTPCR. Hasil: Penelitian ini mendapatkan peningkatan ekspresi (foldchange) STATH dan PIPberdasarkanpemeriksaan microarray 115,33 (FDR 8,81) dan 26,45 (FDR 12,20) dan setelah divalidasi ulang denganpemeriksaan real-time RT PCR didapatkan peningkatan ekspresi 186,59 (IK 95% 6,22–1024,97) (IK 95% 3,37–32,75). Kelompok responder menunjukkan aktivitas transkripsi yang lebih tinggi ermakna pada gen STATH sebesar 300,42 (IK 95% 1,34–1257,32) dibandingkan dengan kelomresponder 72,76 (IK 95% 21,81–1285,91) sedangkan PIP kelompok responder 19,56 (IK 95% 1,75–130,70)dan kelompok non-responder 15,71 (IK 95% 3,84–29,79). Kesimpulan: Analisis perbandingan gen berdasarkan pemeriksaan microarray, real-time RT PCR dari hasil penelitian ini menunjukkan bahwaSTATH dan PIP mempunyai peran untuk respons kesembuhan dalam protokol pengobatan polip hidung. Kata kunci: transpor ion epitel, polip nasi, statherin, prolactin-induced-protein
Hubungan derajat obstruksi hidung pada pasien deviasi septum dengan disfungsi tuba Eustachius Yudianto, Sony; Ratnawati, Luh Made; Setiawan, Eka Putra; Sutanegara, Sari Wulan Dwi
Oto Rhino Laryngologica Indonesiana Vol 44, No 1 (2014): Volume 44, No. 1 January - June 2014
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (224.316 KB) | DOI: 10.32637/orli.v44i1.79

Abstract

Latar belakang: Deviasi septum diduga sebagai salah satu predisposisi terjadinya disfungsi tuba Eustachius, terutama di telinga ipsilateral pada sisi hidung yang tersumbat. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara derajat obstruksi hidung pada pasien deviasi septum nasi dengan disfungsi tuba Eustachius. Metode: Diskriptif dan analitik pada penelitian yang kami lakukan di poliklinik THT-KL RSUP Sanglah Denpasar, diikuti 58 orang yang terbagi dalam kelompok disfungsi tuba Eustachius sebanyak 29 responden dan kelompok fungsi tuba Eustachius normal sebesar 29 responden. Hasil: Analisis penelitian didapatkan hubungan yang bermakna yaitu derajat obstruksi hidung kanan pada pasien deviasi septum meningkatkan risiko kejadian 2,85 kali lebih tinggi dengan terjadinya disfungsi tuba Eustachius kanan. Pada sisi kiri juga didapatkan hubungan yang bermakna yaitu derajat obstruksi hidung kiri pada pasien deviasi septum meningkatkan risiko kejadian 2,17 kali lebih tinggi dengan dengan terjadinya disfungsi tuba Eustachius kiri. Pada derajat sumbatan hidung diketahui pada sisi kanan dan pada sisi kiri dengan hasil responden yang mengalami sumbatan hidung derajat berat secara bermakna meningkatkan risiko terjadinya disfungsi tuba Eustachius pada sisi yang sama dengan nilai (p< 0,05). Kesimpulan: Pada penelitian ini didapatkan hubungan yang bermakna antaraderajat obstruksi hidung pada pasien deviasi septum yang meningkatkan risiko terjadinya disfungsi tuba Eustachius pada sisi yang sama.Kata kunci: Disfungsi tuba Eustachius, obstruksi hidung, deviasi septum nasi. ABSTRACTBackground: Septal deviation is suspected as one of the predisposing factor in Eustachian tube dysfunction, especially in the ipsilateral ear on the side of the obstructed nose. Purpose: To find out the relationship between the degree of nasal obstruction in septal deviation patient with Eustachian tube dysfunction. Method: Descriptive analytic studies that we conducted in ENT clinic Sanglah Hospital that divided 58 people into 29 respondents as the Eustachian tube dysfunction group and 29 others as the normal Eustachian tube function group. Result: We found prevalence of right Eustachian tube dysfunction in 21 respondents and the prevalence on the left Eustachian tube dysfunction in 8 respondents, which was on the same side with the obstructed nose in the case group as measured byPNIF. Bivariate analysis found a significant relationship that increased the risk of occurence was 2,85 times higher in septal deviation patients with right obstructed nose with the right Eustachian tube dysfunction. The left side also showed a significant association 2,17 times. Degree of nasal obstruction performed analysis known on the right side and on the left side showed that respondents with severe degrees of nasal obstruction significantly increased the risk of Eustachian tube dysfunction on the ipsilateral side (p<0,05). Conclusion: In this study we have significant association between the degree of nasal obstruction in septal deviation patients which increased the risk of Eustachian tube dysfunction incidence on the ipsilateral side.Keywords: Eustachian tube dysfunction, nasal obstruction, nasal septal deviation.
Perubahan kualitas hidup, eosinofil mukosa hidung, dan interleukin-5 serum pasien rinitis alergi pasca terapi Arinda Putri Pitarini; Nina Irawati; Niken Lestari Poerbonegoro; Dewi Wulandari; Saptawati Badarsono
Oto Rhino Laryngologica Indonesiana Vol 45, No 2 (2015): Volume 45, No. 2 July - December 2015
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.106 KB) | DOI: 10.32637/orli.v45i2.116

Abstract

 Latar belakang: Rinitis alergi adalah suatu penyakit inflamasi pada hidung yang dimediasi oleh imunoglobulin-E, yang terjadi setelah mukosa hidung terpajan alergen. Sel dan mediator inflamasi yang berperan penting adalah eosinofil, histamin, dan sitokin produk Th2. Penyakit ini ditandai dengan gejala rinorea, bersin berulang, hidung tersumbat dan/atau hidung gatal. Selain dari gejala yang mengganggu, rinitis alergi berdampak buruk terhadap kualitas hidup penderita. Tatalaksana komprehensif, meliputi penghindaran alergen, farmakoterapi, imunoterapi dan edukasi, ditujukan untuk menghilangkan gejala dan memperbaiki kualitas hidup pasien. Tujuan: Mengetahui perubahan kualitas hidup, jumlah eosinofil mukosa hidung, dan kadar IL-5 serum pada pasien rinitis alergi setelah mendapat terapi farmaka sesuai panduan. Metode: Penelitian ini merupakan studi pre-eksperimental analitik dengan pengambilan data sebelum dan sesudah pemberian farmakoterapi. Hasil: Sebanyak 31 dari 33 subjek mengalami perubahan kualitas hidup yang bermakna (MID>0,7). Seluruh pasien, 33 subjek memperlihatkan perubahan yang responsif dari jumlah eosinofil mukosa hidung. Sebanyak 30 subjek dinyatakan responsif dan terdapat penurunan kadar IL-5. Tidak ada hubungan yang bermakna antara perubahan kualitas hidup dan kadar IL-5. Kesimpulan: Perubahan kualitas hidup, jumlah eosinofil mukosa hidung, dan kadar IL-5 serum dapat digunakan sebagai penanda objektif keberhasilan terapi rinitis alergi yang dapat dipakai dalam praktik klinis sehari-hari maupun kepentingan riset. Kata kunci: rinitis alergi, kualitas hidup, eosinofil, interleukin-5ABSTRACT Background: Allergic rhinitis defined as an inflammatory disease of the nose mediated by immunoglobulin-E, induced after nasal mucosa exposure to allergen. Important inflammatory cells and mediators are eosinophils, histamine, and Th2-related cytokines. Symptoms include rhinorrhea, repeated sneezing, nasal congestion and/or nasal itching. Aside from its bothersome symptoms, allergic rhinitis decreases patient’s quality of life (QOL). Comprehensive management consist of allergen avoidance, medication, immunotherapy, and education, aimed to diminish symptoms and improve the patient’s quality of life. Purpose: To evaluate changes in quality of life, nasal mucosal eosinophil count, and level of interleukin-5 in allergic rhinitis after medicamentous treatment. Methods: This was an analytic pre-experimental study with data taken before and after medicamentous treatment. Results: Thirty-one of 33 subjects showed significant changes of QOL (MID>0,7). All samples, 33 subjects, experienced responsive changes in nasal mucosal eosinophil count. Thirty subjects were responsive, which showed decrease of IL-5 level. There was no significant relation between changes of QOL and changes of IL-5 level. Conclusion: Changes in quality of life, nasal mucosal eosinophil count, and IL-5 level are objective markers of treatment efficacy in Allergic Rhinitis, which can be used in clinical practices and researches. Keywords: allergic rhinitis, quality of life, eosinophil, interleukin-5, intranasal steroid, antihistamine
Pengaruh cuci hidung dengan NaCl 0,9% terhadap peningkatan rata-rata kadar pH cairan hidung Ferryan Sofyan; Dyan Riza Indah Tami
Oto Rhino Laryngologica Indonesiana Vol 47, No 1 (2017): Volume 47, No. 1 January - June 2017
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.226 KB) | DOI: 10.32637/orli.v47i1.192

Abstract

Latar belakang: Pedagang kaki lima rentan terkena polusi udara. Hidung merupakan salahsatu organ pelindung tubuh terpenting dan menjadi target utama dari polusi udara. Polusi udara dapatmenurunkan kadar pH hidung dan menyebabkan sistem transpor mukosiliar hidung tidak bisa bekerjaoptimal. Terapi cuci hidung telah digunakan sejak berabad-abad lalu, untuk mengobati penyakit sinuskarena mencegah pembentukan krusta pada rongga hidung. Terapi cuci hidung juga dapat membersihkanpartikel-partikel debu dan polusi yang terperangkap di mukus hidung. Tujuan: Melihat pengaruh cucihidung dengan NaCl 0,9% terhadap peningkatan rata-rata kadar pH cairan hidung pada pedagang kakilima yang rentan terkena debu dan polusi udara.Metode: Penelitian ini bersifat pra-eksperimental denganone group pretest-posttest design. Populasi penelitian adalah seluruh pedagang kaki lima yang berjualan dikawasan kampus Universitas Sumatera Utara dan sampel adalah populasi yang memenuhi kriteria inklusidan eksklusi. Data hasil penelitian diolah dengan uji normalitas Kolmogorov-Smirnov dan dilanjutkandengan uji Wilcoxon.Hasil: Berdasarkan uji normalitas data Kolmogorov-Smirnov didapati nilai P pretest0,000 dan P posttest 0,001. Kedua data tersebut tidak terdistribusi normal, kemudian dilanjutkan denganUji Wilcoxon. Didapatlah hasil Wilcoxon dalam peningkatan kadar pH cairan hidung adalah peningkatanyang bermakna (p=0,000; p<0,05) dan memiliki peningkatan rata-rata pH cairan hidung yaitu sebesar0,0824.Kesimpulan: Terdapat peningkatan rata-rata kadar pH cairan hidung setelah dilakukan cucihidung dengan NaCl 0,9% sebanyak dua kali sehari, selama sepuluh hari pada pedagang kaki lima. Parapedagang kaki lima di lingkungan Universitas Sumatera Utara, dianjurkan untuk melakukan cuci hidungsetiap hari untuk menjaga higiene saluran napas.Kata kunci: pH cairan hidung, cuci hidung, polusi udara, pedagang kaki lima ABSTRACTBackground: Street vendors in Medan and other cities in Indonesia are prone to outdoor airpollution that may compromising the nose as well as the entire respiratory system. Outdoor air pollutantmay reduce nasal pH level causing an in-efficient mucociliary transport system. Nasal washing as oneof modality in personal hygiene aims to clean hazardous particles and pollutants trapped in the nasalmucous blanket. Purpose: This study aimed to find-out that average of pH levels of nasal fluid affectedby nasal washing using NaCl 0,9%. Method: The study design was a pre-experimental with one grouppretest-posttest design. Population of the study were all vendors in surrounding Universitas SumateraUtara, and the subjects were having 8 hours a day exposure to outdoor air pollutant without any evidenceof ongoing infectious inflammation. Research data processed by the normality test, Kolmogorov-Smirnovtest, and followed by Wilcoxon test. Result: Based on Kolmogorov-Smirnov test, result obtained P pretest0.000 and P posttest 0.001. Both were not distributed normally, and then followed by Wilcoxon Testwhich found a significant increase of pH level of nasal fluid (P<0.05) with average pH level of 0.0824.Conclusion: An increase in nasal fluid average pH levels was significantly observed after washing thenose using NaCl 0,9% solution twice a day for ten days. Street vendors in Universitas Sumatera Utarasurroundings are suggested to do daily nasal washing as their new life style to maintain personal hygiene.Keywords: Nasal fluid pH, nasal wash, air pollution, vendor
Disfagia fase oral dan faring pada anak sindrom Down Tamin, Susyana; Zulka, Elvie; Maryadi, Iman Pradana; Yunizaf, Rahmanofa
Oto Rhino Laryngologica Indonesiana Vol 48, No 1 (2018): Volume 48, No. 1 January - June 2018
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (429.379 KB) | DOI: 10.32637/orli.v48i1.261

Abstract

Latar Belakang: Sindrom Down merupakan kelainan kromosom autosomal yang terjadi akibat trisomi seluruh atau sebagian dari kromosom 21, yang terjadi kurang lebih 1 dari 700 kelahiran hidup. Berbagai studi mendapatkan bahwa gangguan makan (feeding difficulty) dan disfagia merupakan masalah yang umum terjadi dan terkadang persisten pada anak sindrom Down. Tujuan: Memaparkan karakteristik kelainan disfagia fase oral dan fase faring yang dapat timbul pada anak dengan sindrom Down menggunakan instrument pemeriksaan Fiberoptic Endoscopic Evaluation of Swallowing (FEES). Laporan kasus: Dilaporkan 8 pasien anak dengan sindrom Down yang didapatkan dari rekam medis pasien sejak Oktober 2016 hingga September 2017, yang dilakukan pemeriksaan FEES di Poli Endoskopi Bronkoesofagologi Departemen Telinga Hidung Tenggorok-Bedah Kepala Leher (THT-KL) Rumah Sakit Dr. Cipto Mangunkusumo. Metode: Pencarian literatur secara terstruktur dilakukan dengan menggunakan Pubmed, ClinicalKey, Cochrane, dan Google scholar, sesuai dengan pertanyaan klinis berupa bagaimana karakteristik disfagia pada pasien anak dengan sindrom Down melalui pemeriksaan FEES. Pemilihan artikel dilakukan berdasarkan kriteria inklusi dan eksklusi. Hasil didapatkan 1 artikel yang relevan. Hasil: Artikel yang didapat merupakan suatu studi retrospektif yang melaporkan gambaran deskriptif karakteristik disfagia pada anak dengan sindrom Down. Kesimpulan: Kelainan anatomis pada sindrom Down berperan pada terjadinya gangguan makan dan disfagia. ABSTRACTBackground: Down syndrome is an autosomal chromosomal disorder caused by entire or partial trisomy of chromosome 21, which occurs in approximately 1 out of 700 live births. Several studies had found that feeding difficulty and swallowing disorder (dysphagia) are common and persistent problems in children with Down syndrome. Purpose: to describe characteristics of abnormalities that can occur in children with Down syndrome using the Fiberoptic Endoscopic Evaluation of Swallowing (FEES) examination. Case report: 8 Pediatric patients with Down syndrome, obtained from medical record of FEES examination in Endoscopic Bronchoesophagology Clinic of Otorhinolaryngology-Head and Neck Surgery Department (ENT-HNS) Cipto Mangunkusumo Hospital, from October 2016 up to September 2017. Method: A structured literature search was performed using Pubmed, ClinicalKey, Cochrane, and Google scholar, according to clinical question of how the characteristics of dysphagia in pediatric patients with Down syndrome through FEES examination? The selection of articles is based on inclusion and exclusion criteria which resulted in 1 relevant paper. Results: The article obtained was a retrospective study reporting descriptive characteristics of dysphagia in children with Down syndrome. Conclusion: Anatomical abnormalities in children with Down syndrome play a role in eating disorders and dysphagia. Keywords:
Pemeriksaan Otoacoustic Emission (OAE) untuk menilai keberhasilan terapi metilprednisolon Brastho Bramantyo; Jenny Bashiruddin; Widayat Alviandi; Risdawati Risdawati
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.193 KB) | DOI: 10.32637/orli.v49i1.285

Abstract

Latar belakang: Penatalaksanaan tuli mendadak menggunakan steroid sebagai terapi utama merupakan hasil konsensus terapi tuli mendadak tahun 2010 di Madrid-Spanyol dan Cochrane systematic review tahun 2009, yang saat ini diterapkan di Divisi Neurotologi Departemen Telinga Hidung Tenggorok-Kepala Leher Rumah Sakit Cipto Mangunkusumo. Evaluasi hasil pengobatan dilakukan dengan pemeriksaan audiometri dan Distortion Product Otoacoustic Emission (DPOAE). Pasien yang mengalami kesembuhan akan memperlihatkan peningkatan ambang dengar dan nilai Signal to Noise Ratio (SNR) emisi otoakustik. Tujuan: Mengevaluasi hasil terapi metilprednisolon dosis terbaru pada tuli mendadak dengan pemeriksaan DPOAE dan audiometri nada murni. Metode: Penelitian ini menggunakan desain pre dan post eksperimental. Diberikan terapi metilprednisolon 1 mg/kgBB dengan tapering off 20 mg setiap 5 hari. Dilakukan pemeriksaan DPOAE dan audiometri sebelum dan setelah terapi. Hasil: Total sampel yang diolah adalah 22 subjek. Penelitian ini mendapatkan perubahan yang bermakna nilai audiometri nada murni sebelum dan sesudah terapi pada semua frekuensi. Nilai SNR pada OAE sebelum dan setelah terapi rata-rata mengalami perubahan nilai pass, dengan perubahan nilai SNR pass terbanyak adalah pada frekuensi 8000 Hz (6 subjek). Tingkat perubahan ambang dengar sesudah terapi yang mengalami perbaikan paling banyak pada frekuensi 2000 Hz, 3000 Hz, 6000 Hz dengan masing-masing 16 subjek. Perbaikan emisi terjadi lebih awal dibandingkan perbaikan ambang dengar. Kesimpulan: Pada penelitian ini terdapat perubahan bermakna nilai audiometri, dan nilai DPOAE. Didapatkan hubungan bermakna perubahan SNR pada OAE dengan tingkat perubahan ambang dengar frekuensi 8000 Hz dan 10.000 Hz, setelah pengobatan metilprednisolon sesuai protokol penelitian ini. Background: Methylprednisolone as a drug of choice in sudden deafness was consented in Madrid, Spain 2010 and in Cochrane systematic review in 2009, and already applied in Neurotology Division, ENT Department Cipto Mangunkusumo Hospital. Sudden deafness treatment evaluation conducted by audiometry and Distortion Product Otoacoustic Emission (DPOAE) examinations. Hearing recovery could be assessed from the improvement of hearing threshold and Signal to Noise Ratio (SNR) of otoacoustic emission (OAE). Objective: To evaluate the current dose of methylprednisolone therapy for sudden deafness, by DPOAE and pure tone audiometry. Methods: This was a pre-post experimental study using methylprednisolone 1 mg/kg body weight tapered off 20 mg in every 5 days. DPOAE and audiometry examination were conducted pre and post therapy. Result: Total sample were 22 subjects. Significant improvement was seen in overall frequencies of audiometry examination. Pass result in SNR of OAE showed remarkable improvement in 8000 Hz (6 subjects). The level of pure tone threshold mainly increased in frequencies of 2000 Hz, 3000 Hz, and 6000 Hz, each 16 subjects. Improvement of the emision level occurred earlier than the hearing threshold. Conclusion: This study revealed significant improvement of audiometry threshold and OAE level. Significant correlation was found between SNR of OAE improvement with increased pure tone level in 8000 Hz and 10.000 Hz after methylprednisolone therapy according to the protocol of this study.
Efektivitas terapi komplementer propolis telaah terhadap SGHT dan IL-33 sekret hidung penderita rinitis alergi Ibnu, Yunis Sucipta; Pawarti, Dwi Reno; Wiyadi, Mansyur Siddiq
Oto Rhino Laryngologica Indonesiana Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.809 KB) | DOI: 10.32637/orli.v49i1.286

Abstract

Latar belakang: Rinitis alergi (RA) adalah inflamasi mukosa hidung yang diperantarai oleh IgE. Gejala dapat dinilai dengan Skor Gejala Hidung Total (SGHT). Patofisiologi dan manifestasi klinis RA dipengaruhi oleh berbagai sitokin diantaranya interleukin 33 (IL-33). Efektivitas propolis maupun flavonoid dalam menurunkan SGHT dan kadar IL-33 sekret hidung masih kontroversi. Tujuan: Membuktikan bahwa penambahan propolis pada terapi komplementer RA lebih efektif menurunkan SGHT dan kadar IL-33 sekret hidung. Metode: Penelitian double blind randomized clinical trial (RCT), dilakukan di Unit Rawat Jalan (URJ) Divisi Alergi Imunologi, Departemen Telinga Hidung Tenggorok-Bedah Kepala Leher (THT-KL) RSUD Dr. Soetomo, dan Institute of Tropical Disease, Universitas Airlangga, Surabaya pada bulan September 2018-Januari 2019. Pasien RA yang memenuhi kriteria inklusi diperiksa SGHT dan kadar IL-33 sekret hidung. Terapi diberikan selama 14 hari, evaluasi SGHT dan kadar IL-33 dilakukan hari ke-15. Hasil: Sepuluh sampel mendapat propolis dan terapi standar (kelompok A), sepuluh sampel mendapat terapi standar (kelompok B). Perbandingan SGHT antar kelompok setelah terapi rerata kelompok A=1,6 (SD 1,7), kelompok B=5,2 (SD 1,6). Uji Mann-Whitney satu arah p=0,001 menunjukkan SGHT antar kelompok setelah terapi berbeda signifikan (p<0,005). Rerata kadar IL-33 setelah terapi kelompok A=0,051 (SD 0,005), kelompok B=0,051 (SD 0,013). Uji t nilai p=0,881 menunjukkan kadar IL-33 sekret hidung antar kelompok setelah terapi berbeda tidak signifikan (p>0,005). Kesimpulan: Penambahan propolis sebagai terapi komplementer lebih efektif dalam menurunkan SGHT dibandingkan dengan terapi standar saja, namun tidak efektif dalam menurunkan kadar IL-33 sekret hidung penderita RA. Background: Allergic rhinitis (AR) is a nasal mucosa inflammation mediated by IgE. The symptoms severity is determined by total nasal symptom score (TNSS). The pathophysiology and clinical manifestations of AR are affected by several cytokines, one of which is interleukin 33 (IL-33). Efficacy of propolis or flavonoid in reducing TNSS and IL-33 level in nasal secretion is still a controversy. Purpose: To find out whether propolis addition to standard therapy could be more effective in reducing TNSS and IL-33 level of nasal secretion. Method: Double blind randomized clinical trial (RCT). The study was conducted at Outpatient unit of Department of Allergic and Immunology, Dr. Soetomo General Hospital, Surabaya and Institute of Tropical Disease (ITD) Universitas Airlangga. Allergic rhinitis patients who met inclusion criteria were examined for TNSS and IL-33 nasal secretion level. Therapy was given for 14 days, after which TNSS and IL-33 levels were evaluated on day 15th. Ten samples received propolis and standard therapy (group A), ten samples received standard therapy only (group B). Result: The comparison of TNSS groups after treatment: mean group A=1.6 (SD 1.7), and mean group B=5.2 (SD 1.6). One way Mann-Whitney test showed p=0.001 indicating the TNSS after treatment was significantly different (p<0.005). The comparison of IL-33: mean group A=0.051(SD=0.005) and mean group B=0.051(SD=0.013), t-test p=0.0881 indicating the IL-33 level of nasal secretion after treatment was not significantly different (p>0.005). Conclusion: Propolis as a complementary therapy was more effective reducing TNSS compared to standard therapy only, but it was not effective in reducing IL-33 level of nasal secretion.

Page 18 of 50 | Total Record : 493

 16   17   18   19   20 

Filter by Year

2004 2025


Reset
Filter By Issues
All Issue Vol. 55 No. 2 (2025): VOLUME 55, NO. 2 JULY - DECEMBER 2025 Vol. 55 No. 1 (2025): VOLUME 55, NO. 1 JANUARY - JUNE 2025 Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024 Vol. 54 No. 1 (2024): VOLUME 54, NO. 1 JANUARY - JUNE 2024 Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023 Vol. 53 No. 1 (2023): VOLUME 53, NO. 1 JANUARY - JUNE 2023 Vol. 52 No. 2 (2022): VOLUME 52, NO. 2 JULY - DECEMBER 2022 Vol 52, No 2 (2022): VOLUME 52, NO. 2 JULY - DECEMBER 2022 Vol 52, No 1 (2022): VOLUME 52, NO. 1 JANUARY - JUNE 2022 Vol. 52 No. 1 (2022): VOLUME 52, NO. 1 JANUARY - JUNE 2022 Vol 51, No 2 (2021): VOLUME 51, NO. 2 JULY - DECEMBER 2021 Vol. 51 No. 2 (2021): VOLUME 51, NO. 2 JULY - DECEMBER 2021 Vol 51, No 1 (2021): Volume 51, No. 1 January - June 2021 Vol. 51 No. 1 (2021): Volume 51, No. 1 January - June 2021 Vol. 50 No. 2 (2020): Volume 50, No. 2 July - December 2020 Vol 50, No 2 (2020): Volume 50, No. 2 July - December 2020 Vol 50, No 1 (2020): Volume 50, No. 1 January - June 2020 Vol. 50 No. 1 (2020): Volume 50, No. 1 January - June 2020 Vol. 49 No. 1 (2019): Volume 49, No. 1 January-June 2019 Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019 Vol 49, No 1 (2019): Volume 49, No. 1 January-June 2019 Vol 49 (2019): Volume 49, No. 2 July - December 2019 Vol. 49 (2019): Volume 49, No. 2 July - December 2019 Vol 48, No 2 (2018): Volume 48, No. 2 July - December 2018 Vol 48, No 2 (2018): Volume 48, No. 2 July - December 2018 Vol 48, No 1 (2018): Volume 48, No. 1 January - June 2018 Vol 48, No 1 (2018): Volume 48, No. 1 January - June 2018 Vol 47, No 2 (2017): Volume 47, No. 2 July - December 2017 Vol 47, No 2 (2017): Volume 47, No. 2 July - December 2017 Vol 47, No 1 (2017): Volume 47, No. 1 January - June 2017 Vol 47, No 1 (2017): Volume 47, No. 1 January - June 2017 Vol 46, No 2 (2016): Volume 46, No. 2 July - December 2016 Vol 46, No 2 (2016): Volume 46, No. 2 July - December 2016 Vol 46, No 1 (2016): Volume 46, No. 1 January - June 2016 Vol 46, No 1 (2016): Volume 46, No. 1 January - June 2016 Vol 45, No 2 (2015): Volume 45, No. 2 July - December 2015 Vol 45, No 2 (2015): Volume 45, No. 2 July - December 2015 Vol. 45 No. 2 (2015): Volume 45, No. 2 July - December 2015 Vol 45, No 1 (2015): Volume 45, No. 1 January - June 2015 Vol 45, No 1 (2015): Volume 45, No. 1 January - June 2015 Vol 44, No 2 (2014): Volume 44, No. 2 July - December 2014 Vol 44, No 2 (2014): Volume 44, No. 2 July - December 2014 Vol 44, No 1 (2014): Volume 44, No. 1 January - June 2014 Vol 44, No 1 (2014): Volume 44, No. 1 January - June 2014 Vol 43, No 2 (2013): Volume 43, No. 2 July - December 2013 Vol 43, No 2 (2013): Volume 43, No. 2 July - December 2013 Vol 43, No 1 (2013): Volume 43, No. 1 January - June 2013 Vol 43, No 1 (2013): Volume 43, No. 1 January - June 2013 Vol 42, No 2 (2012): Volume 42, No. 2 July - December 2012 Vol 42, No 2 (2012): Volume 42, No. 2 July - December 2012 Vol 42, No 1 (2012): Volume 42, No. 1 January - June 2012 Vol 42, No 1 (2012): Volume 42, No. 1 January - June 2012 Vol 41, No 2 (2011): Volume 41, No. 2 July - December 2011 Vol 41, No 2 (2011): Volume 41, No. 2 July - December 2011 Vol 41, No 1 (2011): Volume 41, No. 1 January - June 2011 Vol 41, No 1 (2011): Volume 41, No. 1 January - June 2011 Vol 40, No 2 (2010): Volume 40, No. 2 July - December 2010 Vol 40, No 2 (2010): Volume 40, No. 2 July - December 2010 Vol 34 (2004): Volume 34, No. 4 October - December 2004 More Issue