Jurnal Ilmu Kefarmasian Indonesia
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
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<![CDATA[Pengaruh Air Seduhan Biji Rambutan (Nephelium lappaceum L.) terhadap Glukosa Darah dan Histologi Pankreas Mencit yang Diinduksi Aloksan ]]>
<![CDATA[LESTARI RAHAYU]]>;
<![CDATA[LATIF ZAKIR]]>;
<![CDATA[SESILIA ANDRIANI KEBAN]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Rambutan (Nephelium lappaceum L.) is a plant which can be used to treat various diseases, including diabetes mellitus. This research was conducted to investigate the effect of rambutan seed infusion on the mice blood glucose levels and body weight. In this research, 30 mice (Mus musculus) were divided into 6 groups, each group consists of 5 mice. The 6 groups consists of a normal control group (distilled water), negative control group (alloxan tetrahydrate 250 mg/kg bw + distilled water), three experimental groups (induced with alloxan 250 mg/kg bw) were given rambutan seed infusion of 1.56 gram/kg bw, 2.34 gram/kg bw and 3.12 gram/kg bw and a positive control group (alloxan tetrahydrate 250 mg/kg bw + treated with glibenclamide 0.65 mg/kg bw). After given treatment for 16 days, it was observed that high dose of rambutan seed infusion has significant effects in reducing the blood glucose and body weight of mice. Histology of the pancreas were checked and the ammount of live pancreatic beta cells found in high dose of rambutan seed infusion were almost the same as the positive control group. It can be concluded that the effect of high dose of rambutan seed infusion (3.12 gram/kg bw) was not significantly different from glibenclamide (0,65 mg/kg bw).]]>
<![CDATA[Peningkatan Laju Disolusi Trimetoprim dengan Teknik Co-Grinding Menggunakan Polimer Polivinilpirolidon K-30 ]]>
<![CDATA[AUZAL HALIM]]>;
<![CDATA[SYUKRAN HAMDENI]]>;
<![CDATA[ERIZAL ZAINI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Improvement of the dissolution rate of trimethoprim (TMP) as a model for a poorly water-soluble drug by solid state co-grinding technique with hydrophilic polymer polyvinylpyrrolidone K-30 (PVP K-30) using ball milling apparatus have been investigated. The ratios of drug to hydrophilic polymer were 1:1, 1:3 and 1:5. The solid state interaction of co-ground and physical mixture were characterized by powder X-ray diffraction, thermal DTA, SEM and FT-IR spectroscopy analysis. The dissolution studies were carried out in USP type I apparatus. The result of powder X-ray diffraction analysis showed that the co-grinding of TMP with PVP K-30 decreased the drug’s crystalinity. The endothermic peak of TMP of co-ground products shifted to lower temperature and peak intensity decreased significantly. Powder X-ray diffraction and DTA analysis indicated transformation of crystalline state of TMP to amorphous form by co-grinding with PVP K-30. FT-IR Spectra indicated that no chemical interaction between TMP and PVP K-30 in the co-grounds. Significant enhancement in dissolution rates were observed with the co-ground products of TMP and PVP K-30 as compared to the intact TMP and its physical mixture. In general, the dissolution rates of TMP in the co-grounds were enhanced as the polymer ratio increased.]]>
<![CDATA[Iradiasi Sediaan Obat Herbal Temu Putih Curcuma zedoaria (Berg) Rosc.: Cemaran Mikroba, Sitotoksisitas dan Profil Kromatogram ]]>
<![CDATA[ERMIN KATRIN W.]]>;
<![CDATA[EPSI NARULITA]]>;
<![CDATA[ZUHELMI AZIZ]]>;
<![CDATA[HENDIG WINARNO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Gamma irradiation has been used for preservation of herbal medicines, one of which is temu putih Curcuma zedoaria (Berg) Rosc. to cure cervical cancer. This research aimed to study the gamma irradiation effects on microbial contamination, cytotoxic activity against leukemia L1210 cell lines and chromatogram profile of the temu putih active fraction. Gamma irradiation was performed with a 60Co source at 5, 7.5, 10 and 15 kGy. After irradiation at > 7.5 kGy bacteria and mould were not present on herbs. Control and irradiated samples were consecutively macerated with n-hexane, ethyl acetate and ethanol. Ethyl acetate extract was the most cytotoxic gainst L1210 leukemia cells with an IC50 value of 10.60 μg/mL as compared to n-hexane or ethanol extract. Ethyl acetate extract was fractionated with column chromatography producing six fractions. Fraction 2 was the most cytotoxic against L1210 leukemia cells with an IC50 value of 2.44 μg/mL. The thin-layer chromatographic analysis results of ethyl acetate extract and fraction 2 of control and irradiated samples showed the presence of curcumin and chromatographic pattern similar to the control. Curcumin contents in fraction 2 were between 35 to 51%, which were not significantly changed between samples, although was irradiated up to 15 kGy. The maximum dose for irradiation of temu putih herbal preparation is 15kGy.]]>
<![CDATA[Evaluasi Aktivitas Diuretik Ekstrak Etanol Buah Belimbing Wuluh (Averrhoa bilimbi) Sebagai Diuretik Alami: Kadar Natrium, Kalium, dan pH Urin ]]>
<![CDATA[ANDRIYANTO ANDRIYANTO]]>;
<![CDATA[PONIMAN PONIMAN]]>;
<![CDATA[ABADI SUTISNA]]>;
<![CDATA[WASMEN MANALU]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Previous study reported that Averrhoa bilimbi fruits had a potency as a natural diuretic. This research was conducted to examine the effects of ethanolic extract of Averrhoa bilimbi fruits on diuretic activity, urine sodium and potassium concentrations, and pH of urine male rats Sparague-Dawley. Fifteen rats were divided into 5 groups and 3 replications. Group 1 was given saline (negative control), group 2 was given furosemide 20 mg/kg bw (positive control), group 3 was given extract of Averrhoa bilimbi 0.44 g/kg bw, group 4 was given extract of Averrhoa bilimbi 0.88 g/kg bw, group 5 was given extract of Averhoa bilimbi 1.75 g/kg bw. Averrhoa bilimbi extract, saline, and furosemide were administred orally. The diuretic activity was determined by measuring cumulative urine volume for 10 hours post administration. The result showed that the extract of Averrhoa bilimbi at dosages of 0.88 and 1.75 g/kg bw increased sodium and potassium excretion by 18-36% and 22-27%, respectively. On the other hand, the increased diuretic activity and sodium and potassium excretion dramatically decreased urine pH. It was concluded that extract of Averrhoa bilimbi at dosages of 0.88 and 1.75 g/kg bw increased diuretic activity with enchanced sodium and potassium excretion in urine. The extract of Averrhoa bilimbi cosisted of alkaloid, flavonoid, and saporin that were assumed to have synergic activities as natural diuretics.]]>
<![CDATA[Uji Penyembuhan Luka dan Potensi Iritasi Ekstrak Etanol Daun Binahong (Anredera cordifolia (Ten) Steenis) ]]>
<![CDATA[SRI HARTATI YULIANI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Binahong (Anredera cordi olia (Ten) Steenis) has been used as wound healing in traditional Indonesian medicine. The aim of this study was to examine the wound healing activity and irritation potency of ethanolic extract of Anredera cordifolia (Ten) Steenis. Dry Binahong leaves were ground and screened with mesh no 40. Dry Binahong leaves were macerated with 10 times of volume of 96% ethanol for 90 minutes with constant agitation (200 rpm). It was screened and concentrated until the liquid would be a quarter. Then the extract was incorporated to gel base as 2,5%; 5%; 10% and 20%. Incision wound method was employed to activity test of wound healing. Male mice (strain Swiss), weight between 25 ~ 30 g, was used to this test. The male mice were classified into 7 groups i.e. negative control, control vehicle, positive control and 4 groups of sample. The extract then was assessed to irritation potency using HET-CAM method. Lactic acid was used as the positive control for irritation assessment. The result of this study stated that the highest activity of wound healing was shown by the sample containing 5% of ethanolic extract. The percentage activity of wound healing was 63,3%. Irritation appeared on the 10% and 20% ethanolic extract of binahong leaves.]]>
<![CDATA[Formulasi Nanopartikel Losartan dengan Pembawa Kitosan ]]>
<![CDATA[AKHMAD KHARIS NUGROHO]]>;
<![CDATA[NURI ARI EFIANA]]>;
<![CDATA[RONNY MARTIEN]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Nanoparticle formulation is important for systemic drug delivery via several routes. This research was aimed to establish optimal formation of chitosan nanoparticle formulation with losartan, an antihypertension known as an angiotensin II receptor antagonist. Ionic gelation method was used. Formulation was established in 2 steps. Firstly, determination of the best losartan and chitosan concentrations which can produce physically stable nanoparticles without precipitation, at room temperature within 25 days. Secondly, optimization of the process by factorial design method of two factors, including pH (4.0 and 5.0) and the stirring rate (350 and 700 rpm), with the loading capacity of the nanoparticle as the observed response. The obtained nanoparticles were evaluated further for its particle size and zeta potential. The physichal stability tests indicated that two nanoparticle formulations containing losartan-chitosan of (14 mg% : 35 mg%), and losartan-chitosan of (21 mg% : 35 mg%) were stable. The factorial design studies suggested that pH 4 and the stirring rate of 350 rpm were the optimal conditions which produced the highest loading capacity (47,7%). The particle size and zeta potential of the stable nanoparticle were 290.3±52.6 nm and +50.8 ±4.8 mV respectively.]]>
<![CDATA[Potensi Ekstrak Etanol Daun Sirih Merah (Piper crocatum) Sebagai Antimikrobakterium ]]>
<![CDATA[FARIDA JULIANTINA RACHMAWATY]]>;
<![CDATA[BARMAWI HISYAM]]>;
<![CDATA[MARSETYAWAN HNE SOESATYO]]>;
<![CDATA[TRI WIBAWA]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[: The incidence of tuberculosis in Indonesia is high. There is a tendency for some people to use herbs for the treatment of tuberculosis. This research aims to investigate the potency of antimycobacterium property of red betel Vine (Piper crocatum) ethanolic extract against Mycobacterium tuberculosis (M. tuberculosis). The red betel vine leaf was extracted using standard ethanol solvent. The extract was tested on Mycobacterium tuberculosis H3 7Rv. The experiment was conducted by using serial dilution method with 50%, 40%, 25%, 20%, 12.5%, 10%, and 6.25% red betel vine ethanolic extract in Middlebrook 7H9 medium and subseqently inoculated into Lowenstein Jensen (LJ) medium. The result was analyzed descriptively by observing the minimum bactericidal concentration (MBC). The experiment was repeated three times to obtain consistent result. There is no bacterial growth in LJ media at concentrations of 50%, 40%, 25%, 20%, 12.5%, and 10% of red betel vine ethanolic extract. The bacteria was able to grow only at the concentration of 6.25% red betel vine ethanolic extract. Thus the ethanolic extract of red betel vine (Piper crocatum) indicates an antimycobaterium activity against M. tuberculosis H37Rv. The MBC is found at the concentration of 10%.]]>
<![CDATA[Rasio Efektivitas Biaya Obat Antimalaria Kombinasi Artesunat Amodiakuin dan Kombinasi Sulfadoksin Pirimethamin Dalam Terapi Malaria Falsiparum di Sumba ]]>
<![CDATA[DELINA HASAN]]>;
<![CDATA[ASCOBAT GANI]]>;
<![CDATA[PURWANTYASTUTI PURWANTYASTUTI]]>;
<![CDATA[INGE SUTANTO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Malaria cases continue to increase in Indonesia, and one of the causes is many malaria parasites resistant to antimalarial drugs such as chloroquine and sulfadoxine pyrimethamine. Antimalarial drug combination recommended by the WHO yet widely available. This study aimed to explore alternative antimalarial drugs through examination of drug-effectiveness and cost-effectiveness analysis of antimalarial drug combination artesunate amodiaquine and sulfadoxine pyrimethamine. To assess the effectix eness or antimalarial drug combinations, as many asl64 patients with who meet inclusion and exclusion criteria were divided into 2 groups with 82 patients respectively. First group was given artesunate amodiaquine while the second group was given sulfadoxine pyrimethamine, and observed for 14 to 28 days. Responses to treatment according to the WHO protocol to include clinical response and parasitological response. The cost effectiveness was assessed through the pharmacoeconomic evaluation method. The results showed that fever clearence time and parasites clearence time by the artesunate amodiaquine combination was faster than by sulfadoxine pyrimethamine combination, and the cost effectiveness ratio of artesunate amodiaquine combination was lower than of sulfadoxine pyrimethamine. In conclusion, the antimalarial drug artesunate amodiaquine combination was more effective and more eflicient than the sulfadoxin pyrimethamine combination, and its cost effectiveness ratio was lower than the sulfadoxine pyrimethamine combination (p=0.05).]]>
<![CDATA[Aktivitas Biji Klabet (Trigonella foenum-graecum L.) terhadap Pertumbuhan dan Apoptosis Sel Kanker Payudara MCF-7 ]]>
<![CDATA[KURNIA AGUSTINI]]>;
<![CDATA[FRANS SUYATNA]]>;
<![CDATA[NURJATI CHAIRANI SIREGAR]]>;
<![CDATA[WAHONO SUMARYONO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Fenugreek seed (Trigonella foenum-graecum L.) is one of Indonesian medicinal plant with many known activities such as antidiabetic, antihypercholesterolemia, phytoestrogen and anticancer. Fenugreek seed contains steroidal sapogenines (i.e. diosgenin, yamogenin, gitogenin, tigogenin and trigoneoside), alkaloid trigonellin and flavonoid (i.e vitexin, orientin). This experiment was carried out to investigate the cytotoxic activity and its potency to induce apoptotic on breast cancer cell line, MCF-7. Cytotoxic activity was carried out by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium) method. Fenugreek seed was prepared by extraction (methanolic and ethanolic extract) and fractionation using solvents with different polarity (hexane, ethylacetic, buthanolic and water fractions). The potency of apoptotic induction assay was carried out using flowcytometric method staining with propidium iodide (20μg/mL) on 100 ppm sample. Apoptotic potency was evaluated based on % population of cells in subG0/G1 phase. Results showed that ethylacetic fraction has the lowest IC50 (41.81 ppm) and significantly (p<0.05) increase % population of cells in subG0/G1 phase (20.87%) on 100 ppm concentration. It is concluded that fenugreek seed posses cytotoxic activity and potency of apoptotic induction on MCF-7 cells.]]>
<![CDATA[Evaluasi Hasil Edukasi Farmasis Pada Pasien Diabetes Melitus Tipe 2 Di Rumah Sakit Dr. Sardjito Yogyakarta ]]>
<![CDATA[SESILIA ANDRIANI KEBAN]]>;
<![CDATA[LUTFAN BUDI PURNOMO]]>;
<![CDATA[MUSTOFA MUSTOFA]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Diabetes mellitus (DM) is a metabolic disorder caused by a defect in insulin secretion or insulin action. Number of diabetic patients will increase if strategies are not prepared for preventing and controlling diabetes. This study aimed to evaluate the outcome of pharmacist education on the level of knowledge, level of medication adherence and diet, as well as the A1C value of type 2 diabetic patients in Dr. Sardjito Hospital Yogyakarta. This research was conducted prospectively using Nonrandomized Concurrent Control Trial. The number of subjects recruited were based on a three-months period and subjects were taken by consecutive sampling method. There were two groups: one group received education intervention for 3 months, and the other group as control did not receive education. Data were analyzed descriptively and quantitatively using Independent T and T-Paired test. The results showed that patients in the control group have developed an increase in the level of knowledge and adherence by themself, on the other hand patients in this group showed a decrease in A1C values, but the decrease was not as big as patients in the intervention group. Patient’s adherence to diet did not improve in either control nor intervention group. It can be concluded that education given by pharmacist can increase knowledge and adherence towards medication and decrease the A1C values of DM type-2 patients.]]>
