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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 9 Documents
 1 
Search results for , issue "Vol 3 No 2 (2005): JIFI" : 9 Documents clear
Produksi Senyawa Kuinina dengan Fermentasi Mikroba Endofit Tanaman Cinchona pubescens Vahl. Esti Mumpuni; Herman Suryadi; Partomuan Simanjuntak
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This study deals with endophytic microbes, known as a potential source of secondary metabolites. The microbes (F) were isolated from Cinchona pubescens Vahl and fermented in Phoma media, observing the pH, biomass growth and secondary metabolites of alkaloids for 14 days. The result obtained showed that the pH was between 4 and 5, the biomass growth relative stable after 8 days and the production of alkaloids reached its maximum also after 8 days (32.81 mg/l).
Aplikasi Metode Aktivasi Netron untuk Penetapan Mineral Selenium dalam Produk Suplemen Kesehatan Titiek Martati; June Mellawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Recently, there are some health supplement products that are useful as an antioxidant in the market, and one of them is Selenium (Se) tablet. Therefore issue of falsification of drug due to the control of health supplement product become very important. In this research the determination of Se in health supplement tablet using neutron activation analysis has been carried out. Sample was irradiated using thermal neutron with 1013 neutron cm-?secondfluxes within 15 minutes, and based on n, y reaction 75Se isotope would be formed that could identified using Gamma spectrometer on 136, 264, and 279 keV energies. The result showed that neutron activation analysis method can analysis Se mineral that contained in health supplement tablet with accuracy ranged between 101.81 – 102.29 % and precision 99.02 -99.37%. The recovery test of Se mineral concentration to the labeled attached showed 105.79 - 116.66%, and this value was still in the recommended range according to the USP 28 (90 – 125%).
Fermentasi Diam dan Goyang Isolat Kapang Endofit dari Brucea javanica L. Merr. dan Uji Aktivitas Antimikroba Shirly Kumala; Wibowo Mangunwardoyo; Peny Budiarti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Exploring an antibiotic from microorganism is potential to discover the new antibiotic. The endophytic microorganism is one of the minimanufacturer producing the secondary metabolite such as antibiotic. Screening on the endophytic molds isolated from Brucea javanica L. Merr has been carried out. Fermentation in still and shake culture were used to produce the antibiotic using PDY medium. Antimicrobial activity was assayed using diffusion agar method. The results revealed that shake culture gave a better antimicrobial activity than still culture. Amount of eight isolate studied showed microbial activity against Gram positive bacteria: Staphylococcus aureus and Bacillus subtilis also Gram Negative bacteria: Escherichia coli and Salmonella typhi, however no microbial activity recorded againts Candida albicans. Isolate number 1.2 gave the highest antimicrobial activity on still culture and isolate number 1.7 gave the highest antimicrobial activity on shake culture. Further research should be carried out on identification and purification of the antimicrobial agent.
Kemotaksonomi dan Farmakologi Tumbuhan Keluarga Guttiferae Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The Guttiferae family has many species with interesting phytochemical properties. Is has been widely used in the traditional medicine and contains xanthones as constituent, exhibiting biological and pharmacological activities for example, e. g. as antimalaria, antimicrobe, antioxidant, anticancer and HIV-1 protease inhibitor.
Identifikasi Golongan Senyawa Flavonoid dalam Fraksi n-butanol dari Ekstrak Metanol Buah Muda Phaleria macrocarpa Ratna Djamil; Tri Astuti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Unripe fruits of Mahkota Dewa (Phaleria macrocarpa [Scheff.](Boerl) containing alkaloid, flavonoid, saponin, terpenoid, volatile oil and tannin, were extracted with methanol and partitioned by the Charaux-Paris method, with. n-butanol Identification by UV-Visible spectrophotometry showed that the flavonoid from that isolate NB-1 was chalcone with OH on 3, 4, 4' position and o-diOH on ring B, and isolate NB-II was also a chalcone with OH on 4, 2', 4' position, oxygenation on 3' and o- diOH one ring B, while isolate NB-III was a flavonol with OH on 3,5,4' position with prenil on 6, and o-diOH on ring A (6,7 or 7,8).
Penghambatan Ekspresi Gen dengan Antisense Oligonukleotida sebagai Upaya Pengobatan Penyakit Dian Ratih Laksmitawati; Ani Retno Prijanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Due to the development of biomolecular science eg. overexpression genes, genes that cause diseases can be identfied, Based on this fact, researchers developed a therapeutic strategy by inhibiting the gene expression using oligonucleotide antisense. Therapy using oligonucleotide antisense was based on a natural process of gene expression. Specific artificial antisense will match complementary with DNA and mRNA. By this process the transcription will stop. The effort of therapy is relatively new but a few have been carried out in the clinical trial phase. Obstacles are encountered in reaching the target cell by the oligonucleotide antisense.
Penapisan Fitokimia dan Uji Hayati secara BSLT dari Daun, Buah dan Biji Phaleria macrocarpa Suci Eka Lestari; Ratna Djamil
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Mahkota Dewa (Phaleria macrocarpa [Scheff] Boerl), is Indonesian herb that famous for its medicinal activity. The chemical constituens of the leaves, fruits and seeds have been examined, and BSLT (brine shrimp lethality test) have been carried out. On phytochemical screening, the leaves showed the existence of: volatile oil, sterol, triterpene, higher fatty acid, alkaloid, flavon aglycon, coumarine, tannin, steroid glycoside, flavonoid, polyuronide and triterpene, the fruits contain: volatile oil, sterol, triterpene, higher fatty acid, alkaloid, flavon aglycon, coumarine, tannin, reducing compound, steroid glycoside, flavonoside, polyuronide and saponine; while the seeds contain: steroid, triterpene, higher fatty acid, alkaloid, flavon aglycon, coumarine, tannin, reducing compound, steroid glycoside and flavonoid. Brine shrimp lethality test showed that the LCs of the n-hexane fraction of the leaves, fruits and seeds are 2.34 ppm, 32.62 ppm and 4.33 10-28 ppm respectively; the aethyl acetate fraction of the leaves, fruits and seeds are 10.55 ppm, 29,12 ppm and 4.71 ppm respectively; while the methanol fraction of the leaves, fruits and seeds are 1.46.10-5ppm, 39.32 ppm, and 53.31 ppm respectively. From this study it may be concluded that the n-hexane and aethyl acetate fraction of the seeds have the most active compounds, while the leaves have the most active compounds in the ethyl acetate fraction.
Kapasitas Pengikatan Iodida dan Iod pada Karbon Aktif Konvensional dan Terbrominasi Sunarhadijoso Soenarjo; Swasono R. Tamat; Ade Saputra
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Related to the activities in a radioisotope processing laboratory at CDRR, BATAN, active carbon has a great potency and a role as adsorber for radioisotope immobilizing agent in process and installation systems. KAKEN Corporation, a CDRR's collaboration partner in Japan, has introduced a new type of active carbon namely KAKEN Brominated Active Carbon (KBAC) which is claimed to have an anionic exchange character. The presented experiment was thus performed to determine the iodide and iodine binding capacities of the KBAC resin as well as comparing to those of the conventional active carbon, which was also provided by KAKEN (KCAC). The experiment had been done using solutions of natural iodide and iodide - iodine mixtures. The binding capacities were determined by iodometry and iodatometry. In general the results obtained showed that the iodide-binding capacity of KBAC was higher than that of KCAC, but that the iodine-binding capacity of KCAC was higher. The KBAC showed that the binding capacity of iodide from iodide solutions was smaller than that from iodide-iodine samples, while the KCAC showed the reverse.
Pengaruh Iradiasi Sinar Gamma dan Konsentrasi Kitosan terhadap Pembentukan Hidrogel Polivinil Alkohol-Kitosan Zuhelmi Aziz; Gatot Trimulyadi; Trivena Fithriany A
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Chitosan is one of the product from the shrimp disposal. Its medicinal and pharmaceutics application are now developed by pharmaceutical industries, i.e as bioplastics and hydrogel. A research about the effect of gamma radiation and chitosan as a raw material for production of polyvinilalcohol has been carried out. PVA-chitosan hydrogel was made from a mixture of composition of 80% PVA in 10% solution and 20% of chitosan in 0, 1, 2 ,and 3% solution respectively. The mixture was heated in oven at 80°C for two hours and then irradiated with 0, 15, 25, and 35 kGy gamma radiation. The physical characteristic of the gel was determined, e.g. colour, swelling degree and gel fraction. The colour of hydrogel more yellow darker to raising of chitosan concentration and radiation dosage. Swelling degree PVA-chitosan hydrogel increased meanwhile chitosan concentration and radiation dosage decreased. In absolute ethanol medium (96%) PVA-chitosan hydrogel was deswelling. The swelling degree PVAchitosan hydrogel decreased with increased gel fraction.

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