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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 9 Documents
 1 
Search results for , issue "Vol 4 No 1 (2006): JIFI" : 9 Documents clear
Isolasi dan Uji Antimikroba Substansi Bioaktif Mikroba Endofit Ranting Tanaman Johar (Cassia siamea Lamk.) Shirly Kumala; Syarmalina Syarmalina; Atut Ruswita Handayani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Assay for secondary metabolite of endophytic fungi from Cassia siamea Lamk.. (Johar Plant) has been investigated. Endophyitic fungi are microorganisms that live asymtomatically within the living tissue of host plants. Endophytic fungi associate with plant, they can help the metabolism of host plant and produce potensial secondary metabolite. The purpose of this experiment were to investigate endophytic microbial agents. Isolate of endophytic fungi from twig of Cassia siamea Lamk., using direct seed method was carried out. The microbial activity was carried out with dilution method using paper disk and glass cylinder. The results showed 3 isolates of bacteria and 7 isolates of endophtyic fungi. The metabolite from three isolates of bacteria had the anti-microbial activity more poten toward Gram positive than Gram negative and four isolates of fungi had anti-Aspergillus agent.
Kapang Endofitik Tanaman Brucea javanica (L.) Merr yang Berpotensi menghasilkan Enzim Xilanase Wibowo Mangunwardoyo; Shirly Kumala; I. G.A. Ayu Wiratih
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Xylanase enzyme activity of endophytic fungi from Brucea javanica (L.) Merr has been done. Fruit, leave and stem of the plant collected from Bogor, Cianjur, and Tawangmangu which used in this study. To evaluate the enzyme activity the endophytic fungi isolate were inoculated on PDY medium and fermented at room temperature, shake at 150 rpm for 14 days. The supernatan were used to examine the extracellular enzyme and the biomass for intracellular enzyme. The DNS methods was used to test the enzyme activity. The results showed isolate 1.1.8; 1.2.17; 1.3.16 and 1.3.6 produced intra and extracellular xylanase enzyme. Isolate 1.1.6 produced only extracellular enzyme while isolate 1.2.2 did not produce both intra and extracellular enzyme.
Ekstrak Propolis sebagai Imunomodulator Irma L. M.; Syamsudin Syamsudin; I. W.T. Wibawan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

A study was done to evaluate the effect of propolis on phagocytic activity and capacity of cells phagocyts with induction SGB (Streptococcus Grup B). In vivo methods were used on the study. In vivo study treatments were divided in four groups. Each group was inducted by 109 cell/ml of SGB. The group consists of treatment by given propolis at dosage 25 mg/kgBW, 50 mg/kgBW, 100 mg/kgBW, and group control, not given propolis. The result showed activity dosage value of propolis were significantly different (p<0.01) at dosage 50 mg/kgBW and capacity dosage value of propolis were significantly different (p<0.01) at dosage 100 mg/kgBW.
Identifikasi Senyawa Flavonoid dalam Fase n-Butanol dari Ekstrak Metanol Daun Wungu (Graptophyllum pictum (L.) Griff) Zuhelmi Aziz; Wiwi Winarti; Kona Nate
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Wungu leaves is one of the herbal plants in Indonesia that have been used significantly by the society to cure scare, swollen, ulcer, gall stone, abscess, skin diseases, liver, hearing disfunction, hemorrhoids, bloody cough, fever and laxative, isolation and identification of the type of flavonoid substance found in n-butanol phase of Wungu leaves methanol extract have been conducted by employing identification by UV-visible spectrophotometry, the result of the examination showed that isolate NB-IV was presumably considered as flavonol substance with 3-OH (with or without 5-OH), isolate NB-V was presumably considered as antosianidin substance with o-diOH on ring A, isolate NB-VI and isolate NBVII was presumably considered as flavonol substance with OH on position 3,5,7 and o-diOH on ring B.
Teknik Isolasi Protoplasma Kapang Trichoderma ssp. Menggunakan Enzim Lisis Priyo Wahyudi; Zainal Abidin; Retno Lestari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Trichoderma is well known industrial fungi producing many kinds of industrial enzymes and as biological control agent. The applications of modern biotechnology using Trichoderma or its derived metabolites. Considering to the variety of the species of Trichoderma and enzymes or metabolites produced by Trichoderma lead to create a fusan of Trichoderma. The first step toward protoplast fussion is protoplasm isolation. In this experiment has been conducted protoplasm isolation of Trichoderma harzianum, T. viride, T. aureoviride and T. pseudokningii using lysing enzyme in room temperature for 1- 5 hours incubation. The aim of this experiment is to find the best condition and time of incubation in producing protoplast optimally. Trichoderma mycelia (1 mg) sink in osmotic stabilizer solution (pH 5.8), crushed and add 1 ml lysing enzyme 2%, then incubate in shaker incubator (room temperature) for 5 hours. Observation of the protoplast is conducted using haemacytometer for 1 until 5 hours incubation. After 5 hours incubation in room temperature showed the T. harzianum protoplast is the highest number of protoplast (40,150 protoplast/ml), followed by T. pseudokoningii (10,375 protoplas/ ml), T. viride (15,075 protoplast/ml) and T. aureoviride (10,050 protoplas/ml).
Identifikasi, Uji Antioksidan, dan Uji Toksisitas Senyawa Bioaktif dalam Caulerpa sertularioides (Vahl.) C. Agard. Thamrin Wikanta; Swasono R. Tamat; Magdalena Sinta Maryati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Caulerpa sertularioides (Vahl.) C. Agard. is a green seaweed species in the Caulerpaceae family which has been used for medication. Extraction of bioactive compounds from Caulerpa sertularioides have been carried out and screened based on the antioxidative property against DPPH and on toxicity test by the brine shrimp lethality test (BSLT) method. Phytochemical screening of the methanol extract indicated the presence of a triterpen. The methanol extract was partitioned in sequence with n-hexanewater (1:1) and chloroform-water (1:1). The IC50 value of the water extract was found 327 ug/ml and the LCs value was 115 ug/ml as compared to the ICs of vitamin C positive control of 21 ug/ml. Fractination of the water extract in a silica gel column with various ratio of chloroform-methanol did not produce distinct separation. Fractions were analyzed on TLC and fractions of similar components were collected. Fraction I has IC50 value of 326 ug/ml and LC50 value of 68 ug/ml. Further separation and purification of fraction I on a preparative thin layer chromatographic system using chloroform-methanol (50:1) produced five isolates bearing antioxidative activity. The third isolate that showed the strongest activity, when analyzed using a GC-MS system indicating seven compounds, but only [(2-fluorophenyl)methyl)-1H-purin-6-amine that may have an antioxidative activity.
Stres Oksidatif di dalam Model Kerja Obat Antimalaria Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Several antimalarial drugs may act by producing free radicals, anion superoxide through a redox cycling process with oxygen. The mode of action of chloroquine, primaquine, artemisinin, anthraquinone and xanthones as antimalarial drug is partly increasing the oxidative stress in the parasitized red blood cell.
Pengaruh Pembentukan Dispersi Padat Meloksikam - PVP K-25 terhadap Penetrasi Perkutan dari Sediaan Gel Sukmadjaya Asyarie; Sasanti Tarini D; Deni Rahmat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Most drugs are weak acids or bases and have a low water solubility. Ionized molecules are generally in small amounts absorbed by biological membranes. One possibility of drug modification for transport through biological membranes is by solid disperse system which enhances drug solubility. The solubility of drugs in such a system increases due to particle size reduction and transformation of its crystalline form. In this study, the dispersion system was used to increase the solubility of meloxicam which can influence the percutaneous permeation. Solid dispersion was prepared by modified solvent method using various ratios of PVP K-25 and was also able to lower the meloxicam melting point. Solid dispersion of meloxicam-PVP-K-25 (1:5) was characterized by infrared absorption spectroscopy, differential scanning calorimetry, X-ray diffraction analysis, and thin layer chromatography. Percutaneous penetration was studied by using a flow-through diffusion cell system, and besides that showed a lower diffusion rate of solid dispersion of meloxicam-PVP-K-25 compared to meloxicam.
Uji Sitotoksik Ekstrak Buah Phaleria macrocarpa terhadap Sel Kanker Lestari A 549 dan THP-1 Pertamawati Kartakusumah; Susi Kusumaningrum; Hendig Winarno
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Fruits of Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) has been used to cure various health problems, including empirical treatment for cancer. The therapeutic effect of natural material is related to the chemical compound contains. In fruits of Phaleria macrocarpa, various chemicals are present such as alcaloid, flavonoid saponin, fenol and tannin, which showed anticancer activity, as well as unknown compounds which ones presumably supportive for cancer treatment. An in vitro experiment is therefore set up with the objective of examining the effect of fruit extract on male human lung carcinoma epithelial cells (A-549 cell line) and human peripheral blood leukemia acute cells (THP-1 cell line). Various concentrations: 5, 10, 25, 50 and 100 ppm of fruit extract were evaluated. Observations were made 72 hour after incubating A-549 cells and THP-1 cells in each treatments. The results showed that fruit might inhibit the growth of A-549 cells and THP-1 cells. Inhibitory concentration (LC) of fruit extract after 72 hours of incubation is 9,43 ppm for A-549 cells and 5,36 ppm for THP-1 cells. Inhibitory potential effect of these fruits in THP-1 cells are better than in A-549 cells. The effect might be associated to the active compounds contained in these material.

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