cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota denpasar,
Bali
INDONESIA
ISM (Intisari Sains Medis) : Jurnal Kedokteran
Published by Universitas Udayana
ISSN : 25033638     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.
Arjuna Subject : -
Articles 1,063 Documents
 96   97   98   99   100 
Autoimmune Hemolytic Anemia (AHA) with hyperglycemia in a 22-year-old woman: a case report Fran Siska; Saskia Ramadhani; Anik Widijianti
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.173 KB) | DOI: 10.15562/ism.v13i2.1311

Abstract

Background: Autoimmune hemolytic anemia (AIHA) is defined as increased erythrocyte destruction due to anti-erythrocyte autoantibodies with or without complement activation. Diabetes Mellitus (DM) is a chronic metabolic disease characterized by elevated blood glucose levels, which cause serious damage to various organs, including the heart, blood vessels, eyes, kidneys, and nerves. The impact of DM on a patient's survival with AIHA is unknown. Case Presentation: A 22-year-old woman complained of dizziness and fainting before admission. The patient looked pale; on physical examination, we found jaundice on the sclera. This patient was diagnosed with AIHA and DM with increased HbA1c (10.8%) since 2017 but did not take the anti-diabetic drugs regularly. Hematological examination showed anemia, increased reticulocytes, and a positive direct Coombs test. The result of increased fasting glucose, 2 hours OGTT, and HbA1c levels (4.6%) tests were not relevant to hyperglycemia. In this patient, we also found normal C-peptide levels. The decrease in HbA1c levels was thought to be due to hemolytic anemia; therefore, HbA1c was falsely low due to rapid erythrocyte turnover. Conclusion: This patient was diagnosed with DM based on American Diabetes Association criteria with normal C-peptide levels, suggesting Maturity Onset Diabetes of the Young with HbA1c incompatibility with glucose levels may be due to rapid erythrocyte turnover.
Profil penggunaan antibiotik pada pasien pneumonia di komunitas: tinjauan pustaka Nanda Faradita; Rika Yulia; Fauna Herawati
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (450.98 KB) | DOI: 10.15562/ism.v13i2.1312

Abstract

Background: Community pneumonia referred to as community acquired pneumonia is pneumonia that is often found in the community and the leading cause of death for infectious diseases. This pneumonia requires therapy with antibiotics. One of the main problems in using antibiotics is the occurrence of antibiotic resistance. This study aims to determine the profile of antibiotic use in patients with community acquired pneumonia, which is commonly referred as acquired pneumonia in the community. Methods: This study is a literature review that uses articles with a randomized controlled trial design and articles in Indonesian or English and has a publication year, namely the last 10 years. The keywords used were "Treatment" AND "Community acquaired pneumonia" AND "Antibiotic or Antimicrobial" AND "Mortality OR Clinical response OR Severity". Results: The quality of journals in this study was assessed by means of a critical appraisal skills program checklist and journal reputation. The results obtained were 9 articles that met the inclusion and exclusion criteria. The antibiotic that is often used in outpatient community acquired pneumonia without comorbidities is nemonoxacin 500 mg and in non-severe hospitalized patients the commonly used antibiotic is beta-lactam monotherapy. Conclusion: The conclusion in this study is that the antibiotic that is often used in outpatient CAP patients is Nemonoxacin 500 mg while inpatient CAP is beta-lactam monotherapy so that in both groups the use of antibiotics is not in accordance with the 2019 ATS guidelines therefore requires monitoring the use of antibiotics in patients with community acquired pneumonia.   Latar belakang: Pneumonia komunitas atau biasanya disebut dengan community acquired pneumonia yaitu pneumonia yang sering didapatkan di masyarakat dan merupakan penyebab kematian penyakit menular tertinggi. Pneumonia ini membutuhkan terapi dengan menggunakan antibiotik. Salah satu masalah utama dalam penggunaan antibiotik adalah terjadinya resistensi antibiotik. Penelitian ini bertujuan untuk mengetahui profil penggunaan antibiotik pada pasien community acquired pneumonia atau biasanya disebut dengan pneumonia yang didapatkan di komunitas. Metode : Penelitian ini merupakan kajian literatur yang menggunakan artikel dengan desain randomized controlled trial dan artikel yang menggunakan bahasa Indonesia atau bahasa inggris dan memiliki tahun publikasi yaitu 10 tahun terakhir. Kata kunci yang digunakan adalah "Treatment" AND "Community acquaired pneumonia" AND “Antibiotic or Antimicrobial” AND “Mortality or Clinical response or Severity”. Hasil : Kualitas jurnal pada penelitian ini dinilai dengan checklist critical appraisal skill program dan  reputasi jurnal. Hasil yang didapatkan adalah 9 artikel yang memenuhi kriteria inklusi dan ekslusi. Antibiotik yang sering digunakan pada pasien community acquired pneumonia rawat jalan tanpa komorbiditas adalah nemonoxacin 500 mg dan pada pasien rawat inap non severe antibiotik yang sering digunakan adalah monoterapi beta-laktam Kesimpulan : pada penelitian ini adalah Antibiotik yang sering digunakan pada pasien CAP rawat jalan adalah Nemonoxacin 500 mg sedangkan pada  CAP  rawat inap  adalah monoterapi beta-laktam sehingga pada kedua kelompok tersebut penggunaan antibiotik tidak sesuai dengan guideline ATS tahun 2019 sehingga masih membutuhkan pengawan penggunaan antibiotik pada pasien community acquired pneumonia.
Osteomielitis kronis pada pasien anak laki-laki setelah cakaran kucing: laporan kasus Martin Gabe Tua Sihotang; Anak Agung Ngurah Ronny Kesuma; I Komang Agus Krisna Saputra; I Komang Mahendra Laksana
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (421.22 KB) | DOI: 10.15562/ism.v13i2.1314

Abstract

Background: Chronic osteomyelitis is still an important problem in the orthopedic field, especially in developing countries. Cat's claws contain many harmful microorganisms and can cause significant morbidity ranging from infection of skin tissue, muscle, and even deeper to bone tissue (osteomyelitis). The aim of this study was to report that injuries caused by cat-scratches and not receiving proper treatment can develop into chronic osteomyelitis. Case presentation: A 14-year-old boy came to the orthopedic polyclinic of Wangaya General Hospital with complaints of a left leg wound that had not healed since 2 years ago after got cat-scratches. The wound was oozing pus, tenderness, and the ankle area was found to be difficult to move because the patient's leg felt stiff. On physical, laboratory, and radiographic examination were found to be suggestive of chronic osteomyelitis. Conclusion: In general, cat scratch injuries are simple and harmless wounds, but if left untreated can lead to infection and morbidity in the future. Persistent symptoms and unrelieved wound conditions should be important indications for patients and practitioners of the possibility of infection that extends to soft tissue or bone tissue. A good understanding of acute wound management is very important in preventing serious infections.   Latar belakang: Osteomielitis kronik masih merupakan masalah penting di bidang ortopedi terutama di negara berkembang. Pada cakaran kuku kucing mengandung banyak mikroorganisme berbahaya dan dapat menyebabkan morbiditas yang signifikan mulai dari infeksi jaringan kulit, otot, bahkan lebih dalam sampai mengenai jaringan tulang (osteomielitis). Tujuan dari penelitian ini adalah untuk melaporkan cidera yang disebabkan oleh cakaran kucing dan tidak mendapatkan pengobatan dengan baik dapat berkembang menjadi osteomielitis kronis. Laporan kasus: Seorang anak laki-laki berusia 14 tahun datang ke poliklinik ortopedi RSUD Wangaya dengan keluhan luka kaki kiri yang tidak kunjung sembuh sejak 2 tahun yang lalu, luka mengeluarkan nanah, nyeri tekan, serta pada daerah ankle ditemukan sulit untuk digerakkan yang dikarenakan kaki pasien terasa kaku. Pada pemeriksaan fisik dan laboratorium ditemukan mengarah pada osteomielitis kronis.  Simpulan: Pada umumnya cidera cakaran kucing hanya luka sederhana dan tidak berbahaya, tetapi jika diabaikan dapat menyebabkan infeksi dan morbiditas dikemudian hari. Gejala yang menetap dan kondisi luka yang tidak membaik harus menjadi indikasi penting bagi penderita dan praktisi terhadap kemungkinan infeksi yang meluas ke jaringan lunak ataupun jaringan tulang. Pemahaman yang baik tentang penanganan luka akut menjadi sangat penting dalam mencegah terjadinya infeksi yang serius.
Perpanjangan hasil Polymerase Chain Reaction (PCR) pada pasien Acquired Immunodeficiency Syndrome (AIDS): laporan kasus Yoelius Wijaya Saputra; I Komang Parwata; Ni Komang Krisnawati
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.824 KB) | DOI: 10.15562/ism.v13i1.1316

Abstract

Background: Since its emergence in Wuhan in 2019, SARS-Cov-2 has become the virus that causes the ongoing pandemic situation. The number of infected humans continues to grow over time. Moreover, there is also the HIV virus which continues to be a global health problem. To date, the available data on the coinfection of SARS-Cov-2 with AIDS are limited. Case Presentation: This patient was found to have prolonged positive results on the Polymerase Chain Reaction (PCR) examination for 113 days. Female patient, aged 48 years, with complaints of shortness of breath since 3 days before admission to the hospital. Physical examination of the patient was compos mentis with a pulse rate of 113 beats per minute and a body temperature of 37.40C. On auscultation, crackles were found in both lung fields. The patient had anemia, leucocytosis, neutrophilia, lymphopenia, and elevated D-dimer. Conclusion: The destruction of CD4 and CD8 in AIDS patients can provide a protective effect against the inflammatory process and cytokine storm, but this milder symptom causes inadequate production of neutralizing antibodies. This low number of Neutralizing Antibodies causes prolonged PCR results in SARS-Cov-2 patients.   Latar Belakang: Sejak kemunculannya di Wuhan tahun 2019, SARS-Cov-2 telah menjadi virus yang menyebabkan situasi pandemik yang sedang berlangsung. Data manusia yang terinfeksi terus bertambah dengan sejalannya waktu. Disamping itu terdapat juga virus HIV yang terus menjadi masalah kesehatan global. Sampai saat ini, data yang tersedia tentang ko-infeksi penyakit SARS-Cov-2 dengan AIDS masih terbatas. Presentasi Kasus: Pada pasien ini ditemukan perpanjangan hasil positif pada pemeriksaan Polymerase Chain Reaction (PCR) selama 113 hari. Pasien perempuan, usia 48 tahun dengan keluhan sesak nafas sejak 3 hari sebelum masuk rumah sakit. Pemeriksaan fisik pasien compos mentis dengan laju nadi 113 kali permenit dan suhu tubuh 37,40 C. Pada auskultasi ditemukan ronchi di kedua lapang paru. Pasien mengalami anemia, leukositosis, neutrofilia, limfopenia, dan peningkatan D-dimer. Simpulan: Destruksi CD4 dan CD8 pada pasien AIDS dapat memberikan efek protektif terhadap proses inflamasi dan badai sitokin, akan tetapi gejala yang lebih ringan ini menyebabkan produksi Neutralizing Antibody yang terbentuk tidak adekuat. Jumlah Neutralizing Antibody yang kurang ini menyebabkan pemanjangan hasil PCR pada pasien SARS-Cov-2.
Case report: a rare case of ocular leptospirosis I Made Surya Dinajaya; Ida Ayu Ary Pramita; I Gusti Ayu Made Juliari; Ni Ketut Niti Susila; I Made Agus Kusumadjaja
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i1.1320

Abstract

Background: Ocular leptospirosis is a rare condition. Transmission of leptospirosis is caused by the bacterium leptospira interrogans transmitted directly or indirectly from animals to humans (zoonosis). Ocular manifestations often caused by leptospirosis are conjunctivitis, keratitis, uveitis (anterior, intermediate, posterior, and panuveitis), complicated cataracts, choroiditis, papillitis, and macular edema. Uveitis is a latent manifestation of leptospirosis. Proper management can lead to a good prognosis of visual.Case Presentation: Male patient, 55 years old, with complaints of both red and blurry eyes since 5 days. Blurring comes slowly with pain, glare, and seeing shadows like spider webs. The patient's previous medical history was hospitalized because of Weil's disease. Examination of the anterior segment of both eyes revealed eyelid spasm, conjunctival injection, corneal infiltrate, keratic precipitate, and posterior synechiae on both eyes. While in the posterior segment found cells 4+ in the vitreous. The patient was treated with antibiotics and topical steroids, and visual acuity was improved.Conclusion: Leptospirosis uveitis can have various presentations during the acute and chronic phases of the disease. Even when ocular involvement is extensive and severe, most patients have a good visual prognosis with appropriate therapy. Timely diagnosis is essential to maximize the potential for visual acuity improvement and appropriate systemic monitoring and treatment of extraocular involvement in this potentially fatal condition. Good sanitation in the community plays an important role in preventing exposure to leptospirosis.
Efektifitas daun salam dalam mengurangi cemaran mikroba penyebab busuk telur itik Yulidia Iriani; Yan Ramona; Ni Putu Adriani Astiti
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (712.767 KB) | DOI: 10.15562/ism.v13i2.1321

Abstract

Background: Pathogenic bacteria on eggshells or egg contents will be very dangerous for the health of humans who consume them. Chemicals should not be an option for preservatives because they will cause side effects. In this study, we explored the possibility of using bay leaf extract (Syzygium polyanthum (Wight) Walp) to control the growth of polluting bacteria in salted duck eggs so that the shelf life can be extended. The purpose of the study was to determine the potential of the active compounds contained in bay leaves in reducing the total plate count/microbial contamination in salted duck eggs. Methods: Extraction of bay leaf powder was carried out by the infusion method. The activity test of bay leaf decoction (ARDS) was carried out using the in vitro diffusion well method on Mueller Hinton media. Identification of active compounds was carried out using the GCMS technique. Results: ARDS crude extract at a concentration of 5% (v/v) could significantly reduce ALT and inhibit the in vitro growth of Proteus mirabilis bacteria at a concentration of 10% (w/v), with an inhibition zone diameter of 19.53 mm, with the minimum value inhibitory concentration (MIC) 0.7%. The results of the GCMS analysis of ARDS showed that the ten peaks produced, possibly synergized, and had antimicrobial activity. These compounds are 2-Pentanone4-Hydroxy-4 Methyl (CAS) Diacetone Alcohol; Ethanol, 2-(Ethoxythoxy) (CAS); 1,2,3 Propanetrriol Cas) Glycerol; Citronella (2,6-Octadien-1-Ol, 3,7-Dimethyl, (CAS); Beta Citronellol 6-Octen-1-Ol, 3,7 Dimethyl-(CAS); Trans Geraniol; Dodecanoic Acid, Methyl Ester (CAS) Methyl Laurate; Tetradecanoic Acid, Methyl Ester (CAS) Methyl Myristate; 1-Tetradecanol (Cas) Alfol 14 and Hexadecanoic Acid Methyl Ester CAS) Methyl Palmitate Conclusion: Leaf decoction can inhibit the growth of Proteus mirabilis in vitro, and the addition of ARDS with a concentration of 5% (v/v) can significantly reduce the value of bacterial contamination in salted duck eggs.   Latar Belakang: Bakteri pathogen pada kulit telur atau isi telur akan sangat membahayakan kesehatan manusia yang mengkonsumsinya. Bahan kimia seharusnya tidak menjadi pilihan untuk pengawet, karena akan menimbulkan efek samping, Pada penelitian ini dieksplorasi, kemungkinan dipakainya ekstrak daun salam (Syzygium polyanthum (Wight) Walp) untuk mengontrol pertumbuhan bakteri pencemar pada telur itik yang diasinkan, sehingga masa simpannya dapat diperpanjang. Tujuan penelitian untuk mengetahui potensi senyawa aktif yang terdapat pada daun salam dalam menurunkan angka lempeng total/cemaran mikroba pada telur itik yang diasinkan. Metode: Ekstraksi serbuk daun salam dilakukan dengan metode infusa. Uji aktifitas air rebusan daun salam (ARDS) dilakukan dengan metode sumur difusi secara in vitro pada media Mueller Hinton. Identifikasi senyawa aktif dilakukan dengan teknik GCMS. Hasil: Ekstrak kasar ARDS pada konsentrasi 5% (v/v) secara nyata dapat menurunkan ALT dan menghambat pertumbuhan in vitro bakteri Proteus mirabilis pada konsentrasi 10% (b/v), dengan diameter zona hambat sebesar 19,53 mm, nilai minimum inhibitory concentration (MIC) 0,7%. Hasil analisis GCMS terhadap ARDS menunjukan bahwa sepuluh puncak yang dihasilkan, kemungkinan bersinergi dan mempunyai aktifitas sebagai antimikroba. Senyawa-senyawa tersebut adalah 2-Pentanone4-Hydroxi-4 Methyl (CAS) Diacetone Alkohol; Ethanol, 2-(Ethoxythoxy) (CAS); 1,2,3 Propanetrriol Cas) Glycerol; Citronella (2,6-Octadien-1-Ol, 3,7-Dimethyl, (CAS); Beta Citronellol 6-Octen-1-Ol, 3,7 Dimethyl-(CAS); Trans Geraniol; Dodecanoic Acid, Methyl Ester(CAS) Methyl Laurate; Tetradecanoic Acid,Methyl Ester (CAS) Methyl Myristate; 1-Tetradecanol (Cas) Alfol 14 dan Hexadecanoic Acid Methyl Ester CAS) Methyl Palmitate. Simpulan: Air rebusan daun dapat menghambat pertumbuhan Proteus mirablis secara in vitro dan penambahan ARDS dengan konsentrasi 5% (v/v) secara signifikan dapat menurunkan nilai cemaran bakteri (angka lempeng total) pada telur itik yang diasinkan.
Karakteristik dan perjalanan penyakit pasien infark miokard akut dengan elevasi segmen ST (IMA-EST) tanpa tatalaksana reperfusi pada rumah sakit perifer Arina Papita Simanungkalit; Alice Inda Supit
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.045 KB) | DOI: 10.15562/ism.v13i1.1322

Abstract

Introduction: Acute myocardial infarction is coronary heart disease that causes an increase in length of stay in hospital and a high mortality rate. Reperfusion strategy is the main modality in treating ST-elevation myocardial infarction (STEMI), but a limitation in facilities and human resources in peripheral hospitals has made it impossible to do. This study aims to observe the characteristics and course of disease in patients diagnosed by STEMI without reperfusion strategy in peripheral hospitals.Method: This study is a descriptive observational study with a cross sectional research design--retrieving research data using the total sampling method, using secondary data from medical records at Ade M Djoen Sintang Public Hospital in March - December 2021.Results: 56 samples fulfilled inclusion and exclusion criteria, with the majority of the sample being male, the average age was 53 years. Most of the patients had the same complaint during their stay in the hospital, most of the patients were able to discharge from the hospital, and 57,14% of the patients were admitted back to the hospital with the same chief complaints after less than six months of follow-up.Conclusion: Management of patients with STEMI without a reperfusion strategy leads to remain of chief complaints and increase of readmission within 6 months follow-up after discharge. Latar Belakang: Infark miokard akut adalah suatu penyakit jantung koroner yang mengakibatkan peningkatan angka perawatan di rumah sakit dan angka kematian yang tinggi. Strategi reperfusi merupakan modalitas utama dalam penanganan infark miokard akut dengan elevasi segmen ST (IMA-EST), namun pada rumah sakit di perifer, keterbatasan sarana dan prasarana serta sumber daya manusia menyebabkan hal tersebut tidak memungkinkan. Tujuan penelitian ini adalah untuk mengetahui karakteristik dan perjalanan penyakit pasien yang terdiagnosis IMA-EST tanpa tatalaksana reperfusi di rumah sakit di perifer.Metode:  Penelitian ini merupakan penelitian observasional dengan desain penelitian potong lintang. Data penelitian diambil menggunakan metode total sampling, melalui data sekunder dari rekam medis selama periode Maret - Desember 2021 di Rumah Sakit Umum Daerah (RSUD) Ade M Djoen Sintang.Hasil: Terdapat 56 sampel yang memenuhi kriteria inklusi dan eksklusi, mayoritas sampel adalah laki-laki, rata-rata usia 53 tahun. Sebagian besar pasien mengakami keluhan yang menetap selama perawatan, sebagian besar boleh pulang dari rumah sakit. Dalam periode kurang dari 6 bulan, sebanyak 57,14% pasien masuk kembali ke rumah sakit dengan keluhan yang sama.Simpulan: Tatalaksana pasien dengan IMA-EST tanpa strategi reperfusi menyebabkan keluhan yang menetap selama perawatan dan peningkatan pasien masuk kembali ke rumah sakit dengan keluhan yang sama setelah 6 bulan dipulangkan dari rumah sakit.
Korelasi pemeriksaan darah lengkap dengan derajat keparahan COVID-19 pada pasien lansia di Rumah Sakit Umum Daerah (RSUD) Tabanan tahun 2021 Richard Samsudin; I Gede Agus Sastrawan; I Gede Risnawan Suastika Ardanayasa; I Gusti Putu Suka Aryana
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.776 KB) | DOI: 10.15562/ism.v13i2.1323

Abstract

Background: COVID-19 infects all patients of all ages including the elderly. Several studies have shown that complete blood counts can be used as a marker of the severity of COVID-19. This study aims to examine complete blood counts with the severity of COVID-19 in elderly patients at the Tabanan Regional General Hospital (RSUD) in 2021. Methods: This research was conducted using an retrospective study method, using 277 samples taken from secondary data (patient medical records) at Tabanan General Hospital. The independent variables of study including haemoglobin, haematocrit, leukocytes, relative lymphocyte levels, relative neutrophil levels, neutrophil lymphocyte ratio (NLR), relative eosinophil levels, relative basophil levels, relative monocyte levels, platelets, and depending  variable is the severity of the patient, divided to moderate, severe, critically ill. Data analysis using SPSS version 26 for Windows. Results: Complete blood counts were significantly correlated with Lymphocytes (r2 = 0,069; p < 0,001), Monocyte (r2 = 0,045; p < 0,001), Leukocyte (r2 = 0,037; p = 0,001), NLR (r2 = 0,03; p = 0,004), Eosinophil (r2 = 0,022; p = 0,013), and Haematocrit (r2 = 0,069; p = 0,022). Conclusion: In this study, complete blood count (leukocytes, NLR, haematocrit with a positive value correlation, and lymphocytes, eosinophils,  monocytes with a negative value correlations) can be used as  predictors to assess the severity of COVID-19 patients. However, neutrophils, basophils, haemoglobin, and platelets were not correlated significantly.   Latar Belakang: COVID-19 menginfeksi semua pasien dari segala usia termasuk lansia. Beberapa studi menunjukkan bahwa pemeriksaan darah lengkap dapat dipergunakan sebagai penanda derajat keparahan COVID-19. Penelitian ini bertujuan untuk mengevaluasi pemeriksaan darah lengkap dengan derajat keparahan COVID-19 pada pasien lansia di Rumah Sakit Umum Daerah (RSUD) Tabanan tahun 2021. Metode: Penelitian ini dilakukan dengan metode studi retrospektif menggunakan 277 sampel yang diambil dari data sekunder rekam medis pasien di RSUD Tabanan. Variabel independen penelitian meliputi hemoglobin, hematokrit, leukosit, kadar limfosit relatif, kadar neutrofil relatif, neutrofil limfosit ratio (NLR), kadar eosinofil relatif, kadar basofil relatif, kadar monosit relatif, trombosit, dan dependent derajat keparahan pasien yaitu sedang, berat, kritis. Analisis data memakai SPPS versi 26 untuk Windows. Results: Pemeriksaan darah lengkap menunjukkan hasil yang bermakna pada Limfosit (r2 = 0,069; p < 0,001), Monosit (r2 = 0,045; p < 0,001), Leukosit (r2 = 0,037; p = 0,001), NLR (r2 = 0,03; p = 0,004), Eosinofil (r2 = 0,022; p = 0,013), dan Hematokrit (r2 = 0,069; p = 0,022). Conclusion: Pada penelitian ini pemeriksaan darah lengkap (leukosit, NLR, hematokrit dengan korelasi positif, dan limfosit, eosinofil, monosit dengan korelasi nilai negatif) dapat digunakan sebagai prediktor untuk menilai derajat keparahan pasien COVID-19. Akan tetapi neutrofil, basofil, hemoglobin, dan trombosit tidak berkorelasi secara bermakna.
Colonization of Citrobacter koseri and Streptococcus agalactiae in a case of cellulitis cruris dextra et sinistra Luh Gede Melia Puspita Sari; Ni Nengah Dwi Fatmawati; I Gusti Ayu Agung Praharsini; Marvin Giantoro
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (515.511 KB) | DOI: 10.15562/ism.v13i2.1326

Abstract

Background: Cellulitis is a skin infection involving the deep dermis and subcutaneous tissue, characterized by localized pain, swelling, tenderness, erythema, and warmth. The most common causes of cellulitis are group A streptococci and Staphylococcus aureus. Streptococcus agalactiae or the so-called group B Streptococcus can also cause cellulitis. This case report aims to evaluate the colonization of Citrobacter koseri and Streptococcus agalactiae in a case of cellulitis cruris dextra et sinistra. Case Presentation: A 53-year-old married woman presented to the outpatient clinic complaining of swelling and redness in her left and right legs since five days ago. At first, there was only a little redness around the calf, but it became wider and pain in that area. On examination, there were multiple erythematous macules, patches, and multiple erosional lesions, warm palpable and tender to palpation, and the diascopy test disappeared with pressure. Based on the wound culture results, isolated Citrobacter koseri and Streptococcus agalactiae bacteria were considered colonization. Both of these bacteria were less virulent. The patient was treated with systemic and topical antibiotics, analgesics, wound care management and elevated lower limbs. Conclusion: The diagnosis of cellulitis is based on history and physical examination. On examination of the wound culture of this case, Citrobacter koseri and Streptococcus agalactiae were found, considered as colonization. The patient showed clinical improvement at each observation after administration of antibiotics and wound care management. The patient's prognosis is dubious ad bonam.
Skor assessment of different neoplasias in the adnexa (ADNEX) untuk memprediksi keganasan ovarium di RSUP Sanglah Denpasar I Nyoman Gede Budiana; Ketut Suwiyoga; Tjokorda Gde Agung Suwardewa; Anom Suardika; Made Bagus Dwi Aryana; Heni Sunyoto
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i1.1328

Abstract

Introduction: Ovarian cancer is cancer of the female reproductive organs with the highest mortality and is in the third position of female cancer after mammary and cervical cancer. The mortality rate and survival rate of ovarian cancer is mainly determined by the stage at which ovarian cancer is diagnosed. Until now there is no method for early detection of ovarian cancer with good sensitivity and specificity. Assessment of different neoplasias in the adnexa (ADNEX) is a model proposed by international ovarian tumor analysis (IOTA) to help distinguish benign or malignant adnexa tumors.Methods: This study is a observational clinical test to find out the accuracy of ADNEX model to predict ovarian malignancy conducted at the Obstetric and Gynecology Outpatient Ward in Sanglah hospital, Denpasar from November 2019 to April 2020. Consecutive sampling was done and 88 sample was recruited with a diagnosis of ovarian tumors. Then the research sample was sent to the Pathology Anatomy laboratory of Sanglah Hospital for histopathological examination. This result would then be compared to the prediction results of the ADNEX model.Results: 35 samples of benign ovarian tumors and 53 samples of ovarian cancer were found with the ADNEX method. There were 46 samples with malignant tumor both by the ADNEX model and histopathology results, 7 samples of malignant tumor at histopathology result but benign by the ADNEX model, 6 samples of benign tumor according to histopathology but malignant using the ADNEX model, and 29 samples of benign tumor according to histopathology and the ADNEX model. Using cut off of 49,6%, the study reported a sensitivity level of 86.8%, specificity 82.6%, positive predictive value 88.5%, negative predictive value 80.6%, and 85.2% accuracy.Conclusion: The ADNEX model has a high level of specificity, sensitivity and diagnostic accuracy in diagnosing ovarian cancer and can be used in combination with other clinical markers for early detection of malignancy in ovarian tumors.  Pendahuluan: Kanker ovarium merupakan salah satu jenis kanker organ reproduksi wanita dengan mortalitas tertinggi dan berada pada posisi ke-tiga kanker perempuan setelah kanker mammae dan serviks. Angka mortalitas dan survival rate kanker ovarium sangat ditentukan oleh stadium saat kanker ovarium terdiagnosis. Hingga saat ini belum tersedia metode pemeriksaan untuk deteksi dini kanker ovarium dengan sensitivitas dan spesifisitas yang memadai. Assessment of different neoplasias in the adnexa (ADNEX) adalah model yang diajukan oleh International Ovarian Tumor Analysis (IOTA) untuk membantu membedakan tumor adnexa sebagai tumor jinak atau ganas. Metode: Penelitian ini merupakan penelitian observasional uji klinik untuk mengetahui akurasi model ADNEX untuk memprediksi keganasan ovarium yang dilakukan di Poliklinik Kebidanan dan Penyakit Kandungan RSUP Sanglah, Denpasar pada bulan November 2019 hingga April 2020. Sampling dilakukan secara consecutive dan didapatkan 88 orang dengan diagnosis tumor ovarium. Sampel penelitian dikirimkan ke laboratorium Patologi Anatomi RSUP Sanglah dan dilakukan pemeriksaan histopatologi untuk kemudian dibandingkan dengan hasil prediksi dari model ADNEX.Hasil: Dalam penelitian ini didapatkan 35 sampel dengan tumor jinak ovarium dan 53 sampel dengan kanker ovarium dengan menggunakan metode ADNEX. Terdapat 46 sampel dengan hasil pemeriksaan model ADNEX ganas dan hasil pemeriksaan histopatologi ganas, 7 sampel histologi ganas namun model ADNEX jinak, 6 sampel histopatologi jinak namun model ADNEX ganas, dan 29 sampel histopatologi jinak dan model ADNEX jinak. Hasil penelitian memperlihatkan tingkat sensitifitas 86,8%, spesifisitas 82,6%, nilai prediksi positif 88,5%, nilai prediksi negatif 80,6%, dan akurasi 85,2%.Simpulan: Model ADNEX memiliki tingkat spesifisitas, sensitivitas dan akurasi diagnostik yang tinggi dalam mendiagnosis kanker ovarium dan dapat digunakan bersama dengan penanda klinis lain untuk deteksi dini keganasan pada tumor ovarium.

Page 98 of 107 | Total Record : 1063

 96   97   98   99   100 

Filter by Year

2014 2022


Reset
Filter By Issues
All Issue Vol. 13 No. 3 (2022): (In Press 1 December 2022) Vol. 13 No. 2 (2022): (In Press : 1 August 2022) Vol. 13 No. 1 (2022): (Available Online : 1 April 2022) Vol. 12 No. 3 (2021): (Available online: 1 December 2021) Vol. 12 No. 2 (2021): (Available Online: 1 August 2021) Vol. 12 No. 1 (2021): (Available online : 1 April 2021) Vol. 11 No. 3 (2020): (Available online: 1 December 2020) Vol. 11 No. 2 (2020): (Available online: 1 August 2020) Vol. 11 No. 1 (2020): (Available online: 1 April 2020) Vol. 10 No. 3 (2019): (Available online: 1 December 2019) Vol. 10 No. 2 (2019): (Available online: 1 August 2019) Vol. 10 No. 1 (2019): (Available online 1 April 2019) Vol. 9 No. 3 (2018): (Available online: 1 December 2018) Vol. 9 No. 2 (2018): (Available online: 1 August 2018) Vol. 9 No. 1 (2018): (Available online: 1 April 2018) Vol. 8 No. 3 (2017): (Available online: 1 December 2017) Vol. 8 No. 2 (2017): (Available online: 1 August 2017) Vol. 8 No. 1 (2017): (Available online: 1 April 2017) Vol. 7 No. 1 (2016): (Available online: 1 December 2016) Vol. 6 No. 1 (2016): (Available online: 1 August 2016) Vol. 5 No. 1 (2016): (Available online: 1 April 2016) Vol. 4 No. 1 (2015) Vol. 3 No. 1 (2015) Vol. 2 No. 1 (2015) Vol. 1 No. 1 (2014) More Issue