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INDONESIA
Jurnal Jamu Indonesia
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : 10.29244
Core Subject : Education, Agriculture,
Agriculture, Biological Sciences & Forestry Other
Jurnal Jamu Indonesia (JJI) didedikasikan untuk pertukaran informasi dan pemahaman keilmuan yang meluas mengenai pengembangan dunia jamu melalui penerbitan makalah-makalah Ilmiah. Tema makalah ilmiah yang menjadi lingkup JJI meliputi tema riset jamu dari hulu kehilir yang tidak terbatas pada riset etnobotani dan pengetahuan lokal, eksplorasi, Konservasi, Domestikasi sumberdaya hayati terkait jamu, pemuliaan varietas, pengembangan Good Agricultural and Collection Practices (GACP) bahan baku jamu, pengembangan standar bahan baku dan produk jamu, pengembangan produk jamu, Identifikasi senyawa aktif serta sintesisnya, Mekanisme kerja bioaktivitas formula jamu, aspek sosial dan ekonomi terkait dengan pengembangan jamu.
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Articles 137 Documents
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Mangrove Plants Use As Medicine In Gedangan Village, Purwodadi District, Purworejo Regency, Central Java Province Slamet Mardiyanto Rahayu; Sunarto
Jurnal Jamu Indonesia Vol. 5 No. 2 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1322.762 KB) | DOI: 10.29244/jji.v5i2.116

Abstract

Coastal ecosystems have high plant levels, for example mangroves and seagrasses. Mangrove forest is a type of forest located in tidal areas, especially on protected beaches, lagoons, river estuaries that are inundated and free from inundation at low tide, whose plant communities tolerate salt. Gedangan Village is one of the villages in Purwodadi District, which has mangrove areas in Purworejo Regency. This study aims to determine the types of mangrove plants that are useful the Gedangan Village, Purwodadi District, Purworejo Regency, Central Java as medicinal products. The study was conducted using roaming method in the form of observations or field observations in the mangrove area of Gedangan Village, Purwodadi District, Purworejo Regency, Central Java. Based on the research, there were eight (8) types of mangrove plants that were found as medicinal plants in Gedangan Village, namely Rhizophora mucronata, Sonneratia alba, Calotropis gigantea, Nypa fruticans, Acanthus ilicifolius, Hibiscus tiliaceus, Ipomoea pescaprae, and Wedelia biflora. Traditionally, these mangrove species can be used as a medicine items for beri-beri, hepatitis, ulcers, wounds, diarrhea, fever, antibacterial, anti-inflammatory, dizziness, asthma, bronchitis, dyspepsia, leprosy, tumors, diabetes, stomach ache, toothache, thrush, tuberculosis, muscle aches, and eczema.
Formulation of Transparent Solid Soap from Palm Kernel Oil Andri Prasetiyo; Lungguk Hutagaol; Lidya Luziana
Jurnal Jamu Indonesia Vol. 5 No. 2 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1279.325 KB) | DOI: 10.29244/jji.v5i2.159

Abstract

Palm kernel oil contains fatty acids, especially lauric acid at 46-52%. Lauric acid has the properties of hardening, cleaning, producing foam and softening that is needed in making soap. The purpose of this study is to make transparent solid soap from a combination of glycerin, sucrose, and ethanol 96% as a transparent agent that meets the requirements of quality tests and organoleptic tests. Made 9 (nine) formulas with some combination of glycerin, sucrose, ethanol 96% by a semi-boiled method that is mixing palm kernel oil and stearic acid which has been melted at 60˚C, then adding 30% NaOH, stirring at 70- 80˚C. Transparent agent and other additives are mixed into the soap mass obtained from the saponification process, then poured into a soap mold and carried out a curing process for 2 weeks. The result of this research is obtained a transparent yellow solid soap that is the bright and distinctive smell of coconut perfume with a pH of 8.35-8.64, the hardness of 21.30-38.13 10-1 mm, moisture content of 21.48-33.33%, free fatty acid content 0,88-0,96%, unsaturated fat content 1,45-2,38%, surface tension 27,93-32,34 dyne/cm. Transparent solid soap that meets the quality requirements and the organoleptic test is formula A with PH 8.64, hardness 25.80 10-1 mm, moisture content 25.55%, free fatty acids 0,94%, unsaturated fat 1,45%, surface tension 30.02 dyne/cm.
Physicochemical Analysis and Antioxidant Activity of Onion Bulbs (Allium cepa L.) Vera Ladeska; Rindita; Nur Amyra; Tamara Dwi Veranthy
Jurnal Jamu Indonesia Vol. 5 No. 2 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1497.871 KB) | DOI: 10.29244/jji.v5i2.170

Abstract

Allium cepa L. (onion bulb) is a cultivated onion extensively and types of onions that are often used for various cuisines in Indonesia. The onion bulb was efficient in reducing blood fat levels and diuretics. This study aims to complete the onion monograph with determine the physicochemical characteristics and antioxidant activity. Microscopic results obtained include: has fibrous roots and it’s white, and about 9.5 cm long. The stem is pseudo, and the water is whitish-green, cylindrical leaves are dark green, elongated like a pipe and hollow with a length of ± 20 cm, and the tip is tapered. Onion tubers are single layer bulbs, having a diameter of 6 mm, which is higher than onions. Microscopic results contained identification fragments, including hair covering and transporting beams with thickening stairs and spirals. From the results of research on ethanol extract, 70% Allium cepa L. shows a drying shrinkage of 9.69%, 5.16% total ash content, 0.07 % acid insoluble acid dust, 14.36% water-soluble extract, and soluble ethanol extracts 23.04%. Phytochemical screening contains flavonoids, saponins, phenols, dan triterpenoids. Total flavonoid content contained in ethanol extract of onion tubers was 1.48 ± 0.12 mg QE/g. Total phenolic concentrations obtained in onion tuber ethanol extract were 103.47 ± 3.09 mg GAE/g. The antioxidant activity of ethanol extract of onion tubers by the DPPH method received IC50 is 65.31 ppm.
Activity of Ethanol Fraction of Luffa Acutangula (L.) Roxb. on Cholesterol Reduction in Dyslipidemic Hamster Daniek Viviandhari; Rini Prastiwi; Elva Fitriani Puspitasari; Pegi Perdianti
Jurnal Jamu Indonesia Vol. 5 No. 2 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1272.132 KB) | DOI: 10.29244/jji.v5i2.171

Abstract

National data shows the prevalence of coronary heart disease is 3,6%. The prevalence of dyslipidemia is around 35,9%. Dyslipidemia has a causal relationship with cardiovascular disease. Based on previous research, 70% ethanolic extract of Ridge Gourd has been shown to have antihyperlipidemic activity. This study aimed to study the activity of 70% ethanolic extract fraction of Ridge Gourd in decreasing the levels of total cholesterol, low-density lipoprotein (LDL-C), and triglycerides in hyperlipidemic hamsters. A total of 32 hamster were divided into 8 groups. Negative control, normal control, positive control (using atorvastatin dose 1,24 mg/kg body weight), positive control (fenofibrate dose 12,35 mg/kg body weight), ethyl acetate fraction, n-hexane fraction, water fraction (fraction doses 36,75 mg/kg body weight), and ethanol extract group (extract dose of 240 mg/kg body weight). The results showed that fraction group (n-hexane, ethyl acetate, water) and ethanol extract group experienced a decrease in total cholesterol, LDL-C, and triglycerides levels. Statistical analysis with one-way ANOVA showed an effect on the treatment given (p = 0,005). Tukey's test showed that ethyl acetate fraction group had an effect comparable to positive control with a decrease in total cholesterol, LDL-C, and triglycerides level by 56,03%, 52,14%, and 59,51% consecutively. Ethyl acetate fraction (doses 36,75 mg/kg body weight) was the most effective fraction in reducing total cholesterol, LDL-C, and triglycerides.
The Isolation and Identification of Active Compound of Dendrophthoe praelonga (Blume) Miq. Extract Against Breast Cancer Cells (MCF-7) M Irfan Junedi Irfan; Hendig Winarno; M Hanafi; Nina Artanti
Jurnal Jamu Indonesia Vol. 5 No. 3 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v5i3.117

Abstract

Petai mistletoe (Dendrophthoe praelonga (Blume) Miq) is semi-parasitic plant. Parasite plant has been used traditionally in Indonesia to prevent or treat degenerative diseases, such as cancer. The purpose of this study was to indentify anticancer compound of petai mistletoe leaves extract and to examine its antioxidant activity (based on DPPH method) and cytotoxic activity on breast cancer (MCF-7) cell lines in vitro using Alamar blue method. This research aims to isolating, characterize, determine antioxidant activity and cytotoxic activity. Separation was conducting column chromathography and characterize was conducted using TLC, FT-IR, LC-MS and NMR-1D. From the result obtained, the isolated compound is flavonol quercetine (3,3,7,3’,4’ pethahydroxyflavone) which active antioxidant with IC50 value of 9.4 μg/mL and the value of cytotoxic activity with IC50 750.62 μg/mL
Heme Polymerization Inhibitory Activity And Phytochemical Screening Of Ethyl Acetate Fraction In Manuran (Coptosapelta tomentosa Valeton ex K. Heyne) Stem Arnida; Siti Humairah Z.A; Sutomo; Fadlillahturrahmah
Jurnal Jamu Indonesia Vol. 6 No. 1 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i1.165

Abstract

The native Indonesian plant that is empirically used as an antimalarial agent is manuran (Coptosapelta tomentosa Valeton ex K. Heyne). This study aims to determine chemical compound and heme polymerization inhibitory activity of ethyl acetate fraction of C. Tomentosa stem based on IC50 value. The method identification of chemical compound used tube test, and the method of heme polymerization inhibitory activity was Basilico through in vitro method. The results of chemical compound identification of the ethyl acetate fraction of C. Tomentosa showed the presence of flavonoids, terpenoids, saponins, tannins, and anthraquinones. The average percentages of heme polymerization inhibitory activity of ethyl acetate fraction of C. Tomentosa stem from concentration 20; 10; 5; 2.5; 1.25; 0.625; 0.3125 mg / mL were 98.507; 97,872; 96,407; 93,560; 88,419; 80,680; and 45.467%.The averages of IC50 of ethyl acetate fraction and chloroquine diphosphate were 0.24 ± 0.018 mg/mL and 0.214 ± 0.012 mg/mL. This shows that the ethyl acetate fraction of C. Tomentosa stem has heme polymerization inhibitory activity. The result of the independent sample t-Test obtained the significance value of 0.111 (p more than 0.05) that there was no significant difference. It means that the ethyl acetate fraction of C. Tomentosa stem has heme polymerization inhibitory activity as well as chloroquine diphosphate. This suggests the potentiation of the methyl acetate fraction of the stem C. Tomentosa as anti-malarial.
Anti-allergic Activity of 70% Ethanol Extract of Strawberries in Ovalbumin Induced Male Mice Siska; Diene Roufiani; Ema Dewanti
Jurnal Jamu Indonesia Vol. 5 No. 3 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v5i3.167

Abstract

Anaphylaxis is the most common allergic reaction triggered by allergens such as insect poisons, food, and drugs through skin contact, injection, or inhalation. In vitro previous research showed that strawberries fruit have activity as antioxidant, anticancer, anti-inflammation, and anti-allergic. The research aimed to determine the antianaphylaxis strawberry fruit extract in mice (Balb/C strain) with ovalbumin-induced. Twenty-four Balb/C strain mice were divided into six groups (n=4). Group I and II as a normal and control group. Group III till VI as a treatment group was given cetirizine dose 0.042 mg/20 g BW and strawberry extract doses 0,68; 1,36; and 2,72 mg/20 g BW, respectively. This research showed that 70 % of ethanol extract of strawberries fruit have antiallergic activity in response to active cutaneous anaphylaxis. 70% ethanol extract of strawberries doses 2.72 mg/20 g BW had similar antiallergic activity compare with cetirizine. The conclusion of this study showed that strawberries fruit extract could be developed as an alternative medicine to anti-anaphylaxis or anti-allergic.
In Silico Analysis of Antiviral Activity of Analog Curcumin Compounds Esti Mulatsari; Titiek Martati; Esti Mumpuni; Nidya Luciana Dewi
Jurnal Jamu Indonesia Vol. 5 No. 3 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v5i3.173

Abstract

Some studies state that curcumin analog compounds can improve the bioavailability and biological activity of curcumin. One of the methods to predict the bioactivity of curcumin was computational using molecular docking method. This study has done bioactivity tests of curcumin analog compounds as antiviral using the molecular docking method with the software used are PLANTS, YASARA, MarvinSketch, and Pymol for visualization. This study used analog curcumin compounds derived from previous research. This study used five different viral reseptor types. The maraviroc, docosanol, ribavirin, and zanamivir were used as compound control in this research. The validated target protein consists of 5 (five) receptors with PDB codes 1V2I, 4WEG, 2HWI, 2QAD, and 3ALP. Based on this research, compounds that are predicted active as antiviral on each receptors that are: 2,5-bis(3,5-ditertbutyl-4-hydroxy benzyl)cyclopentanone (1V2I), 1,7- diphenyl-1,6-heptadiene-3,5-dione (4WEG), 1,7-bis(3,4-dibenzyloxiphenyl)-1,6-heptadiene-3,5-dione (2HWI), and 2,5-bis(3,5-ditertbutyl-4-hydroxybenzyl)cyclopentanone (3ALP).
Red and White Galangal Puree Antioxidant Activity and Phytochemistry Screening Kana Mardhiyyah; Yunita Intan Ryandini; Yopi Hermawan
Jurnal Jamu Indonesia Vol. 6 No. 1 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i1.174

Abstract

Antioxidant prevents oxidative stress. One of the antioxidant sources is plant. Red and white galangal are herbal plants that are easy to grow and they may have antioxidant activity. The aim of this study was to compare antioxidant activity and phytochemistry screening of red galangal (Alpinia purpurata (Vieill.) K. Schum) and white galangal (Alpinia galanga (L.) Willd.). The method of this study used was the DPPH method and qualitative analysis. The results of this study showed that the value of antioxidant activity of red galangal was significantly higher than white galangal (p<0.05). The results of phytochemistry screening showed that red galangal contained alkaloids, flavonoids, phenolics, tannins, saponins, and triterpenoids. While white galangal contained alkaloids, flavonoids, phenolics, tannins, and triterpenoids. It is can be concluded that red galangal is more effective than white galangal.
Effect of Seaweed Ethanol Extract on Cholesterol Levels and Obesity in White Rats Magfirah; Indah Kurnia Utami; Syafika Alaydrus
Jurnal Jamu Indonesia Vol. 5 No. 3 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v5i3.175

Abstract

Seaweed (EucheumaCottonii J. Agardh) is one of the biological resources found in coastal and marine areas. Seaweed contains secondary metabolites such as flavonoids, alkaloids, polyphenols and tannins which can reduce cholesterol levels in the blood. This study aims to determine the effect of seaweed ethanol extract on reducing cholesterol and obesity levels by comparing plasma cholesterol levels, body weight, and weight of vital organs (liver, kidneys and jantumg) of obese rats, mice given seaweed ethanol extract with normal mice . Rats were grouped randomly into 6 groups. group one was given 0.5% CMC Na, group two was given high fat diet food, group three was given simvastatin, group four was given seaweed ethanol extract 100 mg / kgbb, group five was given ethanol extract of seaweed 200 mg / kgbb and group six was given ethanol extract of seaweed 300 mg / kg with a long suspension of extract for 14 days. Measurement of cholesterol levels in the blood using the CHOD-PAP method, body weight and organs carried out by weighing. The results showed that seaweed ethanol extract has the effect of inhibiting an increase in plasma cholesterol levels and has anti-obesity potential at a dose of 300 mg / kgbb.

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