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<![CDATA[Pengaruh Ekstrak Etanol Daun Binahong (Anredera Cordifolia (Tenore) Steen) Terhadap Penyembuhan Luka Sayat Pada Tikus Putih Jantan ]]>
<![CDATA[Aried Eriadi]]>;
<![CDATA[Helmi Arifin]]>;
<![CDATA[Zet Rizal]]>;
<![CDATA[Barmitoni Barmitoni]]>
<![CDATA[ Jurnal Farmasi Higea Vol 7, No 2 (2015) ]]>
Publisher : <![CDATA[STIFARM Padang ]]>
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DOI: 10.52689/higea.v7i2.127
<![CDATA[Wound healing is a normal process as responds by the skin tissue injury. This research is purposed to see the effects of ethanol extract in binahong leaf to healing the wound of male white rats. There are rats which are divided into five treatment groups, group I (negative control), group II is given providone iodine 10% (positive control), group III, IV and V are given the extract of binahong leaf ointment consist of 5%, 10%, 15% for each. By making a wound on the back of the rats about 20 mm long and 2 mm deep. The ointment is applied based on the treatment for each group twice a day during ten days, the lenght count every day by using caliper. The data is analyzed by using two ways ANOVA and continued by Duncan Test. The result showed that ethanol extract in binahong leaf can heal the wound in scale concentration about 10%-15%, length of wound was decrease on seventh day. The more extract concentration given, the more effect in wound healing]]>
<![CDATA[Penetapan Kadar Protein Secara Kjeldahl Beberapa Makanan Olahan Kerang Remis (Corbiculla moltkiana Prime.) dari Danau Singkarak ]]>
<![CDATA[Henni Rosaini]]>;
<![CDATA[Roslinda Rasyid]]>;
<![CDATA[Vinda Hagramida]]>
<![CDATA[ Jurnal Farmasi Higea Vol 7, No 2 (2015) ]]>
Publisher : <![CDATA[STIFARM Padang ]]>
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DOI: 10.52689/higea.v7i2.123
<![CDATA[A study on protein content of fresh mussel shells, curry soup mussel shells and fried mussel shells by using Kjeldahl method had been researched. The procedur involve destruction, destilation and titration. Each sample were destructed with consentrated sulfuric acid and catalyst mixture of selenium. The solution of sodium hydroxyde was then added to the resulting solution and the amonia liberated was destilled into solution of hydrochloric acid prepared in excess. Its then the hydrochloric solution was titrated with solution of sodium hydroxide 0.1 N using methyl red as and indicator. Protein content can be calculated by multiplying the total nitrogen content of the sample with protein conversion factor (total nitrogen X 6.25). The highest protein content is fried mussel shells 7.1491 % ± 0.0249, than curry soup mussel shells 6.5771 % ± 0.1095 and the last fresh mussel shells 6.3927 % ± 0.0206.]]>
<![CDATA[Studi Sistem Dispersi Padat Asam Mefenamat Menggunakan Polivinilpirolidon K-30 ]]>
<![CDATA[Maria Dona Octavia]]>;
<![CDATA[Erizal Zaini]]>;
<![CDATA[Vina Oktavia]]>
<![CDATA[ Jurnal Farmasi Higea Vol 7, No 2 (2015) ]]>
Publisher : <![CDATA[STIFARM Padang ]]>
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DOI: 10.52689/higea.v7i2.128
<![CDATA[Mefenamic acid was categorized as Non-Steroidal Anti-Inflamatory Drugs (NSAIDs) which has useful as analgesic, anti inflammatory, and antypiretic effect but it has poor solubility in water. The aim of this study was to increase the dissolution rate of mefenamic acid in a solid dispersion system which made by solvent method. Solid dispersion and physical mixture prepared with ratio 1:1, 1:3, and 1:5. Solid dispersion was prepared by solvent method Preparation of solid dispersion mefenamat acid – PVP-K30 in formula 1:3 was increased of dissolution significantly. Characterization of Solid dispersion Mefenamic Acid with Polyvinylpyrrolidone used Scanning Electron Microscopy (SEM), X-Ray, Spectroscopy IR, Differentyal Thermal Analysis (DTA). The result of X-ray diffraction characterization the dissolution Mefenamic Acid-Polyvinylpyrrolidone in which the intensity is visible. The characterization with DTA showed a change in the peak of Mefenamic Acid where the endoterm, the characterization using infrared spectroscopy shows no functional group interaction between Mefenamic Acid and Polyvinylpyrrolidone.]]>
<![CDATA[Toksisitas Sub Akut Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) Terhadap Fungsi Hati dan Ginjal Pada Mencit Putih Jantan ]]>
<![CDATA[Ifora Ifora]]>;
<![CDATA[Helmi Arifin]]>;
<![CDATA[Diana Idrifa]]>
<![CDATA[ Jurnal Farmasi Higea Vol 7, No 2 (2015) ]]>
Publisher : <![CDATA[STIFARM Padang ]]>
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DOI: 10.52689/higea.v7i2.124
<![CDATA[Sub-acute toxicity testing of the ethanol extract of basil leaf (Ocimum sanctum L.) has been done to the liver and kidney function male white mice. This testing includes checks alanine aminotransferase activity, serum creatinine levels and the relative weight of organs (liver and kidney). Extract administered orally at a dose variation of 100 mg/kg, 200 mg/kg and 400 mg/kg for 7, 14 and 21 days. The results showed basil leaf extract at a dose of 100, 200 and 400 mg/kg no significant effect on the activity of SGPT, serum creatinine levels and relative organ weight (p > 0.05).]]>
<![CDATA[Penetapan Kadar Zink Pada Sediaan Farmasi Dengan Metode Kompleksometri dan Spektrofotometri Serapan Atom ]]>
<![CDATA[Dwi Dinni Aulia Bakhtra]]>;
<![CDATA[Zulharmita Zulharmita]]>;
<![CDATA[Valeria Pramudita]]>
<![CDATA[ Jurnal Farmasi Higea Vol 7, No 2 (2015) ]]>
Publisher : <![CDATA[STIFARM Padang ]]>
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DOI: 10.52689/higea.v7i2.129
<![CDATA[Research on the determination of zinc in pharmaceutical preparations have been carried out by complexometry and atomic absorption spectrophotometry. This research aims to determine and compare the levels of zinc in pharmaceutical preparations by complexometry method and atomic absorption spectrophotometry. Samples used zinc tablets were Zinkid® (PT. Indofarma), Zincare® (PT. Kalbe Farma) and Zinc generic tablets (PT. Kimia Farma). Zinc calibration curve at wavelength 213.9 nm used standard solution ZnSO4.7 H2O have correlation coefficient 0.9937 and linear regression equation y = 0.1124 + 0.4403x. Standard deviation 0.088. Detection limit 0.5996 mg/kg and quantitation limit 1.9986 mg/kg. The assay of zinc by complexometry method trademarks Zinkid® obtained zinc content 3.57 %, Zincare® 6.12 % and Zinc generic 3.68 %. While the method of atomic absorption spectrophotometry Zinkid® obtained zinc content 3.64 %, Zincare® 6.19 % and Zinc generic 3.72 %. Result of statistical analysis using t-test, it could be concluded that the method complexometry and atomic absorption spectrophotometry for the determination of zinc in pharmaceutical preparations dosage levels were not significantly different (sig.>0.05).]]>
<![CDATA[Pengaruh Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) Terhadap pH dan Tukak Lambung Pada Tikus Putih Jantan ]]>
<![CDATA[Sri Oktavia]]>;
<![CDATA[Helmi Arifin]]>;
<![CDATA[Ria Irawati]]>
<![CDATA[ Jurnal Farmasi Higea Vol 7, No 2 (2015) ]]>
Publisher : <![CDATA[STIFARM Padang ]]>
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DOI: 10.52689/higea.v7i2.125
<![CDATA[The effect of basil (Ocimum sanctum L.) leaf ethanolic extract on pH and gastric ulcers in male rats induced by ethanolic absolute 1 mL /200 g BW orally has been evaluated. The observed parameters where pH change gastric liquid and ulcer index value. The result indicated that the basil (Ocimum sanctum L.) leaf ethanolic extract at doses of 100 mg/KgBW. 300 mg/KgBW and 900 mg/KgBW significantly decreased the ulcer index with curative ratio where 45.82 %, 62.94 % and 80.65 % (for one time given extracts for two days), 49.13 %, 77.69 % and 94.62 % (for one time given extract for four days) 52.71 %, 77.67 % and 97.21 % (for one time given extract for six days) compared to the positive control. The extracts at 100 mg/KgBW, 300 mg/KgBW and 900 mg/KgBW also significantly decreased the gastric acid pH to its normal value (P<0.05).]]>
<![CDATA[Mikroenkapsulasi Karbamazepin dengan Polimer HPMC Menggunakan Metoda Emulsifikasi Penguapan Pelarut ]]>
<![CDATA[Rina Wahyuni]]>;
<![CDATA[Auzal Halim]]>;
<![CDATA[Yustina Susi Irawati]]>
<![CDATA[ Jurnal Farmasi Higea Vol 7, No 2 (2015) ]]>
Publisher : <![CDATA[STIFARM Padang ]]>
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DOI: 10.52689/higea.v7i2.130
<![CDATA[Microencapsulation of Carbamazepine using HPMC as a polymer by emulsification solvent evaporation method had been studied. Microcapsules had been made into 3 formulation with 3 ratio variation between Carbamazepine and HPMC, 1:1; 1:1.5; 1:2. Microcapsules were evaluated by SEM, DTA, FT-IR, particle sized distribution, drug content and dissolution profile. The evaluation result showed that HPMC as a polymer of sustained release was influence characteristic microcapsules of Carbamazepine. Microcapsules were white to slightly yellow and almost perfectly spherical. Disolution profiles of microcapsules showed that the formula containing the greatest amount of HPMC gave the slower release of Carbamazepine. Resistance release of biggest drug shown by formula 3 giving disolution during 6 hour counted 24.5296 %. Dissolution kinetics of microcapsules allowed Higuchi equation, where the realese of Carbamazepine from microcapsules were controlled by diffution process.]]>
<![CDATA[Pengaruh Proses Pengolahan Terhadap Kadar Beta Karoten Pada Ubi Jalar Varietas Ungu (Ipomoea Batatas (L.) Lam) dengan Metode Spektrofotometri Visibel ]]>
<![CDATA[Fitra Fauziah]]>;
<![CDATA[Roslinda Rasyid]]>;
<![CDATA[Reza Fadhlany]]>
<![CDATA[ Jurnal Farmasi Higea Vol 7, No 2 (2015) ]]>
Publisher : <![CDATA[STIFARM Padang ]]>
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DOI: 10.52689/higea.v7i2.126
<![CDATA[Purple sweet potato (Ipomoea batatas) is one of the agricultural commodities as source of carbohydrates and energy which is included in the family of Convolvulaceae. It is also a good source of vitamins and minerals which is good for nutrition and health. One of the compounds contained in purple sweet potato is beta-carotene. Beta-carotene is a precursor of vitamin A. It is useful as an antioxidant, boosts the immune system and treats other diseases. Beta-carotene is unstable, especially at high temperature. This study aims at answering the question as to how the processing of purple sweet potato can effect to beta-carotene level by using Visible spectrophotometry method. This study is conducted by performing three treatments to purple sweet potato i.e. raw, fried and boiled sample. Weight of raw sample is 10 grams, fried and boiled sample is 15 grams. The sample were extracted by liquid-liquid extraction and it is measured by Visibel spectrophotometer at maximum wavelength of 452.5 nm. The results obtained show that the average level of beta-carotene is 75.91 ±1.92 ppm for raw samples, 63.05 ± 3.45 ppm for fried, and 45.66 ± 0.82 ppm for boiled. The result is statistically calculated by one-way ANOVA statistical analysis. It shows that sig 0.000 (P < 0.05), and it indicates that there is an effect of processing to the average level of beta-carotene contained in purple sweet potato.]]>
<![CDATA[Penetapan Kadar Vitamin C Dari Buah Cabe Rawit (Capsicum frutescens L.) Dengan Metode Kromatografi Cair Kinerja Tinggi (KCKT) ]]>
<![CDATA[Junuarty Jubahar]]>;
<![CDATA[Yuliana Astuti]]>;
<![CDATA[Netty Suharti]]>
<![CDATA[ Jurnal Farmasi Higea Vol 7, No 2 (2015) ]]>
Publisher : <![CDATA[STIFARM Padang ]]>
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DOI: 10.52689/higea.v7i2.131
<![CDATA[The study of vitamin C than ripe fruit cayenne pepper (Capsicum frutescens L.) family solanaceae. Isolation of vitamin C with maceration method using ethanol 70% and performed three repetitions with the same solvent. Purification of vitamin C using semi-polar solvent is chloroform (CHCl3) pro analysis and obtained crystalline vitamin C (202 mg). Crystals obtained qualitative and quantitative testing. Testing quantitative with HPLC method. The study as a comparison of vitamin C using of products from Shadhong Bio Technology in the batch number 371-22109. HPLC data turns cayenne pepper ripe fruit contains vitamin C 0.1180% ± 0.0107 with a retention time of 2.557 and an area of 215843.]]>
<![CDATA[Karakterisasi Kompleks Inklusi Ketokonazol-Β-Siklodekstrin Menggunakan Metode Co-Grinding Berdasarkan Variasi Mol ]]>
<![CDATA[Yeni Novita Sari]]>;
<![CDATA[Syofyan Syofyan]]>;
<![CDATA[Yella Matagi]]>
<![CDATA[ Jurnal Farmasi Higea Vol 7, No 2 (2015) ]]>
Publisher : <![CDATA[STIFARM Padang ]]>
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DOI: 10.52689/higea.v7i2.122
<![CDATA[The research about characterization inclusion complex of ketoconazole-β-cyclodextrin with co-grinding method, with variations 1:1, 1:2,5 and 1:3 has been done. The formed inclusion complexes characterized by x-ray diffraction, IR spectrofotometer, scanning electron microscope and dissolution test. Dissolution test done based on Indonesian Pharmacopeia V Edition using apparatus type 2. The result of research showed that x-ray diphractogram was decreased the peak intensity and change crystalline form to amorphous form, while from IR spectrofotometer was a bit stretch compare with pure ketoconazole which indicate the formation of complex. Based on the results, concluded that the form of inclusion complex can increased dissolution rate from ketoconazole.]]>
