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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
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Articles 22 Documents
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Search results for , issue "Vol 5, No 1 (2023): Volume 5 Edisi 1 2023" : 22 Documents clear
Factors Associated with the Level of Non-Adherence to Take Antituberculosis drugs Garuda Nusantara Putra Utomo; Helmia Hasan; Sulistiawati Sulistiawati
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15616

Abstract

Non-adherence to take antituberculosis drugs is one of the causes of tuberculosis (TB) resistance. However, in Indonesia no study identified the factors associated with the level of non-adherence to take antituberculosis drugs in Multi-Drug Resistant Tuberculosis (MDR-TB) patients when they were still pulmonary drug-sensitive TB survivors. The aim of this study was to identify factors associated with the level of non-adherence to take antituberculosis drugs. This was a cross-sectional study which was conducted from October 2021 to December 2021 at Dr. Soetomo Hospital Surabaya. The dependent variable was the level of non-adherence to take antituberculosis drugs, while the independent variables were age, gender, education level, income, distance from home to health care service, role of health workers, role of superintendent of swallowing drugs (PMO), and side effects. Forty out of the 195 secondary-resistant MDR-TB patients were selected as subjects for this study based on their willingness. The instrument was questionnaire which had been tested for its validity and reliability. The results of bivariate analysis showed that gender, the role of PMO, and side effects had a significance of p0.05. The results of the bivariate analysis indicated that gender, role of PMO, and side effects have significance value p0.05. The conclusion of this study is gender, role of PMO, and side effects are associated with the level of non-adherence to take antituberculosis drugs.
Identifikasi Kandungan Natrium Nitrit Pada Jajanan Ayam Krispi Pedagang Kaki Lima Harli Frimana; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15746

Abstract

Sodium nitrite is a food additive that is often used as a preservative in processed meats such as crispy chicken, but excessive and continuous use can cause toxic effects on the body. The purpose of this study was to identify sodium nitrite in crispy chicken in Pontianak city with limits determined by the Regulation of the Head of BPOM RI No 36 of 2013. The research method used in this study was descriptive non-experimental, where as many as 5 samples of crispy chicken were samples A, B, C, D, and E sold by several street vendors in Pontianak City were obtained using purposive sampling technique. Identification of sodium nitrite was carried out qualitatively using BaCl2, AgNO3, and Griess reagents. A positive result for the BaCl2  if it contains sodium nitrite will result in no precipitate forming, a positive result for the AgNO3 will produce a white precipitate, while a positive result for the griess reagent will produce a red-purplish color. The results of the qualitative test using BaCl2 and AgNO3 showed that none of the 5 samples tested were positive for sodium nitrite, while the qualitative test using griess reagent showed that out of the 5 samples tested there were 2 samples containing positive sodium nitrite, namely samples A and D, so that it can be concluded that samples A and D contained positive sodium nitrite in crispy chicken sold by several street vendors in Pontianak city
Uji Kualitatif dan Penetapan Kadar dengan Metode Spiking pada Logam Pb di Dalam Minuman Kopi Kaleng Husnafa Patriani; Fajar Nugraha; Hadi Kurniawan
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15802

Abstract

Lead (Pb) is a heavy metal that is naturally present in the earth’s crust. This metal is dispersed in nature in small amounts through natural processes. Lead that accumulates in the environment is not biodegradable and its toxicity does not change. Contamination of lead (Pb) meta; in canned drinks can occur due to imperfect packaging, damage or rust. Lead metal is obtained from soldering tools. This study aims to identify the presence of Pb metal in canned coffee drinks. In addition, to find out the method of preparation that was carried out correctly the spiking method was used. Samples were taken in Pontianak City with purposive sampling technique. The sample of this research is canned coffee drinks with 3 different brands (brands A, B and C) circulating in the city of Pontianak. The qualitative test was carried out using 0.5 N KI reagent and 2 M HCl which was dropped into the sample. A positive result on a sample that was dripped with 0.5 N KI reagent was a yellow precipitate, while a positive result on a sample that was dripped with 2 M HCl reagent was a white precipitate. The spiking method was carried out by adding 0.3 mL of 1000 ppm Pb standard solution and adding the sample to a volume of 2 mL. Then, wet digestion was carried out using 10 mL HNO3 and 2 mL H2O2 as solvent. The results of the qualitative test showed that all samples with 0.5 N KI reagent were clear and black precipitate formed. All samples that were dropped with 2 M HCl reagent were clear and no precipitate was formed. In assay by spiking method, the levels obtained are 73.54 mg/kg and % recovery is 86.667%. All tested samples did not contain Pb metal and the preparation method used was correct.
Identifikasi Bakteri Batang Gram Negatif Pada Potongan Kuku Pedagang Nasi Tumpang Di Pasar Tradisional binti mu'arofah; Audit Putra Yulian
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.17284

Abstract

Food is one of the basic human needs, there are many kinds of food vendors scattered around us, including traditional markets. The typical food of the City of Kediri is Rice Tumpang, which is sold in many market areas, picking vegetables by hand directly and on average almost all sellers do not use handscoons. This can cause bacterial contamination from the seller's fingernails to move to the food. Bacteria can enter the nails if the nails are 1-3 cm long, the state of the wound or tear, which is damaged can cause bacteria to enter. Therefore, the cleanliness of the rice seller's nails must be trimmed regularly. This study aims to determine the type of Gram-negative bacteria on the nails of Tumpang rice sellers. The sampling technique used was total sampling. Examination was carried out on 16 samples of nail clippings on the right hand 0.5-1.5 mm. The results of the identification of Gram Negative Rod Bacteria in Nail Clips of Tumpang Rice Sellers at the Traditional Market in Mojoroto, Kediri City were 10 samples of Pseudomonas sp. (62.5%), 3 samples of Klebsiella sp. (18.75%), 2 samples of Escherichia coli (12. 5%), and 1 sample of Proteus sp. (6.25%). These bacteria can be found in the nails of Tumpang rice sellers because they do not apply personal hygiene such as washing their hands with soap, not cutting their nails once a week, when selling they do not use disposable plastic handscoons, and do not always clean the selling area. Conclusion: 10 Pseudomonas sp. samples (62.5%), 3 Klebsiella samples sp. (18.75%), 2 Escherichia coli samples (12.5%), and 1 Proteus sp. sample (6.25%) were obtained.
Prevalensi Kejadian Infeksi HIV Sebagai Screening Test Deteksi AIDS Dengan Metode Imunokromatografi Pada Komunitas Homoseksual erawati erawati erawati; Siska Kusumawardani; Leni Anggraini Puspita Sari
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.17164

Abstract

Human Immunodeficiency Virus (HIV) is a virus that can cause AIDS by attacking white blood cells, namely Cluster Of Differentiation 4 (CD4) cells so it can damage the human immune system. After several years the number of viruses increases so that the immune system is no longer able to fight the incoming disease. Acquired Immuno Deficiency Syndrome (AIDS) often manifests with various opportunistic infections, malignancies, metabolic disorders and others. Homosexual men have a greater risk of contracting HIV/AIDS than heterosexual men, particularly through risky sexual behavior, namely sex with more than one partner and anal sex. This study aims to determine the presence or absence of HIV antibodies in the Homosexual Community at the Pesantren I Public Health Center, Kediri City. The research design used is descriptive research design with quota sampling technique. In HIV testing using the Immunochromatography method with whoole blood the Homosexual Community of Gay. The principle of the examination is a qualitative test method by looking at the color changes on the test strip. The results of the study of 30 respondents, there were 2 positive results of HIV antibodies with a percentage of 7% and 28 negative results of HIV antibodies with a percentage of 93%. The conclusion of this study is that HIV examination using the immunochromatographic method can be used to detect the presence of HIV antibodies and can be used as a screening test for AIDS detection in the Homosexual Community.
Karakterisasi Bobot Jenis dan Identifikasi Kalsium Pada Susu Kedelai Bart Agus Raya; Hadi Kurniawan; Fajar Nugraha
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15830

Abstract

Soy milk is a drink that is good for health because it contains protein, unsaturated fatty acids, vitamins, carbohydrates and important minerals needed by the body such as calcium. Calcium functions to help the process of forming bones and teeth, blood clotting, muscle contraction, transmitting nerve cell signals, maintaining bone density, supplements in lowering LDL cholesterol levels. This study aims to determine the density characteristics of soy milk produced and to identify the calcium content qualitatively in soy milk drinks circulating in Pontianak City. The research method used in this study is descriptive non-experimental using 3 samples of soy milk circulating in Pontianak City with purposive sampling technique. Sample preparation in this study was carried out by wet digestion using HNO3 65% p.a solvent. Qualitative identification of calcium content was carried out using 5% ammonium oxalate reagent. The presence of a white precipitate after the addition of 5% ammonium oxalate indicates a positive calcium in the sample. Characterization of the specific gravity of soy milk was carried out using a pycnometer. The results obtained in this study are samples of soy milk A, B and C are positive for calcium because they form a white precipitate when soy milk samples are added with 5% ammonium oxalate reagent and the density of soy milk A, B and C is 1, respectively. ,00894905 g/mL, 1.008108836 g/mL and 1.008789684 g/mL.
Formulasi Sabun Mandi Padat Ekstrak Daun Jeruk Bali (Citrus Maxima Merr.) sebagai Antibakteri terhadap Staphyloccous aureus Noela Riski Riani Sumbung; Vivin Nopiyanti; Siti Aisiyah; Reslely Harjanti
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.16874

Abstract

Solid bath soap is one of the most common cosmetic preparations used by the public to clean the body from dirt. Grapefruit leaves contain flavonoids that are able to maintain healthy skin, and can inhibit the growth of bacteria. The purpose of this study was to formulate the leaf extract of grapefruit into a solid bath soap that has good physical and stability qualities and to determine its antibacterial effect against S. aureus. Grapefruit leaves were macerated with 96% ethanol solvent then the extract obtained was formulated into solid soap preparations with extract variations, namely 1; 3 and 5%. Furthermore, physical quality and stability tests have been carried out as well as testing the antibacterial activity of the bath soap preparations against S. aureus bacteria by agar diffusion method by means of wells. The final stage was statistical data analysis. The results showed that the solid bath soap preparations with grapefruit leaf extract had good physical quality and stability, the formulation of solid bath preparations with extract concentrations of 1%, 3%, and 5% had antibacterial activity with an average diameter of the inhibition zone against S. aureus bacteria were 5.6 mm, 7 mm and 10.8 mm, respectively, which were included in the moderate to strong category. The formulation with the addition of 5% extract had the most effective antibacterial activity with an average inhibition zone of 10.8 mm.
Uji Aktivitas Antibakteri Minyak Atsiri Kulit Jeruk Pontianak (Citrus nobilis Lour. var. microcarpa) terhadap Bakteri Staphylococcus aureus dan Staphylococcus mutans meri ropiqa; Ika Ristia Rahman; Hadi Kurniawan; Erwan kurnianto
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18170

Abstract

Antibacterial is a substance that can inhibit the growth of bacteria and can kill bacteria that cause infection. Currently increasing resistance to antibiotics is an opportunity to utilize bioactive compounds from the diversity of plants in Indonesia, one of which is by utilizing Pontianak orange peels. Based on some literature, it is stated that essential oils from Pontianak orange peels can inhibit the growth of several types of bacteria. In this study, antibacterial tests were carried out on S.aureus and S.mutans bacteria. The essential oil of Pontianak orange peel was first tested for phytochemical screening and then an antibacterial test was carried out with several concentrations of 5%, 10%, 25%, and 50%, the antibacterial activity test was carried out using the disc diffusion method. The results of the phytochemical screening test showed that the essential oil of Pontianak orange peel contains flavonoids, saponins, and terpenoids. Furthermore, in testing the S.aerues bacteria, the essential oil of orange peel can have an inhibition zone with a range of 9-11 mm which is included in the strong antibacterial category, while in testing the inhibition of S. mutans bacteria, it is included in the moderate category, namely in the range of 7-10 mm. In the statistical test, there was no significant difference in the inhibition of S. mutans and S.aereus bacteria in inhibiting the growth of the orange peel essential oil as indicated by the diameter of the inhibition zone in the different treatment groups according to the concentration of orange peel essential oil.
Standarisasi Parameter Spesifik Ekstrak Etanol Daun Jarak Pagar (Jatropha Curcas L) sebagai Vasorelaxan Fahmi Sadik; Muhammad Zulfian A. Disi
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18187

Abstract

Jarak pagar (Jatropha curcas L.) is traditionally used as a medicinal plant and can be used scientifically to treat various diseases based on the scientific results of herbal medicine. This study aims to prove that the ethanol extract of Jarak pagar leaves (Jatropha curcas L.) meets the specific parameters for extract standardization. The ethanol extract of Jarak pagar (Jatropha curcas L.) leaves was obtained by maceration method, and then the extract was observed for specific parameters, which included an organoleptic test, identification of chemical content, determination of water-soluble juice content, and ethanol-soluble juice content, as well as other tests to see the activity of Jatropha curcas as a vasorelaxant using experimental methods. The results and data of specific parameter characteristics show that the extract made has met the requirements of Indonesian Medical Materials, which means that the ethanol extract of Jatropha curcas leaves made has met the standards, and based on activity testing, it is known that Jarak pagar leaves (Jatropha curcas L.) have the same activity as Vasorelaxan.
Analisis Pengelolaan Obat di Puskesmas X Provinsi Kalimantan Selatan Nida Anisah; Sendi Lia Yunita; Ika Ratna Hidayati
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.17046

Abstract

Drug is an important aspect that needs to be considered in health services. Proper drug management is needed so that the availability of drugs is guaranteed and the quality of drugs is maintained. The purpose of this study was to determine drug management which includes planning, requesting, receiving and storing drugs at X Health care Center. This research is a quantitative research with a descriptive observational research design, using secondary data sources LPLPO and RKO as well as primary data sources by direct observation and 13 indicators were used. The results of the analysis of indicators of conformity of items with Fornas 91.10%, accuracy of planning 18.14%, suitability of items and number of requests 105% and 37.18%, suitability of items and number of receipts 96.83%, storage according to dosage forms 99.19% , storage according to pharmacology 0%, storage in alphabetical order 98.37%, storage according to temperature 97,56%, storage of narcotics and psychotropics according to regulations 83.33%, storage of drugs not used for other storages that cause contamination 100%, arrangement paying attention to FEFO 100% , 83.33% high-alert drug storage, 88% LASA drug storage. It can be concluded that drug management at the X Health Center has met the standard in some indicators.

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