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Majalah Patologi Indonesia
Published by Perhimpunan Ahli Patologi Indonesia
ISSN : 02157284     EISSN : 25279106     DOI : https://doi.org/10.55816/
Core Subject : Health,
Health Professions Public Health
Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 369 Documents
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Ekspresi HER-2 pada Adenokarsinoma Gaster dan Hubungannya dengan Tipe Histopatologik dan Derajat Diferensiasi Diah Setiawati; Diah Rini Handjari; Primariadewi Rustamadji
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background Gastric carcinoma is the most common malignant tumor in upper gastrointestinal. According to epidemiologic data, gastric adenocarcinoma intestinal type and diffuse type showed different carcinogenesis. Recently, targeting therapy for adenocarcinoma has established. The aim of the study to know the relationship between HER-2 expression and histopathologic type according to Lauren’s classification and grading of gastric adenocarcinoma. Methods This study has done in Department of Anatomical Pathology Faculty of Medicine University of Indonesia/Cipto Mangunkusumo National Hospital, Jakarta. HER-2 expression is analyzed to see the relationship with histopathologic type and differentiation of gastric adenocarcinoma. The specimens were from resection and biopsy (2007-2011). Histopathologic type evaluated with Hematoxylin Meyer’s staining. HER-2 expression evaluated with immunostaining with HER-2 antibody. Results We found 55 cases from 2007 until 2011 (76.4% men and 23.6% women). The mean age is 50.55 years (the range of age 29-73 years). HER-2 expression 3+,2+ and 1+ are 14.5%, 34.5%, and 25.5% sampling. 25% sample did not show HER-2 expression. We found overexpression HER-2 (3+) in 8 cases (14.5%) of adenocarcinoma gastric intestinal type. Conclusion There is a significant relation between HER-2 expression with histopathologic type (p=0.021). There is no significant relation between HER-2 with grading (p=0.253). Key words: grading, gastric adenocarcinoma, HER-2.
Ekspresi Protein HER-2/neu pada Berbagai Tipe Karsinoma Ovarium Barliana Barliana; Faroek Hoesin; Dyah Fauziah
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background HER-2/neu is second family of epidermal growth factor receptor (EGFR). Amplification of HER-2/neu gene presented in some carcinoma, especially breast carcinoma. Due to increasing incidency of ovarian carcinoma and its poor prognosis because of chemoresistancy, a study on HER-2/neu expression on ovarian carcinoma is conducted. Methods An observasional analytic design with cross sectional approach. Population and samples were paraffin blocks of many type ovarian carcinoma from archives in the Laboratory of Anatomical Pathology of Dr. Soetomo General Hospital, during January-December 2012. Fourty seven samples were obtained and stained with HER-2/neu antibody. HER-2/neu expression assessed by semiquantitative gradation of intensity. Difference of HER-2/neu expression in many type ovarian carcinoma was analyzed with Chi-Square test by probabilitas exact . Results There were 47 cases with mean age 48.51 years (range 19-68 years). Fourteen cases (29.8%) showed HER-2/neu overexpression (score 3+), Statistical analysis showed significant difference of HER-2/neu expression in ovarian carcinoma (p=0.000; coefficient contingency = 0.606). It was showed musinous and clear cell type had more overexpression of HER-2/neu. Conclusion There was HER-2/neu overexpression in ovarian carcinoma especially in mucinous and clear cell type. Key words: clear cell, endometrioid, HER-2/neu, mucinous, ovarian carcinoma, serous.
Aplikasi Metode Whole Chromosome Painting untuk Mendeteksi Aberasi Kromosom pada Tumor Padat Ecie Budiyanti; Des Suryani; Jeanne Adiwinata Pawitan
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

In solid tumor, conventional cytogenetic method usualy fails to detect chromosomal aberation due to failure in obtaining good quality metaphases. Therefore, special technique is required to get the karyotype of solid tumors. Whole chromosome painting (WCP) is a method to paint the chromosomes using Fluorescence In Situ Hybridization (FISH) technique. Application of WCP, both using one and multiple colors (mFISH or SKY) or their modifications can be used to identify chromosomal aberrations, which are valuable in helping to attain a diagnosis, to determine the prognosis and management, and to predict the response to therapy. Key words: chromosomal aberation, FISH, solid tumor, whole chromosome painting.
Ekspresi Matrix Metalloproteinase-9 (MMP-9), HER-/neu, dan Metastasis Kelenjar Getah Bening pada Karsinoma Payudara Duktal Invasif Threeyana Ariyati Kadi; Faroek Hoesin
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background Lymph nodes metastases is the important major prognostic factor in predicting breast cancer mortality. HER-2/neu overexpression will make worse prognosis. MMP-9 is related to tumor invasion and metastases by their capacity to degrade basement membrane. Assessing HER-2/neu and MMP-9 expression before metastates occur is expected to be useful for prognostic and therapeutic assessment that can prevent patient deaths. Methods A retrospective study with cross sectional analytic approach was done. Assessment was performed on paraffin blocks of breast cancer patients who were diagnosed in Dr. Soetomo Hospitals during January 2011-December 2012 and met the criteria. MMP-9 expression was analyzed imunohistochemically. The relation between MMP-9, HER-2/neu, and lymph node metastases was investigated by Chi Square (2) tests. Results There were 26 out of 40 breast cancer cases with lymph nodes metastases, 22 of 26 cases with MMP-9 overexpression (2+ and 3+), and only 10 cases with HER-2/neu overexpression (3+). MMP-9 overexpression was 12 of 17 cases with positive HER-2/neu. There is statistically significant correlation between MMP-9 expression and lymph nodes metastases (p=0.011); whereas there is no statistical significant correlation between expression of HER-2/neu and MMP-9 (p=0.583) and between HER-2/neu expression and lymph nodes metastases (p=0.435). Conclusion MMP-9 is signifantly correlated with lymph nodes metastases. No significant relationship was found between HER-2/neu, MMP-9 and lymph nodes metastasis. Key words : breast cancer, HER-2/neu, lymph nodes metastases, MMP-9.
Ekspresi Epidermal Growth Factor Receptor dan Karakteristik Klinikohistopatologik pada Karsinoma Kolorektal . Reallyani; Mezfi Unita; Zulkarnain Musa; Syarif Husin
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background Colorectal carcinoma is one of the world's fourth most malignancies. Frequency of colorectal carcinoma malignancy most likely to occur in the gastrointestinal tract and causes the death of close to 15% of all cancers. Heterogeneous of the etiology is associated with many risk factors and molecular changes. Epidermal growth factor receptor is a 170 kDa transmembrane glycoprotein which contribute to carcinogenesis, prognostic impact and specific therapeutic targets. The aims this study to determine the relationship between EGFR expression and the clinicohistopathology characteristics in colorectal carcinoma. Methods This study is an observational study with cross sectional approach. The samples were specimens of the 57 samples that had been diagnosed as colorectal carcinoma from January 2010 to August 2012. Samples from histopathological preparations are reviewed and conducted outward EGFR immunohistochemistry with primary antibodies for the primary tumor. Results EGFR expression to histopathological characteristics are as follows pT3 of 45.6%, positive lymph node status was 52.6% and poorly differentiated histological degree of malignancy of 50.9%. Statistical calculations showed no significant correlation between EGFR expression and histopathologic characteristics of the pT in the TNM system (p=0.037), lymph node status (p=0.000), histological grading of malignancy (p=0.001), and high expression (61.4%). Conclusion EGFR expression affects the pT in TNM system, lymph node staging and histological grading of malignancy. Key words: characteristic clinicohistopathology, colorectal carcinoma, epidermal growth factor receptor.
Ekspresi HER-2/neu dan Ki-67 pada Karsinogenesis Endometrium Febrina Diah Puspitasari; Faroek Hoesin; Dyah Fauziah
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background Endometrial cancer is the most prevalent gynecological cancer in the Western World. In Dr. Soetomo Hospital, endometrial carcinoma is the second commonest cancer affecting women. HER-2/neu is a receptor on the cell surface which activate cellular proliferation. Ki-67 protein is present in the nucleus of cells that are actively undergoing proliferation. The role of HER-2/neu and Ki-67 overexpression in carcinogenesis of endometrial carcinoma is not clear. This study is to determine the difference of HER-2/neu and Ki-67 expression in normal endometrium, simple hyperplasia without atypia, and endometrial carcinoma endometrioid. Methods This study used cross sectional design. Samples were retrieved from Pathology archives at Dr. Soetomo Hospital during January 2011-December 2011. Normal endometrium in proliferation phase, simple hyperplasia without atypia, and endometrial carcinoma endometrioid were collected and stained with immunohistochemistry using HER-2/neu and Ki-67. Statistical analysis with Kruskal-Wallis and Mann Whitney were performed. Result There were 9 samples with glandular proliferation, 18 samples with simple hyperplasia without atypia, and 18 samples with endometrial carcinoma endometrioid type. Statistical analysis showed no significant difference of HER-2/neu expression in proliferation phase, simple hyperplasia without atypia, and endometrial carcinoma endometrioid (p=0.054) but Ki-67 expression had significant difference in proliferation phase, simple hyperplasia without atypia, and endometrial carcinoma endometrioid (p=0.001). Conclusion There was not significant difference in HER-2/neu expression but significant difference in Ki-67 expression on glandular proliferation, simple hyperplasia without atypia, and endometrial carcinoma endometrioid. Key words : endometrioid, endometrium, HER-2/neu, Ki-67, simple hyperplasia without atypia.
Hubungan antara Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Karakteristik Klinikopatologik Karsinoma Payudara Duktal Invasif Huratio Nelson; Heni Maulani; Aida Farida; Irsan Saleh
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background Breast cancer is the most common malignancy and related death of female worldwide. The angiogenesis has an important role in the invasive ductal mammary carcinoma carcinogenesis, and vascular endothelial growth factor (VEGF)is a primary angiogenic factor. The aim of this study is to determine the relationship between the VEGF expression and clinicopatologic characteristics of the invasive ductal mammary carcinoma. Methods It was a cross-sectional study. Fifty-five parafin block samples of mastectomy tissue diagnosed as invasive mammary ductal carcinoma were obtained from the archieves of the Anatomical Pathology Department of RSMH, was stained by immunohistochemical method with anti-VEGF antibody. The result was analyzed in relation to age, tumor size, lymph node status, and histological grade. Results The positivity of VEGF expression was more common in the ≤49 years age of group, in the tumor of ≥9,6 cm size group, in the positive lymph node status, and in the high histological grade. There was a significant correlation between the VEGF expression and the category of lymph node status (p=0.047), as well as histological grade (p=0.020). There was unsignificant correlation between VEGF expression and the age category (p=0.781), as well as tumor size category (p=0.700). Conclusion There was correlation between VEGF expression and lymph node status and histological grade in invasive ductal mammary carcinoma. Key words: clinicopathologic characteristics, invasive ductal mammary carcinoma, VEGF.
Penurunan Aktivitas Proliferasi Sel Adenokarsinoma Mamma Mencit C3H akibat Pemberian Ekstrak Etanol Lengkuas (Alpinia galanga) Susanto Winarko; Yanwirasti .; Aswiyanti Asri; Salmiah Agus
Majalah Patologi Indonesia Vol 23 No 2 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background WHO data in 2011 showed that deaths from breast cancer in Indonesia reached 20,052 peoples of all deaths. This is partly due to the high cost of treatment, so that many people are turning to alternative therapies such as traditional plants. Lengkuas (Alpinia galanga (L) Wild is the traditional material that is cheap and easily available in Indonesia. Lengkuas-containing active substances I-acetoxychavicol acetate (ACA), and according to past research has anti-cancer properties by inhibiting the activity through the inhibition of cell proliferation pathways nuclear factor kappa B (NFƙB). To investigate the effect of ethanol extract of lengkuas against mammary adenocarcinoma cell prolifferation activities in C3H mice with various dose levels. Methods This study was an experimental study using C3H mice with post-test only research design controlled group design. Experimental animals consisted of 32 C3H mice were inoculated with tumor cells and then divided into 4 groups: control group (K) and three treatment groups (P1, P2 and P3) were given graded doses of ethanol extract of lengkuas 225 mg/kgBW/day, 450 mg/kgBW/day and 675 mg/kgBW/ day for 2 weeks. After all mice were terminated, examined the proliferative activity of tumor cells with Ki-67 antibody. Differences in proliferative activity between the groups were tested using one-way anova followed by post hoc Bonferroni test. Results There were significant differences in proliferative activities (p=0.000) among the four groups. By the post hoc Bonferroni analysis was found the significant differences in proliferative activities between the control group P1, with P2 controls, P3 control group, between P1 with P3 group, P2 with P3 group (p=
Korelasi antara Imunoekspresi LMP-1 Virus Epstein-Barr dengan Respon Kemoterapi CHOP pada Limfoma Maligna Non-Hodgkin Tipe Diffuse Large B Cell. Inas Susanti; Hasrayati Agustina; Bethy S Hernowo
Majalah Patologi Indonesia Vol 23 No 2 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background Diffuse large B cell lymphoma is the most common type of B-cell non-Hodgkin malignant lymphoma. Epstein-Barr virus (EBV) has been shown to contribute to the development of this tumor especially in the elderly patient (above 50 years). The chemotherapeutic agents CHOP (Cyclophospamide, Hydroxydaunorubicin, Oncovin, Prednison) are standard treatment for non-Hodgkin lymphoma patients, but approximately 30% cases shows non-respone with standard chemotherapy and undergoes progressive disease until death. There are no accurate predictor factors in predicting CHOP chemotherapy respone in patients with DLBCL. The aim of this study is to determine the role of LMP-1 in predicting CHOP chemotherapy respone in patients with DLBCL. Methods This study was done retrospectively in 34 cases of DLBCL. The samples were obtained from the Anatomic Pathology Department of Dr. Hasan Sadikin Hospital from January 2009 to Desember 2011. All cases were reviewed for histopathological diagnoses based on the WHO Classification of 2001 and the specimens were stained with specific antibodies against CD 20 (for diagnoses DLBCL) and LMP-1. The data were analized using rank Spearman’s correlation test. Results This study showed that 31 cases (91.18%) were LMP-1 positive, only 3 cases (8.82%) were negative. Three cases of negative LMP-1 had a good respone to chemotherapy, whereas among 31 positive cases LMP-1 showed good respone to chemotherapy in 21 cases and the remaining 10 cases had a poor respone to chemotherapy. There was no correlation between EBV-LMP-1 immunoexpression with CHOP chemotherapy respone in DLBCL (p=0.436). Conclusion There was no correlation between EBV-LMP-1 immunoexpression with CHOP chemotherapy respone in DLBCL. Key words: CHOP, DLBCL, EBV, LMP-1, non-Hodgkin lymphoma.
Analisis Gambaran Histopatologi Gastritis Kronik dengan dan Tanpa Bakteri Helicobacter pylori Menurut Sistem Sydney Deassy Ariefiany; Abdul Hadi Hassan; Birgitta M Dewayani; Anglita Yantisetiasti
Majalah Patologi Indonesia Vol 23 No 2 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background Histopathology definition of chronic gastritis is a chronic inflammation of the gastric mucosa that can cause glandular atrophy and intestinal metaplasia of the gastric mucosal epithelium. Chronic gastritis can be caused by many factors. The most common etiology chronic gastritis by the bacterium Helicobacter pylori (Hp). The incidence chronic gastritis causes of Hp is more common in developing country than developed country. Histopathological picture on chronic gastritis causes of Hp similar with chronic gastritis non-Hp. The aims of this study to determine the difference of histopathological picture between chronic gastritis with Hp and chronic gastritis without Hp bacteria in the Hospital Dr Hasan Sadikin Bandung. Methods The sample used in this study were 30 cases of chronic gastritis with Helicobacter pylori (Hp) and 30 cases of chronic gastritis non-Hp bacteria from the Pathology Department of the hospital Dr. Hasan Sadikin Bandung. The research start from May 1st until November 30th 2012. All sample cases histopathology is seen the image of the Sydney sistem classification, after that are staining with immunohistochemical with antibody monoclonal Hp was performed to confirm the presence of the Hp. Results Immunohistochemical staining result obtained from 42 cases of the bacteria Hp positive and 18 negative cases the bacteria Hp. Chronic inflammation in chronic gastritis with Hp with chronic gastritis without Hp bacteria are in category 3 (limfosit cell more than 20/10HPF) as much as 88,1% and 88,9%. Conclusion Histopathological picture of chronic gastritis with Hp bacteria did not differ with chronic gastritis without Hp bacteria. Key words: Chronic gastritis, Helicobacter pylori, Sydney system.

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