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Bioscientia Medicina : Journal of Biomedicine and Translational Research
Published by Universitas Sriwijaya
ISSN : -     EISSN : 25980580     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience
BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.
Arjuna Subject : Kedokteran - Anatomi
Articles 1,209 Documents
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The Influence of Knowledge, Attitudes and Behavior of Cleaning Officers with the Number of Mosquito Larvae in the Water Reservoir Punti Kayu Palembang City Aldi Alfian; Chairil Anwar; Iche Andriyani Liberty
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 3 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i3.217

Abstract

Background Mosquito was one of the animals that can transmit deadly diseases.Information about water reservoirs as their habitat as well as human knowledge,attitudes and behavior factors are considered important to help eradicate mosquito.This study aims to determine the effect of knowledge, attitudes and behavior ofcleaners on the number of mosquito larvae in water reservoirs in Palembang.Methods This research was mixed method research (quantitative and qualitative) inthe field and laboratory. The research samples were all mosquito larvae andcontainers found. The research respondents were all cleaning services. Data werecollected by interviewing and filling in questionnaires, observing water reservoirsand identifying the types of mosquito larvae in microscope. Results A total of 40containers were found in Punti Kayu Nature Park. There were 8 containers that wereindoors (20%) and 32 containers were outdoors (80%) with 17 containers containedlarvae. Of all the containers that were positive for larvae, 6 were filled with clearwater and 11 were filled with turbid water. The number of larvae found were 358larvae outdoors and 82 larvae indoor with a total of 440 mosquito larvae with thegenus Culex spp. and Aedes albopictus species. The index of mosquito larvae wereobtained FLI (Free Larva index)=66,67%, HI (House Index)=33,33%, CI (ContainerIndex)=16,67%, BI (Breteau Index)=33.33% from the 3 buildings examined. Fromthese results, it was obtained DF (density figure) or density level of 5. There were 40containers that could be habitats for Culex spp. and Aedes albopictus. ConclusionThe knowledge, attitude and behavior of the cleaning services were good. Thenumber of mosquito larvae could be influenced by the frequency of cleaning and thelack of knowledge of the cleaning services.
Comprehensive Obstetric and Neonatal Emergency Services (PONEK) to Reduce Infant Mortality and Improve Maternal Health Irawan Sastradinata
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i2.218

Abstract

The Millennium Development Goals (Millennium Development Goal's) in2015, there are two targets and indicators that are specifically related tothe health of mothers, infants and children. The Millennium DevelopmentGoal's (MDG's) are for the hospital to implement the PONEK program(Comprehensive Obstetric Neonatal Emergency Services) for reduce infantmortality and improve maternal health. Maternal and perinatal servicesmust be organized in a teamwork and integrated between medical, nursing,midwifery and support services. The hospital as a health serviceorganization for the community needs to make continuous qualityimprovement, which continuously improves performance andservice quality in order to meet the demands of consumers and thehospital environment.
Ferning, Schimer I and Tear Break Up Time (TBUT) Accuracy Test in Post-Operative Cataract Patient with Extra Capsular Cataract Extraction (ECCE) Technique Anang Tribowo; Alie Solahuddin; Lady Kavotiner; Theodorus; Vidya Hestika
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 2 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i2.219

Abstract

A B S T R A C TObjective: To determine the accuracy of the Ferning, Schimer I and TBUT test incataract patients after cataract surgery with the ECCE technique at the EyePolyclinic at Mohammad Hoesin Hospital Palembang and the Special Eye HospitalPalembang Methods: Diagnostic test was undertaken at the Eye Polyclinic atMohammad Hoesin Hospital Palembang and the Special Eye Hospital Palembangfrom May 2019 to January 2020. There were 42 postoperative cataract patients whomet the inclusion criteria. Ferning, Schimer I and TBUT tests were performed beforesurgery and one month after surgery. Data analysis using SPSS version 22.0 (SPSS,Inc Chicago, Illinois). Results: Fourty two samples of postoperative cataract surgerywith ECCE technique obtained by female sex (57,1%) with a mean age of cataractpatients of approximately 58.09 years. The accuracy of Schimer I and TBUT is 0.952with 100% sensitivity, 50% specificity, 95% positive predictive value (PPV) and 100%negative predictive value (NPV), the accuracy of TBUT and Ferning is 0.881 with90.2% sensitivity, 0% specificity , positive predictive value (PPV) 97.4% and negativepredictive value (NPV) 0% while the accuracy of Ferning and Schimer I was 0.928with a sensitivity of 97.5%, specificity of 0%, positive predictive value (PPV) of 95.1%and negative predictive value (NPV) 0%. Conclusion: Schimer I test is more accurateto use as a predictor of dry eye in postoperative cataract patients than Ferning andTBUT
The Role of Serum Omega 3 Levels on Muscle Mass, Muscle Strength, and Physical Performance in the Elderly Community Welly Salutondok; Nur Riviati; Yulianto kusnadi; Erial Bahar; Nova Kuniati; Syamsu Indra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 3 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i3.220

Abstract

A B S T R A C TIntroduction. Old age is related to geriatric syndrome where there are several healthproblems that often occur related to a decrease in body function and an increase inthe inflammatory process. Decrease in muscle mass, muscle strength and physicalperformance will lead to a condition of sarcopenia and frailty syndrome in the elderly.The importance of prevention so that sarcopenia does not occur in the elderly byevaluating the factors that can cause it, one of which is controlling nutritional factors(macro and micro nutrients), such as in research, namely omega-3 macronutrients.The purpose of this study was to determine the correlation between serum omega-3levels with muscle mass, muscle strength, and physical performance in the elderlycommunity at Moehammad Hoesin Hospital Palembang. Methods. This research isan observational analytic study with a cross-sectional approach which wasconducted at the Integrated Geriatric Clinic Internal Medicine RSMH Palembangfrom November 2019 to November 2020. A sample of 21 people aged> 60 years wasexamined for muscle mass, muscle strength, physical performance and omega-levels. 3 serums. All data processing and analysis in this study used SPSS version25 for Windows. Results. Of the 21 subjects, it was found that women were 19people (90.5%) and 2 men (9.5%). The mean value of muscle mass was 37.65 ± 5.7,hand grip strength was 24.04 ± 5 kg, and walking speed was 6.72 ± 1.8 seconds per6 meters. There were 11 subjects with low serum omega-3 levels of 485.25 ± 110.19mg. There was a significant relationship between serum omega-3 levels and musclemass (p = 0.041) with moderate correlation strength (r = 0.448). Conclusion: Musclemass has a significant relationship with serum omega-3 levels in the elderly withmoderate strength. Meanwhile, muscle strength and physical performance did nothave a significant relationship.
Comparison of the Effectiveness 3% Tranexamic Acid Cream Versus 4% Hydroquinone Cream for Treatment of Epidermal Type Melasma Hartika Ketty Marpaung; Theresia L. Toruan; Yuli Kurniawati; Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 3 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i3.221

Abstract

Background: Melasma is an acquired hypermelanosis in areas that are exposed to sun. especially in face. Severity of melasma is measured using modified Melasma Area Severity Index (mMASI) and Melanin Index (MI). Hydroquinone (HQ) is an effective drug and also a gold standard in terms of melasma treatment. However. thedrawback of hydroquinone is the treatment duration which is quite long. the occurence of side effects. and also recurrence potential. Several recent studies shows that one of the anti-pigmentation agent options. the tranexamic acid (TA). is able to prevent melanocyte activation. The results of various studies found that the use of TA showed a significant improvement in MASI scores. Objective: To compare the effectivity of 3% TA cream with 4% HQ cream as an alternative therapy in epidermal type melasma treatment. Methods: A double-blind. matched. randomized clinical trial was conducted during July 2019 until August 2019 at Dr. Mohammad Hoesin General Hospital Palembang. Subjects were divided into two groups. The first group. consists of 30 participants. get 3% TA cream; and the second group. consists of 30 participants. get 4% HQ cream. Subjects who fulfilled the inclusion criteria was included through a simple randomization. Study subjects wer given random cream pot (with label A or B on it) according to the result of simple randomization. Finally. every subjects’ melasma severity was measured using mMASI and mexameter ® . Results: There were differences in terms of baseline. 4 th weeks and 8 th weeks after treatment mMASI scores in 3% TA and 4% HQ group. At 8 th week. the mMASI score the 3% TA group was lower than 4% HQ group. There was no differences in baseline. 4 th weeks and 8 th after treatment MI between the two groups. Melanin index for 3% TA group was lower than 4% HQ group. Conclusion: Three-percent TA cream and 4% HQ cream is effective in decreasing mMASI score and MI in epidermal type melasma. There were differences in terms of the mMASI score during the 8th week after treatment between 3% TA and 4% HQ group.
Activity of Cytochrome P450 Monooxygenase (CYPs) Metabolic Enzymes as Markers of Insecticide Resistance in Anopheles vagus Muara Enim Mosquitoes, Indonesia Dalilah; Muhaimin Ramdja; Dwi Handayani; Lasbudi P Ambarita; R. Irpan Pahlepi; Ahmad Ghiffari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 4 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i4.222

Abstract

The use of synthetic pyrethroids in insecticide-treated bed nets (LLINs) and spray form (IRS) has been carried out since 2012 in Muara Emil Village and since 2016 in all villages in Tanjung Agung District, Muara Enim Regency. Biochemical resistance can occur to the enzymes that play a role in detoxifying the insecticide. This study aims to identify whether there is an increase in the levels of the enzyme Cytochrome P450 monooxygenase (CYPs) through the enzyme biochemical test on the malaria vector mosquito Anopheles vagus originating from Pagar Dewa Village and Muara Emil Village, Muara Enim Regency. The sample of female Anopheles mosquitoes was not full. Blood was taken at night using the resting collection method. Mosquitoes that have been identified as Anopheles vagus species are used to check CYPs enzyme levels using the ELISA method. The results of the biochemical test showed that enzyme levels increased from the Muara emil and Pagar Dewa village mosquitoes with a percentage of 71% and 61.53% (with cut off point OD> 0.165). The value of CYPs enzyme levels for mosquitoes from Muara Emil village was higher than that of the mosquitoes from Pagar Dewa Village (mean 0.005027 ± 0.007). The increased activity of the CYPs enzyme plays a role in the detoxification of synthetic pyrethroid insecticides that can cause resistance. The high levels of enzymes from the villages of Muara Emil and Desa Farah Dewa are in line with intensive insecticide exposure in eradicating malaria vectors in the highest malaria transmission areas in Muara Enim Regency.
The Effect of Ethynil Estradiol and Desogestrel on Proliferation and Apoptosis Hydatidiform Mole Trophoblast Cell Irawan Sastradinata; Andrijono; Mohamad Farid Aziz; Wan Lelly H; Sri Hartini; Bambang Sutrisna
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 4 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i4.223

Abstract

Background: To explore the effect of ethynil estradiol and desogestrel on proliferation and apoptosis hydatidiform mole trophoblast cell. Methods: From April 2008 until March 2009, we collected 15 samples of hydatidiform mole tissue. Trophoblast cells was isolated and culture at RPMI 20% FBS medium. Only 7 samples (46%) shown good growth. Cell was identified using cytology and β HCG test. Trophoblast cells good quality than devided into three groups observation. First group get ethynil estradiol 10 nmol/mL, second group get desogestrel 100 nmol/mL, Third group get DMSO 1%. Cells incubated and observe at 24, 48, 72, 96 hours. Cell cycle, apoptosis and β HCG was evaluated at each time observation. Cell cycle evaluation using BD cycle test plus DNA reagent, apoptosis evaluation using FITC-Annexin V. Analyze using FACSCalibur flowcytometer. β HCG evaluation using Abbott AxSym total β-HCG reagent pack. Results: The group of cell that get ethynil estradiol in concentration 10 nmol/mL had cell proliferation index, amount cells and β HCG level higher than control after 72 hours observation. The group of cell that get desogestrel in concentration 100 nmol/mL have cell proliferation index, amount cells and β HCG level lower than control after 48 hours observation. There are no differences of apoptosis between the two group and control. Conclusion: Ethynil estradiol will increase proliferation of hydatidiform mole trophoblast cell, while desogestrel will decrease proliferation of hydatidiform mole trophoblast cell. There are no effect of ethynil estradiol and desogestrel on apoptosis of hydatidiform mole trophoblast cell.
Relationship between Interleukin 6 Serum Levels and Degree of Depression in Systemic Lupus Erythematosus Patients Internal Disease in Dr. Moh Hoesin Palembang Shinta Suharno; Eddy Mart Salim; Ali Apriansyah; Taufik Indrajaya; Zen Ahmad; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 3 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i3.224

Abstract

Introduction. Systemic Lupus Erythematosus (LES) is a chronic autoimmune inflammatory disease affecting many organ systems with varied clinical manifestations, disease course and prognosis. One of the clinical manifestations that can occur is depression as much as 25%. In LES patients, there is an increase in proinflammatory cytokines, one of which is IL-6, which is often associated with contributing to the pathophysiology of depression. The purpose of this study was to determine the relationship between serum IL-6 levels and the degree of depression in LES patients at RSUP DR. Mohammad Hoesin Palembang. Methods. Analytic observational study in the form of correlation test with cross sectional design which was conducted in the Internal Medicine room RSUP DR. Mohammad Hoesin Palembang from May 2019 to March 2020. The number of study subjects was 40 samples who were LES patients with depression who had been calculated using the BDI (Beck's Depression Inventory). All subjects were examined for serum IL-6 levels and evaluated for factors that influence it. Results. There were 40 study subjects aged 18-56 years. The median degree of depression was 16 with a range of values from 10 to 40. There were 17 people (42.5%) with mild depression degree, 14 people (35%) moderate depression, and 9 people (22.5%) major depression. In LES activities, there were 5 people (12.5%) with light LES activities, 20 people (50%) with moderate LES activities, and 15 people (37.5%) with heavy LES activities. The mean serum IL-6 level was 11.57 pg / mL with a value range of 1.1-50pg / mL. There was a significant correlation between the degree of depression and LES activity (p = 0.004; r = 0.444) and between serum IL-6 levels and the degree of depression (p = 0.025; r = 0.169). However, there was no significant correlation between serum IL-6 levels and LES activity (p = 0.057; r = 0.304). Conclusion. There is a relationship between serum IL-6 levels and the degree of depression in LES patients at Dr. Moh. Hoesin Palembang with a very weak correlation.
Correlation of Vitamin D Serum Levels with Muscle Mass, Muscle Strength, and Physical Performance in the Elderly Community in Mohammad Hoesin General Hospital Palembang Noveldy Calzoum Bachry; Nur Riviati; Yulianto kusnadi; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 3 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i3.225

Abstract

Background: Older people tend to have decreased activity and intake of macronutrients and micronutrients that are not in accordance with the body's needs. Research in 2017 on elderly men and women at the Center for Family Compensation (PUSAKA) in Central Jakarta showed that 80.2% of elderly people have vitamin D deficiency. Low serum levels of vitamin D in the body are the initial risk of decreased muscle mass and physical performance in old age. where there is a significant correlation between low serum vitamin D levels in the body with sarcopenia and mortality. The purpose of this study was to determine the correlation of vitamin D levels with muscle mass, muscle strength and physical performance in the elderly community at RSMH Palembang. Methods: This research is a study analytic observation with a cross-sectional approach that was carried out at the Integrated Geriatric Clinic Internal Medicine RSMH Palembang from November 2019 to November 2020. A sample of 34 people aged> 60 years were examined for muscle mass, muscle strength, physical performance and serum vitamin D levels. All processing and analysis The data in this study used SPSS version 25 for Windows. Results: From 34 subjects, it was found that there were 29 women (85.3%) and 5 men (14.7%). The mean value of muscle mass is38.76 ± 4.1 kg / m2, long runs within 6 meters 6.12± 0.9 m / sec, and hand grip strength 24.9 ± 5.2 kg. It was found that 18 (62.1%) female samples had vitamin D deficiency while 11 (37.9%) samples had vitamin D insufficiency. There was a significant correlation between muscle mass and hand grip strength with vitamin D with weak correlation strength and length of walking with vitamin D with moderate correlation strength. Conclusion: There is a significant correlation between muscle mass and grip strength and walking time of 6 meters with vitamin D.
Correlation between the Serum Level of Interleukin-2 in Hemodialysis Patients and Severity of Renal Pruritus Radema Pranata; Yuli Kurniawati; Fitriani Fitriani; Legiran; Soenarto Kartowigno; Nopriyati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 5 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i5.226

Abstract

Renal pruritus (RP) is a condition or symptom that is often found in end-stage chronic kidney disease (CKD) undergoing hemodialysis (HD). The etiology of RP is multifactorial, one of it due to inflammation mediated by interleukin 2 (IL-2). Study on the correlation between serum level of IL-2 and the severity of RP is still limited. This study will analyze the correlation between serum level of IL-2 in patients undergoing HD and the severity of RP. Our method is cross sectional design at Hemodialysis Installation of Dr. Mohammad Hoesin Hospital. Serum level of IL-2 examined by ELISA, the severity of RP assessed by a 5 dimensional pruritus scale. Inclusion criteria in this study included HD patients with RP ≥ 9, age ≥ 18 years and willing to sign informed consent. The results from 28 male (59.6%) and 19 female (40.4%) are the mean serum level of IL-2 (pg/ml) is 0.424 ± 0.077. The mean RP severity score is 18.98 ± 2.74. A strong positive correlation between serum level of IL-2 and the severity of RP (r = 0.750, p = 0,000). Our conclusion is the increase of serum level IL-2 in line with severity of RP.

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