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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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Risk Factors Related Amputation on Diabetic Foot Patients in Dr. M. Djamil General Hospital Padang Eko Rizki; Raflis Rustam; Vendry Rivaldy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.506

Backgrounds. Diabetic foot is the most common cause of nontraumatic lower-extremity amputation. This study aims to assess the relationship of risk factors with the incidence of amputation in diabetic foot patients based on the Wagner classification at Dr. M. Djamil General Hospital Padang. Methods. The study design is an analytic observational study with a cross-sectional approach. A total of 46 diabetes mellitus patients with diabetic foot complications participated in this study. The risk factors assessed were gender, age, smoking status, hypertension, uncontrolled blood sugar, hypoalbumin, peripheral arterial disease, infection, and peripheral neuropathy. The assessment of the degree of diabetic foot complications was carried out using the Wagner classification. Results. The most age group for diabetic foot sufferers is the age group of 41-60 years, which is 57.7% with the male sex being more dominant (59.6%) than the female gender. In the subject, there were more patients with the Wagner 4 classification (32.7%) than the other classification levels. Based on direct observation of patients, it was found that 53.8% of diabetic foot patients were amputated. Based on the results of the analysis, it was found that PAD (peripheral arterial disease) and peripheral neuropathy are variables that significantly affect amputation. Conclusion. Peripheral neuropathy and peripheral arterial disease are associated with amputation and peripheral arterial disease is a major risk factor for amputation in diabetic foot patients based on the Wagner classification.

Post-Concussion Syndrome Latent Onset Related to Intracranial Lesion on Head Injury Patient in Dr. M. Djamil General Hospital Padang Pela Meyadsa; Saiful Saanin; Hesty Lidya Ningsih
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.507

Background. Post-concussion syndrome is associated with damaged axons in patients with a mild head injury but little is known about their consequences for brain tissue. This study aims to examine the relationship between latent onset post-concussion and intracranial lesions in head injury patients at Dr. M. Djamil General Hospital Padang. Methods. The research design is an analytical observational study with a cross-sectional approach. A total of 25 patients with head injuries participated in this study with inclusion criteria being hospitalized patients alive without physical and mental disabilities and patients diagnosed with latent onset post-concussion syndrome (PCS) without any additional diagnoses for patients with a history of trauma. Results. The average age of the respondents in this study was 34.08 ± 17.45 years and more than half of the respondents were male, namely 18 (72%) respondents. half of respondents with persistent PCS symptoms > 6 months experienced EDH, as many as 5 (55.6%) respondents, ICH 2 (66.7%) respondents, and cerebral contusion 6 (60%) respondents. The results of statistical tests showed that there was no relationship between latent onset PCS and lesion appearance (p>0.05). The results of statistical tests showed that there was no relationship between latent onset PCS and the degree of head injury (p>0.05). Conclusion. There is no significant relationship between post-concussion syndrome (PCS) latent onset with a degree of head injury and lesion description in head injury patients at Dr. M. Djamil General Hospital Padang.

Correlation of Voice Handicap Index 10 with Reflux Symptom Index and Reflux Finding Score in Patients with Dysphonia Ari Utama; Lisa Apri Yanti; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.508

Background. Voice disturbance occurs when the quality, pitch, loudness, or flexibility of other people's voices differ according to age, gender, and similar cultural groups. The Voice Handicap Index (VHI) is one of the most widely used tools worldwide to measure the physical, functional, and emotional aspects of voice disorders. This study aims to determine the correlation of voice handicap index-10 with reflux symptom index and reflux finding scores in patients with dysphonia complaints at Dr. Mohammad Hoesin General Hospital Palembang. Methods. This study is a cross-sectional study using a correlation test design that aims to determine the correlation between VHI-10 and RSI and RFS in patients with dysphonia complaints. Results. The sample of this study includes the demographic factors of the research subjects, namely age, gender, and occupation. This study shows that patients with RFS ≥ 7 affect the VHI-10 score ≥ 11 with a proportion of 72%. Conclusion. There is a moderate positive correlation between the RFS score and the VHI-10 score, where the higher the RFS value, the higher the VHI-10 score in patients with dysphonic complaints.

Comparison of Burn Wound Histopathology Imaging between Epidermal Growth Factor Spray and Silver Sulfadiazine Application: An Invivo Study Muhammad Ihsan; Rizki Rahmadian; Benni Raymond
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.509

Background. Luka bakar adalah luka pada kulit atau jaringan organik lain yang dapat disebabkan oleh panas, radiasi, listrik, dan kontak dengan bahan-bahan kimia. Studi ini bertujuan untuk mengetahui perbedaan gambaran histopatologi luka bakar derajat 2 dengan pemberian epidermal growth factor (EGF) spray dengan silver sulfadiazine (SSD) pada hewan coba. Methods. Desain penelitian ialah studi eksperimental dengan pendekatan post test only with control grup design. Sebanyak 27 ekor healthy male Wistar rats digunakan dalam studi ini (berat 200-300 gram; usia 8 minggu). Hewan coba dikelompokkan menjadi 3 kelompok yakni kelompok control (K), kelompok perlakuan EGF spray (EGF) dan kelompok perlakuan silver sulfadiazine 1% (SSD). Pemeriksaan histopatologi luka dilakukan dengan pewarnaan hematoxylin-eosin. penilaian histopatologi dengan kriteria Burkitt. Results. Rata-rata pengukuran ketebalan epidermis permukaan luka bakar pada kelompok perlakuan baik SSD maupun EGF memperlihatkan epidermis yang lebih tebal dibandingkan kelompok kontrol. kepadatan leukosit pada jaringan granulasi kelompok perlakuan SSD maupun EGF lebih rendah dibandingkan kelompok kontrol, yaitu 107,0 dan 85. Conclusion. Pemberian EGF spray menunjukkan gambaran histopatologi yang lebih baik dibandingkan kelompok kontrol dan kelompok SSD pada luka bakar derajat 2, terutama pada proses regeneratif sel, penekanan inflamasi, dan perbaikan epitelial.

Inhibitory Effect of N-Hexane Fraction of Cherry Parasite (Dendrophthoe pentandra L.) on Alpha Glucosidase Sadakata Sinulingga; Putriana Fuji Safitri; Subandrate
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.399

Background. Cherry parasite (Dendrophthoe pentandra L.) is a semi-parasitic plant that takes food from host body, so that phytochemical same as host plant. These phytochemicals have effect to inhibiting the action of the enzyme alpha glucosidase, such as flavonoids, saponins, tannins, alkaloids, and terpenoids/steroids. The aim of this study is to find out the effect of the cherry parasite to inhibiting the enzyme alpha glucosidase. Methods. This is an in vitro experimental study. Cherry parasite was fractionated with n-hexane and reacted by enzyme. Acarbose used as a positive control. The inhibitory effect on the alpha glucosidase was determined from the IC50 value by measuring the absorbance of p-nitrophenol using spectrophotometry as a result of the reaction of the enzyme. Screening phytochemical to determine the phytochemical of n-hexane fraction. This research was conducted at the Laboratory of Biochemistry and Medical Chemistry, Faculty of Medicine, Universitas Sriwijaya, Palembang. Results. The yield of n-hexane fraction was 7%. Phytochemical test showed that the sample contain flavonoids and terpenoids. IC50 value of n-hexane fraction was 106,333 ppm and categorized not active. Conclusion. The n-hexane fraction of cherry parasite contains flavonoids and terpenoids that considered not active to inhibiting the action of the enzyme alpha glucosidase.

The Comparison of p16 Protein Expression between Single and Multiple Seborrheic Keratosis Indri Widya Sari; Yulia Farida Yahya; Suroso Adi Nugroho; Erial Bahar; Ika Kartika
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.510

Background. Seborrheic keratosis (SK) is a benign epithelial tumor that attacks adults, the elderly, and an increasing number of age-related lesions. Various risk factors influence the pathogenesis of SK, including genetic predisposition and sun exposure. Recently, SK associated with a theory of keratinocytes aging. The aging prevents unlimited and uncontrolled growth of damaged cells, thereby preventing degeneration, but on the other hand, increases the resistance of the cells to apoptosis. From previous studies, the expression of p16 protein increased substantially with age, thus enabling it to be a biomarker of cellular aging at the molecular level. This study was aimed to determine p16 protein expression between single and multiple seborrheic keratoses, the relationship between p16 protein expression in single and multiple SK, and p16 protein expression in the elderly. Methods. Observational study with a cross-sectional design was used to determine the comparison of p16 protein expression between single and multiple seborrheic keratoses was conducted from December 1, 2021, to January 31, 2022. According to the inclusion criteria, study participants with a total of 42 people were selected through the consecutive sampling method. Physical examinations, dermoscopic and histopathologic were carried out until the results were obtained. Then the data were analyzed using the Fisher Test, Chi-Square, with a 95% confidence interval (p <0.05). Results. Most SK patients were found in the age range of 60-69 years (38%), male gender (54.8%), sun-related occasional 3-6 hour per day (50%), location of SK in sun-exposed areas (83.3%), the number of multiple lesions (69%), size 1-2 cm (57.1%), disease duration > 3 years (54.8%), and have no comorbid (69%), an acanthotic subtype of SK (40.5%). All single SK patients have a negative-weak expression of p16 protein (38.2%). Multiple SK patients have a moderate-strong expression of p16 protein (100%) and negative-weak expression of p16 protein (61.8%). Based on statistical analysis using Fisher Exact test has a statistically significant to p16 protein expression with number SK lesion (p-value 0,043). Conclusion. There is a significant correlation between p16 protein expression with single and multiple SK. The study has several limitations. The sample size was small. Other supporting examinations are needed in SK, including polymerase chain reaction (PCR).

Arrhythmia Mechanism on Diabetes Mellitus: A Narrative Review Ricky Juliardi Mezal; Hauda El Rasyid
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.511

Diabetes mellitus is a metabolic disorder characterized by an increase in blood sugar levels. The mechanism of arrhythmias in patients with diabetes mellitus is complex and unique. This is an independent factor in the occurrence of arrhythmias through several slightly different mechanisms in non-diabetics. Hyperglycemia, hypoglycemia, remodeling, autonomic neuropathic dysfunction, fibrosis, and oxidative changes, and metabolic stress play an important role in the occurrence of arrhythmias in diabetes. This narrative review was at least to describe the mechanism of arrhythmia in diabetes mellitus.

Management of Sepsis Patient with Multiple Trauma: A Case Report Liliriawati Ananta Kahar; Talitha Azalia; Kornelis Aribowo
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.513

Background. In critically ill patient, source control surgery is one of the significant determinants of patient treatment and makes it successful. This case report was aimed to describe the management of sepsis patient with multiple trauma. Case presentation. A 20-year-old woman presented with blunt trauma in the chest, abdomen, and right superior and inferior extremities. After the surgical procedure, the patient was treated in the ward with skin traction and simple wound care; a week later, the wound became worse, abscess inside, necrotic tissue and smelled terrible, and the woman had fever and jaundice somnolence, and other clinical symptoms manifested and became sepsis. She underwent twice a debridement surgery for a nasty wound. After that, she was treated in intensive care. A multidisciplinary team was required to treat the patient. Conclusion. Surgical intervention, wound cleaning, and appropriate and adequate antibiotics are also given to prevent worsening sepsis in the future.

Happy Hypoxemia In COVID-19 Ilham; Deddy Herman; Russilawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.514

The new coronavirus disease 2019 (COVID-19) pandemic is becoming a global health crisis that challenges health systems around the world. The clinical spectrum of COVID-19 varies from mild upper respiratory tract infections to severe pneumonia and acute respiratory distress syndrome, but there are also many patients present with an SpO2 < 90% but without symptoms of shortness of breath. This phenomenon is called happy hypoxemia or silent hypoxemia. Shortness of breath or dyspnea is a subjective sensation resulting from inadequate breathing effort and is usually described as constriction in the chest, difficulty breathing air or difficulty breathing. Breathing is controlled centrally by the respiratory center in the medulla oblongata and the pons region which controls the "respiratory drive" and adapts respiration to the body's metabolic needs. The mechanisms that play a role in this phenomenon include the presence of intrapulmonary shunts, loss of pulmonary perfusion regulation, vascular microthrombus and impaired pulmonary diffusion capacity.

Correlation of Interleukin-6 Levels with Clinical Features and Chest X-Ray Imaging in Coronavirus Disease-19 (COVID-19) Patients at Dr. Mohammad Hoesin General Hospital Palembang Raden Yudistira Dwi Ananda; Nova Kurniati; Harun Hudari; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.515

Background. COVID-19 infection, both moderate and severe symptoms can cause pneumonia that can be detected on a chest X-ray. Along with the increasing severity of the clinical picture of COVID 19, it can also trigger a cytokine storm, one of which is an increase in Interleukin-6 levels. This study was conducted to see the correlation between IL-6 levels with clinical features and chest radiographs in patients with COVID-19 Methods. This research is a cross-sectional study using an observational analytic. The samples in this study were confirmed COVID-19 patients who were being treated at Dr. Mohammad Hoesin General Hospital, Palembang. A history and physical examination were performed to determine the clinical picture as well as a chest X-ray and IL-6 levels. Results. There were 31 samples of COVID 19 patients. High levels of IL-6 were found in 26 (83.9%) samples. The clinical picture of the patient was dominated by dyspnea as much as 19 (61.3%), fever 16 (5.6%), low O2 saturation 12 (38.4%) and a chest X-ray of pneumonia 26 (83.9%). There was a significant relationship (P<0.05) between IL-6 levels with clinical features and chest X-rays. The R-value on the thorax with pneumonia (0.692), lesion area (0.711) and clinical features with temperature (0.906), respiratory rate (0.706) indicated a strong correlation, while O2 (-0.732) indicated a strong negative correlation. Conclusion. There is a significantly strong correlation between Interleukin 6 levels with clinical features and chest X-rays in patients with COVID-19.

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Contact Name
Rachmat Hidayat

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dr.rachmat.hidayat@gmail.com

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Journal Mail Official
dr.rachmat.hidayat@gmail.com

Editorial Address
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Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA