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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,143 Documents

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Assessment of the Neutrophil Lymphocyte Ratio and Mean Platelet Volume in Pregnancy Rendy Singgih; Yohanes Firmansyah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 1 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.161

Abstract Introduction: Hypertension in pregnancy is a common complication that affects maternal and fetal morbidity and mortality. Comprehensive handling is needed to overcome the incidence of hypertension in pregnancy so that it does not get worse. The use of inflammatory markers is widely used as a predictor of the incidence of hypertension in pregnancy, especially preeclampsia. Neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV) values are believed to predict the incidence of hypertension in pregnancy. Aim of study: The purpose of this study was to determine the ability of both the NLR and MPV values to predict the incidence of hypertension in pregnancy. Methods: This research is an analytic observational study using secondary data from medical records. The data were taken from the Cimacan Regional Hospital from January to December 2019. The variables were then tested statistically to see the difference in the mean. If there are significant results, the predictor's ability will be tested again with the ROC curve test. Results: The results of statistical tests between the normotensive pregnancy group and pregnancy with hypertension showed that the mean difference was significant in the NLR variable with P-value of 0.004 and MPV with a P-value of 0.005. Then the NLR and MPV values were tested again by the ROC Curve method. The AUC results on the NLR variable (AUC: 0.562 / p-value: 0.022) and MPV (AUC: 0.560 / p-value: 0.022). Conclusion: Although NLR and MPV had differences mean between the two groups, their ability to predict pregnancy with hypertension was very low. Keywords: Pregnancy; Hypertension; Preeclampsia; NLR; MPV.

Efficacy of Alpha Lipoic Acid Supplementation In Chemotherapy-Induced Peripheral Neuropathy Mediarty Syahrir; Yenny Dian Andayani; Norman Djamaludin; Erty Sundarita Maksudin; Putri Farissa Muharramah; Kgs. M. Rosyidi; Hasnawi Haddani; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 1 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.162

Background. Chemotherapy-induced peripheral neuropathy is a side effect of several chemotherapy drugs and a significant cause of chronic pain in cancer patients, which affects patients' long-term quality of life. The neurotoxic chemotherapy agents most reported to cause neuropathic pains are platinum and taxane. This study aimed to determine the efficacy of alpha-lipoic acid supplementation in chemotherapy patients. Methods. This study used a randomized, double-blind clinical trial in the oncology haematology clinic in the Department of Internal Medicine at Mohammad Hoesin General Hospital Palembang from November 2018 to July 2019. Samples were taken from patients who met the inclusion criteria and signed informed consent forms to join the study. This studyused SPSS version 22.0 for Windows to analyze the data. Results. This research studied 30 subjects who were divided into alpha lipoic acid groups and placebo groups with 15 samples each. The alpha-lipoic acid group showed a significant decline in the Toronto Clinical Scoring System (TCSS) after treatment (p = 0.000) compared to the placebo group (p = 0.164). Conclusions. Treatment with a 600 mg single dose each day of alpha-lipoic acid for 12 weeks effectively improved patients condition significantly.

Characteristic of Bacterias And Antibiotic Sensitivity of Blood Culture in Sepsis Jesica Sidabutar; Nurmalia Purnama Sari; Phey Liana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 1 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.163

Introduction: Sepsis is a group of symptoms caused by infection, characterized by organ dysfunction due to compromised hosts response to infection hence may lead to a life-threatening condition. One of the treatments for sepsis stated in one hour-bundle is the administration of broad-spectrum antibiotics before the culture results obtained. Improper use of antibiotics may lead to antibiotic resistance. The purpose of this study was to describe the microbes pattern and their sensitivity to antibiotics in patients with sepsis at Muhammad Hoesin Hospital, Palembang, to contribute to a useful treatment guideline and to provide a reference for further research. Methods: This study was a descriptive observational study with a cross-sectional design using medical record of patients diagnosed with sepsis whose blood culture results were positive. This study was conducted at Muhammad Hoesin Hospital, Palembang, from January 2017 to December 2018. The data was processed and analyzed by univariate analysis using the SPSS 21.0 computer program. Results: The study subjects were predominantly children with Gram-positive bacteria (24.6%) as the most common cause. The most common bacteria observed were Staphylococcus epidermidis (35.7%), Staphylococcus aureus (27.3%), Staphylococcus haemolyticus (24%), and Staphylococcus hominis (21.4%). Linezolid (100%), nitrofurantoin (100%), and quinupristin/dalfopristin (100%) were found to be sensitive to gram-positive bacteria. Conclusion: Gram-positive bacteria were the most common cause of sepsis in Muhammad Hoesin Hospital, Palembang. The bacteria were sensitive to linezolid, nitrofurantoin, and quinupristin/ dalfopristin.

Risk Factors of Congenital Anomalies in South Sumatera Indonesia Ziske Maritska; Theofilus Aswadi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.165

Abstract Introduction. Congenital anomaly is one of the leading causes of neonatal death. It is the third leading cause of neonatal death in Indonesia. More than half of all congenital anomalies can’t be related to a specific cause, suggesting multiple risk factors. This study aims to identify patterns and risk factors of congenital anomalies in RSUP Dr. Mohammad Hoesin Palembang. Methods. This observational descriptive study with a cross-sectional design used 100 patients’ medical records, taken at RSUP Dr. Mohammad Hoesin Palembang, as samples. Missing data were complemented with a phone interview. Samples were picked using a proportional random sampling method. Collected data were counted within each category of congenital anomalies. Results. There were 366 neonatal patients diagnosed with congenital anomalies at RSUP Dr. Mohammad Hoesin Palembang in 2015. The most prevalent (44,8%) congenital anomalies belonged to congenital anomalies of the digestive system, followed by congenital anomalies of the circulatory system (18,6%), and cleft lip/palate (11,5%). Following risk factors were found: the history of maternal active or passive smoking (41%), maternal exposure to chemicals or solvents (31%), family member with congenital anomalies of the same category (27%), maternal drug consumption (26%), maternal infection (22%), maternal diabetes mellitus (4%), and maternal hypertension (4%). Conclusion. History of maternal active or passive smoking was the most frequently found risk factors among patients of congenital anomalies.

Comparison of Phenolic Glycolipid 1 Antibody Levels in Household Contacts of Pausibasilary and Multibacilary Patients Febrina Andarini; Rusmawardiana; Soenarto Kartowigno; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.166

Abstract Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Distribution of leprosy cases in the world in 2015 was highest in the Southeast Asia region, with 156,118 cases. The increase in new cases and the high prevalence of leprosy requires action to break the chain of transmission. Household contact groups are easy to identify by the research group, because the group has good reasons for examining or getting chemoprophylaxis. Objectives: Our objective was to compare Phenolic Glycolipid 1 (PGL-1) antibody levels in household contacts of pausibasilary (PB) and multibacilary (MB) patients. Methods: This study was a analytic observational study with a cross-sectional design. ELISA examination will be conducted at the Leprosy Laboratory of the Institute of Tropical Diseases, Airlangga University, Surabaya. The study was conducted from 3 December 2019 to 31 January 2020, with a total sample of 60 samples. Resuls: PGL-1 antibodies in MB leprosy household contact were greater than PGL-1 antibodies in PB leprosy household contact, and the results showed statistically significant (p = 0.011). Conclusions: There are differences in the levels of PGL-1 antibodies between household contact PB leprosy patients and MB. The household contact PGL-1 antibody levels in MB leprosy are greater than PB leprosy.

Efficacy of Lidocaine and Ketamine Combination on Reduction of Pain Intensity, Improvement of Functional State and Central Desensitization of Chronic Low Back Pain Henry Sugiharto; Hasnawi Haddani; Yuki Fitria; Rizal Zainal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.167

Abstract Background: Chronic low back pain (LBP) prevalence is approximately 20% of world population. Central and peripheral sensitization are considered as the main mechanism of pain chronification. This study hypothesize that lidocaine and ketamine combination reduces pain intensity, improves functional state and central desensitization of chronic low back pain. It is by modulating central sensitization in sub-anesthetic dose, prolonging inactivation of Na-channel, blocking NMDA-receptor and preventing secondary hyperalgesia. Aim of study: To evaluate the efficacy of lidocaine and ketamine combination on the intensity of pain, functional state and central desensitization of chronic low back pain. Methods:. This double blind randomized control trial study was carried out in Mohammad Hoesin General Hospital, Palembang, Indonesia from May 2018 to January 2019. A total of 20 patients with low back pain that last for more than 3 months, aged >18 years old, of either sex who were willing to be enrolled in this study, were randomly allocated into one of the two groups of 10 each. The treatment group (n=10) received standardized therapy (analgesic and physiotherapy) + intravenous ketamine 0.5 mg/kg + lidocaine 2 mg/kg and the control group (n=10) received standardized therapy + 100 ml Nacl 0.9%. Pain intensity, functional state, and central desensitization were measured before the treatment, day 7 after treatment, and a month after treatment using Numeric Pain Rating Scale (NPRS), Functional Pain Scale (FPS), and Central Sensitization Inventory (CSI). Results: The administration of ketamine 0.5 mg/kg + lidocaine 2 mg/kg resulted in NPRS and CSI changes was effective since the 7th day post intervention (p-value=0.021 and p-value=0.001) while on FPS changes, it was effective since the 30th day post intervention (p-value=0.000) Conclusion: From the result, it could be concluded that the administration of ketamine and lidocaine is effective on decreasing pain intensity and central desensitization in chronic LBP.

Are Parent Education Level Have Influence to Choose First Facility / Helper for Fracture in Children with Osteogenesis Imperfecta Yoyos Ismiarto; Doddi Putra Pratama Sudjana; Mahyudin; Sultan Agung Lumban Tobing; Anggrian; Wemdi Priya Prasetya; Adriel Benedict
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.169

Introduction: Osteogenesis Imperfecta (OI) disease can develop fractures with or without trauma. Initial management of fracture cases depends on the patients' parents and it may affect the results. Various kinds of factors can influence parents' decision making in health issues, one of which is the level of education. Methods: This research was conducted by analyzing the results of the questionnaire for the parental education level. Patients that fulfilled the inclusion criteria were part of the study from January to March 2020. Results: The data showed that 38 (31%), 31 (26%), 29 (24%), and 23 (19%) patients were treated by bonesetters, hospitals, primary health care centers, and private clinics. There were 38 (31%) parents who took their children to bonesetters, mostly have intermediate education level. Mostly parents with high level of education bring their children treated in hospitals (49%). There was a significant correlation between their education level (P = 0.000) regarding decision making in the first fracture case. Conclusion: The parents' educational level of patients diagnosed with OI affects decision making in determining the first treatment facility for managing cases of fracture. Practice Implication : Parental education level plays an important role in making appropriate decisions for medical treatment

Factors Affecting Bisphosphonate Therapy Compliance In Patients With Osteogenesis Imperfecta Yoyos Ismiarto; Firdaus Ramli F; Doddi Putra Pratama Sudjana; Naufal Chairulfatah; Wendy Yolanda Rossa
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.170

BACKGROUND: Osteogenesis imperfecta (OI) is a genetic disease with clinical manifestations in patients' bones. This study aims to investigate the factors that influence the compliance of bisphosphonate in patients with OI. METHODS: A cross-sectional analysis method was conducted and data were obtained from questionnaires answered by OI patients that received bisphosphonate. The data obtained were statistically analyzed using chi-square. RESULTS: There were 121 OI patients, age range 0-5 years (62%). Almost all patients have insurance from national health (BPJS). In this study, the average treatment compliance was 81.7%, and patients were reported to have good medication compliance of ≥80% of the treatment cycle, which was shown in 65 patients (53.7%). However, there is a relationship between parent education and treatment compliance (P = 0.046). DISCUSSION: It is a measurement of behavior related to treatment recommendations by medical professionals. On the contrary, the level of non-compliance patients with chronic disease to treatment is quite high. CONCLUSION: Good treatment compliance describes when the patient performs ≥80% of its cycle. Factors affecting it are the condition of the patient and the location of health services. Therefore, there is a relationship between compliance with the number of treatment cycles.

Functional Outcome After Neglected Injury In Pediatric Softball Players Measured By Quickdash Score Yoyos Ismiarto; Sabdillah FT; Ramli F; Kemas Abdul Mutholib Luthfi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.171

A B S T R A C T Introduction : Pediatric softball players are prone to get injured as a result of high forces motions, with improper technique. Low communication and school-age often leads the injury became neglected. The aim of this study is to determine the incidence of Neglected injury in pediatric softball players in Bandung during a single season year of 2019. Method : The study was conducted in softball clubs in Bandung. The inclusion is the softball players aged 18 years old or below, grouped into; (1)never injured, (2)neglected injury by non-professional/traditional massage, and (3)untreated neglected injury/rest only. The samples were evaluated with the Quick Disabilities of the Arm Shoulder and Hand outcome questionnaire (QuickDASH). Data was analyzed with Anova test. Result : Among the 50 players, aged from 12 to 18 years old, 36 players (72%) were at group 1, 8 players (16%) were at group 2 and 6 players (12%) were at group 3. Most site of injuries for group 2 are at shoulder (62,5%) and group 3 are at elbow (66,6%). Significant differrences were identified between three groups with p=0.001. The highest quickDASH score are in group 2 (38,6), and the lowest are in group 1 (0,0). Conclussion : All of the quickDASH Score in this group of age are categorized in mild difficulty. Those whom treated by non-professional has lower functional outcome compared to never injured and untreated injured players.

Polymorphism of the Klotho G-395a Gene Promoter with the Incidence of Preeclampsia Desi Arlindia; Mgs. Irsan Saleh; Zen Hafyy; Legiran; Erial Bahar; Kms. Yusuf Effendi; Ferry Yusrizal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 1 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.178

A B S T R A C TIntroduction. Preeclampsia is one of the leading causes of maternal and perinatalmorbidity and mortality and is still a disease of theory. Klotho is a new gene, inseveral biological processes in the pathophysiology of preeclampsia that play a rolein regulating endothelial nitric oxide production, angiogenesis, production ofantioxidant enzymes and protection against endothelial dysfunction. The Klotho G-395A genotype AA promoter polymorphism is the cause of hypertension. This studyaims to determine the relationship of the Klotho G-395A promoter polymorphism tothe incidence of preeclampsia. Methods. This study is an analytical study with acase-control design. The research was conducted at Pembina community healthcentre of Palembang and the public hospital of Prabumulih in February - July 2020and involving 50 case group and 50 control group. To determine the genotype andallotype of the Klotho G-395A gene promoter polymorphism, using polymerase chainreaction examination. Result. The results showed that the risk factors for maternalage and maternal gestational age had a significant relationship with the incidence ofpreeclampsia (p-value 0.015; p-value 0.000). There was a significant relationshipbetween the Klotho G-395A genotype GA + AA promoter polymorphism and theincidence of preeclampsia (p-value 0.024; OR = 2.571; 95% CI = 1.122-5.895), whileallotypes in the study sample also had a significant relationship with the incidenceof preeclampsia. preeclampsia (p-value 0.025; OR = 1.978; 95% CI = 1.087-3.599).Conclusion: There is a significant relationship between the Klotho G-395A genepromoter polymorphism and the incidence of preeclampsia.

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