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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,143 Documents

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Herpes Zoster: Clinical Manifestation, Treatment, and Prevention Muhammad Izazi Hari Purwoko; Hari Darmawan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 3 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i3.129

Herpes zoster (HZ, shingles, zoster) is a disease due to reactivation and multiplication of persistent varicella zoster virus (VVZ) after suffering from previous varicella with characteristics of dermatomal rashes, pain, and unilateral. Dermatoms most often involved in HZ lesions are thoracal, trigeminal, lumbal, and cervical. The first lesion is usually erythematous macule or papule, which then turns into vesicle, then to pustule and to become crust, and persists for 2-3 weeks. The main goal of antiviral therapy in HZ patients is to reduce the expansion, duration, and severity of rashes and pain in primary dermatomes; prevent the spread of HZ to other places; and prevent post-herpes neuralgia. One of the prevention strategies for HZ in the elderly and high-risk individuals is vaccination using the varicella zoster virus vaccine that is live zoster vaccine or recombinant zoster vaccine.

Dermatologic Lesions in Geriatric Patient with Diabetes Mellitus Fitriani Fitriani; Damai Trilisnawati; Stella Sunur; Inda Astri Aryani; Nopriyati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 3 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i3.132

Introduction: In geriatrics, there are changes in structure and function results in histopathological, physiological and clinical skin changes. The conditions can cause morbidity and decreases the quality of life of patients. This study was the first study that provide the characteristics of geriatric skin disorders in Dr. Mohammad Hoesin Hospital Palembang. Methods: This study was descriptive observational with cross-sectional design using total sampling method performed among patients in Geriatric Outpatient Clinic, Dermatology and Venereology Outpatient Clinic and geriatric inpatient room in Dr. Mohammad Hoesin Hospital on July-September 2019. Results: Physiological skin changes in geriatrics include xerosis cutis (13,95%), seborrheic keratosis (13,17%), guttate hypomelanosis (8,5%), senile lentigen (6,97%), freckle (2,32%), periorbital hyperpigmentation (1,55%), senile purpura (0,77%) and poikiloderma civatte (0,77%). The most skin disorder found were lichen simplex chronicus (11,1%), pressure ulcers (9,25%), senile pruritus (8,32%), asteatotic dermatitis (6.47%) and candidiasis (3,7%). The most common comorbid condition were diabetes mellitus in 16 patients (22,5%), CVD in 7 patients (9,9%), hypertension in 6 patients (8,5%), AKI in 6 patients (8,5 %), and HHD in 4 patients (5,6%). Diabetes mellitus was significantly associated with xerosis cutis (p = 0,0007), senile pruritus (p = 0,015), and guttate hypomelanosis (p = 0,016). Conclusion: The most physiological skin changes found in geriatric patients in Dr. Mohammad Hoesin Hospital were xerosis cutis, seborrheic keratosis, and guttate hypomelanosis, while skin disorder were lichen simplex chronicus, pressure ulcer, and senile pruritus. Diabetes mellitus was significantly associated with skin disorders.

NFATc1 and Tumor Associated Macrophages Affect Progression of Certain Subsets of Diffuse Large B Cell Lymphoma Non-GCB Subtypes Krisna Murti; Muslina Muslina; Ika Kartika; Rachmat Hidayat; Ella Amalia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 3 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i3.136

Introduction: Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma among B cell lymphomas. The interaction of tumor cells with their microenvironment (tumor microenvironment, TME) leads to progressivity of malignancy. CD163 + macrophages known as components of TME. Nuclear factor of activated T cell (NFATc1) and MYC are important transcription factors in malignant transformation and progression. Therapeutic strategies were fast developed, nevertheless, efforts to decrease DLBCL morbidity and mortality are unsatisfied, therefore,new markers for prognosis and or therapeutic options of the patients are necessary. This study was aimed to investigate NFATc1 expression in DLBCL and its TME. Methods: Thirty-two paraffin blocks were selected then immunostained for expression of NFATc1, MYC, and CD163. Clinopathologic data i.e. ages, gender, and proliferation index Ki-67 were obtained. Data was analyzed by statistics Result: Positive expression of CD163 and NFATc1 was among 55% and 45% of cases respectively. All DLBCL cases in this study were non-GCB subtype and more patients were under 60 years (66%). Positive expression of CD163 was higher in males (69%) and in patients under 60 years (63%). Tissues positive for both NFATc1 and CD163 was observed higher among males and patients under 60 years. Conclusion: NFATc1 may affect development and or progression of certain subsets of DLBCL non-GCB subtype.

Correlation of Lymphocyte-Monocyte Ratio with Grading of Breast Cancer Malignancy Muhartono Muhartono; Rizki Hanriko; Suharyani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 3 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i3.139

Introduction: Breast cancer cases are increase and fast becoming the leading cause of oncologic mortality among women worldwide. Delay in management will worsen the prognosis of breast cancer patients. The poor prognosis is correlate with high grade of breast cancer malignancy. Histology can be used as an indicator to assess the grade of breast cancer malignancy. In addition, a high predictive value of lymphocyte-monocyte ratio (LMR) has been suggested to indicate favorable prognosis of various cancer, and used as parameters for assessing breast cancer prognosis. Method: This study is a quantitative research, using an observational approach. Laboratory examination results are collected from 43 breast cancer patients who will conduct treatment at Urip Sumoharjo Hospital from June to September 2019. Data are processed by the Spearman rank test using SPSS 22.0. Results: Correlation test results between lymphocyte-monocyte ratio with histological grading of breast cancer obtained a P value of 0.376. Conclusions: Lymphocytes to monocytes ratio (LMR) value cannot be utilize as a parameter for evaluating prognosis of breast cancer.

Evaluation of Malondialdehyde in Type 2 Diabetes Mellitus Patients as Oxidative Stress Markers in Bengkulu Population Raden Sunita; Sahidan Sahidan; Rachmat Hidayat
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 3 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i3.146

Hyperglycemia in Type 2 Diabetes Mellitus (T2DM) can cause individuals to experience oxidative stress conditions, accompanied by a decrease in antioxidant activity in protecting cellular components against the attack of reactive oxygen species (ROS). ROS oxidized lipid components can produce Malondialdehyde (MDA). Evaluation of MDA can be used as a marker Oxidative stress which can indirectly describe the effects of ROS because ROS compounds are reactive. This study aims to determine the analysis of MDA in T2DM subjects at the Sentinel Public Health Center in Bengkulu City in 2017.research Analytic with a case control study design in 40 samples of T2DM subjects (cases) and 40 Non-DM samples (control) were carried out at the Sentinel DM Health Center in Bengkulu City. Data collection used questionnaires, measurements of Body Mass Index, examination of Fasting Blood Glucose and plasma MDA (spectrophotometry). The results of this study there were differences in characteristics (Gender, Age, BMI, Blood Pressure, Fasting Blood Glucose) in subjects with T2DM and Non-T2DM in the Bengkulu City Sentinel Health Center in 2017 (p <0,000). There was a significant difference (p= 0,000) in higher MDA levels in patients with T2DM than non-DM subjects. The MDA frequency distribution in the case was MDNormal (24%) and MDA Normal (6%), whereas in the control was MDA Not Normal (26%) and MDA Normal (44%). There were significant differences in MDA frequency distribution between cases and controls (p= 0,000). The subjects of T2DM had a risk of 6.77 times an increase in MDA levels compared to Non-DMT2 (p= 0.000, OR 6.77 IK 95% 2.44-18.73). The correlation between levels of GDP and MDA was statistically significant (p <0.001) with a positive correlation direction (0.340). The results of this study are expected to be used as a basis for the development of individual therapy in subjects with T2DM in order to prevent the occurrence of complications early on.

Characteristics Of Patient With Foreign Body Ingestion In Palembang Adelien; Abla Ghanie; Puspa Zuleika; Lisa Apri Yanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 1 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i1.156

Introduction. Foreign body ingestion is a common diagnosis that presents in emergency departments—coins as the oesophagal foreign body most commonly found in infants and children. Coins retained in the oesophagus require intervention to prevent complications. This study aimed to determine oesophagal coin foreign body patient's characteristic at Mohammad Hoesin General Hospital Palembang. Method. This study design was retrospective descriptive. Samples were all patient diagnosed with oesophagal coin foreign bodies which underwent Extraction with esophagoscopy guidance that was performed at Mohammad Hoesin General Hospital Palembang during January 2013 – August 2017. Result. Forty-three patients had diagnosed with oesophageal coin foreign bodies consist of 22 males and 21 females. The most frequent age was 4fouryears old. The most presenting symptoms are Globus sensation on the throat (79%) and odynophagia (51,1%). Radiologist confirmation was done in every patient with foreign coin bodies in oesophagus. All patients underwent oesophagoscopy. 65,1% of cases of foreign coin bodies were found in the second constriction of throat. Duration of stay in hospital was the range from 1- 4 days, with the most frequent, was two days. There was no complication found in all patients. Conclusion. Oesophagal coin foreign body is most commonly ingested in children. The most presenting symptom is globus sensation on the throat. There is no complication found in this study.

Fiberoptic Endoscopic Examination of Swallowing (FEES) Evaluation in Post Stroke Patients Puspa Zuleika; Abla Ghanie; Adelien; Indriati Purwasari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.157

Introduction. Complications caused by post-stroke dysphagia increase the morbidity and mortality of patients. Although it has a significant effect on the functional abilities and worsening of the patient's prognosis, post-stroke dysphagia is still under-noticed and often undiagnosed. The importance of knowing the incidence of post-stroke dysphagia, not only to determine its relationship to the pathology of the disease but also to determine treatment plans or follow-up interventions. This study aims to determine the incidence of FEES findings in post-stroke dysphagia both hemorrhagic and non-hemorrhagic stroke. Methods. Forty post-stroke patients in the Inpatient and Outpatient Installation of the THTKL Section and the Neurology Section of Dr. Hospital. Mohammad Hoesin Palembang conducted a FEES examination to see leakage, residue, penetration, and aspiration after being given six different types of food boluses ranging from filter porridge, rice porridge, oatmeal, water, milk, and biscuits. The results of the assessment are recorded and analyzed descriptively. Results. From 40 research subjects found 25 people experiencing dysphagia, where subjects with non-hemorrhagic stroke types were 21 people (52.5%), while hemorrhagic stroke types were four people (10%). The occurrence of leakage of filter porridge was 5 findings, leakage of rice porridge was eight findings, oatmeal leakage, water, and milk were seven findings each, and biscuit leakage was two findings. The incidence of filtered pulp residues was 12 findings, rice porridge residues were 14 findings, oatmeal residues were 15 findings, water and milk residues were five findings each, and biscuit residues were eight findings. The incidence of penetration of filter porridge, rice porridge, and biscuits was one finding each, oatmeal penetration was not found, while water and milk penetration were six events each. The aspirations of filter porridge, rice porridge, oatmeal, and biscuits were not found, while water and milk aspirations were seven findings. Conclusion. The incidence of dysphagia in post-stroke patients both hemorrhagic and non-hemorrhagic in the Inpatient and Outpatient Installation of the THTKL Section and the Neurology Section of the Mohammad Hoesin Hospital Palembang Palembang is quite high at 62.5%. The occurrence of food residues is the most FEES findings. While aspirations are the fewest findings.

The Effect of KatG S315t M. Tuberculosis Gene Mutation on Conversion Rate of MDR-TB Patients with Shorter-Course Treatment Raden Ayu Linda Andriani; Zen Ahmad
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.158

Background. Resistance to the INH drug is most often caused by a mutation of the KatG S315T M.Tb gene. MDR TB treatment with short-term WHO mixes using high-dose INH drugs is considered less effective in this mutation condition because it causes high resistance to INH. The effectiveness of MDR TB treatment can be seen from the sputum smear conversion rate. This study was aimed to determine the effect of the S315T katG gene mutation on the treatment response of patients with MDR TB who received WHO short-term alloys at Dr Moh Hoesin general hospital, Palembang, Indonesia. Method. This study uses observational analytic with a prospective cohort approach. The study subjects were MDR TB patients at Dr Moh Hoesin general hospital, Palembang, Indonesia, and a PCR-RFLP examination was performed to see the katG gene, followed by sputum smear evaluation at the end of the first and second months of treatment to assess the speed of conversion. Data analysis using SPSS 25 with the chi-square statistical test. Results. The frequency of katG S315T M.Tb gene mutations was 51.85%. The majority of MDR TB sufferers experience rapid conversion (92.59%). 64.29% of the katG S315T gene mutation group experienced sputum smear conversion after one month, 28.57% after two months, and 7.14% after three months of treatment. There was no significant difference in conversion speed in the two groups (p = 0.741). Conclusion. There was no effect of the S315T M.Tb katG gene mutation on the speed of sputum smear conversion of MDR TB patients who received short-term alloy treatment.

The Role of Peer-group Influence and Neurobiological Factors in Internet Gaming Disorder Tesaviani Kusumastiwi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.159

Abstract Internet game disorder (IGD) is characterized as an excessive and uncontrolled game designed for functional problems or difficulties. During the last discussion, uncontrolled internet games have resulted in public health and social problems around the world. Although brave games are more accessible in young adulthood, brave game disturbances are more experienced by teens. Teenagers and young adults are strong predictors of overcoming the challenges of online game addiction, besides peer-group factors in adolescents, and neurobiological factors that influence the influence of internet gaming disorders. This literature review will discuss the influence of peer groups and neurobiological factors that underlie the expenditure of internet games in their teens.

Prevention of Irritant Contact Dermatitis Due to Hand Hygiene in The Era of COVID 19 Pandemic Nopriyati; Damai Trilisnawati; Yulia Farida Yahya; Mutia Devi; Theresia L. Toruan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 4 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i4.160

Irritant contact dermatitis (ICD) is an inflammatory epidermal disorder associated with physical or immunological provocation that results in impaired skin barrier. The prevalence of ICD is found to be 17-30% in healthcare workers compared to general population. The first-line management strategies of ICD is based on prevention. Intensive hand cleansing is one of the causes of ICD. Hand hygiene is general term that refers to any action of hand cleansing. Hand hygiene practices include hand washing and hand rubbing with antiseptics. Hand hygiene is the most effective preventive measure in preventing infection control, especially in the era of coronavirus (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since December 2019. This disease is transmitted through inhalation or contact with infected droplets. Prevention and mitigation actions are key in controlling infection.

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Contact Name
Rachmat Hidayat

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dr.rachmat.hidayat@gmail.com

Phone
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Journal Mail Official
dr.rachmat.hidayat@gmail.com

Editorial Address
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Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA