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Medical and Health Science Journal
Published by Universitas Nahdlatul Ulama Surabaya
ISSN : 25497588     EISSN : 25497596     DOI : https://doi.org/10.33086/mhsj
Core Subject : Health, Social,
Health Professions Social Sciences
Medical and Health Science (MHSJ) published peer-reviewed original articles research, case report or article review. This journal is published twice (February and August) by Faculty of Medicine Universitas Nahdlatul Ulama Surabaya.
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Articles 8 Documents
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Search results for , issue "Vol 7 No 02 (2023): AUGUST" : 8 Documents clear
Antimicrobial Profile and Prevalence of Salmonella Species from Blood Culture in A Tertiary Care Hospital Jain, Charu; Nikita
Jurnal Ilmu Kesehatan dan Kesehatan Vol 7 No 02 (2023): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v7i02.3943

Abstract

Background & Aim: Enteric fever is a major public health concern around the world and endemic in low- and middle-income countries like, India. Typically, it spreads through contaminated food or water. Salmonella Typhi proliferate and spread throughout the bloodstream seeding multiple organs in the body. Incidence data of culture confirmed Typhoid cases is approximately 377per 100000 population with an approximate case fatality rate of 1% in India. The management of cases are hampered due to emerging the drug resistance of isolates because of rampant and misuse of antibiotics. This study investigates to analyse the current pattern of antibiotic susceptibility among Salmonella isolates from cases of enteric fever seen at ESIC Medical College & Hospital, Faridabad. Material & Methods: This is a retrospective, cross-sectional study. Blood cultures from patients with suspected enteric fever from Jan 2017 to Dec 2019 were included. The blood cultures were processed using the BacT/Alert automated blood culture system. Results: During the study period, a total of 4064 blood culture specimens were received from the patients suspected for fever. Out of a total of 2717 culture positive samples, 373 (13.73%) were found positive for the growth of Salmonella enterica [Salmonella typhi 87.13% (325/373), Salmonella paratyphi A (12.86%)], confirming the enteric fever. Conclusion: Treatment with appropriate antimicrobial drugs is crucial for patients with typhoidal infections and the antimicrobial susceptibility of such isolates must be reported as soon as possible.
Transcriptional analysis of Metalloprotease, Metallocarboxypeptidase, Isocitrate lyase, Citrate synthase, Malate synthase and Dipeptidylpeptidase V of Trichophyton rubrum isolates from dermatophytosis patients. Datt, Shyama; Datt, Thakur; Das, Shukla; Battacharaya, Sambit Nath
Jurnal Ilmu Kesehatan dan Kesehatan Vol 7 No 02 (2023): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v7i02.4044

Abstract

Introduction: Dermatophytes are pathogenic fungi that cause cutaneousinfection of human and animal and grow exclusively on the stratumcorneum, nail and hair. Methods: The present study was conducted on 160 samples from clinicallydiagnosed onycomycosis patients, further subjected to culture from nailsamples of patients attending dermatology OPD of a tertiary care hospital,Delhi from January 2016 to December 2018 Results: In a soy protein culture, a substantial proteolytic activity was seen, which was secreted by Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum canis. This proteolytic activity was 55–75% inhibited by O-phenanthroline, which authenticate that metalloproteases were secreted by all three species. A consensus probe was constructed on previously characterized genes, which encodes metalloproteases (MEP) of the M36 fungalysin family in Aspergillus fumigatus, Aspergillus oryzae and M. canis. From genomic libraries of T. rubrum, T. mentagrophytes and M. canis, T. rubrum & T. Mentagrophytesa five-member MEP family was isolated and also secretes MCP A & MCPB, MEP 3, MEP4, IL, CS, MS AND DPP V of the M14 family accordingto the MEROPS proteolytic enzyme database. Conclusion: This study shows that Metalloprotease, Metallocarboxypeptidase, Isocitrate Lyase, Citrate Synthase, Malate Synthase and Dipeptidylpeptidase V are expressed in Trichophyton Rubrum Isolates from Dermatophytosis Patients.
Kinetics IgM and IgG SARS-CoV-2 in Recovery patients with Negative Evaluation RT-PCR Endang, Jusup; Sariyanti, Mardhatillah; Triana, Dessy; Rizqoh, Debie; Enny, Nugraheni
Jurnal Ilmu Kesehatan dan Kesehatan Vol 7 No 02 (2023): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v7i02.4359

Abstract

Background: Coronavirus is the major pathogens at human respiratory system. The antibody is a response infected patients largely not clearly. We need to understanding of antibody responses to great diagnosis and treatment studies. Objective: In this article the objective is to describe that kinetics of IgM and IgG SARS-CoV-2 in recovery patients. Method: Cohort study used a total 19 subjects who had negative evaluation RT-PCR after confirmed. IgG and IgM of SARS-CoV-2 were detected by IFA (Immuno fluorosence assay) used serum. Serum were collected 3 times after 1 month, 2 month and 4 month negative evaluation RT-PCR We profiled the serological responses (IgM and IgG) to SARS-CoV-2. Result: Majority the IgM SARS-CoV-2 post evaluation RT-PCR were very low after 1,2,4 month negative evaluation. IgG SAR-CoV-2 patients post negative evaluation RT-PCR decreased after 4 months. The level IgM and IgG level increase at first week and decrease after 12 weeks. Conclusion: IgM level lower than IgG level overtime. Quantitative IgG and IgM detection could be point of diagnosis and manifestation.
Synchronization of Sputum Conversion and Resolution of Intensive Phase Lesion Areas on Thorax X-rays Determinants of Prognosis for Pulmonary Tuberculosis Therapy Ambarsari, Utami; Arimbi, Muzaijadah Retno; Veterini, Lysa; Indrianto, Yunita Lestari; Candini, Naura Anindya; Notobroto, Hari Basuki
Jurnal Ilmu Kesehatan dan Kesehatan Vol 7 No 02 (2023): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v7i02.4565

Abstract

Background: Pulmonary tuberculosis (TB) is a chronic infectious disease caused by the bacterium Mycobacterium tuberculosis. Diagnosis of TB can be confirmed in two ways, namely bacteriological diagnosis (if AFB sputum is found (+) and clinical diagnosis is (if BTA sputum is found (-), but chest X-ray is (+) TB). Objective: to determine the alignment of sputum conversion and extensive resolution of intensive phase lesions on chest radiographs which determine the prognosis of pulmonary TB therapy. Methods: The study design was a retrospective cohort analytic with a retrospective longitudinal study design. Data from medical records of pulmonary TB patients who have undergone therapy for six months or more at the Pulmonary Polyclinic RSI Jemursari Surabaya. The number of samples was 48 patients aged 41-60 years. All of these pulmonary TB patients were smear positive (BTA+). X-ray examination was done before and after therapy. Results: analysis using the Wilcoxon Signed Rank test to assess differences in the grade of lung lesions before and after therapy, obtained p = 0.003 (p <0.05) meaning there is a significant difference. Sputum conversion was also carried out after therapy, 89.6% of TB patients in this study experienced sputum conversion (BTA negative). To determine the alignment of sputum conversion with the resolution of lesion area, Kappa coefficient analysis K=0.033 (p>0.05) was performed with the results of 50% of patients, 47.9% showed improvement in lung lesions and sputum conversion, while 2.1% showed no improvement of lung lesions and no sputum conversion. The rest, 50% showed no congruence in the results of lung lesion repair and sputum conversion. Conclusion: The results of Kappa coefficient analysis showed that K=-0.110 (p>0.05) showed that there was no congruence between the results of chest x-ray examination of lung lesions before and after therapy (improved or not) with sputum conversion
Severe Calciphylaxis Secondary to end Stage Renal Failure: A Case Report Mohammad Isa, Muhammad Syafiq bin; Wan Ali, Wan Ahmad Syahril Rozli
Jurnal Ilmu Kesehatan dan Kesehatan Vol 7 No 02 (2023): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v7i02.4639

Abstract

Calciphylaxis is a vascular calcification disease causing skin necrosis which contributes to high morbidity and mortality. Its exact pathogenesis is currently unknown but is commonly associated with chronic renal failure, hypercalcemia, hyperphosphatemia, secondary hyperparathyroidism and a variety of hypercoagulable state. It is relatively rare but may occur in 1-4% of patients with End Stage Renal Failure (ESRF).1 We are reporting a case of young lady with underlying ESRF presented with vascular and skin calciphylaxis.
Conservative Wound Treatment in DMT2 Patients Using Honey Laksmi, Putu Pradnyasanti; Saraswati, Made Ratna; Rooseno, Ratna Rayeni Natasha; Devinta, Made Ratih Santi; Santosa, Agus
Jurnal Ilmu Kesehatan dan Kesehatan Vol 7 No 02 (2023): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v7i02.4645

Abstract

Background : The number of diabetic patients in Indonesia is on the rise. In contrast to typical wounds in non DMT2 patients, chronic wounds in DMT2 patients heal more slowly, which makes it difficult to achieve complete primary wound healing. Thus, surgery is frequently required to achieve optimal healing. Patients' physical condition, age, comorbidities, and financial circumstances such as high medical costs frequently limiting patients from receiving comprehensive care, resulting alternative treatments are required to treat chronic wounds in DMT2 patients whom prefer conventional medications, addressing all circumstances. Honey, in addition to having fructose compounds, which has the benefit of increasing glucose homeostasis and insulin response, resulting in lower insulin and plasma glucose levels, also has been shown to contain anti-inflammatory and antimicrobial substances that aid in wound healing. Thus, it may be an alternative therapy for chronic wound in DMT2 patients. Methods : A Case-series studies of four DMT2 patients who were referred to Plastic and Reconstructive Outpatient ward with chronic wound were evaluated on a monthly basis following conservative treatment using Nusantara local honey-coated gauze. Result : Secondary wound healing, which can be assessed from the epithelialization process started from the peri-wound area has been obtained through monthly observations. Conclusion : Honey is used as an alternative therapy for patients with diabetic foot ulcers due to its anti-microbial and anti-inflammatory properties in the wound healing process. Furthermore, honey is considered less expensive and more affordable alternative for patients with co-morbidities that is impossible to operate, or with financial limitations. Keywords: DMT2, Chronic wound, Honey
Evaluation of Molluscicidal Activities of Aqueous and Ethanolic Extracts of Onion Bulb (Allium Sativum) Against Bulinus Wrighti SARKINGOBIR, YUSUF
Jurnal Ilmu Kesehatan dan Kesehatan Vol 7 No 02 (2023): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v7i01.4697

Abstract

Schistosomiasis is a disease of public health importance in the tropics and subtropics. However, the synthetic materials for prevention of the intermediate host of the disease are harmful, scarce, and toxic. Thus, an evaluation of molluscicidal activities of aqueous and ethanolic extracts of the bulb of Allium sativum against Bulinus wrighti were carried out. Snails were exposed to various concentrations of plant preparations in laboratory conditions in a plastic aquarium containing 3L of de-chlorinated water for 96h continuously. Mortality was recorded at every 24hours interval for 96hours. The study shows that, molluscicidal activities are time and dose dependent against snails. The ethanolic extract was more toxic than aqueous extract. Ethanolic extract of A. sativum was found highly toxic to B. wrighti (24hrs. LC50: 97.07mg/l; 96hrs: 21.70mg/l). Chemical profile of aqueous extracts of A. sativum showed the presence of some secondary metabolites. A. sativum extracts showed histopathological signs to hermaphrodite glands and the digestive tract of the treated snails. This study showed that, this plant can be used as molluscicides. This study recommends the use of ethanolic and aqueous extract of A. sativum for the control of B. wrighti.
Anesthesia Management in Laparotomy of Gastric Perforation Peritonitis: A Case Report and Literature Review Nuh, Yalta Hasanudin; Dita, Diah Ayu Aguspa; Wirastari, Gayatri Ghea; Sahfitri, Feni Dwika
Jurnal Ilmu Kesehatan dan Kesehatan Vol 7 No 02 (2023): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v7i02.4795

Abstract

Gastric perforation has the potential to induce acute peritonitis, leading to intense pain and a significant mortality risk. A female patient, aged 67, presented with symptoms of intense abdominal pain affecting all regions of the abdomen and extending to the shoulder. The pain does not alleviate with rest and is aggravated by physical activity and coughing. The Chest X-ray examination revealed the presence of cardiomegaly, characterized by an enlarged heart and aortic elongation. The Abdomen X-ray examination revealed the presence of a pneumoperitoneum. Laparotomy may be conducted in individuals with gastric perforation to identify the pneumoperitoneum's underlying aetiology. The utilization of a concurrent administration of spinal anaesthesia (SA) and general anaesthesia (GA) demonstrates the effective reduction of hemodynamic impact during pneumoperitoneum while avoiding any associated adverse effects.

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