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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Medical and Health Science Journal Jurnal Ners Community Development Journal: Jurnal Pengabdian Masyarakat International Islamic Medical Journal Prosiding Seminar Nasional Pengabdian Kepada Masyarakat
Lysa Veterini
Universitas Nahdlatul Ulama Surabaya
Religion Humanities Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Perbedaan Ekspresi Siklin D1 dan Ki-67 pada Giant Cell Tumor of Bone Jinak dan Ganas Lysa Veterini; Sjahjenny Mustokoweni
Majalah Patologi Indonesia Vol 25 No 1 (2016): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.353 KB)

Abstract

Latar belakang Giant cell tumor of bone (GCTB) merupakan tumor tulang yang jarang. Di RSUD Dr. Soetomo Surabaya didapatkan 21 kasus GCTB, dengan 7 kasus GCTB ganas dan 14 kasus GCTB jinak, dalam rentang waktu 3 tahun periode Januari 2010-Desember 2012. Siklin D1 memiliki peran dalam siklus sel, sedangkan Ki-67 berhubungan dengan proliferasi sel. Tujuan penelitian ini menganalisis perbedaan ekspresi siklin D1 dan Ki-67 pada GCTB jinak dan ganas. Metode Penilaian dilakukan terhadap 21 blok parafin penderita GCTB di RSUD Dr. Soetomo sejak Januari 2010-Desember 2012 dan memenuhi kriteria. Analisis statistik perbedaan masing-masing variabel dengan uji chi-square dan Mann-Whitney. Hasil Ekspresi Ki-67 lebih tinggi pada GCTB ganas dibandingkan dengan GCTB jinak. Ekspresi siklin D1 dan Ki-67 pada GCTB jinak dan ganas menunjukkan terdapat perbedaan bermakna. Kesimpulan Ekspresi siklin D1 dan Ki-67 dapat digunakan untuk membedakan GCTB jinak dan ganas. Kata kunci : giant cell tumor of bone, Ki-67, siklin D1.
Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review Nur Azizah AS; Lysa Veterini; Hafid Algristian; Hotimah Masdan Salim
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.6354

Abstract

Chronic stress exposure plays a role as a risk factor for depression. In chronic stress, there is prunning of nerve cell dendrites so that depression becomes irreversible. Depression is caused by low serotonin (5-HT2) neurotransmitters in the postsynaptic cleft. Recent findings in experimental animals indicate that serotonergic preparations are required to increase serotonin levels in the synapse opening, thereby triggering the formation of new dendrites to make depression reversible. The different results when these preparations create resistance in cases of chronic depression and actually increase the risk of uncomfortable and even fatal side effects with long-term use. This Systematic Literature Review uses the PubMed and Google Scholar databases for the period 2015-2020. A total of 322 articles at the beginning of identification and those that met the inclusion criteria in this study were six articles. The results of data extraction showed that the depression condition caused by various stressors resulted in BDNF levels in the hippocampus decreased significantly by p≤0.005. Based on the literature study, it was concluded that in depressive conditions, BDNF levels in the brain decreased.
Sosialisasi Tentang Sifat Penyakit COVID-19 yang Baru Diketahui di Pondok Pesantren Zainul Hasan Genggong Lysa Veterini; Fariska Zata Amani; Prima Surya Ardiansyah
PROSIDING SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT UNIVERSITAS NAHDLATUL ULAMA SURABAYA Vol. 1 No. 1 (2022): Prosiding Seminar Nasional Pengabdian Kepada Masyarakat : Perguruan Tinggi Meng
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (709.949 KB) | DOI: 10.33086/snpm.v1i1.908

Abstract

Covid masih menjadi masalah sampai sekarang, terakhir pada Juli 2021 lalu Indonesia telah dihantam gelombang kedua Covid. Walaupun pencegahan mengenai Covid masih relatif sama, namun protokol kesehatan dirasa semakin mengendur. Perlu dilakukan upaya sosialisasi kembali untuk mengembalikan kewaspadaan masyarakat, dalam hal ini dalam lingkungan Pondok Pesantren Zainul Hasan Genggong. Pengabdian masyarakat ini menggunakan metode webinar online tentang sifat Covid yang baru diketahui, diselingi pretest dan posttest. Selesainya webinar online, tanya jawab, serta pretest dan posttest diharapkan menaikan pengetahuan peserta webinar mengenai Covid. Terdapat peningkatan pengetahuan mengenai sifat Covid terbaru diharapkan bisa menjadi bekal para santri untuk menyebarkan pengetahuannya kepada masyarakat di sekitar.
Synchronization of Sputum Conversion and Resolution of Intensive Phase Lesion Areas on Thorax X-rays Determinants of Prognosis for Pulmonary Tuberculosis Therapy Ambarsari, Utami; Arimbi, Muzaijadah Retno; Veterini, Lysa; Indrianto, Yunita Lestari; Candini, Naura Anindya; Notobroto, Hari Basuki
Jurnal Ilmu Kesehatan dan Kesehatan Vol 7 No 02 (2023): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v7i02.4565

Abstract

Background: Pulmonary tuberculosis (TB) is a chronic infectious disease caused by the bacterium Mycobacterium tuberculosis. Diagnosis of TB can be confirmed in two ways, namely bacteriological diagnosis (if AFB sputum is found (+) and clinical diagnosis is (if BTA sputum is found (-), but chest X-ray is (+) TB). Objective: to determine the alignment of sputum conversion and extensive resolution of intensive phase lesions on chest radiographs which determine the prognosis of pulmonary TB therapy. Methods: The study design was a retrospective cohort analytic with a retrospective longitudinal study design. Data from medical records of pulmonary TB patients who have undergone therapy for six months or more at the Pulmonary Polyclinic RSI Jemursari Surabaya. The number of samples was 48 patients aged 41-60 years. All of these pulmonary TB patients were smear positive (BTA+). X-ray examination was done before and after therapy. Results: analysis using the Wilcoxon Signed Rank test to assess differences in the grade of lung lesions before and after therapy, obtained p = 0.003 (p <0.05) meaning there is a significant difference. Sputum conversion was also carried out after therapy, 89.6% of TB patients in this study experienced sputum conversion (BTA negative). To determine the alignment of sputum conversion with the resolution of lesion area, Kappa coefficient analysis K=0.033 (p>0.05) was performed with the results of 50% of patients, 47.9% showed improvement in lung lesions and sputum conversion, while 2.1% showed no improvement of lung lesions and no sputum conversion. The rest, 50% showed no congruence in the results of lung lesion repair and sputum conversion. Conclusion: The results of Kappa coefficient analysis showed that K=-0.110 (p>0.05) showed that there was no congruence between the results of chest x-ray examination of lung lesions before and after therapy (improved or not) with sputum conversion
EDUKASI PENGOLAHAN BAWANG PUTIH PADA MENU SANTRI SEBAGAI ANTIOKSIDAN DAN ANTI KANKER Veterini, Lysa; Bintarti, Tri Wahyuni; Wulandari, Devyana Dyah; Alkatiri, Wardah
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 4 No. 6 (2023): Volume 4 Nomor 6 Tahun 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v4i6.22723

Abstract

Latar belakang: Aktivitas santri yang begitu padat setiap harinya, maka dibutuhkan kondisi yang fit agar dapat menjalani kegiatan pembelajaran di Pondok Pesantren dengan baik. Senyawa yang mengandung antioksidan dibutuhkan untuk melawan radikal bebas yang masuk ke dalam tubuh. Tujuan kegiatan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan para santri PP. KHA Wahid Hasyim Bangil Pasuruan mengenai manfaat bawang putih bagi kesehatan serta cara pengolahannya untuk mendapatkan efek antioksidan dan antikanker yang tentunya berguna bagi kesehatan santri. Metode: Kegiatan pengabdian kepada masyarakat ini dilakukan dengan metode presentasi. Rangkaian kegiatan pengabdian kepada masyarakat ini dimulai dari sesi persiapan yaitu pembuatan materi, pembuatan soal pre dan post-test, dan persiapan dokumen maupun administrasi lain. Soal Pre-test dan post-test diberikan kepada peserta digunakan sebagai indikator tingkat pengetahuan peserta sebelum dan sesudah diberikan materi. Hasil dan pembahasan: Hasil rata-rata nilai pre-test adalah 82, sedangkan nilai rata-rata post-test adalah 89. Hal ini menunjukkan terdapat peningkatan rata-rata nilai sebesar 7% dari sebelum diberikan materi (pre-test) dengan setelah diberikan materi (post-test). Terdapat peningkatan pengetahuan santri mengenai manfaat bawang putih bagi kesehatan serta cara pengolahannya untuk mendapatkan efek antioksidan dan antikanker yang tentunya berguna bagi kesehatan santri. Kesimpulan: Kegiatan pengabdian kepada masyarakat ini telah terlaksana dengan baik. Semua peserta hadir dan mengikuti acara dari awal hingga akhir, serta sangat antusias termasuk dalam sesi diskusi. Hasil akhir kegiatan pengabdian kepada masyarakat ini adalah terdapat peningkatan pengetahuan para peserta pengabdian kepada masyarakat yakni santri PP. KHA Wahid Hasyim Bangil Pasuruan.
The Relationship between Area of Necrosis with Degree of Lymphocytes Infiltration in Breast Rattus norvegicus Induced by DMBA Ainiyah Fairus; Aufar Zimamuz Zaman Al Hajiri; Hidayatul Ulya; Syihabuddin Farid; Lysa Veterini; Mohammad Nasir
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.126

Abstract

Breast cancer is one of the leading causes of death in women in the world. According to WHO, the incidence of breast cancer is about 2.1 million. The high mortality rate is often influenced by various reasons, one of which is the prognosis in patients. The level of lymphocyte infiltration in tumor cell tissue has been shown to correlate with a better prognosis in patients, while necrotic tissue found in breast cancer often shows worse prognostic value. To determine the relationship between the area of necrosis with the degree of infiltration of lymphocytes in the breast of Rattus norvegicus induced by DMBA. Method: True experimental study with post-test only controlled group design method using 40 Wistar strains of female (Rattus norvegicus) mice 12-13 weeks old. The technique for taking uses simple random sampling. Examining 2 variables, namely the dependent variable area of necrosis and the independent variable degree of lymphocyte infiltration. The treated group is injected with subcutaneous DMBA 10 mg/Kg BW between the two lower nipples during the middle of the fifth week with a three-week interval of administration to reach 14 times the total administration. Cancer tissue is taken in the fifth week. Data are analyzed by the Spearman test. Results: This study shows no relationship (P> 0.05) between the area of necrosis with the degree of lymphocyte infiltration. Conclusions: There is no relationship the area of necrosis with the degree of lymphocytes infiltration in breast Rattus norvegicus Induced by DMBA.
The Pro-Apoptotic Effect of Diallyl Trisulfide (DATS) on MDA-MB-231 Breast Cancer Cells Ailany, Erla Syah Dilla; Veterini, Lysa; Putri, Winawati Eka; Kurniasari, Diyan Wahyu
Jurnal Medis Islam Internasional Vol 7 No 1 (2025): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v7i1.7314

Abstract

Introduction: Breast cancer is the most prevalent cancer globally, impacting almost 2.1 million people each year. The MDA-MB-231 exemplifies the aggressive nature of the triple-negative breast cancer (TNBC) subtype. Diallyl Trisulfide (DATS) in Allium sativum (garlic) demonstrates potential anticancer characteristics primarily by causing the generation of ROS that may trigger apoptosis. Objective: The study evaluates the effect of DATS on apoptosis in MDA-MB-231 cells via the ROS pathway. Methods: An in vitro study utilizing MDA-MB-231 cells, categorized into four groups: (1) Medium control, (2) Negative control, (3) 20 µM DATS after 24 hours, and (4) 40 µM DATS after 24 hours. The study used Annexin V-FITC/PI flow cytometry to measure apoptotic cell death, the MTT assay to measure cell viability, and DCFH-DA fluorescence to measure ROS production. Results: Cell viability was decreased after DATS treatment and a substantial increase in intracellular ROS production was observed that varies with time and dose (p < 0.001). In comparison to the other groups, the group that received 40 µM DATS for 24 hours had the highest rate of apoptosis and the largest accumulation of reactive oxygen species (ROS). Conclusions: DATS significantly elevates intracellular ROS levels to promote apoptosis in MDA-MB-231 cells as a pro-oxidant therapy for aggressive breast cancer.
Model Eksperimental Diabetes Melitus Tipe 2 pada Tikus Wistar : Kombinasi Diet Tinggi Lemak, Garam, Fruktosa dan Induksi Streptozotocin Farikhah, Zumrotul; Savitri, Ardyarini Dyah; Bintarti, Tri Wahyuni; Veterini, Lysa; Wijaya, Afira Febriani Surya
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.48318

Abstract

Diabetes melitus tipe 2 (DMT2) merupakan masalah kesehatan global dengan patogenesis kompleks melibatkan resistensi insulin dan disfungsi sel beta. Model hewan yang relevan diperlukan untuk mempelajari mekanisme penyakit dan pengujian terapi. Mengembangkan model DMT2 pada tikus Wistar dengan menggunakan kombinasi diet tinggi lemak-fruktosa-garam dan streptozotocin (STZ) dosis rendah untuk meniru manifestasi klinis dan komplikasi DMT2 pada manusia. Lima ekor tikus Wistar jantan diberi diet tinggi lemak (30%), fruktosa (30%), dan garam (1%) selama 4 minggu, dilanjutkan injeksi STZ (35 mg/kgBB). Parameter yang diukur meliputi kadar glukosa darah puasa, berat badan, serta analisis histopatologi pankreas dan ginjal. Peningkatan signifikan kadar glukosa darah (median: 497 mg/dL) dan penurunan berat badan (21 gram) diamati setelah intervensi. Histopatologi menunjukkan insulitis dengan derajat bervariasi (Score 2: 30% sampel; Score 1: 5% sampel) dan kerusakan tubulus ginjal ringan. Kombinasi diet obesogenik dan STZ berhasil menginduksi hiperglikemia persisten serta perubahan histopatologis yang menyerupai DMT2 manusia. Model ini potensial untuk studi patogenesis dan terapi DMT2, meskipun perlu optimasi untuk mengurangi variabilitas respons.
PEMANFAATAN TEH HIJAU SEBAGAI ANTIOKSIDAN DAN ANTIKANKER DI PONDOK PESANTREN AL HIKAM BANGKALAN Veterini, Lysa; Salamy, Achmad Yarziq Mubarak Salis; Herdiani, Novera; Agnovianto, Yuriske; Wijaya, Annisa' Dharmestha; Wibowo, Novan Kurnia
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 6 (2024): Vol. 5 No. 6 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i6.37402

Abstract

Setiap tahun di seluruh dunia terjadi peningkatan kasus kanker sebesar 3-5%. Hal ini menunjukkan bahwa tindakan pencegahan terhadap penyakit kanker masih belum efektif dan perlu dicari senyawa pencegahnya. Salah satu pilihan yang paling memberikan harapan untuk pencegahan penyakit kanker adalah teh hijau. Selain sebagai antikanker, teh hijau juga sebagai antioksidan. Untuk itu, sangat penting dilakukan penyuluhan “Pemanfaatan Teh Hijau sebagai antioksidan dan antikanker di Pondok Pesantren Al Hikam Bangkalan". Tujuannya adalah meningkatkan pemahaman dengan memberikan edukasi kepada santri agar dapat memahami pentingnya pemanfaatan teh hijau sebagai antioksidan dan antikanker. Metode yang digunakan dalam penyuluhan adalah ceramah dan tanya jawab. Sebelum penyuluhan peserta diberi pre-test, kemudian setelah penyuluhan peserta diberi post-test. Hasil pre-test dan post-test dinilai kemudian dilakukan pengolahan data dan evaluasi. Hasil pre-test dan post-test mengenai pengetahuan pemanfaatan teh hijau sebagai antioksidan dan antikanker melalui kuesioner secara langsung terjadi peningkatan nilai oleh santri yang mengikuti kegiatan ini. Persentase kenaikan nilai rata-rata adalah sebesar 70,5%. Dari hasil analisis Uji T-test, menunjukkan bahwa nilai p sebesar 0,0000 (p < 0,05), yang berarti ada perbedaan yang signifikan antara pengetahuan santri saat sebelum dilakukan penyuluhan dan setelah dilakukan penyuluhan. Kesimpulannya, Penyuluhan Pemanfaatan teh hijau sebagai antioksidan dan antikanker di Pondok Pesantren Al Hikam Bangkalan telah meningkatkan pengetahuan dan pemahaman santri.
Prevalence, Risk Factors, and Management of Hansen’s Disease in Indonesia: Evidence from A Systematic Literature Review Sinantryana Widyaswari, Meidyta; Veterini, Lysa; Masdan Salim, Hotimah
Jurnal Ilmu Kesehatan dan Kesehatan Vol 9 No 2 (2025): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v9i2.8020

Abstract

Background: Hansen’s disease (leprosy) continues to be a public health concern in Indonesia, which ranks among the countries with the highest case numbers globally. Despite national control programs, the detection of new cases and disability rates suggests ongoing transmission and delays in diagnosis. A clearer understanding of prevalence, risk determinants, and management approaches is critical to strengthen interventions. Methods: A systematic literature review was performed using PRISMA guidelines. Relevant studies published between 2014 and 2024 were identified from PubMed, Scopus, and Google Scholar. Eligible publications included original research or program evaluations conducted in Indonesia. From 423 records initially screened, 76 full texts were assessed, and 22 articles met the inclusion criteria. Extracted data included prevalence, associated risk factors, and management strategies. Results: The reviewed studies originated from multiple regions such as Java, Sulawesi, Papua, and Maluku. Study designs comprised cross-sectional surveys, case–control studies, cohort analyses, and program evaluations. Prevalence varied substantially, with Papua, Sulawesi, and Maluku reporting the highest burdens. Commonly reported risk factors were poverty, overcrowded housing, malnutrition, genetic predisposition, and persistent social stigma. Household exposure and treatment delay were additional contributors to transmission. Management strategies mainly emphasized multidrug therapy (MDT) adherence, disability prevention, and stigma reduction. Community education and early case detection programs were associated with improved outcomes. However, several barriers remain, including incomplete adherence, inadequate health worker training, and limited psychosocial support. Conclusion: Hansen’s disease in Indonesia remains endemic in several provinces and is shaped by interconnected socioeconomic and biological factors. While MDT has reduced transmission, substantial gaps exist in disability prevention and stigma management. Enhanced surveillance, improved early detection, and stronger integration of community-based and psychosocial strategies are urgently needed to support national and global elimination goals.
Co-Authors Achmad Yarziq Mubarak Salis Salamy Agnovianto, Yuriske Ailany, Erla Syah Dilla Ainiyah Fairus Algristian, Hafid Alkatiri, Wardah Ambarsari, Utami Arimbi, Muzaijadah Retno Aufar Zimamuz Zaman Al Hajiri Bintarti, Tri Wahyuni Candini, Naura Anindya Devyana Dyah Wulandari FARIKHAH, ZUMROTUL Fariska Zata Amani Hari Basuki Notobroto Hidayatul Ulya Indrianto, Yunita Lestari Kurniasari, Diyan Wahyu Masdan Salim, Hotimah Mohammad Nasir Novera Herdiani, Novera Nur Azizah AS Prima Surya Ardiansyah Putri, Winawati Eka Salim, Hotimah Masdan Savitri, Ardyarini Dyah Sinantryana Widyaswari, Meidyta Sjahjenny Mustokoweni, Sjahjenny Syihabuddin Farid Wibowo, Novan Kurnia Wijaya, Afira Febriani Surya Wijaya, Annisa' Dharmestha