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Medica Hospitalia
Published by RSUP Dr. Kariadi Semarang
ISSN : 23014369     EISSN : 26857898     DOI : https://doi.org/10.36408/mhjcm
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Medica Hospitalia: Journal of Clinical Medicine adalah jurnal ilmiah yang diterbitkan RSUP Dr. Kariadi dan menerima artikel ilmiah dalam bahasa Indonesia dan bahasa Inggris yang diharapkan dapat menjadi media untuk menyampaikan temuan dan inovasi ilmiah dibidang kedokteran atau kesehatan kepada para praktisi dan akedemisi di bidang kesehatan dan kedokteran.
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Articles 529 Documents
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Breast Cancer Metastases Based on Molecular Subtypes at RSUD Dr. H. Abdul Moeloek Lampung Nurmayeni; Islamy, Nurul; Tjiptaningrum, Agustyas; Siregar, Bintang Abadi; Kusumaningtyas, Aditya; Windarti, Indri
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.904

Abstract

BACKGROUND:Breast cancer is the most common cancer in Indonesia and is a leading cause of cancer-related deaths in the country. Metastases are responsible for most deaths among breast cancer patients. Breast cancer is typically classified into four subtypes based on immunohistochemistry: luminal A, luminal B, HER2+, and TNBC. OBJECTIVE:To determine the association between the metastatic pattern of breast cancer and their molecular subtypes at RSUD Dr. H. Abdul Moeloek Lampung. METHOD:This study was an observational analytic study with a cross-sectional design. The sample comprised 81 individuals who had suffered from breast cancer and were recorded in the medical records section of RSUD Dr. H. Abdul Moeloek Lampung between 2013 – 2021 and met the inclusion and exclusion criteria. The association between breast cancer subtypes and the incidence and metastase sites were tested using the Chi-Square test. RESULT:This study found a significant association between breast cancer subtypes and the incidence of metastases (p <0.05). The TNBC subtype had a more frequent rate of metastases (34.5%) than the other subtypes (31% luminal B, 20.7% luminal A, and HER2+ 13.8%). The study also revealed a relationship between ER status and the incidence of metastases (p < 0.05). The luminal A subtype tends to metastasize to the liver, luminal B tends to metastasize to the bone, HER2+ tends to metastasize to the lung and liver, and TNBC tends to metastasize to the lung. However, no significant association was found between breast cancer subtypes and metastatic sites. CONCLUSION:There was a significant association between breast cancer subtypes and the incidence of metastases, but not with the metastatic sites.  
Correlation of Duration of Antipsychotic Therapy with Hemoglobin Levels in People with Schizophrenia Siregar, Jessica Anggun Cristine; Jusup, Innawati; Jaeri, Santoso; Wardani, Natalia Dewi
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.908

Abstract

Background: Schizophrenia is a serious mental disorder with various unknown causes accompanied by a collection of positive symptoms, negative symptoms, disorganization in thinking, speaking or movement and cognitive dysfunction. The therapeutic modality used to treat these symptoms is antipsychotic therapy. Over a certain period of time, the use of antipsychotics can cause hematological syndrome which affects the process of red blood cell formation and hemoglobin levels. Low hemoglobin levels can worsen neuronal function in the brain, thereby aggravating symptoms in schizophrenia. Aim: Analyzing the relationship between duration of antipsychotic therapy <2 years and ≥2 years with hemoglobin levels in schizophrenia patients. Method: This research is an analytical observational study with a cross-sectional approach in which research subjects were obtained using a consecutive sampling method from medical records of patients with schizophrenia (ODS) at RSJD Dr. Amino Gondohutomo Semarang (n=68) divided into 2 groups consisting of patients with a duration of therapy <2 years and a duration of therapy ≥2 years. The relationship between duration of antipsychotic therapy and hemoglobin levels was analyzed using unpaired t-test. Result:  The mean hemoglobin value for people with schizophrenia in the group with a duration of therapy <2 years is 14.09, while that in the group with a duration of therapy ≥2 years is 14.06 with a p value = 0.928. Conclusion: There was no relationship between hemoglobin levels in people with schizophrenia and duration of therapy both <2 years and ≥2 years.
Comparison Of Clinical Response Between Combine Chemotherapy 5 Fluorourasil - Platinum Based And Ifosfamid - Taxane - Platinum Based In Recurrent Nasopharyngeal Carcinoma Sanjaya, Rio; Yusmawan, Willy; Antono, Dwi; Marliyawati, Dwi; Yunika, Kanti
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.926

Abstract

BACKGROUND : Recurrence of Nasopharyngeal Carcinoma (NPC) is the emergence of a tumor remission after administration of chemoradiation based on symptoms and several examinations. The combination of chemotherapy in recurrent NPC still gives good results. The combine of regimens used is still varied and not much study has been done to assess the clinical response. OBJECTIVE : To compare the clinical response between administration of combination 5 Fluorouracil-Platinum based (5-FU) and Ifosfamide-taxan-platinum based (IFO) in recurrent NPC. METHOD :. This observational study used electronic medical record (ERM) data at the ENT oncology clinic at Dr. Kariadi General Hospital for the period January 2020-January 2022. The number of samples that suited to the inclusion and exclusion criteria was 44 subjects divided into two groups of 22 subjects respectively. The chi-square test was used to assess differences in alteration of clinical symptoms, tumor mass size, neck lymph node enlargement, tumours stage reduction, and the effect of confounding factors on response to therapy in both groups. RESULTS : The highest number of patients with recurrent NPC were aged ≥45 Years old and male (75%). WHO type 3 is the most common (95.5%) and ECOG status 1 (95.5%). There was no significant difference administration of the combination of 5-FU with IFO in alteration of clinical symptoms (p=0.500), shrink tumor size (p=0.347), reduction of neck lymph node size (p=0.164), and reduction tumor staging (p=0.347). There was no relationship from confounding factors to clinical response between the administration of the two groups. CONCLUSION : Administration of 5 Fluorouracil-platinum based combination chemotherapy did not provide a better clinical response in terms of clinical symptoms, changes in primary tumor size, neck lymph node size, and decreased tumor stage compared to the Ifosfamide-taxane-platinum based combination based on recurrent NPC.
EFEKTIVITAS SKIN BARRIER ACRYLATE TERPOLIMER TERHADAP KEJADIAN MEDICAL ADHESIVE RELATED SKIN INJURY (MARSI) PADA ANAK YANG DIRAWAT DI RUANG INTENSIF RSUPN DR. CIPTO MANGUNKUSUMO Mutifa, Juanda; Nurhaeni, Nani; Apriyanti , Efa
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.928

Abstract

BACKGROUND: For a long time, the use of medical adhesives in invasive device installation procedures can cause medical adhesive related to skin injury (MARSI) in children; in order to minimize the risk of MARSI incidents, so that a skin barrier is needed before applying the adhesive. OBJECTIVE: The purpose of this study is to determine the effectiveness of acrylate terpolymer skin barrier against medical adhesive related to skin injury (MARSI) prevention  in children who are treated at the intensive care unit. METHOD: This study used a true experimental design which involved 46 children; it was divided into an intervention group of 24 respondents and a control group of 22 respondents who were treated by using medical adhesive due to the procedure for inserting an endotracheal tube and nasogastric tube. Samples were taken by using random sampling technique. The risk level of skin injury was assessed by using the Braden Q scale and the MARSI incidents were observed by using the observational format. RESULT: The results showed that the acrylate terpolymer skin barrier was effective in reducing the MARSI in children who were treated at the intensive care unit with having a p-value of 0.03 (α <0.05). The use of an acrylate terpolymer skin barrier can be recommended to minimize the incidence of MARSI in children. CONCLUSION: The use of acrylate terpolymer skin barrier significantly minimizes the incidence of MARSI in children.  
A 25-year-old Woman with Cholecystolithiasis, Cholecystitis, Choledocholithiasis, and Acute Hepatitis Nathanael, Naldo; Purnomo, Hery Djagat; Permatadewi, Cecilia Oktaria
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 2 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i2.930

Abstract

Introduction: Gallstone disease stands as the foremost gastrointestinal issue leading to hospital admissions, while also emerging as a substantial global public health concern, impacting approximately one-fifth of the population. Case Report: A 25-year-old woman was admitted with abdominal pain with a history of gallstones. She had risk factors such as obesity with a Body Mass Index (BMI) of  35.3 and dyslipidemia. Further examination showed that she had acute hepatitis and choledocholithiasis. The patient underwent Endoscopic Retrograde Cholangiopancreatography (ERCP) with balloon extraction. The patient recovered from her condition then scheduled for cholecystectomy. Conclusion: This case showed a relatively young female with cholecystolithiasis, cholecystitis,  choledocholithiasis, and acute hepatitis presenting with colicky pain. Comprehensive management of gallstone diseases is essential to avert additional complications and the possibility of relapse, especially considering the young age of the patient.
Analysis of the Relationship between Neutrophils, Lymphocytes, and Comorbidities with Time to Death in COVID-19 Patients Tanuwijaya, Hendra; Djajalaksana, Susanthy; Tantular, Rezki
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.932

Abstract

BACKGROUND: COVID-19 caused 5.4 million deaths in 2021. Various parameters such as comorbidities and laboratory findings are known to be predictors of death in COVID-19, but these findings differ in each country, and their relationship to time of death has not been widely studied. This study was conducted to determine the relationship between levels of neutrophils, lymphocytes, neutrophil to lymphocyte ratio (NLR), and comorbidities with time to death in COVID-19. METHODS: A retrospective cohort study was conducted from April 2020 to September 2021 in the COVID-19 Inpatient Room at RSUD dr. Saiful Anwar Malang with 300 COVID-19 patient subjects aged 18 years and over. Data on comorbidities (hypertension, CAD, HF, obesity, COPD, CKD, cancer), time to death, and laboratory were taken from medical records. The Kolmogorov-Smirnov test, Chi square test and Mann Whitney test were carried out to analyze the data. RESULTS: There was a significant relationship between neutrophil levels and time to death, as well as a significant difference in neutrophil levels in the group with time to death >48 hours with comorbidities compared to <48 hours with and without comorbidities. There was a significant difference in lymphocyte levels and NLR in patients with comorbidities with time to death <48 hours and >48 hours (p < 0.05). CONCLUSION: There is a significant relationship between neutrophil levels and time to death, both in subjects with and without comorbidities showing the potential of neutrophil levels as a predictor of time to death in COVID-19.
Correlation Between Testosterone Level With HBA1C Level As Glycemic Control Marker Among Type 2 Diabetes Mellitus Patient Harahap, Raja Iqbal Mulya; Tristina, Nina; Nurhayati, Imas; Rachmayati, Sylvia
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.941

Abstract

BACKGROUND: Type 2 Diabetes Mellitus could cause various complications due to formation of advanced glycation end products (AGEs).  The AGEs could destroy many organs into cellular level, one of them is testis, then causing testosterone production deficiency, and hypogonadism. Meanwhile, the AGEs formation in vivo will depend on on mean glucose level in T2DM patient. HbA1C is one of the most common parameter used to asses glycemic control among T2DM patient. OBJECTIVE: This research was conducted to find out the correlation between serum total testosterone with HbA1C level among T2DM patient METHOD:Research subject was collected from Outpatient Polyclinic of Internal Medicine Departement Hasan Sadikin Hospital. HbA1C examination was conducted with turbidimetry method, meanwhile total testosterone level was performed with ELISA method. The examination of research parameter was done at Clinical Laboratory Installation of Hasan Sadikin Bandung   RESULT: During sample collection periode, 70 patients was collected and fulfilled the inclusion criteria, 18 of 70 subjects has low testosteron level with Mean (SD): 424, 48 (204,82) ng/mL. Correlationntesting between the variables showed r = -0,619 , and p-value <0.001, which means strong and significant correlation between total testosterone and HbA1C among T2DM patient.   CONCLUSION: There was strong and significant correlation between total testosterone with HbA1C level among T2DM patients, further research could be conducted with prospective cohort method or using free testosterone examination.
Functional Capacity COVID-19 Survival Among Workers in Koja Public Health Center Harini, Melinda; Mistivani, Ira; Kusumaningsih, Widjajalaksmi; Sunarjo, Peggy; Laksmitasari, Budiati; Nelfidayani; Wardhani, Rizky Kusuma; M J, Ni Luh Made; Ekawati, Ratna; Edvina; Ockta, Prisca; Adhitya; Rozanti, Reni; Fakhrazi, Ricky; Leo, Felix; Wati, Novita Suprapto; Wahyuningsih, Endang Sri; Oktavia, Dwi; Yuliandra, Rofi; Astuty, Vinnaria; Wahyuni, Sri Puji; Tantri, Julieta; Putra, Gilang Rama
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.942

Abstract

Introduction: Coronavirus disease 19 (COVID-19) primarily affects the respiratory system and other organ systems which limit respiratory and physical status. The aim of this study is to evaluate functional capacity COVID-19 survivor among workers in Koja Public Health Center Methods: participant were enrolled on March-April 2022. Demographics, symptoms, functional scale post COVID-19 questionnaire, risk stratification, and 6-min walk test (6mwt) were analysed. Patients unable to walk were excluded from the study. Results: 79 participants, 38% was a health care worker, had a median age 33 (21-57) years and 43 women (54.4%). Men had higher 6mwt 518.2 (120-625.8) meter while women had 457 (340-600) meter p (<0.001), VO2max 17.47 (9.74-20.67) in men and 16.45 (14.07-19.19) in women p (<0.001), and METs 5.02 (2.78-5.90) in men and 4.69 (4.02-5.48) in women p (<0.001). Most of the participant had good fitness, 10 participant (12.7%) had functional limitation; 2 participants (2.5%) still had symptom. Conclusion: Despite being COVID-19 survivors, the workers at the Koja Public Health Center have good functional capacity.
The Relationship Between Obesity and Allergies with Olfactory Disorders in Covid-19 Patients Pratama, Yudistira; Kusuma Dewi, Anna Mailasari; Muyassaroh; Hariyati, Riece; Yusmawan, Willy
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.949

Abstract

Background: The prevalence of olfactory disorders is around 68% - 85% which occurs in COVID-19 patients with obesity and allergies as risk factors. The abnormalities olfactory pathways can cause by inflammatory response in adipose tissue in obese patients and excessive inflammation due to hyperreactivity of the immune system to allergens in allergic patients. This study aims to analyze the relationship between obesity and allergies to the occurrence of olfactory disorders in COVID-19. Method: It was an observational study during pandemic. Subjects were adult COVID-19 patients in the dr. Kariadi Hospital from June to July 2021. Patient with complete medical record ask for olfactory and allergic questionnaire. Patient with nasal tumor were excluded. Result: We found 100 subjects who meet the criteria. There was a significant difference in smell disturbances between obese and non-obese subjects. (p = 0.019, OR 4.99). There was a significant difference (p=0.001) in complaints of olfactory disorders between allergic and non-allergic subjects, whereas all allergic subjects experienced olfactory disorders. Conclusion: Obesity and allergies are corelated with impaired smell in COVID-19 patients.
Effect of Kinesio Taping on Muscle Spasticity in Post-Stroke Patients Receiving Infrared Therapy and Stretching Exercise : A Quasi-Experimental Study Riswanti, Andirezeki; Kartadinata, Robby Tjandra; Julianti, Hari Peni; Zuhdiana, Hindun; Wibisono, Lilik Sigit
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.952

Abstract

BACKGROUND: Spasticity is one of the symptoms of a stroke. One of the muscles with increased tone is the plantar flexor (66%). Spasticity is commonly treated with infrared therapy and stretching exercises. Kinesio Taping is a skin-based therapeutic procedure that uses elastic tape and can be used with infrared therapy and stretching exercises. Kinesio Taping is predicted to reduce spasticity in the plantar flexor muscle as determined by the Tardieu scale, improving functional walking.   OBJECTIVE: To demonstrate the efficacy of adding Kinesio Taping on lower extremity muscular spasticity in post-stroke patients who had previously received infrared and stretching exercises.   METHOD: This study is a controlled group design with a quasi experimental pre and post test. Post-stroke patients were divided into two groups: the control group (16 patients) and the treatment group (16 patients) who received the addition of Kinesio Taping. Before and after 6 weeks of treatment, the Tardieu scale was measured.   RESULT: Before and after treatment, there was a significant difference in Tardieu scale (both on quality and angle of resistance) in each group (p < 0.05), and there was a significant difference in Tardieu scale in the two groups (p < 0.05).   CONCLUSION : Kinesio Taping has been demonstrated to significantly reduce plantar flexor muscle spasticity in stroke survivors.  

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