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Gambaran Laboratorium pada Sindroma Nefrotik Tjiptaningrum, Agustyas; Aulia, Diana
Jurnal Kedokteran Universitas Lampung Vol 3, No 2 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i2.2500

Seorang anak perempuan usia 13 tahun, datang ke IGD RSUPN Cipto Mangunkusumo dengan keluhan bengkak seluruh badan.. Tiga bulan sebelum masuk RS, terdapat bercak merah di dahi, pinggang, perut, dan kaki, bercak terasa gatal, berobat ke puskesmas diberi obat oles. Setelah dioleskan obat bercak merah bertambah merah sehingga obat dihentikan. Dua bulan sebelum masuk RS, wajah, kaki, dan tangan bengkak, BAK banyak, tidak nyeri, warna urin kadang bening kadang seperti air cucian daging, volume urin banyak, tidak ada demam, riwayat batuk pilek dan sakit tenggorokan disangkal. Pasien berobat ke puskesmas Cibinong dan mendapat obat tablet warna hijau dan amoksisilin. Setelah minum obat ada perbaikan.Dua hari sebelum masuk RS, wajah pasien bengkak, kaki dan tangan juga bengkak. Keluhan disertai mual dan muntah. Riwayat alergi anak maupun keluarga semua disangkal.Pada pemeriksaan fisik tampak sakit sedang, hipertensi dengan tekanan darah 160/100 mmHg, konjungtiva palpebrae anemis, edema pada palpebra superior, wajah, dan kedua ekstremitas, serta asites. Hasil pemeriksaan laboratorium didapatkan proteinuria(+3), leukosituria, hematuria, uremia, peningkatan kreatinin, hipoalbuminemia, hiperkolesterolemia, anemia, leukositosis, dan trombositosis. Berdasarkan data diatas, pasien didiagnosis sebagai sindroma nefrotik dengan diagnosis banding nefritis akut. Untuk pemeriksaan lanjutan disarankan pemeriksaan protein total, protein kuantitatif urin, anti streptolisin O, anti nuclear antibody (ANA), anti dsDNA, C3 dan C4.Kata kunci: edema, hipertensi, kreatinin, proteinuria, uremia, sindroma nefrotik

Hubungan Antara Kadar D-Dimer dengan Angka Mortalitas pada Pasien Dewasa Terkonfirmasi Coronavirus Disease 19 di RSUD Abdul Moeloek Bandar Lampung Periode Tahun 2020 – 2021.docx Attila Firjatullah, Muhammad Daffa; Tjiptaningrum, Agustyas; Putri, Giska Tri
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1055

Lampung is one of the regions with the highest Case Fatality Rate (CFR) in Indonesia, which was 7.7% on September 16, 2021. Several studies have shown that D-Dimer levels influenced the mortality of confirmed Covid-19 patients. This study aimed to analyze the correlation between D-Dimer levels and the mortality rate of confirmed Covid-19 adult patients. This research was an observational analytic study using a cross-sectional approach. The population of this study was all confirmed covid-19 adult patients who fulfilled the inclusion and exclusion criteria in Abdul Moeloek Hospital Medical Record Installation from 2020 to 2021. The samples were taken using simple random technique. Data collected were D-Dimer level, mortality rate, and patient’s personal information. Data were analyzed by Chi-Square using statistical data processing program. There were 94 subjects admitted in our study, divided into groups of survivors and non-survivors. From the non-survivors’ group, 43 (91%) subjects had a high D-Dimer level. The Chi-Square analysis showed a correlation between D-Dimer levels and the mortality rate of Covid-19 patients (p-value = 0,001). Statistically, there was a significant correlation between D-Dimer levels and the mortality rate of confirmed Covid-19 patients.

Efek Perasan Rimpang Kunyit (Curcuma longa L.) Terhadap Gambaran Epitel Lambung Mencit yang Diinduksi Indometasin Shabrina, Annisa Firra; Carolia, Novita; Tjiptaningrum, Agustyas
Jurnal Kesehatan Holistic Vol. 8 No. 1 (2024): Jurnal Kesehatan Holistic Volume 8/ Nomor 1/ Juli 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan RS Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33377/jkh.v8i1.188

Background: Gastric ulcers are stomach lesions characterized by depleted mucosa with the defect extending into the submucosa or muscularis propria. Gastric ulcers could be caused by the use of Indomethacin as an analgesic drug. Turmeric rhizome is a herbal plant that contains curcumin which has been suspected to play a role in gastric ulcer prevention. Objective: The aim of this study was to perceive the effect of turmeric rhizome juice with concentrations of 100%, 75%, and 50% on indomethacin-induced gastric epithelium image in mice. Methods: This experimental study with a Post Test Only Control design was conducted by using 25 samples of male ddY mice for 3 days intervention. Samples were divided into 5 groups, two control groups, and three intervention groups. The organ samples had been observed by assessing the gastric epithelium injury of mice on the antrum under a microscope with an objective lens 100x for eight fields of view. Results: The Kruskal-Wallis test had been used for analysis and showed a p-value of 0,025 which means it had a significant difference. Turmeric juice with concentrations of 100%, 75%, and 50% showed different effects on mice gastric epithelium image induced by Indomethacin (18 mg/kg). Conclusion: There were different effects of turmeric juice on gastric epithelium image induced by Indomethacin in mice.

Breast Cancer Metastases Based on Molecular Subtypes at RSUD Dr. H. Abdul Moeloek Lampung Nurmayeni; Islamy, Nurul; Tjiptaningrum, Agustyas; Siregar, Bintang Abadi; Kusumaningtyas, Aditya; Windarti, Indri
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.904

BACKGROUND:Breast cancer is the most common cancer in Indonesia and is a leading cause of cancer-related deaths in the country. Metastases are responsible for most deaths among breast cancer patients. Breast cancer is typically classified into four subtypes based on immunohistochemistry: luminal A, luminal B, HER2+, and TNBC. OBJECTIVE:To determine the association between the metastatic pattern of breast cancer and their molecular subtypes at RSUD Dr. H. Abdul Moeloek Lampung. METHOD:This study was an observational analytic study with a cross-sectional design. The sample comprised 81 individuals who had suffered from breast cancer and were recorded in the medical records section of RSUD Dr. H. Abdul Moeloek Lampung between 2013 – 2021 and met the inclusion and exclusion criteria. The association between breast cancer subtypes and the incidence and metastase sites were tested using the Chi-Square test. RESULT:This study found a significant association between breast cancer subtypes and the incidence of metastases (p <0.05). The TNBC subtype had a more frequent rate of metastases (34.5%) than the other subtypes (31% luminal B, 20.7% luminal A, and HER2+ 13.8%). The study also revealed a relationship between ER status and the incidence of metastases (p < 0.05). The luminal A subtype tends to metastasize to the liver, luminal B tends to metastasize to the bone, HER2+ tends to metastasize to the lung and liver, and TNBC tends to metastasize to the lung. However, no significant association was found between breast cancer subtypes and metastatic sites. CONCLUSION:There was a significant association between breast cancer subtypes and the incidence of metastases, but not with the metastatic sites.

Efek Perasan Rimpang Kunyit (Curcuma longa L.) Terhadap Gambaran Epitel Lambung Mencit yang Diinduksi Indometasin Shabrina, Annisa Firra; Carolia, Novita; Tjiptaningrum, Agustyas
Jurnal Kesehatan Holistic Vol. 8 No. 1 (2024): Jurnal Kesehatan Holistic Volume 8/ Nomor 1/ Juli 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan RS Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33377/jkh.v8i1.188

Background: Gastric ulcers are stomach lesions characterized by depleted mucosa with the defect extending into the submucosa or muscularis propria. Gastric ulcers could be caused by the use of Indomethacin as an analgesic drug. Turmeric rhizome is a herbal plant that contains curcumin which has been suspected to play a role in gastric ulcer prevention. Objective: The aim of this study was to perceive the effect of turmeric rhizome juice with concentrations of 100%, 75%, and 50% on indomethacin-induced gastric epithelium image in mice. Methods: This experimental study with a Post Test Only Control design was conducted by using 25 samples of male ddY mice for 3 days intervention. Samples were divided into 5 groups, two control groups, and three intervention groups. The organ samples had been observed by assessing the gastric epithelium injury of mice on the antrum under a microscope with an objective lens 100x for eight fields of view. Results: The Kruskal-Wallis test had been used for analysis and showed a p-value of 0,025 which means it had a significant difference. Turmeric juice with concentrations of 100%, 75%, and 50% showed different effects on mice gastric epithelium image induced by Indomethacin (18 mg/kg). Conclusion: There were different effects of turmeric juice on gastric epithelium image induced by Indomethacin in mice.

Dampak Asap Rokok terhadap Kadar SGPT Nirwana HR, Herlingga; Tjiptaningrum, Agustyas; Karima, Nisa
Jurnal Penelitian Perawat Profesional Vol 6 No 5 (2024): Oktober 2024, Jurnal Penelitian Perawat Profesional
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jppp.v6i5.3284

Indonesia adalah negara ketiga yang paling tinggi terhadap kejadian merokok di dunia, menurut data WHO (World Health Organization). Menghirup asap rokok secara rutin dapat memicu sejumlah penyakit, termasuk kerusakan hati. Meningkatnya kadar SGPT dalam aliran darah menandakan adanya kerusakan hati. Enzim SGPT merupakan komponen umum sel hati dan berguna dalam diagnosis kerusakan hepatoseluler. Dengan menelusuri berbagai majalah nasional dan internasional, tinjauan pustaka ini berupaya mengetahui dampak asap rokok terhadap kadar SGPT. Artikel yang digunakan berkisar pada tahun 2014–2023 menggunakan kata kunci “merokok” dan “kadar SGPT”. Dua puluh makalah yang memenuhi kriteria ditemukan di database Pubmed, NCBI, dan Google Scholar. Selanjutnya, temuan penelitian dirangkum dan makalah diperiksa dan dievaluasi. Kadar SGPT diketahui meningkat sebagai respons terhadap paparan asap rokok.

Pengaruh HbA1c Terhadap Profil Lipid pada Pasien Diabetes Melitus Tipe 2 Suci, Maghfirly Juniarti Eka; Tjiptaningrum, Agustyas; Setiawan, Gigih; Kurniati, Intanri
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1263

Diabetes Mellitus (DM) is characterized by a state of hyperglycemia due to insulin resistance, decreased insulin production, or both of these conditions which are classified into metabolic diseases. When checking the condition of type 2 DM, HbA1c can be checked as an indicator. High and uncontrolled HbA1c levels will cause disturbances in lipid profiles such as increased triglycerides, LDL, total cholesterol, and decreased HDL. The purpose of this study is to determine whether or not there is an effect of HbA1c on lipid profiles in type 2 DM patients. This method uses scientific publication search media such as Google Scholar, Pubmed, and old medical scientific journals using the keywords “lipid profile, HbA1c, type 2 diabetes mellitus, and dyslipidemia” obtained 15,700 articles and scientific journals. In patients with type 2 diabetes mellitus, glycemic control can be determined by HbA1c examination, high HbA1c levels are associated with disruption of lipid profile levels. The results of the study discuss the effect of HbA1c levels on lipid profiles in patients with type 2 diabetes and determine the relationship between the two.

Hubungan Rasio Neutrofil Limfosit (RNL) Dengan Lama Rawat Inap Pada Pasien Pneumonia Di Rumah Sakit Umum Daerah Dr. H. Abdul Moeloek Provinsi Lampung Julianti, Dinul Aliya; Sangging, Putu Ristyaning Ayu; Pardilawati, Citra Yuliyanda; Tjiptaningrum, Agustyas
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1316

Pneumonia is an acute infection of the lung tissue due to bacteria, viruses, and fungi. Increased RNL values in pneumonia patients are biomarkers to systemic inflammatory responses that are easily quantified, inexpensive, and easily interpretable in the prognosis of pneumonia patients associated with length of stay. However, there is still not much relevant amount of research, and its application in daily practice is still minimal. This study aimed to identify the relationship of NLR with the length of hospitalization in pneumonia patients. This study used a cross sectional design. The data collection technique is a total sampling with a sample size of 39 patients. The research location is at Dr. H. Abdul Moeloek Regional General Hospital, Lampung Province and will take place in July-December 2022. The independent variable is RNL, while the dependent variable is the length of stay. Data obtained from the results of laboratory supporting examinations in the medical records of pneumonia patients. The collected data were then analyzed using the Chi-square test with a CI of 95%. The results showed that the majority of patients came from the age group of 51-60 years (51.3%) and were male (61%). The average pneumonia patient had a high ANC value (9,260) and a normal ALC (1,244) so that a high NLR average (10,067) was obtained with an average long stay (6 days). There is a relationship between NLR and length of stay in pneumonia patients at Dr. H. Abdul Moeloek Regional General Hospital, Lampung Province (p<0.05).

Penatalaksanaan Holistik Penyakit Kulit Neurodermatitis Sirkumskripta Pada Seorang Pria Lanjut Usia Di Desa Sukaraja V Gedong Tataan Saraswati, Andini; Tjiptaningrum, Agustyas; Karyus, Ayla
JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Vol. 2 No. 1 (2016): JURNAL PENGABDIAN MASYARAKAT RUWA JURAI
Publisher : FK Unila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpmrj.v2i1.1168

Neurodermatitis sirkumskripta adalah peradangan kulit kronis, gatal, sirkumskrip, dengan ciri khas kulit yang tebal dan likenifikasi (garis kulit tampak lebih menonjol). Neurodermatitis sirkumpskripta sering ditemui pada masyarakat umum usia dewasa (lebih dari 20 tahun), puncak insidennya antara 30-50 tahun. Insiden terjadi lebih sering pada wanita daripada pria. Studi ini merupakan laporan kasus. Pada laporan kasus ini diterapkan pendekatan dokter keluarga secara holistik dan komprehensif untuk mendeteksi faktor risiko serta menyelesaikan masalah berbasis Evidence Based Medicine yang bersifat family-approached dan patient-centered.Data primer diperoleh melalui anamnesis, pemeriksaan fisik dan kunjungan ke rumah pasien. Data sekunder didapat dari rekam medis pasien. Pasien pria, 66 tahun datang dengan keluhan gatal, kulit yang menghitam dan menebal serta kering pada bagian lengan kiri sejak tiga tahun yang lalu.Gatal terutama dirasakan saat malam hari dan saat pasien tidak sedang beraktivitas. Pasien tidak memiliki alergi terhadap apapun. Stres menjadi pemicu dari keluhan yang dirasakan pasien. Pasien memiliki kebiasaan mandi air hangat. Pasien seorang pensiunan dengan status duda. Pasien dan keluarga tidak mengetahui penyakit kulit yang diderita oleh pasien. Pada pemeriksaan fisik didapatkan makula hiperpigmentasi batas tidak tegas serta likenifikasi. Intervensi dilakukan sebanyak tiga kali kunjungan rumah terhadap pasien dan keluarga. Pada evaluasi didapatkan kemajuan berupa berkurangnya keluhan pasien dan meningkatnya pengetahuan mengenai penyakitnya. Pelayanan dokter keluarga dalam terapi farmakologis maupun nonfarmakologis mampu menyelesaikan masalah kesehatan dan meningkatkan kualitas hidup pasien.Kata kunci: dokter keluarga, likenifikasi, sirkumskripta

Upaya Pencegahan Dermatitis Kontak Akibat Kerja pada Pengrajin Batik di Bandar Lampung Anggraini, Dwi Indria; Yusran, Muhammad; Rahmayani, Fidha; Tjiptaningrum, Agustyas; Sibero, Hendra Tarigan
JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Vol. 4 No. 1 (2019): JURNAL PENGABDIAN MASYARAKAT RUWA JURAI
Publisher : FK Unila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpmrj.v4i1.2530

Dermatitis kontak akibat kerja (DKAK) adalah peradangan kulit yang diakibatkan oleh lingkungan kerja. DKAK merupakansalahsatumasalahkesehatan yang sering terjadi pada pekerja di dunia, termasuk Indonesia. Beberapa penelitian melaporkan DKAK pada pengrajin batik cukup tinggi. Di Bandar Lampung dilaporkan kejadian DKAK pada pengrajin batik di Bandar Lampung sebesar 53,3%. Terdapat beberapa faktor eksogen dan endogen yang mempengaruhi kejadian DKAK. Pengetahuan pengrajin batik terhadap faktor-faktor tersebut masih kurang. Kegiatan ini bertujuan untuk meningkatkan pengetahuan pengrajin batik tradisional Lampung mengenai DKAK dan upaya pencegahan timbulnya DKAK. Kegiatan dilakukan di Batik Siger, Jalan Bayam No.38 Kemiling, Bandar Lampung pada tanggal 19 Oktober 2019. Khalayak sasaran yang mengikuti kegiatan adalah pengrajin batik tradisional, pengeloladan pemilik Batik Siger berjumlah 25 orang. Program dilakukan dengan beberapa cara, yaitu: pemberian materi kepada khalayak sasaran mengenai penyebab, tanda dan gejala klinis, cara pemeriksaan, penatalaksanaan, dan upaya pencegahan dan pengobatan DKAK; pemberian poster dan leaflet mengenai DKAK; pelatihan perawatan diri dan penggunaan APD pada khalayak sasaran; Focus group discussion (FGD). Hasil kegiatan ini menunjukkan rerata skor pengetahun sebelum dilakukan penyuluhan adalah 56,8 meningkat menjadi 93,2 sesudah penyuluhan. Seluruh peserta (100%) mengalami peningkatan pengetahuan setelah dilakukan intervensi. Terjadi peningkatan kemampuan perawatan diri menggunakan pelembap dan APD pada 100% pengrajin batik setelah dilakukan pelatihan. Simpulan kegiatan ini dapat meningkatkan pengetahuan dan kemampuan perawatan diri pengrajin batik tradisional.Kata Kunci: dermatitis kontak akibat kerja, pengrajin batik tradisional Lampung

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