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Biomolecular and Health Science Journal

BHSJ
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Published by Universitas Airlangga

ISSN : - EISSN : 26208636 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.

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Search results for , issue "Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal" : 16 Documents clear

Etiology Based on Clinical Manifestation of Acute Diarrhea Incidence of Children Hospitalized in Dr. Soetomo General Hospital Surabaya Period 2011-2013 Ashfahani Imanadhia; IGM Reza Gunadi Ranuh; Djohar Nuswantoro
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Diarrhea is one of the most common causes of morbidity and mortality of children worldwide, especially in developing countries. Acute diarrhea can occur from a large number of causes. We aim to describe the clinical manifestation characteristics of acute diarrhea on pediatric patients that are presented to the hospital.Methods: A cross-sectional study from all pediatric patients treated in Dr. Soetomo General Hospital Surabaya in 2011-2013.Age, gender, nutritional status, length of hospital stay, duration of breastfeeding, clinical signs and symptoms, as well as laboratory results collected and analyzed descriptively.Results: One hundred and fifty patients were included with characteristics of male(54%), infant (55.3%)with a mean age of 6-7 month. History of being exclusively breastfed(54%) and lack of nutrition(48%). Vomiting is mostly present (72.7%) and commonly come with a combination of two symptoms (42%) which were vomiting and fever. Mild to severe dehydration degree could be found on the patient who had vomiting, seizure, and fever. The most length of stay was frequently >72 hours. The occurrence of acute diarrhea on a child who was treated in Dr. Soetomo General Hospital Surabaya is dominated by vomiting and it could be inferred that the most acute diarrhea has a tendency of being caused by a virus, where liquid acute diarrhea without blood, mucus, or fever is found.Conclusion: The etiology of acute diarrhea is mostly caused by viruses and symptoms dominated by a combination of vomiting, fever, and diarrhea without blood caused by villi damage.

Antibacterial Effects of Fluoride in Streptococcus mutans Growth in Vitro Yura Pradiptama; Marijam Purwanta; Harianto Notopuro
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Streptococcus mutans is a gram-positive coccus commonly found in the human oral cavity and is a pathogen of dental caries. S. mutans known to form biofilm in infective endocarditis heart-valve. Fluoride usage known to reduce the risk of dental caries. This study aims to analyze how usage of fluoride in inhibiting S. mutans growth.Methods: This study was an experimental study. Antibacterial activity test was performed to evaluate the minimum inhibitory concentration (MIC) using dilution method of sodium fluoride. The minimum bactericidal concentration (MBC) was determined by culturing from the previous dilution test into Chocolate Agar Plate.Results: MIC for sodium fluoride is 4,8 mg/ml and the MBC for sodium fluoride to S. mutans is 4,8 mg/ml. We found S. mutans growth in higher concentration than 19,2 mg/ml. Conclusion: S. mutans was inhibited in dilution test. Growth of the bacteria in higher concentration of sodium fluoride is explained with quasi-irreversible inhibtior effects of fluorida.

Head Computed Tomography Images of HIV/AIDS Patients with Suspected Cerebral Toxoplasmosis in Dr. Soetomo General Hospital Surabaya Ria Wibawani; Bambang Soeprijanto; Widiana Ferriastuti; Erwin A Triyono
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Toxoplasma gondii is an intracellular pathogenic parasite with the majority of co-infections occurring in HIV/AIDS patients. This study assesses the head computed tomography (CT) images of cerebral toxoplasmosis in patients with HIV/AIDS.Methods: This study was a cross-sectional design using head CT images of 35 HIV/AIDS patients with suspected cerebral toxoplasmosis. Variables include lesion type, location, size, CD4 count, and therapeutic result with anti-cerebral toxoplasmosis. All data analysed descriptively.Results: From total 110, 35 patients met the inclusion criteria. 24 patients (68.6%) were male and 11 (31.4%) female, average age, was 36.1. 8 patients (22.3%) had lesions in cortical, 31 patients (88.6%) had < 1 cm lesion. Single lesions mainly calcified and found in the right centrum semiovale while multiple lesions were subcortical. A hypodense lesion with rim or nodular contrast enhancement is found in 75% of patients with CD4 > 200 in contrast to slight rim contrast enhancement and perifocal edema in patients with CD4 < 200. 20 patients (57.4%) had improved condition after anti-toxoplasmosis therapy.Conclusion: Cerebral toxoplasmosis lesions in HIV/AIDS patients have various types of imaging findings, mostly multiple, with most frequent location being cortical and diameter < 1 cm. Total recovery is achieved in the majority of patients with therapy.

Infant Birth Weight in Mothers with Maternal Anemia at Dupak Public Health Center Surabaya Working Area in 2017 Marisabell Giovanni; Gwenny Ichsan Prabowo; Widati Fatmaningrum
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Anemia in pregnant women is a factor that directly affects the incidence of LBW and can be measured to determine nutritional status during pregnancy. This research is to determine the association of infant birth weight in mothers with maternal anemia at Public Health Center working area in Surabaya.Methods: This research was a cross-sectional approach The sample of this research were 75 pregnant women at Dupak Public Health Center in Surabaya City in 2017 taken by total sampling technique. The data used was taken from the 2017 mother cohort book.Results: The incidence of LBW at Dupak Public Health Center Surabaya working area in 2017 was 12 people (16%). The incidence of anemia at Dupak Public Health Center Surabaya working area in 2017 was 38 people (50.7%). The correlation between LBW and anemia in pregnancy using Chi-Square was p = 0.496.Conclusion: There was no correlation between maternal anemia and LBW There are other factors that can affect the incidence of LBW, such as body weight and maternal height, the number of parity, a short pregnancy distance, and the existence of problems in the history of previous pregnancy and childbirth.

Risk Factors for Urinary Tract Infection in Hospitalized Patients Hadiati Setyorini; Nunuk Mardiana; Artaria Tjempakasari
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Urinary tract infection (UTI) is the most common infection that can be fatal and has higher rate mortality especially in some patient. This study is aim to analyze risk factors for urinary tract infection in hospitalized patients for prevention and more aggressive approach can be taken.Methods: Consecutively, medical records of 285 patients with urinary analysis was recorded for risk factors and urine culture results if suspected UTI. Risk factors for sex, age, urinary catheter, urolithiasis, DM, and immobilization was analyzed with bivariate analysis and multivariate analysis.Results: From 285 patients, 92 patients had UTI with average age was 52.45 years old, 48 (56.49%) were female. Most common pathogen were E. coli (41.3%), Enterobacter sp. (8.8%) and Enterococcus faecalis (7.6 %). From bivariate analysis, geriatric age (>60 years) has RR 1.421 (95% CI 1.015-1.989, p=0.046) and immobilization has RR 1.861 (95% CI 1.266-2.738, p=0.007), whereas sex (RR 1.190 95% CI 0.851 – 1.664, p=0.310), diabetes (RR 1.171 95% CI 0.833 – 1.645, p=0.367), insulin usage (RR 0.900 95% CI 0.519 – 1.561, p= 0.703), glycosuria (RR 1.152 95% CI 0.741 – 1.791, p=0.522), and CKD (RR 1.475 95% CI 0.896 – 2.430, p= 0.126) give insignificant result. From multivariate analysis, urinary catheter has OR 4.506 (95% CI 2.312-8.872, p=0.000), urolithiasis with OR 4.970 (95% CI 1.931-12.787, p=0.001), and hyperglycemia has OR 2.871 (95% CI 1.485-5.551, p=0.002).Conclusion: Geriatric age and immobilization are risk factors for urinary tract infection, and urinary catheter, urolithiasis, and hyperglycemia are independent risk factors for urinary tract infection.

Effects of Climatic Factors on The Incidence Rate of Dengue Virus Infection in Surabaya During 2010-2013 Winni Aprillia Putri; Abu Rohiman; Sulistiawati Sulistiawati; Dwiyanti Puspitasari
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Dengue Virus Infection (DVI) is one of cautious mosquito-borne virus disease that transmitted by Aedes aegypti and Aedes albopictus. Surabaya has the highest incidence rate of DVI in East Java. Transmission of dengue virus were significantly affected by the change of climatic factor components (precipitation, temperature, and humidity). This study is aimed to analyze the correlation between climatic factor components with the incidence rate of DVI in Surabaya and its distribution.Methods: This is a cross-sectional study using analytic observational approach. The Incidence rate of DVI during 2010-2013 datas were taken from Surabaya Health Office. Climatic factor datas on the same years were taken from Juanda Meteorological Station. Correlation tests were performed by using Spearman Test.Results: As the result, there were 7,685 DVI patients during 2010-2013. Male patients have less proportion (51.89%). The highest DVI cases are from the age group of 5-14 years (>40%). Incidence rate of DVI was increased during February to April, and highest incidence rate occured in 2010 (n=3,379). There were significant correlation between precipitation (r=0.419, p-value p=0.003) and humidity (r=0.502, p-value=0.000) with the incidence rate of DVI in Surabaya during 2010-2013.Conclusion: Therefore, precipitation and humidity are two climatic factor components that may effect the incidence rate of DVI in Surabaya.

Epidemiological Study of Clinical and Laboratory Profiles of Patients with Acute Lymphoblastic Leukemia at Dr. Soetomo Hospital Surabaya Kezia Warokka Putri; I Dewa Gede Ugrasena; Yetti Hernaningsih
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Considering the high number of acute lymphoblastic leukemia (ALL) and it being the type of cancer with the highest fatality rate among the children, this study seeks to determine the epidemiological description of the clinical and laboratory profiles of patients with ALL.Methods: This research used a descriptive study by using medical data record of patients with ALL. The research variables were gender, age, leukemia history of the patient’s family, nutritional status, symptoms and signs, laboratory examination, ALL subtypes, risk factors, and result outcomes. All data presented descriptively.Results: From a total of 50 patients, 54 % of them were male aged 1,5 – 10 years old. 84% of the patients’ family had no medical record related to leukemia. 42% of the patient malnutrition. Pale (78%), fever (64%), pain (32%), hepatomegaly (38%), lymphadenopathy (28%), splenomegaly (26%), patients with anemia (82%), leukocytosis (38%), thrombocytopenia (54%). The highest types were ALL–LI (68%), SR-ALL (54%), and remission outcome reached 82%.Conclusion: Insidence higher in male, aged 1,5 – 10 years old, malnourished at the start of the diagnosis. Most of the patients’ family had no medical history of leukemia. Symptoms and medical signs mostly appeared were pale, fever, and bone/joint pain. The physical examination showed hepatomegaly, lymphadenopathy, and splenomegaly and laboratory first test showed the patients had anemia, leukocytosis, and thrombocytopenia.

Characteristic of Hemophilia A Patients in Initial Diagnosis in Dr. Soetomo General Hospital Surabaya Angela Dinaria Kemala Swary; Mia Ratwita Andarsini; Arifoel Hajat
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: This research is conducted to describe the characteristic of Hemophilia A patients.Methods: Cross-sectional study conducted in 55 patients with Hemophilia A. The variables were age, bleeding episode, factor VIII level, and bleeding site. The data presented descriptively.Results: The largest group was 2-10 years old (52,73%). The most common bleeding episode occured in the patients was moderate level (60,0%). The most common patient’s factor VIII level was moderate level (52,7%). The patient’s bleeding most likely took place in muscle or known as hematoma (41,8%). While the less likely bleeding were intracranial and nose bleeding.Conclusion: 2-10 years old patient are the largest group because of hemophilia A mostly diagnosed in childhood, where children are actively moved so that the spontaneous bleeding or abnormal bleeding can be seen easily. Parents needs to be aware if there were abnormal or spontaneous bleeding which takes place in muscle or known as hematoma with moderate episode of bleeding which meant that the occurrence of spontaneous bleeding is periodically happened or in prolonged bleeding accompanied by minor trauma or invasive action.

Correlative Study Between Nutritional Status and Remission Outcome in Childhood Acute Lymphoblastic Leukemia in Dr. Soetomo General Hospital Surabaya Asma' Athifah; Siti Nurul Hidayati; Sulistiawati Sulistiawati
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: The most common malignancy that is diagnosed in children is acute lymphoblastic leukemia. Undernourished children tend to have poorer long term survival. This descriptive analytic study is aimed towards analyzing the correlation between nutritional status at diagnosis and outcomes of induction phase therapy in childhood acute lymphoblastic leukemia at the Department of Pediatrics Dr. Soetomo General Hospital Surabaya in 2014.Methods: A cross-sectional method using the medical records of patients is used in this study. The nutritional statuses of patients are calculated using weight for length/height trough curves of WHO 2006 or CDC 2000.Results: The results show that from 45 children diagnosed with ALL, 53% are of the age ≤ 5 years old, with 58% males and 42% females. 13% of the patients are in the high risk group and 87% are in the standard risk group. Nutritional statuses of patients are 2% of them obese experienced remission after induction phase therapy, 56% normal with 80% of them experienced remission. 40% underweight with 89% of them experienced remission and 11% not experienced remission, 2% malnutrition and experienced remission. There is no correlation between the nutritional status of children with acute lymphoblastic leukemia with the outcome of induction phase (p = 0.798).Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes.

The Role of Imaging In The Diagnosis of Pulmonary Embolism Alfian Nur Rosyid; M. Yamin; Arina Dery Puspitasari
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Pulmonary embolism is a common condition and sometimes can be life-threatening. A proper diagnosis can reduce mortality. Some examinations are needed to diagnose pulmonary embolism, including assessing the risk factors, clinical examination, D-dimer tests, and imaging. Imaging is necessary when the previous assessment requires further investigation. There are more imaging that can be used to diagnose and assess the severity of pulmonary embolism. However, it is still controversial regarding imaging modalities for optimizing pulmonary embolism diagnose. Chest X-Ray cannot exclude pulmonary embolism, but it is needed to guide the next examinations and to find alternative diagnoses. Pulmonary Multi-Detector CT Angiography is the gold standard to diagnose pulmonary embolism.

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Contact Name Muhammad Miftahussurur

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Journal Mail Official bhsj@journal.unair.ac.id

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Location Kota surabaya, Jawa timur INDONESIA

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Contact Name
Muhammad Miftahussurur

Contact Email
bhsj@journal.unair.ac.id

Phone
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Journal Mail Official
bhsj@journal.unair.ac.id

Editorial Address
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Location
Kota surabaya,

Jawa timur

INDONESIA