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Pharmacoscript
Published by Universitas Perjuangan Tasikmalaya
ISSN : 26224941     EISSN : 26851121     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology Public Health
Pharmacoscript merupakan jurnal penelitian yang dikelola oleh Prodi Farmasi dibawah Lembaga Penelitian dan Pengabdian Universitas Perjuangan Tasikmalaya (P-ISSN: 2622-4941 E-ISSN: 2685-1121) Jurnal ini merupakan media publikasi penelitian dan review artikel pada semua aspek ilmu farmasi yang bersifat inovatif, kreatif, original dan didasarkan pada scientific yang diterbitkan 2 kali dalam 1 tahun yakni pada bulan Agustus dan Februari. Jurnal ini memuat bidang khusus di farmasi seperti kimia farmasi, teknologi farmasi, farmakologi, biologi farmasi, farmasi klinik, dan bioteknologi farmasi.
Arjuna Subject : -
Articles 238 Documents
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FORMULASI DAN KARAKTERISASI HARD DAN GUMMY CANDY MENGGUNAKAN PEWARNA ALAMI Monascus purpureus Yuliana Anna; Hendari Melliany Rosna; Hidayat Taufik; Eff Aprilita Rina Yanti
Pharmacoscript Vol. 9 No. 1 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i1.2646

Abstract

Angkak merupakan beras yang difermentasi oleh Monascus purpureus dan diketahui menghasilkan pigmen alami berwarna kuning, jingga, dan merah yang berpotensi dimanfaatkan sebagai pewarna pangan. Penelitian ini bertujuan untuk mengevaluasi karakteristik hard candy dan gummy candy yang diformulasikan dengan ekstrak angkak sebagai pewarna alami. Hard candy dan gummy candy dibuat dengan variasi konsentrasi ekstrak angkak sebesar 1,0;1,5; dan 2,0%. Karakterisasi produk yang dilakukan meliputi uji organoleptik, keseragaman bobot, kadar air, tekstur (kekerasan dan kekenyalan), angka lempeng total (ALT), serta uji hedonik. Mengacu pada standar SNI, hasil penelitian menunjukkan bahwa seluruh formula hard candy dan gummy candy memiliki karakteristik warna, rasa, aroma, dan bentuk yang dapat diterima. Uji keseragaman bobot dan angka lempeng total memenuhi persyaratan mutu, serta kadar air berada di bawah batas maksimum. Uji kekerasan hard candy memenuhi kriteria, namun beberapa formula gummy candy belum memenuhi parameter kekenyalan. Berdasarkan uji hedonik, formula dengan konsentrasi ekstrak angkak 1,5% baik pada hard candy maupun gummy candy paling disukai panelis. Dengan demikian, ekstrak angkak berpotensi digunakan sebagai pewarna alami dalam produk permen (candy).
CLINICAL FACTORS ASSOCIATED WITH PAIN INTENSITY AND ADJUVANT ANALGESIC USE IN OSTEOARTHRITIS PATIENTS Nuh Muhammad; Darmawan Endang; Surono Sugiyarto
Pharmacoscript Vol. 9 No. 1 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i1.2660

Abstract

Osteoarthritis (OA) is a degenerative joint disease that commonly causes chronic pain and functional limitations. In routine practice, adjuvant analgesics are frequently used as part of multimodal pain management; however, clinical factors associated with pain intensity and adjuvant analgesic use are not well characterized. This retrospective observational study aimed to identify clinical factors associated with final pain intensity and their relationship with adjuvant analgesic use in patients with OA. Medical records of OA patients treated at Sultan Agung Islamic Hospital, Indonesia, between 2020 and 2025 were reviewed. Data included patient characteristics, OA severity based on the Kellgren–Lawrence (KL) grading system, pain intensity assessed using the Visual Analog Scale (VAS), and types of adjuvant analgesics prescribed, Multivariate logistic regression analysis showed that severe OA (KL grade ≥3) was the strongest factor associated with higher final pain intensity (OR = 3.56; 95% CI: 2.9–4.3). Knee OA (OR = 1.70; 95% CI: 1.1–2.4) and hyperlipidemia (OR = 2.33; 95% CI: 1.3–4.1) were also independently associated with higher final pain intensity. The use of adjuvant analgesics, particularly joint supplements and neuropathic pain agents, was associated with higher final pain intensity, reflecting greater disease severity and clinical complexity rather than direct analgesic effectiveness. Muscle relaxants were not significantly associated with pain intensity. In conclusion, final pain intensity in OA is primarily associated with disease severity and clinical complexity, and causal relationships cannot be established due to the observational design.
THE POTENTIAL OF TURMERIC RHIZOME EXTRACT AS ANTIBIOFILM AGAINST Staphylococcus aureus THROUGH IN SILICO AND IN VITRO APPROACHES Aji Nur; Risnawati Risnawati; Rahmaan Naufal Maulana; Tabina Nadine Elysia
Pharmacoscript Vol. 9 No. 1 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i1.2680

Abstract

Escalating antibiotic resistance in Staphylococcus aureus is driven by biofilm formation, which undermines the efficacy of antibiotics. This study evaluated curcumin from turmeric (Curcuma longa L.) as a natural antibiofilm agent using in silico and in vitro methods. Molecular docking and toxicity predictions were used to test curcumin's interaction with S. aureus biofilm proteins. In vitro efficacy was measured by disc diffusion and crystal violet staining assays. In silico analysis identified LuxS (PDB ID: 5V2W) as a viable target. Docking validation yielded an RMSD of 3.00 Å and identified 10 potential ligands, including curcumin, auratiamide, and chlorogenic acid. Phytochemical profiling showed that the ethyl acetate fraction had the highest curcuminoid content (24.88% w/w), higher than the 70% ethanol extract (21.69% w/w) and the methanol fraction (0.83% w/w). The ethyl acetate fraction showed moderate antibacterial activity but the strongest antibiofilm effects, with a minimum biofilm inhibitory concentration (MBIC) of 0.05% and an IC50 of 0.01%. In conclusion, the ethyl acetate fraction of turmeric enriched with curcuminoids shows strong potential as a natural antibiofilm agent. Computational and experimental evidence support this. These findings suggest the fraction is a promising candidate for topical antibiofilm development. Future research should focus on formulating this fraction in topical delivery systems and testing its efficacy in ex vivo skin or dermal infection models to assess clinical potential.
DETERMINATION OF SHELF LIFE USING ACCELERATED SHELF LIFE TEST (ASLT) METHOD ON INSTANT POWDER PROBIOTIC ORANGE SWEET POTATO FREEZE DRY Yulia Nunung; Rubiyanti Rani; Tjitda Putra Jiwamurwa Pama; Mbunga Dominus
Pharmacoscript Vol. 9 No. 1 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i1.2697

Abstract

Probiotic beverages produced using freeze-drying techniques are commonly developed to extend shelf life. In this study, instant probiotic powder made from orange sweet potato was prepared using the freeze-drying process at -56°C with the addition of 20% maltodextrin as a coating material. This study aimed to determine the shelf life of instant orange sweet potato probiotic powder using the Accelerated Shelf Life Testing (ASLT) method based on the Arrhenius equation model. The instant orange sweet potato probiotic powder was stored at temperatures of 4°C, 28°C, and 40°C for 56 days. The parameters observed every seven days were moisture content, pH, total acidity, and total lactic acid bacteria (LAB). The experimental results showed a linear relationship between the increase in moisture content and pH, and the decrease in total acidity and total LAB count over storage time at each temperature. The estimated shelf life of the instant orange sweet potato probiotic powder stored at 4°C, 28°C, and 40°C was 49, 45, and 43 days based on moisture content; 34, 42, and 46 days based on pH; 212, 207, and 206 days based on total acidity; and 236, 306, and 344 days based on total LAB, respectively. The shelf life of instant probiotic orange sweet potato powder can be determined using the ASLT method, with variations depending on the quality parameters evaluated.
EXPLORING MULTIMORBIDITY PATTERNS IN PATIENTS WITH OSTEOARTHRITIS USING MACHINE LEARNING Sari Dewi Nirmala; Darmawan Endang; Surono Sugiyarto
Pharmacoscript Vol. 9 No. 1 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i1.2755

Abstract

Osteoarthritis (OA) is a degenerative joint disease often accompanied by multimorbidity, particularly cardiometabolic diseases. OA is also associated with comorbidities, thus requiring an analytical approach capable of identifying patterns of relationships between diseases and rational therapies. This study aims to explore patterns of multimorbidity and treatment patterns in hospitalized patients with osteoarthritis using a machine learning (ML) approach. This study employed a retrospective design using medical records of hospitalized OA patients from January 2020 to January 2025 at Sultan Agung Islamic Hospital in Semarang. Analysis was performed using the Frequent Pattern Growth (FP-Growth) algorithm with support, confidence, and lift parameters. The minimum support value was set at 1% to identify a wider variety of patterns. A total of 25 patients were analyzed, with the majority being female (14 patients; 56%) and aged ≥59 years (14 patients;96%), with comorbidities predominantly obesity and hypertension. Association Rule Mining (ARM) results showed cardiometabolic multimorbidity patterns, with the strongest association in the combination OA+HTàDM (lift 1.93). Therapy pattern analysis indicated that disease combinations were associated with the use of therapies such as NSAIDs for OA and metformin for diabetes, as well as the addition of adjuvant therapies. Multimorbidity patterns in hospitalized OA patients are dominated by the cardiometabolic group, with complex therapeutic regimens. ML approaches are effective in identifying patterns of disease and therapy relationships, therapy supporting more rational clinical decision-making.
THE EFFECTS OF ARABICA COFFEE (Coffea arabica) FRUIT SKIN FERMENTED WITH KOMBUCHA ON NICOTINE-DEPENDENT MICE Fahmy Ahsanul, Haq; Suci Nar, Vikasari; Muhamad Ridho, Maulana
Pharmacoscript Vol. 9 No. 1 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i1.2763

Abstract

Nicotine is an addictive substance in cigarettes that causes dependence, making it difficult for smokers to quit. Treatment for nicotine dependence has limitations in terms of low effectiveness and side effects. Alternative treatments based on natural ingredients, such as coffee fruit skin or cascara (CA), which is rich in polyphenols, flavonoids, caffeine, and chlorogenic acid, offer neuroprotective potential to reduce nicotine dependence with minimal side effects. Fermentation using kombucha (KO) can increase the content of these bioactive compounds. This study aims to evaluate the effect of cascara fermented with kombucha on mice experiencing nicotine dependence. The study used a Conditioned Place Preference (CPP) design in male Swiss Webster mice induced by nicotine at a dose of 0.5 mg/kg BW. The test animals were given cascara and cascara-kombucha preparations at the same dose of 0.65 mL/20 g BW orally. In the pre-test stage, the initial residence time of the mice in each compartment was measured for baseline preference. The conditioning phase was conducted by administering test preparations and nicotine to selected compartments. The post-test measured the residence time in the nicotine compartment for 15 minutes. The CPP score was calculated as the difference between the post-test and pre-test residence times. Cascara and cascara-kombucha produced lower CPP scores than the nicotine group. Cascara-kombucha showed a better effect with a lower CPP score than cascara alone. Fermented cascara kombucha has suggested potential as an alternative therapy to overcome nicotine dependence.
PERBANDINGAN AKTIVITAS EKSTRAK AIR DAN ETANOL RUMPUT KEBAR (Biophytum petersianum Klotzsch) SEBAGAI NITRIT OKSIDA INHIBITOR Suryani, Suryani; Riska, Damayanti; Elin Yulinah, Sukandar
Pharmacoscript Vol. 9 No. 1 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i1.2766

Abstract

Stres nitrosatif yang dimediasi oleh nitric oxide (NO) berlebih berkontribusi pada patogenesis berbagai penyakit degeneratif dan inflamasi kronis. Rumput kebar (Biophytum petersianum Klotzsch) merupakan tanaman obat asal Papua yang memiliki potensi antioksidan, namun data komparatif efektivitas pelarut air dan etanol dalam menghambat aktivitas NO masih terbatas. Penelitian ini bertujuan untuk membandingkan aktivitas ekstrak air dan ekstrak etanol rumput kebar sebagai nitrit oksida inhibitor serta menentukan profil fitokimianya. Herba rumput kebar diekstraksi menggunakan metode perebusan (air) dan maserasi (etanol 96%). Analisis fitokimia dilakukan melalui skrining kualitatif dan kromatografi lapis tipis (KLT), sedangkan aktivitas penghambatan NO diuji menggunakan metode sodium nitroprusside (SNP) dengan reagen Griess. Hasil menunjukkan ekstrak air memiliki rendemen 3,43% berbentuk serbuk cokelat, sedangkan ekstrak etanol memiliki rendemen 15,91% berupa ekstrak kental hijau kehitaman. Keduanya teridentifikasi mengandung flavonoid, tanin, dan polifenol. Uji aktivitas menunjukkan ekstrak air memiliki nilai IC₅₀ sebesar 71,55 ± 5,57 µg/mL dan ekstrak etanol sebesar 165,90 ± 10,65 µg/mL. Ekstrak air menunjukkan aktivitas penghambatan NO sekitar 2,32 kali lebih kuat dibandingkan ekstrak etanol. Temuan ini menyimpulkan bahwa ekstrak air rumput kebar merupakan inhibitor NO yang lebih potensial, sehingga air dapat dipertimbangkan sebagai pelarut yang lebih efektif untuk aplikasi farmakologis terkait stres nitrosatif.
PENGARUH KOMBINASI POLIMER KITOSAN DAN PHARMACOAT615 TERHADAP SIFAT FISIK SEDIAAN DOMPERIDON PATCH DENGAN DESAIN FAKTORIAL Nira, Purnamasari; Mira Andam, Dewi; Zian Azka, Prahira
Pharmacoscript Vol. 9 No. 1 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i1.2767

Abstract

Patch dibuat menggunakan polimer, polimer merupakan komponen utama yang berperan penting dalam mengatur pelepasan obat dan sifat fisik serta mekanik. Sifat fisik dan mekanik Patch yang baik dapat dicapai melalui pemilihan dan rasio polimer yang tepat. Berdasarkan latar belakang tersebut pengaruh perbandingan kominasi terbaik polimer kitosan dan Pharmacoat 615 patch domperidon terhadap sifat fisik dengan desain faktorial akan diteliti. Metode pembuatan Patch dengan penguapan pelarut. Penelitian menggunakan perbedaan konsentrasi polimer Pharmacoat 615: Kitosan yaitu F1 (3:0,2), F2 (3:0,45), F3 (5:0,2), dan F4 (5:0,45). Evaluasi berupa uji organoleptis, ketahanan lipat, uji ketebalan, uji keseragaman bobot, uji kadar air, uji kekuatan mekanik Patch, uji kadar Patch, dan uji pelepasan in vitro Patch kemudian di analisis akan diolah secara statistika. Bobot dan tebal Patch menunjukkan keseragaman dan kadar air seluruh formula <10%. Hasil tensile strength F1>F2<F3>F4 nilai %elongasi seluruh formula 21-220%. Kadar zat aktif dalam sediaan berada dalam rentang 90,00%-110,0%. Hasil difusi F1, F2, F3, dan F4 pada menit ke 180 adalah 37,466±0,165; 53,251±0,286; 28,471±1,547; 36,060±0,07. Hasil SEM yang diperoleh Patch yang disimpan 14 hari muncul kristal domperidon. Kesimpulan penggunaan kombinasi polimer kitosan dan pharmacoat 615 domperidon Patch mengalami rekristalisasi. Berdasarkan data statistika, Komposisi polimer berpengaruh pada hasil % elongasi. F2 merupakan hasil yang optimal terhadap karakteristik fisikomekanik Patch dan profil pelepasan obat.

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