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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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Author Guideline and Subcribes Form Dian Wahyu Utami
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 23 No. 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1801

Abstract

Subjects and Authors Index Dian Wahyu Utami
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 23 No. 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1802

Abstract

Author Guideline and Subcribes Form Dian Wahyu Utami
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 23 No. 2 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i2.1805

Abstract

Analysis of Neutrophil Gelatinase-Associated Lipocalin in Type 2 Diabetes Mellitus Patients Yunita Rapa'; Liong Boy Kurniawan; Asvin Nurulita; Fitriani Mangarengi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1807

Abstract

Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a small protein with a molecular weight of 21 kDa, belongs to the lipocalin protein family and functions as a growth factor and differentiation of various cell types such as renal tubular epithelial cells. This aim of study was to determine the level of NGAL in controlled and uncontrolled type 2 Diabetes Mellitus (DM) patients. This study was a cross sectional study involving 70 type 2 DM patients with 30 patients with controlled type 2 DM and 40 uncontrolled type 2 DM groups. HbA1c, urea, creatinine, and urinalysis data were measured. NGAL level was measured using the ELISA method. The statistical tests used were Chi-Square, unpaired T test, Mann-Whitney test and Spearman test. The test result is significant if the p-value <0.05. NGAL normally found in the circulation will be filtered by the glomerulus and reabsorbed by the epithelial cells of the proximal renal tubule. Increased levels of NGAL can be found 2-6 hours in the blood and urine after injury to the kidneys. Excretion of NGAL in blood occurs when there is damage to the epithelial cells of the proximal tubule of the kidney. There was a significant difference in NGAL levels in the controlled and uncontrolled groups of type 2 DM patients. Positive correlation indicates that the higher the HbA1c and creatinine levels, the higher the NGAL level. There was a significant difference in NGAL levels in the controlled and uncontrolled type 2 DM groups (25.09 ± 6.83 vs 112.54 ± 170.38 ng / mL, with p value <0.001). There was a positive correlation between NGAL and HbA1c levels with p value <0.001, r =0.507 and creatinine levels with p value <0.001, r =0.769. NGAL normally found in the circulation will be filtered by the glomerulus and reabsorbed by the epithelial cells of the proximal renal tubule. Increased levels of NGAL can be found 2-6 hours in the blood and urine after injury to the kidneys. Excretion of NGAL in blood occurs when there is damage to the epithelial cells of the proximal tubule of the kidney. There was a significant difference in NGAL levels in the controlled and uncontrolled groups of type 2 DM patients. Positive correlation indicates that the higher the HbA1c and creatinine levels, the higher the NGAL level.
D-dimer Analysis in COVID-19 Patients Abd. Rahim Mubarak; Tenri Esa; Yuyun Widaningsih; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 1 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i1.1812

Abstract

The COVID-19 incidence is increasing around the world. Some countries are experiencing worsening conditions, even deaths. One coagulation marker that noticeably increases in COVID-19 patients is D-dimer. This study aimed to analyze D-dimer levels of COVID-19 patients. Retrospective study using medical records of 84 COVID-19 patients, conducted from April to August 2020 at UNHAS Hospital. Patients were grouped based on the severity of the disease as non-severe and severe. D-dimer levels were measured using the Alere Triage® D-dimer with the fluorescent immunoassay method. The statistical test used was Mann-Whitney, D-dimer prognostic levels were calculated with ROC analysis to get the cut-off. Significant if the p < of 0.05. The sample consisted of 74 non-severe and ten severe COVID-19 patients, mostly in the 30-39 age group. D-dimer levels in non-severe (0.31±0.38 μg/L) significantly differ from severe group (3.09±2.56 μg/L) (p<0.001). The Receiver Operating Characteristics (ROC) curve showed D-dimer sensitivity and specificity of 90.0% and 89.2%, respectively at the ≥ 0.80 μg/L cut-off, Negative Predictive Value (NPV) of 98.5%, and Positive Predictive Value (PPV) of 52.9%. D-dimer levels increased in severe COVID-19 patients due to an increased inflammatory response resulting in excessive thrombin. The ROC D-dimer curve indicated a cut-off rate of 0.80 μg/L, providing optimal sensitivity and specificity. D-dimer has a significant difference in non-severe and severe COVID-19 patients and shows good value to determine the severity of COVID-19 disease with a cut-off value ≥ 0.80 μg /L.
Campylobacteriosis in An Outbreak of Foodborne Disease at Bantar Gadung Village Palabuhan Ratu Luhung Budiailmiawan; Ida Parwati; Coriejati Rita; Dewi Lokida
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1815

Abstract

Campylobacteriosis is a rare enteritis case in Indonesia. On September 12, 2019, there was an outbreak of foodborne diseases with the symptoms of fever, abdominal cramps, and bloody diarrhea after eating food from the Tahlilan (funeral prayer) ceremonial at Bantar Gadung village Palabuhan Ratu Sukabumi. The laboratory and epidemiological investigationwere performed. Fresh stool samples were collected from 18 suspected cases. Gram stain, routine stool examination, and PCR were performed. The PCR method was used based on the nested PCR method by Platts-Mills et al. for Campylobacter spp. The positive result was identified by visualization in gel electrophoresis at 816-bp. Interview, environmental investigation, and analysis of incidence rate were performed for epidemiological study. The majority of patients were males aged 33-48 years old. The main symptoms were fever (100%), abdominal cramps (100%), and bloody diarrhea (11/18;61%). Nine of them (9/11; 82%) were confirmed by Gram staining as Gram- negative bacteria, with comma, s-shaped, or seagull appearance, as presumptive Campylobacter spp. Two patients (2/18;11%) were confirmed infected with Campylobacterspp. by PCR and sequencing tests. It has been found that this outbreak was caused by food contaminated with Campylobacter spp. The incidence rate of Campylobacteriosis in this outbreak was 11%.
Correlation between Inflammatory Markers of Platelet Index and Vitamin D with Body Mass Index Grace Yuni Harviendo; Ariosta Ariosta; Meita Hendrianingtyas
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1816

Abstract

Weight loss is more of a worldwide health problem and a risk factor for chronic disease. The decrease in serum vitamin D levels in body weight leads to more low grade inflammation. This study aims to determine the relationship between the platelet index, namely MPV, P-LCR as a marker of inflammation and vitamin D with body mass index (BMI). This study was a cross-sectional study of 78 women at the Diponegoro National Hospital with overweight (BMI> 23) in July - September 2020. Data analysis was done using Pearson and Spearman tests and significant if p <0.05. Of the 78 research samples, there was a significant relationship between BMI and MPV (r = 0.404; p = 0.000); P-LCR (r = 0.425; p = 0.000) and 25 (OH) D (r = -0.231; p = 0.04). Low vitamin D levels in obesity and low-grade inflammation increase pro-inflammatory cytokines. Increased leptin levels in obesity contribute to platelet hyperreactivity. Increased platelet activity compensates for the platelets so that the MPV and P-CLR values increase. There is a moderate significant positive relationship between MPV, P-CLR and BMI and a weak significant negative relationship between 25 (OH) D and BMI.
Procalcitonin and Troponin-I as Predictor of Mortality in Acute Myocardial Infarction Patients Novi Khila Firani; Jennifer Prisilla
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1817

Abstract

Acute Myocardial Infarction (AMI) is known as one of the leading causes of death in the world as well as in Indonesia. Procalcitonin is a marker of inflammation that has been recognized as a predictor of mortality in sepsis patients. The role of procalcitonin as a predictor of mortality in AMI patients has not been widely studied. Troponin-I has been recognized as a biomarker of AMI. It is unclear whether Troponin-I can also act as a biomarker to predict the death of AMI patients. This study aim is to determine the role of procalcitonin and troponin-I as predictors of mortality in AMI patients. A 5-month analytical observational study was performed on AMI patients who were admitted to Dr. Saiful Anwar, Malang. Patients with sepsis or infection were excluded. There were 51 study subjects, of whom median procalcitonin and troponin-I levels of patients who died were significantly different from survivors (p<0.05). Procalcitonin level with a cut-off of 2.16 ng/mL had a sensitivity of 77% and specificity of 87%. Troponin-I level with a cut-off of 3.1 ng/mL had a sensitivity of 61% and specificity of 84%. Odds ratio of procalcitonin to mortality was 17.78 (p=0.001), while troponin-I was not significant. Procalcitonin correlated with mortality (r= 0.519, p= 0.005). The conclusion of this research is procalcitonin acts as a predictor of in AMI patients.
Agreement of Urine Sediment Using Shih-Yung Method in Aspirated and Decanted Supernatant Removal Technique Jesi Anggraini; Rikarni Rikarni
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1819

Abstract

The technique of supernatant removal in urine sediment examination using the Shih-Yung method can be done by aspirating and decanting. The aspirated technique is the recommended technique. The Central Laboratory Installation of Dr. M. Djamil Hospital, Padang used decanted supernatant removal technique. The variety of preanalytical procedures affect the results of urine sediment examination. This study aimed to analyze the agreement of erythrocyte, leukocyte, and non-hyaline cast sediment examination results using the Shih-Yung method in aspirated and decanted supernatant removal technique. This study was an analytical observational study with a cross-sectional design of 37 urine specimens that met the inclusion and exclusion criteria at the Central Laboratory Installation of Dr. M. Djamil Hospital, Padang from July to September 2020. Examination of erythrocyte, leukocyte, and non-hyaline cast sediment using Shih-Yung method with aspirated and decanted supernatant removal technique. Numeric data were analyzed using the Mann-Whitney U test and Cohen's Kappa test for the degree of agreement, p-value < 0.05 was considered significant. The agreement test results for erythrocyte, leukocyte, and non-hyaline cast sediment in aspirated and decanted supernatant removal technique were (Kappa=0.88, p < 0.05), (Kappa=0.83, p < 0.05), and (Kappa=0.86, p < 0.05), respectively. The degree of agreement test results for erythrocyte, leukocyte, and non-hyaline cast sediment using the Shih-Yung method in aspirated and decanted supernatant removal technique were almost perfect and statistically significant. The technique for supernatant removal in urine sediment examination using the Shih-Yung method can be done by decanting.
Diagnostic Performance of NLR, Type IV Collagen and Fibrosis Score in Chronic Hepatitis B WA. Arsana; BRA. Sidharta; A. Kurniati; JB. Suparyatmo; MID. Pramudianti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1826

Abstract

Hepatitis B Virus (HBV) infection cause damage to the liver parenchym and continuous injury resulting in liver fibrosis. The neutrophil-lymphocyte ratio is a non-invasive marker of inflammation. Type IV collagen is a direct marker of hepatic fibrosis indicating transformation of the extracellular matrix of the liver, and its concentration is proportional to the degree of damaged liver cells and impaired liver function. APRI score and FIB-4 index are non-invasive methods for determining the degree of liver fibrosis. This study aimed to determine the performance of the neutrophil lymphocyte ratio, type IV collagen and fibrosis score on liver fibrosis in chronic hepatitis B. The study design was analytical observational with cross-sectional approach. The subjects included 42 chronic hepatitis B patients who admitted to Internal Medicine Department of Dr. Moewardi Hospital Surakarta from September to November 2020. The subject were grouped into fibrosis 21(50%) and non fibrosis groups 21(50%) based on transient elastography. Neutrophil lymphocyte ratio, type IV collagen and fibrosis score cut off point was determined with receiver operating curve (ROC) and diagnostic test was performed with 2x2 table. The cut-off point of 1.89 from the neutrophil lymphocyte ratio obtained sensitivity 61.9% and specificity of 38.1% with an AUC value of 0.524, while type IV collagen with a cut off point of 18.32 ng/mL obtained sensitivity 80.9% and specificity of 42.6% with an AUC of 0.642, a cut off 0.25 from the APRI score obtained a sensitivity of 81% and specificity of 61.9% with an AUC of 0.857, and cut-off FIB-4 of 0.68 obtained a sensitivity of 85.7% and specificity of 71.4 with AUC of 0.827. Neutrophil lymphocyte ratio with cutoff point of 1.89 has a weak diagnostic value on liver fibrosis in chronic hepatitis B. Further study by comparing or combining with other markers are needed. Type IV collagen with a cut off of 18.32 ng/mL, APRI score with a cut off of 0.25 and a FIB-4 index with a cut off of 0.68 can be used for screening liver fibrosis in chronic hepatitis B patients

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