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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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Correlation between Alpha Fetoprotein and Platelet Profile in Hepatocellular Carcinoma Rahmawati Rahmawati; Agus Alim Abdullah; Ibrahim Abdul Samad
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1353

Abstract

Hematology abnormalities are commonly found in Hepatocellular Carcinoma (HCC) patients. Platelet (PLT) count in HCC can be low, normal or high, and influenced by tumor and liver damage. There are limited studies about the correlationp between AFP and platelet profile of HCC in Indonesia, especially in Makassar. This study is aimed to analyze the correlation between AFP and platelet profile in HCC patients. A retrospective cross-sectional study was carried out from  January 2016 to June 2017 on 231 HCC subjects. The correlation between AFP and platelet profile, the correlation of AFP and platelet profile with the diagnosis were analyzed by Independent t-test and Chi-Square. There was no significant correlation between AFP and PLT profile and no significant correlation between AFP and HCC with and without cirrhosis with p>0.05 and p=0.094, respectively. Platelet count and PCT were significantly lower in cirrhotic HCC ompared to non-cirrhotic HCC (p<0.01, p<0.01, respectively), PDW and MPV were significantly higher in cirrhotic HCC compared to non-cirrhotic HCC  (p<0.05, p<0.05,  respectively). Mean platelet count and PCT in cirrhotic HCC were significantly lower compared to non- cirrhotic HCC, and mean PDW and MPV in cirrhotic HCC c were significantly higher compared to non-cirrhotic HCC. Further research was suggested to evaluate tumor size and nodules of HCC.
ANALISIS EOSINOFIL DARAH TERKAIT RADANG SEL GINJAL AKUT/ NEFRITIS INTERSTISIAL AKUT (NIA) Yedid Lebang; Sulina Yanti Wibawa; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 2 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i2.964

Abstract

Acute Interstitial Nephritis (AIN) is the main cause of acute renal failure because of hypersensitivity to many antibiotics and otherdrugs that potent to induce allergic response in renal interstitial tissue. Gold standard for AIN diagnosis upheld from clinical sign,laboratory, USG, Gallium renal tests and renal biopsy. A cross sectional study was carried out among 120 (AIN) patients and none (AIN)from the Paediatrics and Internal Medicine Department Wahidin Sudirohusodo hospital from June until September 2008. Eosinophilcount was performed using haematology auto analyser. The data was analyzed by Mann-Whitney test using SPPS for windows. Thetotal 120 samples consisted of 60 samples of AIN and 60 samples Non AIN were included in this study. Mean eosinophil in AIN 4. 9 %and non AIN 3. 1%. There were statistical difference of eosinophil level between AIN and non AIN with p < 0. 00. Eosinophil level canbe used to differentiated between AIN and non AIN in conjunction to the clinical sign.
Diagnostic Value of Encode TB IgG and IgM Rapid Test to Support Pulmonary Tuberculosis Diagnosis Notrisia Rachmayanti; Aryati Aryati; Tutik Kusmiati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1524

Abstract

Diagnosis of tuberculosis can be established through the detection of antigens by Acid Fast Bacilli (AFB), microscopy,culture, and Polymerase Chain Reaction (PCR). The World Health Organization (WHO) 2012 issued a recommendation not touse antibody detection in the diagnosis of tuberculosis. However, there is high demand from clinicians to detectanti-tuberculosis antibody in patients who are challenging to do a bacteriological examination. The purpose of this researchwas to determine the diagnostic value of anti-M.tuberculosis IgG and IgM Encode TB to support lung tuberculosis diagnosis.This study was a cross-sectional by using consecutively sampling, which was performed in the Dr. Soetomo Hospital,Surabaya, Indonesia, from November 2017 until May 2018. A total of 52 patients were included and evaluated for clinical orbacteriological examination using AFB microscopy or PCR (Gene Xpert) as the gold standard and tested theanti-M.tuberculosis IgG and IgM with immunochromatography. Encode Tuberculosis (TB) IgG was positive in 12 patientsfrom the tuberculosis group and one false-positive in the non-tuberculosis group. The diagnostic sensitivity, specificity,positive predictive value, negative predictive value, and accuracy of Encode TB IgG dan IgM were 35%, 94%, 92%, 43% and55.7%, respectively. The specificity was high that the positive result was considered as TB; the sensitivity was low that thenegative results were not excluded from TB. Encode TB IgG/IgM rapid test was not recommended to use as a singlediagnostic test and must be combined with other diagnostic tests to increase the sensitivity.
EOSINOFIL PASCA MENGEROK MUKOSA HIDUNG DAN PEMERIKSAAN DARAH RUTIN DI RINITIS ALERGI Rima Yuliati Muin; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.995

Abstract

Diagnostic of rhinitis allergy was based on anamnesis, physical examinations. Examine including anterior rhinoscopy, nasal endoscope, skin test and laboratory assay of nasal cytology, eosinofil count in the blood. Eosinofil mucosal nasal brushing assay andeosinofil routine hematology can be used as other examination to diagnose rhinitis allergy and to evaluate therapy response. The aimof the study was to know the correlation between eosinofil level on mucosal nasal brushing and routine hematology in suspect allergyrhinitis. The study used cross sectional methods, and was done among 37 suspected Rhinitis Allergy patients in the Clinical PathologyLaboratory, and the Clinic of Ears, Nose and Throat at Wahidin Sudirohusodo hospital Makasar, during the period of March - August2008. Eosinofil mucosal nasal brushing assay used Hansel stain and routine hematology assay used automatic blood cell counter Sysmex1800i. The data were analyzed with Pearson Correlation test using SPSS for Windows version 12,0. In the results were found from the37 samples by a correlation test the mean eosinofil level of mucosal nasal brushing. In men was 12.9/HPF and in women was 5/HPF.While eosinofil in routine hematology in men was 1595/µl and in women was 551/µl, with p < 0.000 and r = 0.930. The conclusionso far from this study that the correlation of eosinofil count between mucosal nasal brushing and hematology routine in those patients suspect rhinitis allergy was very strong. So this test can be used as an alternative examination to diagnose rhinitis allergy.
PENGARUH PENGAWET BEKU (CRYOPRESERVATION) TERHADAP KADAR EPIDERMAL GROWTH FACTOR (EGF) PADA SELAPUT AMNION Ety Retno S; Gunawan Effendi; Gatut Suhendro; I. Handojo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 1 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i1.953

Abstract

to measure the difference of EgF concentration in between fresh amniotic membranes and with cryopreservation in 16 amnioticmembranes. Each amniotic membrane was divided into two parts. the first part was extracted in fresh forms and the second partunderwent cryopreservation with glycerol 50% and was stored at –80° C during 1 month before extraction. Both parts of the membranewere extracted using ultrasonic disintegrator and concentration of EgF was measured from the obtained extract using ELISA method.the average concentration of EgF in the fresh amniotic membrane was 122.76 ± 11.59 pg/g while the average concentration of EgFin the amniotic membrane underwent cryopreservation was 99.34 ± 9.49 pg/g. Average degradation of EgF concentration due tocryopreservation is 18.49% ± 10.20%. EgF concentration in fresh amniotic membrane is significantly higher than the EgF concentrationin amniotic membrane underwent cryopreservation (p = 0.000). Degradation of EgF concentration due to cryopreservation at 95%fidence interval is 12.33% to 24.66%
Diagnostic Value of Plasmotec Malaria-3 Antigen Detection on Gold Standard Microscopy Trieva Verawaty Butarbutar; Puspa Wardhani; Aryati Aryati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1529

Abstract

Plasmotec Malaria-3 is a rapid malaria diagnostic test that uses four-line tests and targets three malaria proteins,namely Plasmodium falciparum specific protein (HRP-2), Plasmodium vivax-specific LDH (Pv-LDH) and non-specificPlasmodium LDH (pLDH). Microscopy as a gold standard has many disadvantages and the availability of malaria RapidDiagnostic Tests (RDTs) in detecting three proteins is still very limited. This study aimed to determine the diagnostic value of® ® Plasmotec Malaria-3 against gold standard microscopy, comparing the Plasmotec Malaria-3 and microscopy antigen® species detection, determining the Parasitemia Index (PI) cut-off using Plasmotec Malaria-3. This study was across-sectional study with 105 whole blood samples obtained from the Merauke Papua General Hospital which fulfilled theinclusion and exclusion criteria. Samples were examined by thick and thin drops and then examined with Plasmotec®® Malaria-3. Diagnostic values of Plasmotec Malaria-3 against the microscopy were Sn 100%, Sp 98.04%, PPV 98.18%, NPV® 100%, LR + 51, LR-0, diagnostic accuracy of 99.05%. Comparison of Plasmodium species between Plasmotec Malaria-3 and® microscopy was not significantly different, p-value = 0.172. The cut-off of PI in P.falciparum and P.vivax in PlasmotecMalaria-3 based on the Receiver Operating Characteristic (ROC) curve could not be determined with AUC=0.577,p-value=0.385 and AUC=0.423, p-value=0.385, respectively. This study concluded that the comparison of Plasmodium® species between Plasmotec Malaria-3, and microscopy was not significantly different. This study suggested that further® research is needed to find the diagnostic value of non-falciparum and non-vivax Plasmodium against Plasmotec Malaria-3.
KORELASI ANTARA HITUNG TROMBOSIT DENGAN JUMLAH CD4 PASIEN HIV/AIDS M. I. Diah Pramudianti; Tahono Tahono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1023

Abstract

The Acquired Immune Deficiency Syndrome (AIDS) is the presence of symptoms caused by Human Immunodeficiency Virus (HIV)which belongs to human retroviruses (retroviridae). Thrombocytopenia is a common finding in patients with HIV infection. HIV infectionmay induce thrombocytopenia through immune and non-immune mechanisms, autoimmune combination and inhibition of plateletproduction. The aim of this study is to analyze the correlation between thrombocyte and CD4 count in HIV/AIDS patients. This studyuses a cross sectional design with a total of 17 patients. The subject of this study is HIV/AIDS patients who came to and examined atVCT clinic, dr. Moewardi Hospital Surakarta. To analyze this result the researchers used Spearman (r) correlation with p<0.05, andconfidence interval 95%. Patients’ median age was 30 (21–49) years, 11 (64.7%) men and 6 (35.3%) women. The subjects with AIDSwere 11 (64.7%), and HIV were 6 (35.3%) patients. The duration of antiretroviral (ARV) was 7.5 (4–20) months in 10 subjects.The median of thrombocyte count was 203 (143–327)×103/μL, CD4 absolute 207 (5.0–734)/μL, and CD4 (% lymphocytes) 13.0(2.0–29.0)%. The thrombocyte count was not correlated with CD4 absolute (r=0.456; p=0.066) and CD4% (r=0.218; p=0.400). InHIV patients, low platelet counts will be the result of a host of problems and complications that are associated with the progressive HIVinfection or its management.
Toll-like Receptor (TLR) dan Imunitas Natura Suprapto Ma’at
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 3 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i3.978

Abstract

In all living species, the first line of defence against microbial aggressions is constituted by innate immunity. Toll-like receptors(TLRs) are a family of pattern recognition receptors that are activated by specific components of microbes and certain host molecules.They constitute the first line of defense against many pathogens and play a crucial role in the function of the innate immune system.Recognition of pathogen-associated molecular pattern (PAMP) by TLR, alone or heterodimerization with other TLR or non-TLR receptors,induces signals responsible for the activation of genes important for an effective host defense, especially proinflammatory cytokines, orinitiates signal transduction pathways, which trigger expression of genes. These gene products control innate immune responses andfurther instruct development of antigen-specific acquired immunity.
CORRELATION BETWEEN SERUM TISSUE POLYPEPTIDE SPECIFIC ANTIGEN LEVEL AND PROSTATE VOLUME IN BPH Mahrany Graciella Bumbungan; Endang Retnowati; Wahjoe Djatisoesanto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 2 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i2.1136

Abstract

Volume prostat menjadi informasi yang penting karena dapat memperkirakan kematian pada Benign Prostatic Hyperplasia (BPH).Volume prostat diukur menggunakan TRUS (Transrectal Ultrasonography) sebagai baku emas namun TRUS mempunyai beberapakekurangan. Dibutuhkan suatu tolok ukur lain yang dapat memperkirakan volume prostat. Tissue Polypeptide Specific Antigen (TPS)yang terdeteksi di peredaran terdiri dari fragmen sitokeratin yang terdapat dalam jaringan dan menunjukkan status proliferasi. Selepitel di BPH yang mengandung sitokeratin 18 akan mengalami hiperplasia sehingga dapat terdeteksi dengan pemeriksaan TPS. Tujuanpenelitian ini adalah membuktikan adanya kenasaban antara kadar TPS serum dan volume prostat. Subjek penelitian terdiri dari 28pasien BPH yang datang berobat ke Poli Rawat Jalan Urologi RSUD Dr. Soetomo Surabaya. Volume prostat diukur menggunakan alatTRUS. Kadar TPS serum diukur menggunakan metode ELISA (TPS® ELISA IDL Biotech). Kadar TPS serum berkisar antara 82,45–1771,5U/L (195,35±349,79 U/L). Volume prostat beragam antara 20,7-87,4 cm (34,70±15,31 cm). Tidak terdapat kenasaban positif yangbermakna antara kadar TPS serum dan volume prostat (p=0,404; r=0,164).
DETEKSI MOLEKULER Mycobacterium tuberculosis DI DAHAK CARA POLYMERASE CHAIN REACTION P. B. Notopuro; J. Nugraha; H. Notopuro
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 1 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i1.944

Abstract

tuberculosis is a chronic infectious disease which is found in developing and developed country. It is one of community healthproblems which become priority in national and international health programs. Microbiologic examination is used to establish thediagnosis of tuberculosis beside clinical examination and radiologic examination. Conventional microscopic and culture examinationhave many limitation ie: such as for example low sensitivity, specificity and need a lot of time. New Molecular technique gives morevalue in sensitivity, specificity and the time for examination. the aim of this study was to know the diagnostic value of PolymeraseChain Reaction for detection of Mycobacterium tuberculosis in sputum. the sputum was collected from twenty eight patients suspectedtuberculosis based on the clinical and radiological examination. the study was performed from September 2006 until July 2007. Wedid the conventional culture technique as a diagnostic gold standard and molecular technique to detect the Mycobacterium tuberculosisin the sputum. For molecular technique, we used Polymerase Chain Reaction (PCR) with a set of IS6110 region primer which is specificfor the Mycobacterium tuberculosis Complex. the sensitivity of PCR with IS6110 region primer is 100% (very high), specificity is 82.4%(high), positive predictive value is 89.7% and negative predictive value is 100%. there was statistically no significant difference betweenthe result of PCR and conventional culture method. Based on the result, the Polymerase Chain Reaction examination with primer IS6110region primer can be used as the screening tool for tuberculosis infection, while the clinician waits for culture result.

Page 47 of 133 | Total Record : 1328

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