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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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JAMUR DI PERALATAN neonATAL InTenSIve CARe unIT Ariani Said; Irda Handayani; Nurhayana Sennang
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.468

Abstract

Fungus is the one of the micro organisms that causes nosocomial infections. Fungal infections are becoming more frequent occurred from the irrational use of broad spectrum antibiotics, steroids, cytostatica drugs, and chronic disease, and malignancy, babies with low birth weight and patients with decreased immunity. Neonatal Intensive Care Unit (NICU) is a room with specialized treatment, care and equipment to treat infants with high risk. The purpose of this study was to know by identification of the fungus species on the instrument at the NICU of dr. Wahidin Sudirohusodo hospital, Makassar at June 2011. The study design was a cross sectional one. The samples are the incubators and the Continuous Positive Airway Pressure (CPAP) at the NICU of dr. Wahidin Sudirohusodo hospital. The sampling was done by rubbing swab on the incubator and CPAP. The identification of the fungus were carried out with lacto phenol cotton blue staining performed at the Central Public Health Laboratory, Makassar. The Streptomyces sp and Penicillium sp were identified at four incubators, Candida sp was identified at one incubator and so was the Aspergillus sp identified; The fungus that identified at the CPAP was only Penicillium sp. Based on this study it can be concluded that Penicillium sp, Streptomyces sp, Aspergillus sp, as well as Candida sp were found at all incubators and only Penicillium sp was found at CPAP.
VOLUME PLASMA DAN FAKTOR VIII DALAM KRIOPRESIPITAT Dian Widyaningrum; Purwanto AP; Julia Setyati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.396

Abstract

Blood product such as cryoprecipitate required a quality control. This includes development, implementation and the standard operating procedures use of each step of the process in the production of cryoprecipitated substance to ensure that the produced product contains a minimum of 80 international units (IU) of factor VIII. Cryoprecipitation is prepared from fresh frozen plasma that thawed and centrifuge by immediate spinning the excess plasma which then removed and leaving approximately 40ml which deposit 10 mL cryoprecipitate. One unit of cryoprecipitate contain 70–80 IU/unit factor VIII, ≥100 mg/unit von Willebrand factor, fibrinogen 5–10 mg/dL. The levels of factor VIII and von Willebrand factor (VWF) lowered in individuals with blood group O compared to individuals groups with non-O blood. This research is aimed to investigate whether plasma volume are correlated with the levels of factor VIII in cryoprecipitation. In this study purposive sampling is done in which 25 bags of cryoprecipitate materials (was storage for 11 months) from all types of blood group which were taken from storage, thawed, weighed and the plasma volume measured. Factor VIII was measured by coagulometric method. The researcher used Spearman correlation test to analyze the product, with significance degree p<0.05 and confidence interval 95%. In this study it is found plasma volume which was not related to the factor VIII level in cryoprecipitattion substance (p=0.585). Mean plasma volume of the cryoprecipitated matter was 56 mL, mean factor VIII was 83.3UI. Highest factor VIII level was 160.6 UI of cryoprecipitated blood group AB and lowest factor VIII level was 21.3 UI of cryoprecipitated blood group A.
Infection of Cytomegalovirus in Cholestasis Infant with Biliary Atresia Lasmauli Situmorang; Bagus Setyoboedi; Sjamsul Arief; Gondo Mastutik
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1496

Abstract

Biliary Atresia (BA) is extrahepatic cholestasis that results in death within the first two years if the diagnosis andintervention are delayed. The etiology and pathogenesis of BA are still undetermined. Viral infections, includingCytomegalovirus (CMV), are presumed to be one of the causes. Cytomegalovirus infection is more common in intrahepaticthan extrahepatic cholestasis such as BA. There are limited data about Cytomegalovirus infection in cholestatic infants withBA. This study compared the incidence of CMV infection in cholestatic infants with biliary atresia and non-biliary atresia.A cross-sectional study was performed in December 2017 - August 2018 in cholestatic infants aged 1-6 months. Liverbiopsy, histopathological examination followed by PCR CMV examination were performed on cholestatic infants. Theresults of the PCR examination were compared between BA and non-BA infants. Statistical analysis of Chi-Square, t-testindependent and Mann-Whitney U resulting in p<0.05 were stated as significant. Thirty-seven children were obtainedduring the study period, consisting of sixteen children with BA and twenty-one children with non-BA. Biliary atresia waspredominantly found in female than male children, despite no differences were found between the groups (p=0.163). Therewere differences in body weight (p=0.002) age (p=0.009), birth weight (p=0.02) and gestational age (p=0.03) betweenchildren with BA and non-BA. There was no significant difference in the incidence of CMV infection in cholestatic infants withBA and non-BA (p=0.338). Cytomegalovirus infection in cholestatic infants with BA was less than non-BA cholestatic infants.
Correlation between Changes of NT-Pro BNP and HS-Troponin I Level with Cardiotoxicity in Locally Advanced Breast Cancer After Three Cycles of Neoadjuvant CAF Chemotherapy Cicilia Indriaty; Leonita Anniwati; J.Nugroho Eko Putranto; Desak Gede Agung Suprabawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1352

Abstract

Chemotherapy with cyclophosphamide, adriamycin, and fluorouracil (CAF) regiment in patients with locally advanced breast cancer have a risk of cardiotoxicity. Cardiotoxicity examination standards using left ventricular ejection fraction (LVEF) by echocardiography are considered insensitive for detection of subclinical ventricular dysfunction. NT-pro BNP and Hs-Troponin I (hs-TnI) as cardiac biomarkers are expected to help detect early cardiotoxicity. This study intended to analyze the correlation between changes of NT-pro BNP and hs-TnI levels with cardiotoxicity in breast cancer after three cycles of chemotherapy.This was a cross-sectional observational study, conducted at the Dr. Soetomo General Hospital Surabaya. The subjects consisted of 23 breast cancer patients who underwent chemotherapy with CAF regiment. NT-proBNP and hs-TnI examination used CLIA methods (Immulite 1000, ADVIA Centaur TnI-Ultra). Cardiotoxicity based on decreased  LVEF to more than 10% of the initial LVEF value using echocardiography. Significant increases in NT pro BNP and hs-TnI levels were obtained before and after treatment (p=0.000, p=0.002). A significant decrease in LVEF was obtained before and after treatment (p=0.000), but only 2 patients (8.7%) showed cardiotoxicity. There was no correlation between changes in NT-pro BNP and hs-TnI levels with changes in LVEF before and after chemotherapy (p=0.666 and r=0.095; p=0.254 and r=-0.28). There was no correlation between changes in NT-pro BNP and hs-TnI levels with cardiotoxicity, which was assessed based on LVEF reduction, in locally advanced breast cancer after three-cycles of chemotherapy with CAF regiment.
DETEKSI MOLEKUL MUTASI GEN rpoB MYCOBACTERIUM TUBERCULO SIS PADA DAHAK DENGAN POL YME RASE CHAIN REACTION DAN SINGLE STRAND CONFORMATION POLYMORPHISM P B Notopuro; J Nugraha; H Notopuro
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 2 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i2.973

Abstract

Tuberculosis is a chronic infectious disease which is found in the developing as well as the developed country. This disease is oneof the community health problems which become the priority programs in the national as well as international health. In the lasttwo decades, they can be found in the emergency tuberculosis problems that is related with the Multi Drug Resistance (MDR) Strain.The detection of rifampicin resistance in M. tuberculosis infection can help clinical laboratory to find the MDR strain. Related to thisproblem the proportional culture method is still the gold standard for rifampicin resistance detection for M. tuberculosis infection. Butthis method needs 4−6 weeks to obtain the result, while its sensitivity is not very high. The development of the molecular detection forM. tuberculosis rifampicin resistance in a direct clinical specimen such as sputum, cerebrospinalfLuid, etc. will give an improvement inthe diagnosis, because it has an accurate, fast, sensitive and a specific result. Isolates from twenty six of M. tuberculosis derived fromthe sputum of tuberculosis patients that have failed the tuberculosis treatment, were examined with the proportional culture method.In this study PCR-SSCP were used for the molecular detection of rifampicin resistancy using direct sputum samples. The proportionalculture method was used as a gold standard for the rifampicin resistance detection. A set of primers was directed to conserve the regionof rpoB gene of M. tubercuLosis. This RNA polymerase gene was encondes?, which is bound on rifampicin. A 157-bp fragment wasamplified by PCR and analyzed by SSCP technique. The sensitivity of PCR-SSCP is 80% (high), its specificity is 95.2% (very high), thepositive predictive value is 80% and the negative predictive value is 95.2%. Statistically there were no significant difference between theresult of PCR-SSCP and the proportional culture method. Based on the study result, the molecular detection technique for rifampicinresistance on M. tuberculosis infection can be used as the screening device /means for Multi Drug Resistance Tuberculosis (MDR-TB),while the clinician waits the culure result.
MEMBANGUN SENDIRI SISTEM INFORMASI LABORATORIUM Yogi Sucahyo; Supri .; Prihatini .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 3 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i3.939

Abstract

LIS (Laboratory Information System) include software, hardware and brain ware. It could accepted the laboratoryinformation’s,analyze and organize the activity clinical laboratory The laboratory information system confirm laboratory’s businessfrom input and output process According this Semen Gresik Hospital was increase the quality of clinical laboratory information. TheLIS needs computers as workstations, instrument interface server, as well as laboratory automation systems. The recorded ID barcodelabels used for patients identification as well as for administration and labeling the samples. The samples were process (analyses) andthe results were printout. LIS will decrease the patients’ turn around time as well as the praeanalytic errors. The self-building of LIS ischeaper than the laboratory instruments bought including.
KADAR SERUM KREATININ DAN KALIUM PASIEN DENGAN DAN TANPA DIABETES JENIS (TIPE) II Tonang Dwi Ardyanto; Tahono Tahono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1018

Abstract

Hyperkalemia is a metabolic disorder caused by either renal insufficiency for potassium excretion (like in renal failure), thedysmechanism of potassium transportation into the intracellular space (regards on the hyperglycemia status) or combinations of thoseetiologies. In nephropathy diabetic patients, hyporeninemic hypoaldosteronism syndrome might also be the etiology resulting from thehigh potassium level. The objective of the present study was to evaluate the correlation between the serum creatinine and potassiumlevel in patient with and without type II diabetes. The data of this study were drawn from patients admitted to the laboratory for themeasurement of serum creatinine and potassium with or without the measurement of blood glucose level at the Clinical PathologyLaboratory of Moewardi Hospital in Surakarta. The subjects were then classified into two groups: A (non-diabetic patients) and B(diabetic patients). The data were analyzed statistically with T-student test and Pearson Correlation test based on the total samples, pereach group (A and B groups) and the diabetic status (only B group) one. In this study so far it was found that the serum creatinine andpotassium level were significantly correlated in the total sample and group A analysis (p<0.05). Surprisingly, the correlation was notfound or very weak in group B (p>0.05). Furthermore, no correlation was found in the analysis based on the diabetic status amongthe B group subjects (p>0.05). It can be suggested that other factors may play a significant influence on the correlation between thehyperglycemia state, renal failure and serum potassium level in diabetic patients. Further detailed analysis should be warranted toelucidate those factors.
Correlation of C3c complement, NT-pro BNP and Left Ventricle Ejection Fraction in Heart Failure Julious, Julious; Nugraha, Jusak; Aminuddin, Mohammad
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1341

Abstract

Introduction. Heart failure is a health problem in Indonesia. The 2013 Basic Health Research Data showed that the estimated heart failure in Indonesia was 530,068 people. Echocardiography examination which has been a routine examination of heart failure patients is not necessarily available in all hospitals, so that a more applicable and inexpensive alternative examination is needed. Previous studies have shown an increase in C3c levels associated with improved survival and better cardiac remodeling. On this basis, this research needs to be performed in order to determine the correlation between C3c complement levels, NT-proBNP and LVEF in heart failure patients. Method. A cross-sectional study was conducted at the Dr Soetomo Hospital between August 2018 to September 2018 with 30 samples. Samples were taken consecutively from patients with heart failure who were treated at the integrated heart service center. Examination of C3c complement, NT-proBNP and echocardiography (LVEF data) was carried out in all patients. Result. The result of this study showed no significant correlation between C3c complement and NT-proBNP (r = -0.253, p = 0.177). The correlation between C3c complement and LVEF was also not significant (r = -0.074, p = 0.696). A significant moderate correlation between NT-proBNP and LVEF was found (r = -0.444, p = 0.014). Conclusion. The C3c complement could not be used as an alternative examination for NT-proBNP and LVEF. The limitations of the study were heterogeneous sample characteristics. A further study with more stringent criteria is needed to minimize the bias of examination results.
ANALISIS FILOGENETIK DENGUE DI INDONESIA Aryati Aryati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 2 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i2.1009

Abstract

Molecular epidemiology is needed to solve the problem for endemic Dengue Hemorrhagic Fever in Indonesia.This research has been carried out consisting of 525 Dengue Hemorrhagic Fever sera, according to the WHO criteria.These sera were collected from 19 cities in Indonesia comprising the islands of Sumatera, Batam, Kalimantan, Sulawesi, Papua, Java,Bali and Lombok from 2003 until 2005. The immune response profile was as follows 57.14% (300/525) secondary infection, 12.57%(66/525) primary infection, 4.20% (22/525) equivocal and 26.09% (137/525) negative. From 192 PCR samples, 100 (52%) serawere positive, consisting of 65% DEN-2, 15% DEN-3, 12% DEN-4 and 8% DEN-1. Homology analysis showed nucleotide differences incapsid region DEN-2 serotypes, while DEN-3 serotypes were relatively consistent. Phylogenetic analysis using envelope (E) gene revealedthat the Cosmopolitan genotype from Gorontalo in 2005, is currently circulating locally, with the potential to cause a severe hemorrhagicdisease. Members of this genotype were closely related to viruses from Malaysia, Singapore, Thailand, Philippines and Australia. Theisolate from Jakarta, 2003 showed DEN-3 with I genotype. This genotype was similar to the isolate from Indonesia 1978, 1985, andalso from Thailand 1992, Philippines 1997, and Fiji 1992. These results showed Cosmopolitan genotype from DEN-2 was similar toSoutheast Asia countries. It was also revealed that genotype-I from DEN-3 showed no change over the years since 1978.
CD4-T Lymphocyte in Cervical Cancer Patients on Pre-and Post-Chemotherapy Endah Indriastuti; Endang Retnowati; Wita Saraswati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1367

Abstract

Introduction : Cervical cancer is a gynecology cancer with the highest incidence in the Dr.Soetomo Hospital, Surabaya. Neoadjuvant chemotherapy with cisplatin has been used to increase radiosensitivy of cancer cells before radiotherapy done in advanced stage cervical cancer patients. This research aimed to know the differences of CD4-T lymphocyte profile in stage IIIB patient before and after chemotheraphy administration.Methods : This research was done in February-September 2018. Seventeen patients out of 31 stage IIIB cervical cancer patients planned to receive neoadjuvan chemotherapy with cisplatin every 3 weeks for 3 series were checked for the CD4+ T lymphocyte count and percentage. The examinations were done before the first and after the third chemotherapy administration.Results : Mean±SD of the CD4-T lymphocyte count before chemotherapy was 817±314 cells/μL and mean±SD of the CD4-T lymphocyte  percentage was 38.96±8.47%. While mean±SD of the CD4-T lymphocyte count after chemotherapy was 881±335 cells/μL and mean±SD of the CD4-T lymphocyte percentage was 39.01±8.50%. There was no significant  difference of CD4-T lymphocyte count between before and after chemotherapy (p=0.471). There was also no significant difference of CD4-T lymphocyte percentage between before and after chemotherapy (p=0.866). Both the CD4-T lymphocyte count and percentage tended to increase in postchemotherapy condition.Conclusion : The CD4-T lymphocyte count and percentage were not significantly different between before and after chemotherapy administration in stage IIIB cervical cancer patients. Both the CD4-T lymphocyte count and percentage tended to increase in postchemotherapy condition.

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