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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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Analysisi Platelet Indices in Patient Type 2 Diabetes Mellitus with Vascular Complication Nelly Tolla Taggara; Suci Aprianti; Darmawaty ER
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1411

Abstract

ANALYSIS PLATELET INDICES IN PATIENT TYPE 2 DIABETES MELLITUS WITH VASCULAR COMPLICATION      Nelly1, Suci Aprianti2 ,Darmawaty ER31Medical Doctor Specialist Education Program of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo hospital, Makassar2Departement of Clinical Pathology, Faculty of Medicine, Hasanuddin University3Departement of Clinical Pathology, Faculty of Medicine, Hasanuddin University /Dr. Wahidin Sudirohusodo Hospital, Makassar ABSTRACT Introduction :Type 2 Diabetes Mellitus(T2DM) is an endocrin disease that is marked by hyperglycemic condition due to a decrease increase in insulin secretion and insulin resistance or both. Indonesia is the 7th country with the highest incidence of diabetes mellitus in the world. Progression of the disease is slow and cause vascular endothelial damage. The increase  of platelet indices is suspected to be an indications   of vascular complicationsObjective :To evaluate the  platelet indices in diabetics patients with complication and correlate these indices with GDP and HbA1c. Materials and methods :We analyzed platelet indices and biochemical data of patients seen in outpatients by clinicans of  wahidin soedirohusodo hospitals. 120 patients with type 2 diabetes mellitus were included with 64 patients vascular complication and 56 patients without complication.Result :We observed an increase in mean platelet volume (MPV): 9,96 + 1.99vs 8.87 + 1.35(p-value: 0,001) ;in platelet distribution width (PDW): 15.29 + 3.45 vs 12.36 + 2.819(p-value: 0,000; without increase  plateletcrit (PCT); 0.28 + 0.14 vs 0.25 + 0.12 (p-value: 0.168). we observed  a correlation between FBG with PDW (P=0.044).Conclusion :The study findings point to the significant differences in platelet indices (MPV and PDW) in patients with T2DM with complication and without complication, suggesting the presence of platelet in diabetics type 2 patients more reactive and aggregatable  in this group of individuals. These suggest that platelet evaluation may be useful in the early detection of long term complication in diabetics patients.Keyword :T2DM, platelet indices, complication vascular   
CORRELATION BETWEEN TIME TO POSITIVITY BLOOD CULTURE AND PROCALCITONIN ON BACTEREMIA PATIENT Nelly Elfrida Samosir; Ricke Loesnihari; Adi Koesoema Aman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1506

Abstract

IntroductionBacteremia causes a high mortality rate. Detection of bacteremia is needed as quickly as possible. The gold standard for bacteremia is blood culture which takes between 24-48 hours. Procalcitonin (PCT) is a marker of infection that is caused by bacteria that can be detected quickly in 2-6 hours. Time to positivity (TTP) blood culture is affected by the initial amount of bacteria and the addition of procalcitonin stimulated by bacteria that causes bacteremia where short TTP and high PCT show bad clinical conditions. Materials and MethodsAnalitical cross sectional research on patients with bacteremia. Fourty six bacteremia cases become the sample of research. Time to Positivity is calculated with Bactec 9050 and Procalcitonin is analyzed with mini VIDAS B.R.A.H.M.S. Examination is conducted in Department of Clinical Pathology FK-USU/ Installation of Clinical Pathology of RSUP H. Adam Malik, Medan, June – October 2016. ResultsThere was significant correlation between Time to Positivity blood culture and procalcitonin on bacteremia patients (p<0.05). There was no significant correlation between Time to Positivity and procalcitonin on bacteremia which was caused by gram-positive bacteria or gram-negative bacteria (p>0.05). Procalcitonin was significantly higher on bacteremia which was caused by gram-negative bacteria compared to gram-positive bacteria (p<0.05). ConclusionThere was significant correlation between Time to Positivity blood culture and procalcitonin on bacteremia patients. Significantly higher levels of procalcitonin in cases of bacteremia are more likely to be caused by Gram-negative bacteria than Gram-positive bacteria
Diagnostic Test of PIVKA-II as A Tumor Marker for Hepatocellular Carcinoma Dwi Priyadi Djatmiko; I Putu Adi Santosa; Elvin Richela Lawanto; Bogi Pratomo; Hani Susianti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i2.1436

Abstract

Alpha-Fetoprotein (AFP) is a tumor marker that has been widely used for HCC, but there has been no increased AFP in35-45% patients with HCC. Protein induced by vitamin K absence or antagonist II (PIVKA-II) is abnormal prothrombinsecreted in HCC and is expected to be used as a diagnostic marker of HCC. The objective of this study was to compare serumPIVKA-II levels in the patients with HCC, cirrhosis, and healthy control and determine the diagnostic value of PIVKA-II forhepatocellular carcinoma. This was a cross-sectional, analytical observational study to identify the diagnostic value ofPIVKA-II for HCC diagnosis. The diagnosis of 20 cirrhotic patients and 15 patients with HCC was established by using medicalhistory, physical examination, and additional tests according to the diagnosis criteria. A group of 12 individuals with normalliver function was used as healthy control subjects. Serum PIVKA-II levels were analyzed with the immunoassay method. Forthe comparison study, the independent-samples Kruskal Wallis test was used. Also, to determine sensitivity, specificity,positive and negative predictive value (PPV and NPV), ROC curve analysis, and 2x2 contingency table was used. The serumPIVKA-II levels in the patients with HCC were significantly higher than in cirrhotic patients (p=0.000) and healthy control(p=0.000). Sensitivity, specificity, PPV, and NPV of PIVKA-II for diagnosis of HCC in cirrhotic patients at a cut-off value of140.85 mAU/mL were 93.33%, 75%, 73.68%, and 93.75%, respectively (AUC=0.87).PIVKA-II had a high diagnostic value forHCC diagnosis. Diagnostic tests that compare serum PIVKA-II levels in any size of HCC nodules might be needed in thefuture.
DIAGNOSIS LABORATORIK FLU BURUNG (H5N1) B. Mulyadi; Prihatini Prihatini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 2 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i2.848

Abstract

Pandemic of Avian influenzae (AI) cause outbreak in Asia including in Indonesia. Transmission of virus are caused by direct contactwith avian animals, swine poultry, horses or dogs to human, maybe could also happened between human being. Some victims of AIshowed signs and symptoms of repiratoric failure, such as:progresive respiratoric failure difuse, bilateral, infiltration and like ARDS(=acute respiratoric distress syndrome ). Beside those multiorgan failure which showed signs of renal disfunction, including cardiacdilatation and supraventricular tachyarrythmias.Other complications that may happened including ventilator- associated pneumoniae,pulmonary hemorrhage, pneumothorax, pancytopenia, Reye’s syndrome and sepsis syndrome without documented bacteremia.The illnessbegins abruptly acute, worse and manifested with high fever, myalgias, and non-productive cough frequently present in AI (H5N1)infections. This biblography study, consist of reviewing the screening examination such as serologic assay, exactly assay of viral cultureand RT-PCR. The results of this study may get the information which is sensitive and spesific for diagnosing the disease. In this caseshould be known the neccesity of some assays phases to assist the exact diagnosis of AI. AI disease spreading in poultry or migrationendemic area must be monitored.
PENINGKATAN AMINOTRANSFERASE SEBAGAI PENANDA CEDERA HATI PADA PENDERITA DEMAM DENGUE Madina Sahnaz; Corriejati Rita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.899

Abstract

Dengue infection can give unusual manifestation such as acute liver failure. The increased frequency of this complication in dengueinfection have been reported and have a high mortality. Elevated serum transaminase levels of dengue patients indicate the possibleimpact of dengue virus infection on liver function. The aim of this study was to know the frequency of the increased of aminotransferasein patient with dengue fever. An analysis was made of 67 serologically confirmed dengue cases at Hasan Sadikin Hospital. Thegrade of hepatic aggression was establish according to the alteration in the aminotransferase levels: grade A, have a normal levelsof aminotransferase, grade B have elevated aminotransferase, with increased levels of at least one of the enzymes, grade C elevatedaminotransferase, with the level of at least one of the enzymes increased more than three times the reference value. Among the 67serologically confirmed dengue cases, 7% (n = 5) have a primary dengue infection, 49% (n = 33) have secondary dengue infection,43.3% (n = 29) have a mix infection (secondary and primary infection). 88% (n = 59) have elevated levels of serum aspartataminotransferase (AST) and 68% (n = 46) have elevated level of serum ALT. 67.2% (n = 45) have elevated both AST and ALT. 1.7%(n = 1) presented a normal level of amiotransferase (grade A), 31.3% (n = 21) presented alterations in the aminotransferase (gradeB), 56% (n = 38 ) have elevated aminotransferase more than three times the reference value (grade C). As a conclusion, liver damagewith elevation of aminotransferase was common complication of dengue virus infection.
PENYEBARAN GUMPALAN DALAM PEMBULUH DARAH (DISSEMINATED INTRAVASCULAR COAGULATION) AKIBAT RACUN GIGITAN ULAR Prihatini .; Trisnaningsih .; muchdor .; U N Rachman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.923

Abstract

Cases of snake bites were seldom happened in town. From the 2500–3000 world-wide distributed species of snakes, 500 are venomous. The snake produce some toxic substance which is dangerous in men , and could cause morbidity or mortality. It’s caused byophitoxaemia, which influence the permeability of capilers with consequence bleeding. There patients must be examined physically, localas well systemic. The laboratoric examinations were based on clinical symptoms, by determination of the snake venom causal and thesequalae in the human body, including coagulopathy, anemia as well as renal failure, etc. The snake venom may cause necrotic tissue offoot and anemia by trombocytopenia.The condition of this victim patient was severre due to his diabetic syndrome. This article presenteda study of snake bite incident on an old man with DIC laboratoric results, following anemia and renal failure which caused his death.
PERBANDINGAN SEDIAAN BASAH DENGAN SEDIAAN GRAM HAPUSAN SEKRET VAGINA UNTUK DIAGNOSIS BACTERIAL VAGINOSIS P B Notopoero; Prihatini Prihatini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.888

Abstract

Bacterial vaginosis (BV) is a clinical condition with changes in the vaginal ecosystem. Under normal conditions, the vaginalecosystem contains Lactobacilli microflora but in BV condition, it contains mixed microflora ie combination of anaerobic bacteria andGardnerella sp. There are approximately 300 cases of BV a year in the Dr. Soetomo General Hospital. We can examine vaginal fluidmicroscopically to diagnose BV with wet mount and Gram stain method. Wet mount method is fast to do that clinicians can establishthe diagnosis and therapy earlier. Gram stain method is the gold standard method and more common to do in the laboratory but thestaining method can affect the result. This study aims to know the diagnostic value of wet mount method compared with Gram stainmethod for BV. There were 30 subjects from the Gynaecology Outpatient Clinic in the Dr. Soetomo General Hospital. They presentedwith from the leucorrhoea and fullfiled the clinical criteria for BV. We took the vaginal fluid and examined them with wet mount andGram stain microscopy. The percentage of agreement between wet mount and Gram stain method for BV Grade I is 66%, BV grade IIis 66%, BV grade III is 84.6%, and BV grade IV is 100%. The sensitivity of wet mount method is 85.71%, the specificity is 88.88%, thepositive predictive value and negative predictive value are 94.73% and 72.72%. Based on these data, wet mount method can replaceGram stain method to diagnose BV microscopically in the case that there is not enough time and resource for Gram stain. The wet mountmethod has good sensitivity, specificity, positive and negative predictive value. Wet mount method has a shortcoming in identifying themicroorganism, but this problem can be solved by combining this method with Gram stain method.
KEMAMPUAN UJI TABUNG WIDAL MENGGUNAKAN ANTIGEN IMPORT DAN ANTIGEN LOKAL Puspa Wardhani; Prihatini Prihatini; Probohoesodo M.Y
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.838

Abstract

Despite of its higher specificity than Widal-slide test, Widal-tube test is not widely used by medical laboratories because it is not practical and each laboratory has to produce their own antigens. The Laboratory must have sufficient microbiology equipments and reagents to produce antigens. REMEL® provides ‘ready for use’ antigens to perform Widal-tube test. To Compare and correlate Widal-tube test using REMEL® imported antigens and local antigens (produced by lab. Clinical pathology Dr. Soetomo hospital). The samples were tested by Widal-tube test, using REMEL® and local antigens, comparing Salmonella typhi (ST) O antigen, ST H antigen, S. paratyphi (SP) A H antigen, and SP B H antigen for each method, with twofold dilution from 1/40 until 1/1280. The number of samples was 55. The results are defined as pathologic (above cut-off value) and non pathologic (below cut-off value). REMEL® ST O antigen had a significant correlation to local antigens (r = 0.665, p < 0.01). REMEL® ST H antigen also had a significant correlation to local antigen (r = 0.671, p < 0.01), REMEL® SP B H has no significant correlation to local antigen (r = 0.389, p < 0.01). All samples (55) showed negative results (non pathologic) using SPA H local antigen. When using REMEL® SPA H antigen, 51 were non pathologic and 4 were pathologic. Widal-tube test using REMEL® antigens has significant correlation with local antigens so it might be considered to be used for diagnosing typhoid fever.
GLUT 4 DI JARINGAN ADIPOSA (GLUT 4 in Adipose Tissue) Dewi Ratna Sari; Rimbun Rimbun; Tri Hartini Yuliawati; Joni Susanto; Ari Gunawan; Harjanto JM
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1263

Abstract

The decreasing of glucose transporter 4 (GLUT 4) in adipose tissue of diabetic and obesity patients are associated withhyperinsulinaemia and insulin resistance. The adipose tissue can be used as therapeutic targets in the treatment of Diabetes Mellitus(DM). Visceral adipose tissue has different morphology and functional with subcutaneous adipose tissue and Vitamin D has been knownto have contributed in DM. The aim of this study is to know the role of cholecalciferol on the expression of GLUT 4 in subcutaneous andvisceral adiposity of diabetic rats by elucidated in those tissues. The subjects of the study consisted of nineteen male diabetic rats of Wistarstrain, which were divided into control group (K) and three (3) treatment groups (X1, X2 and X3). In order to induce the condition ofDM, the animals were fed with high fat diet for three (3) weeks and administered a single intraperitoneal injection of streptozotocin (35mg/kgBW) at the end of the second week. Cholecalciferol were administered with doses of 6.25 μg/kgBW in X1, 12.5 μg/kgBW in X2and 25 μg/kgBW in X3 per oral everyday within 14 days. The subcutaneous and visceral adipose tissues of the subjects were processedinto histological slides with immunohistochemistry staining. The data were analyzed by one way ANOVA test and paired t-test (α= 0.05,significance p<0.05). In this study was found the significance of GLUT 4 expression in subcutaneous adiposity (p=0.035) is differentbetween the groups, the differences were found between group K and groups X1, X2 and X3. Also there were found the significance differentof GLUT 4 expression in subcutaneous adiposities compared with visceral adiposities in all treatment groups (p>0.05). Based on thisstudy it can be concluded that cholecalciferol could increase the expression of GLUT 4 in the subcutaneous adiposity, but not in visceraladiposity of the diabetic rats.
MIELOMA MULTIPEL NONSECRETORY (Nonsecretory Multiple Myeloma) Maimun Zulhaidah Arthamin; Nyi R. Wahidah; Boy A. Sihite
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i1.1231

Abstract

The incidence of non-secretory multiple myeloma ranged between 1−5% cases of plasma cell dyscrasia (PCD). In the developedcountries like in Europe, cases of MM ranged from 4.5 up to 6.0/100.000 population/year with a median age at diagnosis between63 and 70 years. A very rare disease with difficulties in diagnosis in the clinical practice is the main reason for reporting this case.A nonsecretory MM (MMNS) case was reported in a 36–year-old male with multiple osteolytic lesions and bone pain; whereas renalinsufficiency as well as anemia was not found. The protein electrophoresis result showed a presence of hypoglobulinemia. On bone marrowaspiration (BMA) there was an infiltration of about 40% of plasma cells. Nonsecretory was due to a disruption of immunoglobulinsecretion, so M protein was not found in immuno-fixation electrophoresis. Epidemiological data showed that the incidence of MM inyoung age is very low. The diagnosis of MMNS is established when a plasmocyte neoplasm is not accompanied by renal insufficiency,hypercalcemia and decreased levels of normal immunoglobulin.

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