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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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MYCOBACTERIUM TUBERCULOSIS SISTEM IMUN ALAMIAH TERKAIT PENERIMANYA Jusak Nugraha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.395

Abstract

Various attemp to investigate immune response towards tuberculosis has been done in order to eradicate or to make vaccination against tuberculosis (TB) effectively. Recently it is known that innate immunity has an important role in immunity to TB despite adaptive immune response, because it was proved that adaptive immune response alone was not sufficient to eradicate this microorganism thoroughly and completely in patient’s body. After Toll-Like Receptor (TLR) was found in the end of the 20th century, many progresses has been obtained in understanding about the activation of this innate immune response. But it is still needed to understand more deeply in the immune response to M. tuberculosis to lead the development of therapy or vaccination that bring into more precise target. The activation through TLR by parts of Mycobacterium induce cytoplasm protein adaptor MyD88 (Myeloid Differentiation factor 88). MyD88 has the function to activate NF- κB and secrete pro-inflammatory cytokine such as TNF-α, IL-6, IL-12. Involvement of MyD88 is not solely dependent of TLR2 receptor and there are another pathways to induce protective function of immunocompetent cells in TB.
CHRONIC MYELOGENEOUS LEUKEMIA TRANSFORMATION INTO ACUTE LYMPHOBLASTIC LEUKEMIA Endah Indriastuti; Arifoel Hajat
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1395

Abstract

Introduction : Chronic myelogeneous leukemia (CML) is a myeloproliferative neoplasm that can progress into various conditions. Transformation of CML into acute lymphoblastic leukemia (ALL) is a rare case. Case :  A 22-year-old male with history of CML since 2014 and positive BCR-ABL p210 in 2017 came with complaint of weakness. Physical examination showed hepatosplenomegaly. CBC results Hb  7.1 g/dL, WBC 290,620/μL, platelet 434,000/μL. Blood smear evaluation (BSE) suggested CML blastic crisis dd AML-M5. Patient’s condition got worse. CBC result showed  WBC 96,770/μL and  platelet 7,000/μL in 2 weeks later. BSE was dominated by mononuclear cells with scanty blue cytoplasm, no granules, no auer rods, loose chromatine and indistinct nucleoli, suggesting lymphoblasts with a proportion of 60%. Bone marrow aspiration (BMA) and immunophenotyping was done to confirm BSE. The BMA result was dominated by lymphoblast, consistent with ALL. The immunophenotyping result was CD10+, CD34+(0,99%), CD79a+, HLA-DR+, and CD20+.  Molecular examination showed positive RUNX1 and NRAS while negative FLT3, NPM1 and del(5q). Discussion : BCR-ABL gene can be found both in CML and ALL. CML transformation into ALL had been reported to be related with deletion of a transcription gene. Diagnosis of ALL can be established by BMA and immunophenotyping. CD34+ expression of lymphoblast in ALL can be varied, but in this case was minimal. Conclusion : Patient with history of CML showed an ALL picture based on BSE, BMA and immunophenotyping suggesting CML transformation into ALL although CD34+ expression was minimal.
TAMPANG JENUH TRANSFERIN PENDONOR DARAH ANEMIA Christina Roosarjani; Titis Wahyuono; J B Suparyatmo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 3 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i3.977

Abstract

Iron deficiency remains one of the most frequent adverse effects of blood donation. Iron status test used on blood donor screeningis haemoglobin concentration. Other iron status parameters are transferrin saturation. The study aims to determine the profile oftransferrin saturation among certain groups of blood donors at the Blood Transfusion Unit of the Indonesian Red Cross SurakartaBranch. The samples were drawn from blood donors at the Blood Transfusion Unit from June to December 2005. A total of 148 specimenswere classified into 3 groups consist of 49 first time blood donations as group I, 50 of fifth time blood donations as group II, and 49of tenth time blood donations as group III. Transferrin saturation was measured by ratio between serum iron and Total Iron BindingCapacity (TIBC). The data analysed by Anova test to distinguish the difference of transferrin saturation among three groups. The resultsshowed the transferrin saturation decreased from group I to group II and from group II to group III. The transferrin saturation amongthree groups showed significantly difference (p=0.000). It can be concluded that there is a decrease in transferrin saturation accordingto the blood donation frequency among blood donors at the Blood Transfusion Unit of the Indonesian Red Cross Surakarta Branch.Transferrin saturation measurement is needed for another parameter of iron deficiency anaemia among blood donors.
KADAR N TERMINAL-PRO BRAIN NATRIURETIC PEPTIDE PADA PENDERITA PENYAKIT JANTUNG HIPERTENSI Febria Asterina; B Nasution; N Akbar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.924

Abstract

Patients with hypertension are at high risk for development of Left Ventricle Hypertrophy (LVH) and Left Ventricular Systolic Dysfunction (LVSD). These conditions should be identified earlier to prevent cardiac morbidity and mortality. To measured serumlevel of NT-proBNP in hypertensive and mild symptomatic Hypertensive Heart Disease (HHD) patients (NYHA class I-II), to performechocardiography evaluation to all of the patients and associated with serum level of NT-proBNP. A cross sectional study was done at H.Adam Malik Hospital Medan, participants were recruited from consecutive samples of 15 hypertensive and 16 mild symptomatic HHDpatients whose visited cardiovascular and internal medicine out patient clinics. Of these patients, blood samples were taken and a twodimension echo-Doppler study was performed. The patients divided into three groups based on echocardiography studies respectively:Group 1: 9 hypertensive patients with normal echocardiography finding; group 2: 13 patients with LVH and ejection fraction (EF) ≥60%; and group 3: 9 patients with LVH and EF < 60%. Mean NT-proBNP serum level (in pg/mL) for groups 1-3 respectively, were:56.4 ± 34.5, 245.4 ± 339.2 and 852.0 ± 1218.9. Mean NT-proBNP serum level differed among all three groups (p = 0.050), butthe significant difference found between group 1 and group 3 (p < 0.05) only. There were significant correlation between NT-proBNPserum level and the three stages of echocardiography finding (r = 0.488 and p = 0.005). The result suggests that NT-proBNP serumlevel correlated with deterioration of heart function and structure according echocardiography studies. The Significant rise in NT-proBNPserum level happened only when Left Ventricular Systolic Dysfunction (LVSD) develops in hypertension.
Deteksi Resistensi Fluorokuinolon di Salmonella sp dengan Menggunakan Uji Kepekaan Asam Nalidiksat Lim Bing Tiam; Tjan Sian Hwa; Sri Mulyani; Widiyani Widiyani; Diyah Asmawati; Prastika N; Meyra Fajarochwati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 1 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i1.348

Abstract

Fluoroquinolone is used as first line drug for Salmonella sp infection, but there were reports of increasing treatment failure with fluoroquinolone in infection caused by Salmonella sp, which in vitro is still succeptible to fluoroquinolone. The identification of nalidixic acid resistance, a first generation quinolone provides a high sensitivity and specifity for the detection of such fluoroquinolone resistance. The researchers aim is to study the prevalence and the minimum ciprofloxacin inhibitory concentration of nalidixic acid resistant but fluoroquinolone sensitive Salmonella sp at Premier Jatinegara Hospital. Blood cultures sent to Premier Jatinegara Hospital Laboratory during 2010 were evaluated according to Clinical and Laboratory Standards Institute guidelines. Identification and MIC succeptibility testing were determined by VITEK® 2 Compact (Biomerieux®) and nalidixic acid succeptibility testing was performed by disc diffusion method according to Kirby Bauer. Thirty eight Salmonella sp isolates were identified, all were succeptible to ciprofloxacin (MIC  0,25 mg/L), but 5 (13,2%) isolates were resistant to nalidixic acid and reported as resistant. This study found that 13,2% of Salmonella sp were resistant to fluoroquinolone but not detected by the recommended CLSI breakpoint values. The researchers recommend that nalidixic acid testing be included in Salmonella sp succeptibility testing in Indonesia and consider 3rd generation cephalosporin as the first line drug before a succeptibility test result is available.
IMMUNOLOGY OF MULTIPLE SCLEROSIS Uleng Bahrun; Chelvi Wijaya
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 2 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i2.1323

Abstract

Multiple Sclerosis (MS) is an autoimmune disease that causes myelin destruction in the Central Nervous System (CNS). Characteristics of this disease are perivascular infiltration by inflammatory cells, demyelination and loss of axons, accompanied by multiple plaque formation in the brain and spinal cord. According to the National Multiple Sclerosis Society, 400,000 people suffer from MS in the United States and about 2.5 million people worldwide. The disease is usually diagnosed in patients aged 20-45 years and more often found in females than males with a ratio of 2: 1. Nevertheless, the etiology of MS is still unknown, but it is suspected that genetic and environmental factors may induce a response to central nervous system autoantigen, such as Epstein-Barr Virus (EBV) infection. It then causes edema, demyelination, axon destruction and loss of oligodendrosites, resulting in neurological deficits, plaque formation, scarring and reduced brain volume. Multiple sclerosis symptoms and signs actually vary greatly depending on the location of the lesions and the course of the various diseases. Multiple sclerosis, moreover, can be divided into four clinical categories, namely Clinically Isolated Syndrome (CIS), Relapsing Remitting Multiple Sclerosis (RRMS), Secondary Progressive Multiple Sclerosis (SPMS) and Primary Progressive Multiple Sclerosis (PPMS). Diagnosis of Multiple sclerosis is established based on clinical symptoms and supporting investigations, such as MRI, CSF and neurological examination. In CSF examination, oligoclonal bands are found in over 90% of patients, considered as one of the laboratory criteria supporting the diagnosis of MS. There are four kinds of drugs that have been approved by the FDA as disease modifying therapy for the initial treatment of MS patients, namely interferon beta-1a, subcutaneous (SC) interferon beta-1a, interferon beta-1b and glatiramer acetate  In conclusion, life expectancy in MS patients is only slightly reduced and survival is related to the disability occurred. 
ANEMIA DAN DEFISIENSI BESI PADA SISWA SLTP NEGERI I CURUG, TANGERANG Fify Henrika; T. Silangit; Riadi Wirawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 1 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i1.943

Abstract

A research was conducted to 69 female students from a junior high school (SLtP) Negeri I Curug, tangerang aged 12–14 yearsto obtain percentages of anemia and iron deficiency in female adolescents. Anemia was found on 10.2% of the students, with 4.3%of normocytic normochromic anemia and 5.8% of microcytic hypochromic anemia. Microcytic hypochromic erythrocytes was foundon 21.7% of the subjects which consist of 2.9% iron deficiency anemia, 1.4% phase 2 iron deficiency (latent) with possibility ofhemoglobinopathy, and 2.9% phase 1 iron deficiency (pre-latent) with possibility of hemoglobinopathy. Anemia without iron deficiencywith possibility of chronic diseases and/or hemoglobinopathy was 2.9%, and without anemia nor iron deficiency but with possibility ofhemoglobinopathy was 11.6%. Iron deficiency was found among 26.1% of subjects which consist of 11.6% pre-latent iron deficiency,8.7% latent iron deficiency, and 5.8% iron deficiency anemia with 2.9% and 2.9% were normocytic normochromic anemia andmicrocytic hypochromic anemia, respectively.
PENENTUAN STRATEGIK PRIORITAS PELAYANAN LABORATORIUM KLINIK MENGGUNAKAN TEKNIK SFAS (STR ATEGIC FACT ORS ANALYSIS SUMMARY) BERSARANA ACUAN SWOT Mulyono, B.
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 2 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i2.889

Abstract

To face the global competition of clinical laboratory services, some techniques are needed for strategic formulation. SWOT, external,and internal analysis have been known as techniques for those purposes. SFAS technique was introduced recently as a simple procedureto be used as complementary tool. To evaluate an program prioritization using SFAS technique. Qualitative descriptive case analysis.Observation was done into Clinical Pathology Department of Sardjito Hospital, Yogyakarta during its activities in the year of 2006.IFA and EFA matrices showed the total scores > 2.5 and SWOT analysis revealed that the position was in 1st quadrant of the matrix.SFAS technique showed the total score > 3.0 that mean the prioritization was appropiate. SFAS technique is valuable in supportingthe formulation of strategy.
SUHU PENYIMPANAN KREATININ DAN ASAM URAT DALAM AIR KEMIH SELAMA 24 JAM AAN. Subawa; Sianny Herawati; I Nyoman Wande; I Wayan Putu Sutirta Yasa; Tjokorda Gede Oka
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1107

Abstract

Creatinine and uric acid is a product that excreted in the urine by normal kidney functions. The examination of creatinine and uricacid in urine is done on 24-hour urine collection. During the storage of the urine, it is recommended to be stored in a refrigerator withthe grade temperatures ranging from 2–8°C and is not recommended to use any preservative for the examination of creatinine anduric acid in urine. To know the comparation of creatinine and uric acid concentrations in urine between the urine tested immediatelyafter the collection with urine that was stored at a temperature 2–8°C and those at room temperature for 24 hours. A total of 45 urinesamples from outpatient clinic that came to the laboratory, were collected in particular urine vacutainer. Each urine sample is divided intothree tubes. The first tube (P1) examined concentrations of creatinine and uric acid immediately after collection, was considered as thebaseline value. The second tube (P2) stored at 2–8°C and the third tube (P3) is stored at room temperature for 24 hours, then followedby the examination of creatinine and uric acid concentrations. The examination of creatinine in urine was using reagent CREP2 RocheDiagnostic and uric acid in urine was using reagent UA2 Roche diagnostics by Cobas Integra ® 400 plus ® instrument. The mean ofcreatinine in urine concentrations which immediately examined (P1) is (125.10±74.85 mg/dL), concentrations after storage at 2−8°C(P2) and at room temperature (P3) were (123.42±73.80 mg/dL) and (124.09±73.95 mg/dL) respectively. Based on the analysis ofone-way ANOVA, there were no significant differences between the concentrations of creatinine in urine immediately checked which werestored at 2–8°C and at room temperature (P>0.05). The mean of uric acid in urine concentrations which immediately examined (P1) is(52.61±35.48 mg/dL), where as after storage at 2–8°C (P2) and room temperature (P3) were (45.11±31.62 mg/dL) and (46.38±28.91mg/dL) respectively. Based on the analysis of one-way ANOVA, there were no significant differences between the concentrations of uricacid in urine immediately checked by those stored at 2–8°C and at room temperature (P>0.05). Based on this study, it can be concludedthat there were no effect of storage temperature on the concentrations of creatinine and uric acid in urine within 24 hours.
BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) PASCACEDERA KEPALA BERAT SEBAGAI FAKTOR PERAMALAN PERJALANAN PENYAKIT {(Brain Derived Neurotrophic Factor (BDNF) as a Prognostic Factor in Severe Head Injury)} Ridha Dharmajaya
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 1 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i1.1261

Abstract

Severe head Injury result in primary and secondary brain damage. The secondary brain damage produces a more worse effect thanthe primary one. Therefore, the process of the secondary brain damage should be prevented in order to obtain a maximum result ofpatient management. The difficulty is to make sure, whether the secondary brain damage is already very bad or, on the other hand, isstill in a positive condition, causing patient management to have a good result. The prognostic decision, is the most important thing inpatient management. The objective of this research was to find an accurate prognostic factor which is simple and non invasive for severehead injury for each time lapse, 24, 48, 72 and 120 hours after the brain damage which had caused the head injury. The installation ofan intracranial pressure (ICP) monitor for the first 24 hours, after the head injury, followed by taking a cerebrospinal fluid sample forBDNF examination at the first 24 hours, 48 hours, 72 hours and 120 hours as well. Enzyme Linked Immunosorbent Assay was used todetermine BDNF. Each subject was assessed by Glasgow Outcome Scale classification, three months after the injury. The result of thisresearch was that BDNF at 48 hours after head injury showed a significant difference (p < 0.05) between good and bad Glasgow OutcomeScale classification. Thus, it can be concluded that patients with an increase in BDNF (>6.16 pg/mL) 48 hours after head injury, mayhave a good prognosis.

Page 7 of 133 | Total Record : 1328

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