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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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PENINGKATAN MUTU PEMERIKSAAN DI LABORATORIUM KLINIK RUMAH SAKIT Kahar, Hartono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.839

Abstract

Clinicians always needs the results of clinical laboratory with quality assurance. The performance of good quality laboratory depends on pre-analytic, analytic as well as post analytic processes. It is also influenced by reagents and methods types as well as personal laboratory work. The goal of laboratory examinations quality runs between QMS, or Five Q’s, which consist of: Quality planning, laboratory practice, control, and assurance and Quality improvement. The quality laboratory examinations depend on the accuracy and precision results.
RERATA VOLUME TROMBOSIT, HITUNG LEUKOSIT DAN TROMBOSIT DI APENDISITIS AKUT Jayadi Festiawan; Nurhayana Sennang; Ibrahim Abdul Samad
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 2 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i2.1075

Abstract

The diagnosis of acute appendicitis and its complications still depends on the radiological examination and laparoscopy techniques.The aim of this study was to know the Mean Platelet Volume (MPV), WBC and platelet value in the diagnosis of acute appendicitis,associated with the incidence of existing complications. This research was carried out by a retrospective study by taking secondary datafrom the medical records, including the results of routine blood tests of acute appendicitis patients with and without complications atthe Dr. Wahidin Sudirohusodo Hospital between May 2011− May 2012. The data obtained in the study were MPV, White Blood Cell(WBC) and platelet count which were then analyzed using independent T test. The results obtained from 44 samples were that MPVvalues showed a significant difference (p=0.02), while WBC (p=0.12) and platelet count (p=0.13) were statistically not significantlydifferent between patients with and without complications. In conclusion, it was found that acute appendicitis with complications hadhigher MPV average values than those without complications and although there were significant differences between them, these werestill within the normal values.
VERY SEVERE HYPERTRIGLYCERIDEMIA IN SUSPECTED FAMILIAL CHYLOMICRONEMIA INFANT Fitry Hamka; Liong Boy Kurniawan; Suci Aprianti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1165

Abstract

Seorang bayi perempuan berusia 6 bulan, masuk rumah sakit dengan keluhan utama muntah dialami sejak satu hari sebelummasuk rumah sakit dengan kekerapan lebih dari sepuluh kali dalam sehari dan demam dialami sejak 6 jam sebelum masuk rumah sakit.Pasien ini lahir prematur secara sectio secarea dengan berat badan lahir 1,5 kg. Serum pasien lipemik seperti susu. Kadar kolesterol totalserum pasien 477 mg/dL, trigliserida 4370 mg/dL (hipertrigliseridemia sangat berat), LDL direk 135 mg/dL, HDL 5 mg/dL dan kadarhemoglobinnya 8,0 gr/dL. Pasien ini mendapatkan cairan intravena, antibiotik dan transfusi darah akibat anemia yang diderita. Dikasus ini, hipertrigliseridemia sangat berat diduga terkait dengan kilomikronemia familial. Penapisan profil lipid dari orang tua bayidan keluarga lainnya sangat penting dilakukan untuk menegakkan diagnosis.
HUBUNGAN OKSIDA NITRAT DAN NILAI HISTOPATOLOGIS PADA ENDOTOKSEMIA Sotianingsih, Sotianingsih; Suharyo, Suharyo; S, Lisyani; HA, Guntur
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.467

Abstract

Lipopolysaccharide (LPS) is an endotoxin from the outer membrane of Gram-negative bacteria, which has an important role in the occurrence of sepsis. Exposure to LPS will stimulate increase of nitric oxide (NO). Nitric oxide is a bioregulator of apoptosis and has some sepsis prognostic role of apoptosis regulators within the gastrointestinal cells. The objective of the study is to know if endotoxemia induces an increase in NO levels and histopathology scores as well as the existing relationship between them. This study is an observational intervention. The subjects were 48 male mice Balb/C, divided into 2 groups. The samples consisted of 24 tail as control group (group A) and 24 as treatment group (group B). The A group as well as the B group is divided into 4 subgroups according to the time of termination. The levels of NO were examined by Griess method. Histopathology score was examined by HE and read as a score of 0–5. There was a statistically significant difference between the mean NO in the treatment group with the control group at the termination of the group of 12h (p=0.009), 24h (p=0.015), 36h (p=0.014), 48h (p=0.002) and the whole group (p=0.0001), as well as between the mean histopathology score at the termination time of 12 h (p=0.0001), 24h (p=0.0001), 36h (p=0.0001), 48h (p=0465) and the whole group (p=0.0001). Increase in NO and histopathology scores in all groups of mice (r=0.527) showed a statistically significant correlation. NO levels and histopathology scores are increased during endotoxemia and thus have a significant correlation.
NITRIT OKSIDA DAN VOLUME EDEMA OTAK PADA STROK PERDARAHAN DALAM OTAK DENGAN POLIMORFISME G894T (Nitric Oxide and Cerebral Edema Volume in Intracerebral Hemorrhagic Stroke with G894T Polymorphism) Iskandar Zakaria; Arif Faisal; Sri Sutarni; Ahmad Hamim Sadewa; Imran Imran
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i1.1229

Abstract

Nitric Oxide (NO) is a vasodilator that regulates vascular smooth muscle tone. Low levels of NO can cause vasoconstriction andhemodynamic disturbances. In stroke the levels of NO are increased. Endothelial nitric oxide synthase gene polymorphism (eNOS) isbelieved to reduce levels of NO in blood. NO levels decreased in stroke patients with G894T polymorphisms of eNOS gene. Mortality rateof hemorrhagic stroke are increased in case with increased peri focal edema volume. The mechanism of the increased of peri focal edemavolume completely unknown yet, suspected genetics factor. This study was conducted to know the correlation between the NO and perifocal edema volume in stroke with eNOS gene G894T polymorphism by determination. The study was conducted by comparing the levelsof NO and edema volume of intra cerebral hemorrhagic stroke of 46 subjects from Neurology department of dr. Zainoel Abidin generalhospital in Banda Aceh from September 2014 through January 2015 with comparison to ischemic stroke patients the same amount.NO levels checked with Cayman Systems kit following the protocol Griess. G894T polymorphism was determined by PCR-RFLP method.The volume of edema was measured with semi-automatic CT volumetry. Chi Square test was used for comparison of two variables andSpearman correlation test to assess the relationship between the NO and perifocal edema volume. The result is significant, if p valuewas <0.05. The results of these study were levels of NO decreases if there were polymorphism (p=0.001). Peri focal edema volume wasincreased if there were G894T polymorphism (p=0.038). The correlation between low levels of NO and increase of edema volume wasobtained p=0.040 and R=0.304. The researchers concluded that in intra cerebral hemorrhagic stroke the level of NO were decreasedand peri focal edema volume increased if there was G894T polymorphism of eNOS gene. There was a less correlation between low levelsof NO and peri focal edema volume.
PERAN ANTIGEN NS1 DENGUE TERHADAP PENGHITUNGAN TROMBOSIT DAN PENAMPAKAN (MANIFESTASI) KLINIS PENJANGKITAN/PENULARAN (INFEKSI) VIRUS DENGUE J Nugraha; T.E Widijatmoko
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i3.1038

Abstract

Dengue virus infection has become the major health problem in Indonesia. Dengue haemorrhagic fever is a part of dengue virus infection. 95% of this disease commonly affects children less than 15 years. However, in the last five years the incidence of DHF hasalso increased in adults. In 2008, the case fatality rate of DHF was 0.99% in East Java and 0.47% in Surabaya. The diagnosis of DHFis based on the 1997 WHO criteria. Thrombocytopenia is a haematological abnormality occurring in DHF. There is a hypothesis aboutthe role of non-structural 1 antigen (NS1 antigen) during initial virus replication leading to immunological reaction manifestationin thrombocytopenia. To analyze the role of NS1 antigen dengue to platelet count and clinical manifestations to know the degree ofdengue virus infection. This study used a cross-sectional design. The samples are comprised of 52 patients with dengue fever anddengue haemorrhagic fever grade I until III hospitalized at Tropical Disease Ward, Dr.Soetomo Hospital, and Surabaya. Data wereanalyzed using Mann-Whitney test, t-two sample test (p = 0.05). The result of this study using Mann-Whitney test show no difference between NS1 antigen dengue with the clinical manifestations in dengue virus infection (p = 0.882). Analysis using t-two sample test showed a significant difference between NS1 antigen dengue positive and NS1 antigen dengue negative with a change in platelet count (p = 0.006). Although, the test showed no significant difference between NS1 antigen dengue and the platelet count in dengue virusinfection (p = 0.062). There were found no significant association between NS1 dengue antigen with platelet count and clinicalmanifestations in dengue virus infection.
BERBAGAI KESALAHAN TATA LANGKAH PEKERJAAN LABORATORIUM KLINIK Prihatini Prihatini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 3 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i3.968

Abstract

Laboratory procedure errors occurred in some cycle parts during prae-analytic, analytic and post analytic sessions, they must beexcluded and prevented in the process because the outcome would support the diagnosis of diseases also to enhance their confidence.The laboratory works were carried out in the right methods, is suppervised accurately base on haematological, microbiological, clinicalchemistry and immunological standard examinations. Any deviation although the procedure results according the standard one mustbe registered. Laboratory errors revealed must be monitored as the means to reduce errors and to threat them well. Beside it is necessaryto have a good communication between patients, doctors as well as with the laboratory services.
IDENTIFIKASI CEPAT MIKROORGANISME MENGGUNAKAN ALAT VItEK-2 prihatini .; aryati .; hetty .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.915

Abstract

Vitek-2 is automatic microbiologic equipment which used to identify antimicrobial sensitivity by micro organism test have been launched in Indonesia. In some private laboratory and hospital this equipment has been used already. The purpose of this study is toknow how to operate this equipment to ID and AST as well as to compare with the conventional methods. The material used to test withthis equipment consist of pure colony culture which derived by suspension of one inoculation to ID or AST card. The reagent consistsonly of saline suspension. After the suspension installed to VITEK2, the result was verified in the printout about 1.5 hours. The colour ofID and AST is difference and couldn’t change with each other. The results are appear more rapid than the others conventional methods.VITEK-2 can be used as a means to diagnose faster than the conventional methods., so that the physician could prescribe earlier as soonas possible to patients and reduced the hospital budgets as well.
DIAGNOSTIC VALUE OF URIC ACID IN PLEURAL EFFUSION Saraswati Wulandari Hartono; Nurhayana Sennang; Fitriani Mangarengi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 2 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i2.1314

Abstract

Pleural effusion is excessive pleural fluid accumulation in the aimed pleural cavity, are categorized into exudate and transudate. Light’s criteria (1972) has become a classic criteria to distinguish pleural effusion types. Other criteria were evaluated such as pleural fluid uric acid. The aimed of this study was to analyze the difference of uric acid level between transudate and exudate and to compare it with Light’s criteria. A cross-sectional study was conducted in Clinical Pathology Laboratory of the Dr. Wahidin Sudirohusodo Hospital Makassar in September 2016. Uric acid level of pleural effusion samples was measured by ABX Pentra 400. Statistical analysis used Mann-Whitney U test, significance was indicated if p<0.05. Cut-off, sensitivity and specificity of uric acid used ROC curve. Total subjects were 56 patients, mean age 49.54+13.63 years-old, 31 males (55.4%) and 25 females (44.6%). Most cases were exudative effusion (58.9%) with 19 malignancy cases (33.9%). Uric acid level median was 6.6 mg/dL (3.24-17.50 mg/dL) higher in transudate than exudate 5.01 mg/dL (0.6-9.40 mg/dL) (p=0.001). The cut-off point for pleural fluid uric acid was 5.845 mg/dL, with a sensitivity of 78.3% and specificity of 66.7%. Sensitivity and specificity of Light’s criteria was 97% and 60.9%. There was a significant difference between pleural fluid uric acid level in transudate and exudate, higher in transudate than exudate. Light’s criteria were higher in sensitivity than uric acid, but lower in specificity. Further research is needed with better sampling method to reduce bias. 
HITUNG KOLONI Candida Albicans DI TINJA ANAK GANGGUAN AUTISM SPECTRUM R Herawati; I Parwati; I Sjahid; C. Rita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.879

Abstract

Candida albicans is part of the normal flora of the digestive tract, however in immunocompromised host can cause opportunisticinfection. According to Shaw’s case series study in North Carolina USA, colonization of C. albicans is increased in autism spectrumdisorders (ASD) patients. C. albicans is a dimorphism fungus, the yeast phase is grown at 37 °C and the mould phase is grown at roomtemperature. The aim of this study was to compare C. albicans colony count in stools of ASD patients and normal children, and to findcorrelation between C. albicans colony count and state of ASD. A cross sectional study was conducted from December 2004 to March 2005on 50 ASD patients and 50 normal children as controls. Diagnosis of ASD was based on the Diagnostic and Statistical Manual of MentalDisorders (DSM) IV criteria. The range of age in both groups was 2 to 6 years old. Stool specimens were collected in Sachs transportmedia. All specimens were examined in the Division of Infectious and Tropical Medicine, Department of Clinical Pathology RSHS/FKUPBandung. The specimens were examined microscopically and cultured on Sabouraud dextrose agar incubated at room temperature and37 °C. The colonies were interpreted in colony forming unit (CFU). The C. albicans was identified by colony microscopic examinationand germ tube test. The differences of C. albicans colony count between ASD and normal subject were analyzed by t-test. Correlationbetween colony count C. albicans and ASD state was analyzed using point biserial correlation. Of 50 subjects, 14 (28%) were diagnosedas pervasive developmental disorder not otherwise specified (PDD-NOS) and 36 (72%) were diagnosed as autistic disorders. There wereno significant statistical differences between ASD and normal subjects in age, sex, and nutritional status (p > 0.05). A significantcorrelation between direct microscopy and the result of Candida colony count was found (p = 0.0000). We did not find a significantdifference between the two temperature of incubations (p = 0.390). Mean of C. albicans colony count in normal subjects was 4 CFU.In contrast, the mean of C. albicans colony count in ASD subjects was 39 CFU. The mean C. albicans colony count in ASD subjects wassignificantly higher than normal subject (p = 0.012). There was a significant correlation between C. albicans colony count and the stateof ASD (Rpb0.253372; p = 0.0106) : C. albicans colony count from stool of ASD subjects was significantly higher than normal subjects.We also found a significant correlation between C. albicans colony count and the state of ASD

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