cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Dr. dr. Puspa Wardhani, SpPK
Contact Email
admin@indonesianjournalofclinicalpathology.org
Phone
+6285733220600
Journal Mail Official
majalah.jicp@yahoo.com
Editorial Address
Laboratorium Patologi Klinik RSUD Dr. Soetomo Jl. Mayjend. Prof. Dr. Moestopo 6-8 Surabaya
Location
Kota adm. jakarta selatan,
Dki jakarta
INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
 85   86   87   88   89 
Laboratory Aspect of Broken Heart Syndrome Y. Kusumo Adi Arji Atmanto; Sulina Yanti Wibawa; Darmawaty E Rauf
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.1990

Abstract

Broken Heart Syndrome (BHS) is the weakness of the heart muscle due to emotional stress or physical stress called cardiomyopathy.  The main etiology is a sudden release of stress hormones (catecholamines), such as norepinephrine, epinephrine, and dopamine. About 90% of BHS patients are female with average age of 67-70"‰ years, most of them are post-menopausal females. The most widely supported pathological theories are catecholamine-induced cardiotoxicity and microvascular dysfunction. The clinical condition resembles that of acute myocardial infarction, consisting of chest pain, electrocardiographic changes, elevated cardiac biomarkers, and abnormalities of heart wall motion. There is transient systolic dysfunction in the apical and/or middle segment of the left ventricle resembling acute myocardial infarction but absence of coronary artery obstructive disease. There are BHS criteria according to Mayo Clinic. Laboratory tests can be performed by examining Natriuretic Peptides, cardio myonecrosis markers (Troponin I and T, creatinine kinase, and myoglobin), and catecholamines. There is no single established biomarker for initial diagnosis of BHS that distinguishes it from STEMI. It was found that the most accurate ratio as a marker capable of differentiating BHS from STEMI in early stages was NTproBNP/TnI ratio. The InterTAK diagnostic score was used to predict the probability of BHS, differentiating it from ACS in an acute stage, prior to coronary angiography. The main differential diagnosis of BHS is ACS, besides acute myocarditis infectious. Patients with BHS should be treated as ACS until proven otherwise. The prognosis for BHS patients is generally very good.
Analysis of Erythrocyte Indices and Reticulocyte Hemoglobin Equivalent in Iron Deficiency Anemia on Treatment Agnes Theresia Motulo; Rachmawati Muhiddin; Nadirah Rasyid Ridha; Mansyur Arif; Agus Alim Abdullah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.1991

Abstract

Assessment of treatment response is needed in the management of iron deficiency anemia (IDA). This study aims to analyze erythrocyte indices (MCH, MCV, MCHC) and Ret-He as indicators of IDA diagnosis and treatment response. A prospective cohort study in children ages 2-18 years old in orphanages throughout Makassar. Grouped into normal group and therapy group, consisting of IDA and iron deficiency groups. Elemental iron therapy 3mg/kg/day was given. Levels of MCV (fl), MCH (pg), MCHC (g/dL), and Ret-He (pg) were measured before and on the 8th day of therapy. The normality test of numerical variable data used the Kolmogorov-Smirnov test. The statistical test used the Mann-Whitney test, Wilcoxon Signed Rank test, and the Kruskal-Wallis test.  Diagnostic value and cut-off determination using ROC curve analysis. Test results were significant if p<0.05. The sample consisted of 40 subjects each in both normal and therapy groups. The therapy group was divided into 7 IDA and 33 iron deficiency. ROC IDA curve on MCV obtained a cut-off of 76 fl, a sensitivity of 100%, a specificity of 95%, NPP of 77.8%, NPN of 100%, MCH obtained a cut-off of 25 pg, a sensitivity of 100%, 97.5% specificity of 97.5%, NPP of 87.5%, NPN of 100%, Ret-He obtained cut-off 29 pg, sensitivity of 100%, specificity of 95%, NPP of 77.5%, NPN of 100%. MCV levels increased by 7.3% (p<0.05) while Ret-He increased by 19.6% (p<0.05) after therapy. The ROC curve coordinate on IDA showed that cut-off levels of MCV 76 fl, MCH 25 pg, and Ret-He 29 pg provided optimal sensitivity and specificity. Increasing MCV after therapy described increasing levels in erythrocyte and hematocrit synthesis. Increasing Ret-He after therapy described improving erythropoiesis quality. MCV, MCH, and Ret-He as indicators of diagnosing IDA. MCV and Ret-He monitor the success of IDA treatment response.
Correlation between Neutrophil to Monocyte Ratio, C-Reactive Protein, and D-dimer Levels among COVID-19 Patients Melkior Krisna Arondaya; Banundari Rachmawati; Santoso Jaeri; Dwi Retnoningrum
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.1992

Abstract

COVID-19 is a disease caused by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) and leads to various clinical manifestations. This condition can cause inflammation and cardiovascular disease that can result in increased Neutrophil-to-Monocyte Ratio (NMR), C-Reactive Protein (CRP), and D-dimer. The correlation between variables needs further investigation that can be a reference. This study aimed to analyze the correlation between NMR and CRP also NMR and D-dimer in COVID-19 patients with moderate dan severe illness. The research was an observational analytical study with a cross-sectional design on 40 subjects.  Data were secondary data from COVID-19 patient’s medical records in RSND Semarang. This study was carried out from April to September 2021. Correlation analysis using the Spearman Rank test with p<0.05 was considered significant. The Mean of NMR, CRP, and D-dimer was 16.69±10.65, 113.94±70.42 mg/L, and 1.72±2.35 mg/L, respectively. There was a weak positive correlation between NMR and CRP (p=0.023 and r=0.358) and there was no correlation between NMR and D-dimer (p=0.638 and r=0.077). It was expected that this knowledge about the correlation between NMR and CRP and D-dimer can help healthcare providers in planning therapy and preventing complications that may occur due to CRP and D-dimer increase.
Blood Supply Management During COVID-19 Pandemic and Ramadhan Fasting at a Tertiary Hospital Teguh Triyono; Usi Sukorini; Rukmono Siswishanto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.1993

Abstract

The worldwide pandemic of Coronavirus Disease 2019 (COVID-19) has a major implication for blood donation. The beginning of the pandemic occurred at the same time as Ramadhan fasting. This study aimed to evaluate blood donation, blood use trends, and several factors associated with the need for transfusion during the COVID-19 pandemic and Ramadhan fasting in Dr. Sardjito General Hospital (SGH). Information on blood donation and the use of blood components in the SGH-Blood Centre (SGH-BC) from 1 February to 30 September 2019 and 2020 were collected and analyzed. The average number of blood donations from February to September 2020 declined by 11.22% compared to the previous year. The average use of blood components from February to May 2020 also declined compared to the previous year. the decline found in this study was Packed Red Cells (PRC) by 15.43%; Thrombocyte Concentrate (TC) by 23.03%; Whole Blood (WB) by 73.64%; Fresh Frozen Plasma (FFP) by 10.56%; and Thrombocyte Apheresis (TA) by 32.87%. Two characteristics of donors remain unchanged between 2019 and 2020. Most of them were males and age younger than 25 years old. However, there was a shifting characteristic of donors in blood group, weight, and hemoglobin level. Declined number of blood donations might be caused by the pandemic situation and Ramadhan fasting. Blood usage also decreased in the early of this pandemic. The SGH-BC had modified some strategies to increase blood donation and decrease blood component use in this situation.
C-Reactive Protein as The Predictor of Mortality for COVID-19 Patients in Indonesia Astari Rahayu Afifah; Phey Liana; Soilia Fertilita; Nelda Aprilia Salim; Verdiansah Verdiansah; Fadhilatul Hilda; Chris Alberto Amin; Tungki Pratama Umar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.1997

Abstract

Coronavirus Disease 2019 (COVID-19) confirmed cases and deaths continue to rise. When a virus infects the body, the immune system tries to eliminate the virus. C-Reactive Protein (CRP) is a substance produced in the body in response to infection and inflammation. The study aimed to determine the role of CRP in predicting COVID-19 patients’ mortality. From the 1st of March to the 31st of August 2020, data on patients confirmed with COVID-19 were collected from medical records. The correlation between CRP levels and patient mortality was determined using a Chi-Square test. A Receiver Operator Curve (ROC) analysis was used to determine the best CRP cut-off point, and a survival analysis was used to assess the patient outcome. This study included a total of 210 eligible patients. Survivors and non-survivors were divided into two groups of patients (159 patients and 51 patients, respectively). The CRP cut-off was 54 mg/L, with an AUC of 0.817 (p<0.001). C-reactive protein levels were related to COVID-19 patient mortality (p=0.000). According to the survival analysis, patients with CRP levels > 54 mg/L had a lower chance of 30-day survival (p=0.0001). This study presented that CRP levels can be used to predict mortality in COVID-19 patients.
Correlation between Ubiquinone Levels, Lactate Dehydrogenase, and Lactate on Acute Myocardial Infarction Ariosta Ariosta; Purwanto Adhipireno; Lisyani Budipradigda Suromo; Charles Limantoro; Andreas Arie Setiawan; Jessica Christanti; Dwi Retnoningrum; Nyoman Suci Widiastiti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.2001

Abstract

Ubiquinone is an antioxidant that plays a role in preventing endothelial damage, thereby reducing the risk of myocardial infarction. In myocardial infarction, there is a decrease in ubiquinone levels and energy production in the form of ATP. Both stimulate anaerobic metabolism, which increases lactate dehydrogenase and lactate levels. This study aimed to analyze the correlation between ubiquinone levels, lactate dehydrogenase levels, and lactate levels in patients with acute myocardial infarction. This study was an analytical observational study with a cross-sectional approach. The normality of data was analyzed using the Kolmogorov-Smirnov test, and the correlation among variables was analyzed using the Spearman Rank test. The number of research subjects was 52, consisting of 25 research subjects with STEMI and 27 with NSTEMI. The median of ubiquinone, LDH, and lactate levels was 12.52 ng/mL (5.6–412.2); 310 U/L (3-1212); and 4 mmol/L (0.8 – 22), respectively. The correlation test results between ubiquinone levels with LDH levels obtained p=0.4 with r=-0.35; correlation test results between LDH levels and lactate levels obtained p=0.09, with r = -0.14. There was no correlation between acute myocardial infarct patients' ubiquinone levels, LDH levels, and lactate levels in AMI patients.
Correlation between Platelets Count and C-reactive Protein in COVID-19 Patient in Jember Regency Rini Riyanti; Faliqul Bahar Muhammad; Adelia Handoko
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.2002

Abstract

The laboratory test for Coronavirus disease 2019 (COVID-19) is very important for initial treatment and predicting the prognosis of the patients, but there have been reports of false negative COVID-19 diagnostic test results. Another study reported changes in COVID-19 patient biomarkers, namely platelets count and C-Reactive Protein (CRP) levels. This study investigated the correlation between platelet count and CRP in COVID-19 patients. This study was conducted using a cross-sectional analytic observational method, through secondary data analysis of COVID-19 patients who hospitalized between June – August 2021 at Dr. Soebandi Hospital and Jember Klinik Hospital. Of 30 patients, there were 16 male patients (53%) and 14 female patients (47%); 18 patients in the 46-59 years old age group (60%) and 12 patients in ≤ 4 years old (40%) age group; and there were 8 patients admitted to ICU (26.67%). There was a negative correlation between platelet count and CRP in COVID-19 patients (r = -0.733; p<0.001). A strong correlation between platelet count and CRP is related to prognostic and predictive factors of severity in COVID-19 patients. Further studies about the analysis of other biomarkers in COVID-19 are needed to obtain more prognostic and predictive factors of severity in patient.
A Comparative Study of PTS and Manual Transportation for Platelet Count and Aggregation Test Sri Suryo Adiyanti; Bernadette Elvina Setiadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.2010

Abstract

The transportation effect of the Pneumatic Tube System (PTS) on platelet activity remains controversial. This study aimed to analyze the effect of PTS in the platelet aggregation test in Dr. Cipto Mangunkusumo Hospital, Jakarta. This cross-sectional study was carried out in the Clinical Pathology Laboratory of Dr. Cipto Mangunkusumo Hospital (RSUPNCM) from March to April 2021. There were 50 subjects involved in this study, each of whom 6 sodium citrate blood tubes were extracted. Three tubes were sent through PTS while the rest were transported manually. All tubes were then tested for platelet count and platelet aggregation using ADP agonists of 1 uM, 5 uM, and 10 uM. There was a lower platelet count (p=0.046) and platelet aggregation in ADP 1 uM (p=0.037), ADP 5 uM (p <0.001), and ADP 10 uM (p <0.001) at PTS-transported samples. Eleven samples were interpreted distinctively as low platelet aggregation in PTS transportation became normal in manual delivery. Cohen’s Kappa value was 0.51 (p <0.001). A decreasing platelet count and platelet aggregation in PTS samples indicated that acceleration and deceleration during transportation could lead to platelet activation, thus resulting in a lower result after being added to an agonist. Cohen's Kappa test showed that manual transportation could not be replaced with PTS for the platelet aggregation test. Platelet count and platelet aggregation were found to be lower in PTS-transported samples. It was suggested to centralize specimen taking for platelet aggregation tests, thus manual transportation can be conducted more efficiently.
Obesity Indices Could Predict High Apolipoprotein B/Apolipoprotein A1 Ratio in Non-menopausal Indonesian Adult Females Liong Boy Kurniawan; Martina Rentauli Sihombing; Endy Adnan; Gita Vita Soraya; Tenri Esa; Yuyun Widaningsih; Uleng Bahrun; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.2049

Abstract

Previous researches have demonstrated associations between high obesity indices with increased risk of metabolic and cardiovascular disorders. It has also been established that abnormalities of lipoprotein metabolism have an important role in atherogenesis and that non-menopausal females are protected from atherosclerotic cardiovascular events relative to menopausal females and males. This study aimed to investigate the relationship between obesity indices such as body mass index (BMI), waist circumference (WC), body fat percentage (BF), and visceral fat (VF) with apolipoprotein B/apolipoprotein A1 ratio in non-menopausal Indonesian adult females. A total of 75 non-menopausal Indonesian adult females were included as subjects in this cross-sectional study. Measured indices included BMI, WC, BF, and VF. Measurement of apolipoprotein B and A1 were performed by immunoturbidimetry, followed by calculation of the ratio. A cut-off value of 0.8 was used to define high apolipoprotein B/apolipoprotein A1 ratio. Apolipoprotein B/Apolipoprotein A1 ratio was significantly correlated with BMI (r=0.384, p=0.001), WC (r=0.363, p=0.001), BF (r=0.385, p=0.001), VF (r=0.380, p=0.001). The area under curve of BF (0.754) was slightly larger than BMI (0.722), VF (0.721), and WC (0.686) in predicting high apolipoprotein B/apolipoprotein A1 ratio. A positive significant correlation was observed between obesity indices with the apolipoprotein B/apolipoprotein A1 ratio. Obesity indices could be used to predict high apolipoprotein B/apolipoprotein A1 ratio.
Cover and Contents Dian Wahyu Utami
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cover and Contents

Page 87 of 133 | Total Record : 1328

 85   86   87   88   89 

Filter by Year

2005 2025


Reset
Filter By Issues
All Issue Vol. 32 No. 1 (2025) Vol. 31 No. 3 (2025) Vol. 31 No. 2 (2025) Vol. 31 No. 1 (2024) Vol. 30 No. 3 (2024) Vol. 30 No. 2 (2024) Vol. 30 No. 1 (2023) Vol. 29 No. 3 (2023) Vol. 29 No. 2 (2023) Vol. 29 No. 1 (2022) Vol 29, No 1 (2022) Vol 28, No 3 (2022) Vol. 28 No. 3 (2022) Vol. 28 No. 2 (2022) Vol 28, No 2 (2022) Vol 28, No 1 (2021) Vol. 28 No. 1 (2021) Vol. 27 No. 3 (2021) Vol 27, No 3 (2021) Vol. 27 No. 2 (2021) Vol 27, No 2 (2021) Vol. 27 No. 1 (2020) Vol 27, No 1 (2020) Vol 26, No 3 (2020) Vol. 26 No. 3 (2020) Vol. 26 No. 2 (2020) Vol 26, No 2 (2020) Vol 26, No 1 (2019) Vol. 26 No. 1 (2019) Vol. 25 No. 3 (2019) Vol 25, No 3 (2019) Vol 25, No 2 (2019) Vol. 25 No. 2 (2019) Vol 25, No 1 (2018) Vol. 25 No. 1 (2018) Vol 24, No 3 (2018) Vol. 24 No. 3 (2018) Vol. 24 No. 2 (2018) Vol 24, No 2 (2018) Vol. 24 No. 1 (2017) Vol 24, No 1 (2017) Vol. 23 No. 3 (2017) Vol 23, No 3 (2017) Vol 23, No 2 (2017) Vol. 23 No. 2 (2017) Vol 23, No 1 (2016) Vol 22, No 3 (2016) Vol 22, No 2 (2016) Vol 22, No 1 (2015) Vol 21, No 3 (2015) Vol 21, No 2 (2015) Vol 21, No 1 (2014) Vol 20, No 3 (2014) Vol 20, No 2 (2014) Vol 20, No 1 (2013) Vol 19, No 3 (2013) Vol 19, No 2 (2013) Vol 19, No 1 (2012) Vol. 19 No. 1 (2012) Vol 18, No 3 (2012) Vol. 18 No. 3 (2012) Vol 18, No 2 (2012) Vol. 18 No. 1 (2011) Vol 18, No 1 (2011) Vol 17, No 3 (2011) Vol 17, No 2 (2011) Vol 17, No 1 (2010) Vol 16, No 3 (2010) Vol 16, No 2 (2010) Vol 16, No 1 (2009) Vol 15, No 3 (2009) Vol 15, No 2 (2009) Vol 15, No 1 (2008) Vol 14, No 3 (2008) Vol 14, No 2 (2008) Vol 14, No 1 (2007) Vol 13, No 3 (2007) Vol 13, No 2 (2007) Vol 13, No 1 (2006) Vol 12, No 3 (2006) Vol 12, No 2 (2005) Vol 12, No 1 (2005) More Issue