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Andalas obstetrics and gynecology journal
Published by Universitas Andalas
ISSN : 25798324     EISSN : 25798413     DOI : https://doi.org/10.25077/aogj
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health
Andalas Obstetrics And Gynecology Journal (AOJ) (e-ISSN: 2579-8324) is a peer-reviewed, open-access national journal published by Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of obstetrics, gynecology, and other related disciplines.
Arjuna Subject : Kedokteran - Obstetrics and Gynaecology
Articles 469 Documents
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Clinical Profiles and Outcomes of Patients With Placenta Accreta Spectrum at Dr. M. Djamil Hospital, Padang During 2019 –2022 Sriyanti, Roza; Sri Rahayu MK
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.86-94.2025

Abstract

Objective: Placenta accreta spectrum (PAS) is one of the severe obstetric complications which can cause serious morbidity and mortality to both maternal and neonatal. The incidence of PAS increases globally because of the increasing rate of cesarean deliveries (CS). The aim of this study was to describe the clinical profiles and outcomes of patients with PAS during 2019-2022 at Dr. M. Djamil Hospital, Padang. Method: This study was a retrospective descriptive study that had women with PAS who gave birth and referred to Dr. M. Djamil Hospital Padang, from January 2019-December 2022 as study participants. This study described clinical profiles, PAI score and USG findings and maternal neonatal outcomes of patients with PAS. Result: One hundred eighty-seven cases were involved in this study. Most women with PAS aged ≥ 35 years (45%), parity 2 (47%), previous CS (96%), ≥ 2 times CS history (59%). A PAI score ≥ 5 has the higher proportion (66%) than a PAI score <5. There were still 53 patients (28%) who were admitted in intrapartum and postpartum. Most of the participants underwent hysterectomy (74%). Conclusion: Advanced maternal age, multiparity, previous CS, and placenta previa were risk factors for PAS. PAI score, which combines previous CH hostory and USG findings in antenatal care, can assist in determining whether pregnant women have a high risk of PAS. Antenatal diagnosis and proper perioperative management in PAS are needed to optimize maternal and neonatal outcomes.  Keywords: Placenta accreta spectrum, clinical profiles, Outcomes
Pengaruh Pemberian Magnesium Sulfat (MgSO4) Terhadap Kadar Nitric Oxide dan Prostacyclin pada Preeklampsia Pangkahila, Evert; Kade Yudi Saspriyana; Clara Amanda; Winty Septiani
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.1-15.2025

Abstract

Introduction :  Preeclampsia is a pregnancy-related syndrome with significant maternal and neonatal risks, affecting 4.6% of pregnancies globally. Its pathophysiology, linked to an imbalance between prostacyclin (a vasodilator) and thromboxane (a vasoconstrictor), remains poorly understood. Magnesium sulfate (MgSO4) is widely used for seizure prophylaxis in preeclampsia, but its effect on nitric oxide (NO) and prostacyclin levels is still debated. Methods: This quasi-experimental study included 30 pregnant women diagnosed with severe preeclampsia. Baseline serum levels of NO and prostacyclin were measured before MgSO4 administration and re-evaluated after 24 hours of treatment. Changes in biomarker levels were assessed using paired t-tests, with a significance threshold of p < 0.05. Results: The mean NO level increased from 35.2 ± 5.6 µmol/L before treatment to 49.8 ± 6.3 µmol/L after MgSO4 administration, showing a statistically significant difference (p < 0.001). Similarly, prostacyclin levels rose from a baseline of 42.1 ± 4.8 pg/mL to 58.7 ± 5.2 pg/mL post-treatment (p < 0.001). These findings suggest a robust enhancement of vasodilatory activity, supporting the role of MgSO4 in improving vascular endothelial function. Conclusion: MgSO4 administration significantly increases NO and prostacyclin levels, demonstrating its efficacy in reducing vascular resistance in preeclamptic pregnancies. These results reinforce its clinical utility, offering a mechanistic insight into its vasodilatory and anti-convulsive properties. Keywords: Preeclampsia, magnesium sulfate, nitric oxide, prostacyclin, vascular biomarkers
DIFFERENCES IN PROTEASE ACTIVATED RECEPTOR-1 AND THROMBINE LEVELS IN PREECLAMPSIA AND NORMAL PREGNANCY Khatimah, Gistin Khusnul; Serudji, Joserizal; Basyir, Vaulinne
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.27-34.2022

Abstract

Introduction: Preeclampsia is a condition caused by alterations in endothelial function during pregnancy. Changes in endothelial function result in an increase in coagulation and microvascular fibrin accumulation, which results in impaired placental perfusion. Thrombin, which converts fibrin to fibrinogen, as well as platelet activity, the fibrinolytic system, and anticoagulants, are all procoagulant circumstances in preeclampsia. Thrombin contributes to the pathogenesis of preeclampsia by increasing the expression of sFlt-1 thereby providing an antiangiogenic response. Protease Activated Receptor-1 (PAR-1) is a mediator of thrombin for coagulation and inflammation in preeclampsia. Inhibition of Protease Activated Receptor-1 expression in trophoblasts can enhance placental angiogenesis and vascular remodeling. Recently, only few studies have assessed the levels of Protease Activated Receptor -7 and thrombin in preeclampsia.Objective: To determine the difference in levels of Protease Activated Receptor-1 and thrombin in preeclampsia and normal pregnancyMethods: This study is observational with a cross-sectional comparative study design. Sampling was conducted from March 2020 to March 2021. A total of 66 patients were investigated, with 33 samples of preeclampsia and 33 samples of normal pregnancy. The independent sample T-test was used for statistical analysis.Results: The mean levels of Protease Activated Receptor-1 in the preeclampsia group were higher at 28.56 ± 7.68 ng/mL while normal pregnancy was 21.67 ± 6.92 ng/mL. The results of statistical tests showed that there was a significant difference in levels of Protease Activated Receptor-1 between the preeclampsia and normal pregnancy groups (p<0.05). The mean thrombin level in the preeclampsia group was higher at 72.23 ± 7.99 ng/mL, while in normal pregnancy it was 63.70 ± 8.92 ng/mL. The difference in thrombin levels between the preeclampsia and normal pregnancy groups was statistically significant (p<0.05).Conclusion: Preeclampsia was associated with greater levels of Protease Activated Receptor-1 and thrombin than normal pregnancy. There was a significant difference in the mean levels of Protease Activated Receptor-1 and thrombin between preeclampsia and normal pregnancy.Keywords: Thrombin, Protease Activated Receptor-1(PAR-1), Preeclampsia
ISOLATION OF AMNIOTIC FLUID MESENCHYMAL STEM CELLS (AF MSCs) OBTAINED FROM CAESAREAN SECTIONS Utama, Bobby Indra
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.1.1-9.2018

Abstract

Amniotic fluid is a liquid that fills the amniotic cavity which has defense and nutritional functions in fetal development. Human aterm amniotic fluid can be an ideal alternative as a source of mesenchymal stem cells, originating from the neonate. Preclinical studies of second and third trimester amnion fluid cells confirmed the number of potential donors from this wasted material. In several studies, AF-MSCs express mesenchymal markers such as CD90, CD73 (SH3, SH), CD105 (SH2), CD29, CD166, CD49e, CD58 and CD44 (MHC class I). These cells also express HLA-ABC antigens, CD 34, CD 45 which are hematopoietic markers, and endothelial CD31 markers. There is no expression of CD10, CD11b, CD14, CD34, CD117, EMA and HLA-DR, DP, DQ antigens. Most of AF-MSCs have pluripotent properties which are characterized by the discovery of octamer binding protein 3/4 (Oct-3/4), transcription factors Nanog (Nanog), and stage-specific embryonic antigen 4 (SSEA-4) on RT-PCR examination. From this study, 8 million cells was isolated. These cells will be used for research on pelvic organ prolapse therapy by using AF-MSCs. AF-MSCs isolation totally takes 6 weeks. From 1 flask, 2 million of stem cells was obtained. Keywords: amniotic fluid, AF-MSCs
PERBEDAAN RERATA FAKTOR HEMOSTASIS PADA PREEKLAMPSIA BERAT DAN EKLAMPSIA Setia, Dyhan Purna; Ferry, Ferdinal; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.1.10-15.2018

Abstract

Objective : To find the difference in mean hemostatic factors in severe preeclampsia and eclampsia.Method : The study was analytic descriptive using a cross sectional study design by looking at the subject's Medical Record according to the time and place of research. The sample is the entire medical record of pregnant women who suffer from preeclampsia and eclampsia in the obstetric and gynecology departments of Dr. M. Djamil Padang Hospital in the period 15 January 2016 to 31 December 2017. The assessment was in the form of assessed platelet levels, PT, APTT and D-Dimer. Samples were taken from populations that met the inclusion criteria and did not have exclusion criteria. Sampling using consecutive sampling techniques taken from the Medical Record Dr. M.Djamil Padang. Statistical analysis to assess significance using the T-Test.Result : The severity the condition of pregnancy the lower the platelet mean and PT. Significant differences were obtained between platelets in PEB and eclampsia (p> 0.05). The mean PT, APTT and D-Dimer showed no significant differences in pregnancy conditions. Statistical test with T-Test did not show significant differences in mean PT, APTT, and D-dimer between eclampsia and PEB (p> 0.05).Conclusion : There were significant differences in mean in platelets, whereas in PT, APTT, and D-dimers in PEB and eclampsia there were no significant differences.Keywords: Pregnancy, severe preeclampsia, eclampsia, platelets, PT, APTT, D-Dimer.
PERBEDAAN RERATA KADAR NATRIUM MATERNAL ANTARA PREEKLAMPSIA BERAT DAN EKLAMPSIA DI RSUP DR. M. DJAMIL PADANG Efri, Gunawan; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 1 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.1.16-20.2018

Abstract

Objective: To determine the difference in mean ratio of sodium content between pregnancy with severe preeclampsia and eclampsia.Method: This is an analytical study using a cross sectional study design. The study was conducted inMaternity room of Dr. M. Djamil Padang from January 15th, 2016 to December 31st, 2017, there were 60 patients as subjects, the sample was divided into 2 groups: severe preeclampsia and eclampsia. Furthermore, history and physical examination to obtain data and clinical diagnosis. Data is recorded in a research form that has been provided, then performed blood electrolytes of Sodium and Potassium. Statistical analysis to assess significance using T-test.Results: In the severe preeclampsia and eclampsia, multiparous parity had the highest respondent. This is consistent with the literature in which the incidence of preeclampsia is more common in late pregnancy.Conclusions: There was no significant difference in the mean sodium ratio between normal severe preeclampsia pregnancy and normal pregnancy.Keywords: pregnancy condition, severe preeclampsia, eclampsia, and sodium.
HUBUNGAN ANTARA SKIN PREPARATION DENGAN INFEKSI LUKA OPERASI POST SECTIO CAESAREA DI RS ACHMAD MOCHTAR BUKITTINGGI Leenesa, Calvindra; Sriyanti, Roza
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 2 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.2.67-73.2018

Abstract

Background : Surgical wound infection is a problem that is often found today in surgery. The Indonesian Ministry of Health reported that in 2011, 55.1% of surgical wound infections were found in government hospitals. This is in line with WHO data in 2010, where the sectio caesarean rate in Indonesia was recorded at 6%. Skin preparation can be used to prevent surgical wound infection by reducing the number of germs on the skin prior to incision.Objective : To see the relationship between skin preparation and post sectio caesarea surgical wound infection at Achmad Mochtar Bukittinggi Hospital.Methods : This study was an analytical study using a cross sectional study design by looking at the subject's medical records according to the time and place of the study. Samples were all medical records of mothers giving birth by sectio caesarea in the Obstetrics and Gynecology Section of Achmad Mochtar Bukittinggi Hospital in the period 1 January 2017 to 31 December 2017. Samples were taken from populations that met the inclusion and exclusion criteria. The sample was taken using simple random sampling technique which was taken from the medical records of Achmad Mochtar Hospital Bukittinggi. Statistical analysis to assess significance used the chi-square test.Results : The sectio caesarean group that carried out skin preparation without using chlorhexidine gluconate had the highest number (59.8%), with post sectio caesarean wound infection of 70.7%.Conclusion : There was a significant relationship between skin preparation and post sectio caesarean surgical wound infection (p <0.021) at Achmad Mochtar Bukittinggi Hospital.Keywords: Sectio caesarea, skin preparation, surgical wound infection
Efektifitas Konseling Kesehatan Reproduksi Terhadap Peningkatan Pengetahuan Kesehatan Reproduksi Pasangan Calon Pengantin di KUA Kota Padang Indah, Harly Pratiwi; Desmiwarti, Desmiwarti
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 2 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.2.74-77.2018

Abstract

Objective : To find out the effectiveness of reproductive health counseling on reproductive health knowledge for bride and groom couples in the KUA, Padang City, October 2017 - March 2018.Methods : This study is an analytical study using a cross-sectional study design with a population, namely couples who received prenuptial counseling and a sample of respondents who received prenuptial counseling at KUA Padang City during the period October 2017 - March 2018. The sample was taken using simple random sampling technique. The data were taken from post counseling questionnaires that were distributed to the prospective bride and groom couples. Data were analyzed by univariate and bivariate using chi-square test and independent T test with 95% CI. The research results are presented in tabular form.Results : During the study period, 147 respondents were given a post-counseling questionnaire on reproductive knowledge. It is known that more than half of the respondents (61.2%) had a low level of education, namely elementary, junior high and high school education, while 38.8% of respondents had higher education, namely at the diploma, undergraduate and postgraduate levels. Of the 147 respondents, more than half (79.6%) with a high level of knowledge about reproductive health after being given prenuptial counseling and all respondents (100%) stated that premarital counseling was beneficial. And it can be concluded that there is no difference in the mean age between respondents with high knowledge of reproductive health after being given counseling with low knowledge (p> 0.05). The results of the analysis showed that there was a significant relationship between the education level of the respondents and knowledge about reproductive health after being given counseling (p <0.05).Conclusion : More than half of the respondents (79.6%) have a high level of knowledge about reproductive health after being given pre-marital counseling on reproductive health.Keywords: Pre-marital Counseling, Reproductive Health
Hubungan Skor Plasenta Akreta Indeks (PAI) dengan Kejadian Plasenta Akreta pada pasien bersalin di bagian kebidanan RSUP.dr.M.Djamil Padang Putri, Intan Firmana; Ariadi, Ariadi
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 2 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.2.78-82.2018

Abstract

Objective: To determine the relationship between PAI scores and the incidence of placenta accreta in placenta previa accreta suspects who gave birth at RSUP M. Djamil Padang. Method: This study is an analytical study using a cross-sectional study design with a sample of all patients with placenta previa totalis suspected accreta who gave birth in the obstetrics department of RSUP M. Djamil Padang during the period January 1, 2017 - April 30, 2018. The data were taken from the patient's medical records that included age, parity status, labor history, and PAI score from ultrasound examination results. The relationship between PAI scores and the incidence of placenta accreta was analyzed using an independent T-test with a significant degree of <0.05. The research results are presented in tabular form.  Results: During the study period, 30 patients with placenta previa suspected of accreta at RSUP M. Djamil Padang. It is known that cases of placenta accreta were more common in multiparous (57.7%), suspected accreta (57.7%), had a history of SC (65.2%), and the mean age of patients with accreta was 34.7 ± 3.5 years. Furthermore, it can be concluded that the mean PAI score in patients with placenta accreta is higher than non-accreta, and there is a significant relationship between PAI scores and cases of placenta accreta (p> 0.05).Conclusion: The mean PAI score in patients with placenta accreta is higher than without accreta and there is a significant relationship between PAI scores and cases of placenta accreta.Keywords: Placenta Accreta, PAI Score
Gambaran Hasil HPV Test dengan PAP Test pada Pasien dengan Lesi Prakanker Serviks di RSUP Dr M Djamil Padang Prima, Angga Trifianda; Friadi, Andi
Andalas Obstetrics And Gynecology Journal Vol. 2 No. 2 (2018)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.2.2.83-86.2018

Abstract

Objective: To determine the description of the HPV Test results with the PAP Test in patients with cervical precancerous lesions at Dr. M. Djamil Padang.Methods: This study used a descriptive method with a sample of all patients with cervical precancerous lesions who had the HPV test and PAP test results in Dr. M. Djamil Padang from January 1, 2015 - December 31, 2017. Data were taken from the patient's medical records, including diagnosis, PAP test results using the Hybrid Capture (HC) method, and HPV test. Results: During the study period, 80 patients had PAP test results leading to precancerous lesions and cervical cancer. Of the 80 patients, only 4 cases with positive HPV test results. Conclusion: In this study, there were many cervical precancerous lesions with negative HPV test results.Keywords: Cervical precancerous lesions, PAP test, the HPV test

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