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Andalas obstetrics and gynecology journal
Published by Universitas Andalas
ISSN : 25798324     EISSN : 25798413     DOI : https://doi.org/10.25077/aogj
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health
Andalas Obstetrics And Gynecology Journal (AOJ) (e-ISSN: 2579-8324) is a peer-reviewed, open-access national journal published by Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of obstetrics, gynecology, and other related disciplines.
Arjuna Subject : Kedokteran - Obstetrics and Gynaecology
Articles 451 Documents
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Management of Hyperprolactinemia Caused by Pituitary Microadenoma Muttaqin, Ibnu; Yuad, Haviz
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.642-647.2024

Abstract

Hyperprolactinemia is an increase in fasting levels of the hormone prolactin above 20 ng/ml in men and above 25 ng/ml in women. Hyperprolactinemia occurs more often in women of reproductive age, with a percentage of 9 – 17%. The etiology of hyperprolactinemia can occur due to abnormal pituitary secretions, systemic disease, use of drugs, damage to the hypothalamus-pituitary axis. A 33-year old female patient came to the FER Polyclinic at M. Djamil Hospital with complaints of not menstruating for the past 2 months. Irregular menstruation since 15 years ago, menstruation 2-3 times in 6 months, irregular cycle for 7-8 days. The patient also complained of a fluid like breast milk coming out of the breast for 5 years, initially the fluid came out in a trickle and then gradually reduced and now the fluid comes out occasionally if the breast is squeezed. From the supporting examinations carried out, it was found that the prolactin hormone level in this patient was 134.53, and the results of the MRI examination showed a mass measuring 1.05x1.12x0.5 mm, which was diagnosed as secondary amenorrhea, hyperprolactinemia, and suspected pituitary microadenoma. The patient will be monitored for general condition and vital signs, as well as consultations with colleagues involved, such as consultations to the Internal Medicine section, Endocrinology, Metabolic and Diabetes Subdivision.
Peritional Tuberculosis in Young Age Lady Miicking Gynecology Malignancy: a Case Report Sari, Lusi Jelita; Antonius, Puja Agung; Muhammad, Syamel
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.654-660.2024

Abstract

Background : Peritoneal tuberculosis is one of the most challenging forms of extrapulmonary tuberculosis to diagnose. Extrapulmonary TB is very difficult to diagnose because of its non-specific signs and symptoms, thus it sometimes leads to a diagnosis of gynaecological malignancy such as advanced ovarian carcinoma. Case Report : A teenage girl, 12 years old, with a chief complaint of intermittent abdominal pain since the last 1 month. There was no history of an enlarged abdomen, fever and weight loss. Ultrasound examination revealed an irregular adnexal mass suggesting an ovarian malignancy with other possibilities of an infectious process. Diagnostic laparoscopy and peritoneal biopsy were performed on the patient. Intraoperatively, multiple friable nodular-mylar peritoneal masses with abdominopelvic attachments and fibrin fibres and white vesicles were found on the entire surface of the genitalia, peritoneum, and intestines. A mass biopsy was performed with histopathological results showing peritoneal tuberculosis. Currently, the patient is undergoing anti-tuberculosis drugs (OAT) treatment. Discussion : The diagnosis of this disease is difficult to establish. Symptoms are highly variable and non-specific and can lead to the wrong tumour pathology. The clinical characteristics are dominated by changes in general condition, abdominal pain and transit disorders, as well as masses (20 to 25%). The gold standard for definitive PTB diagnosis remains laparoscopy with peritoneal biopsy and subsequent pathological or microbiological confirmation. Yellow/white nodules in the peritoneum observed on the patient's laparoscopic images are the hallmark of wet peritoneal TB. Omental thickening and abdominal cocoon with matted small bowel are other classic laparoscopic findings for peritoneal TB. Conclusion: PTB has similar characteristics to peritoneal carcinoma, which makes diagnosis difficult for clinicians. Early and correct diagnosis of PT
PAPP-A Levels and IGF-1 Levels in Early-Onset Preeclampsia and Late-Onset Preeclampsia Soufal, Juan Habli; Yusrawati, Yusrawati; Basyir, Vaulinne
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.519-524.2024

Abstract

Introduction: The pathophysiology of preeclampsy is not yet fully understood, but failure of tropoblast invasion and placentation, which is influenced by factors such as pregnancy-associated plasma protein A (PAPP-A) and insulin-like growth factor 1 (IGF-1), is thought to play a role. Aims: This study aimed to explore the difference in PAPP-A and IGF-1 levels between Early-Onset Preeclampsia (PEAD) and Late-Onset Preeclampsia (PEAL), assuming that the role of PAPP-A and IGF-1 is more significant in the pathogenesis of PEAD than PEAL. Methods: This is an analytical observational study with a cross-partition comparative study design. Clinical data were obtained at Dr. M. Djamil Padang Hospital, while PAPP-A and IGF-1 levels were measured at the Biomedical Laboratory of the Faculty of Medicine, Andalas University. Samples are tested according to reagent procedures and analyzed by experts.Results: Average PAPP-A levels were 2.45+0.35 pg/mL in the early onset preeclampsy group and 2.85+0.50 pg/mL in the late onset preeclampsy group. These two levels differed statistically significantly (p=0.006). That means that low levels of PAPP-A are associated with and play a role in the pathogenesis of early onset preeclampsy. Average IGF-1 levels were 4.66+0.91 pg/mL in the early onset preeclampsy group and 5.39+0.74 pg/mL in the late-onset preeclampsy group. These two levels differed statistically significantly (p=0.010). That means that low levels of IGF-1 are associated with and play a role in the pathogenesis of early onset preeclampsy. PAPP-A levels were significantly positively correlated with IGF-1 levels (p=0.000). Conclusion: PAPP-A levels are lower in PEAD than PEAL, as are IGF-1 levels. These findings confirm the role of PAPP-A and IGF-1 in preeclampsia. Both of these hormones have potential as indicators and markers for the prediction and management of preeclampsy in early and late onset periods.
The Relationship of The Incident o Metabolic Syndrome and Overactive Bladder in Female Patients at DR. M. Djamil Padang in 2023 Anggra Pramana; Utama, Bobby Indra; Yetti, Husna
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.538-547.2024

Abstract

Overactive Bladder (OAB) is a chronic medical condition that has a negative impact on an individual's health and quality of life. Cardiovascular problems are considered to be one of the risks associated with OAB where one of the higher cardiovascular parameters is metabolik syndrome. Aim to determine the relationship between  metabolik syndrome and Overactive Bladder in female patients at Dr. M. Djamil Hospital Padang. Quantitative research with a case control design using a questionnaire according to the Overactive Bladder Symptom Score (OABSS) and examination based on metabolik syndrome symptoms. The research was conducted at Dr. M. Djamil Hospital Padang in November 2022 to September 2023. There were 60 respondents who were divided into the OAB (28/60) and no-OAB group (32/60). Most respondents were aged 50-59 years (45,0%), graduated from high school (53.3%), worked as housewives (76.7%) and had diabetes mellitus (78,3%). In this study it was also found that 48,3% of respondents suffered from hypertension and 45.0% suffered from obesity. A total of 46.7% of respondents experienced OAB symptoms with a higher percentage of OAB found in the metabolik syndrome group (76,7%) than no-metabolik syndrome group (16.7%). Bivariate analysis found a relationship between metabolik syndrome and overactive bladder symptoms (p = 0.000) with metabolik syndrome affected the incidence of overactive bladder by 16.4 times (OR 16.42, (CI 95% 4.56-59.07). There is a relationship between metabolik syndrome and the incidence of OAB.
Factors Affecting the Age of Menopause in Padang City in 2023 Bennovry, Rizky Rivonda; SA, Syahredi; Utama, Bobby Indra
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.525-537.2024

Abstract

Menopause is characterized by a consecutive period of amenorrhea lasting 12 months without any underlying causes or surgical interventions. The age at which menopause occurs can be influenced by various factors, including menarche, number of childbirths, body mass index, and the utilization of hormonal contraceptives. This study aims to determine the factors that influence the incidence of menopause in Padang. This study is an analytical research with a cross-sectional study design. The research was conducted in the working areas of all primary public health centers in Padang from Januari 2023 to September 2023. The sample consisted of middle-aged women who visited the working areas of all primary public health centers during the study period. This study is using a questionnaire as the research instrument and employing the simple random sampling technique to obtain a sample size of 124 participants. The data analysis was conducted using the Chi- Square test, and utilize the statistical software SPSS. A significant relationship between variables was defined if the p-value < 0.05. The results of this study revealed that the majority of respondents experienced early menarche (36.3%), had multiparous pregnancies (33.9%), had underweight body mass index (33.1%), used hormonal contraceptives (52.4%), and experienced late menopause (40.3%). The analysis showed a significant relationship (p<0.05) between the age of menarche (p=0.036) and parity (p=0.002) with the occurrence of menopause. However, there was no significant relationship (p>0.05) between body mass index (p=0.141) and history of contraceptive use (p=0.069) with the occurrence of menopause. This study found a significant relationship between the age of menarche and parity with the occurrence of menopause, while there was no significant relationship between body mass index and history of contraceptive use with the occurrence of menopause among middle-aged women visiting the primary public health center areas in Padang.
The Relationship of Vitamin D Topolycystic Ovary Syndrome (PCOS) Teenagers at Koto Tangah Padang District High School in 2022 Utomo, Hardi Cahyo; Yuad, Haviz; Burhan, Ida Rahmah
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.615-631.2024

Abstract

PCOS is characterized by increased ovarian and adrenal androgen secretion, hyperandrogenic symptoms such as hirsutism, acne and/or alopecia, menstrual irregularities, and polycystic ovaries. The prevalence of PCOS in 2016 was 6−21% of reproductive age worldwide. PCOS is the most common female endocrine disorder with a prevalence of around 4-6% in women of reproductive age in Indonesia. Vitamin D deficiency can increase PCOS symptoms. The research design was cross-sectional. The study was conducted at SMA N 7, SMA N 8 and SMA N 13 Padang in Koto Tangah District in May-August 2022. The research sample was high school students who experienced menstrual cycle disorders and were willing to agree to informed consent for the study with a sample size of 59 respondents. Vitamin D levels were examined using the 25-Hydroxyvitamin D ELISA Kit. Data were analyzed by chi-square test. The results showed that 86.4% of respondents experienced vitamin D deficiency. Statistically there was a relationship between PCOS in adolescents accompanied by hyperandrogens and vitamin D levels, there was a relationship between PCOS in adolescents accompanied by obesity and vitamin D levels, there was no relationship between PCOS in adolescents accompanied by acanthosis nigrican and vitamin D levels, and there was no relationship between PCOS in adolescents accompanied by hyperandrogens, obesity and acanthosis nigrican with vitamin D levels in SMA Koto Tangah District Padang in 2022. The conclusion of this study is that there is a relationship between PCOS in adolescents accompanied by hyperandrogens and vitamin D levels and there is a relationship between PCOS in adolescents accompanied by obesity and vitamin D levels.
Characteristics of Advanced Epithelial Ovarian Cancer Patients in Dr. M. Jamil Padang Hospital Azwan, Reyhan Julio; Muhammad, Syammel; Karmia, Hudila Rifa
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.560-568.2024

Abstract

Background: Ovarian cancer is a major global health concern, often diagnosed at advanced stages, impacting five-year survival rates. This study examines the demographic and clinical characteristics of 64 patients with advanced epithelial ovarian cancer, shedding light on the disease complexity. Methods: Conducted at General Hospital Dr. M. Djamil Padang, this cross-sectional study analyzed patient data using SPSS. The research, approved by the Health Research Ethics Committee of Andalas University, included detailed demographic and clinical assessments. Results: Predominantly, patients were aged 40-64, exhibited normal BMI, and a significant portion had not given birth. Evaluation of clinical factors, including Peritoneal Cancer Index (PCI) and residual tumor size, provided insights into the cohort's characteristics. Optimal cytoreduction (<1 cm residual tumor) was prevalent, emphasizing the role of surgery in enhancing survival. Conclusion:The study underscores the multifaceted nature of advanced epithelial ovarian  cancer and advocates personalized treatment approaches tailored to individual patient profiles. The findings contribute valuable insights to the existing knowledge, emphasizing the importance of age, BMI, and surgical interventions in influencing outcomes.
Comparison of Microbiota in Threatened Preterm Labor and Normal Pregnancy at RSUP DR.M. Djamil Padang Ryfki SA, Muhammad; Yanti, Roza Sri; Utama, Bobby Indra
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.548-559.2024

Abstract

One of the threats in pregnancy is threatened preterm labor. Several studies show that the composition of the microbiota in the vagina of premature births and normal pregnancies is different. This study aims to determine the comparison of microbiota in pregnancies with premature parturition and normal pregnancies at Dr M Djamil General Hospital, Padang. This research is an analytical observational study with a case–control study design conducted at the Department/SMF of Obstetrics and Gynecology, RSUP Dr. M. Djamil Padang from July – September 2023. The study population in this research were all pregnant women with a gestational age of 20-37 weeks who were diagnosed with imminens preterm labor and normal pregnant women with a gestational age of 20-37 weeks who received antenatal care at RSUP Dr. M. Djamil Padang. Respondents had vaginal swabs taken for microbiological culture at the Biomedical Laboratory, Andalas University, Padang. There were 33 respondents each in the imminence premature birth and normal pregnancy groups. Vaginal swab results showed that the most common microorganism found in normal pregnancy was Lactobacilus sp. (73%) while in threatened preterm labor Staphylococcus aureus (37%), Staphylococcus epidermidis (27%) and E.coli (15%) were more commonly found with only a small proportion of Lactobacilus sp (12%). Chi square analysis showed a significant difference between the vaginal microbiota of normal pregnant women and pregnant women with PPI. The conclusion of this study is that there is an increase in Staphylococcus aureus, Staphylococcus epidermidis and E.coli in pregnant women on PPI with a decrease in the number of normal flora, namely Lactobacilus spp.
Clinical Characteristics, Laboratory, Maternal and Fetal Outcomes in Pregnancy with Covid-19 at RSUP dr. M. Djamil Padang Sriyanti, Roza; Farnas, Heri; Djanas, Dovy
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.569-578.2024

Abstract

Introduction : The data obtained from various studies about covid-19 conducted in several hospitals in the world are currently considered not sufficient to provide a clinical picture that occurs in pregnancies with Covid-19 infection. The aims to provide an overview of the clinical, laboratory, maternal and fetal outcomes in pregnancy with Covid-19 infection at dr. M. Djamil Padang. Methods: This study used a descriptive design with data collection starting from March 01, 2020 - March 31, 2021 based on medical record data. Carried out in a single center at RSUP dr. M. Djamil Padang in pregnant patients with confirmed Covid-19 by PCR examination. Results: Total 136 pregnant patients confirmed Covid-19 by PCR examination. Most of the symptoms were asymptomatic (47.1%) and without any comorbidities (76.5%). There were 3 patients who experienced critical symptoms (2.2%). Maternal mortality was found at 2.3% and fetal death 4.7%. The values of d-dimer and NLR were found increasing significantly, 2025.35±1392.18 for d-dimer and 6.39±4.43 for NLR. Pregnancy terminations done for 77.9% patients with cesarean section is the most method (83%). There were 4 cases (3.8%) of babies infected with Covid-19 from mothers who had pregnancy terminations. Conclusions: Most cases had asymptomatic clinical symptoms (47.1%). There are 2.3% cases of maternal death and 4.7% cases of fetal death. Most of the pregnancy terminations were performed by cesarean section (88%). On laboratory examination, there was a significant increase in maternal d-dimer (2,025.35±1.392.18) and NLR (6.39±4.43) in pregnancies with Covid-19.
Early Haemorrhage Postpartum (HPP); With Complication Disseminated Intravascular Coagulation, Sepsis, Acute Kidney Injury Oktavian, Rizki; Gunawan Efri; Sriyanti, Roza; Taslim, Emilzon
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.632-641.2024

Abstract

Background : Hemorrhage Postpartum (HPP) is the leading cause of maternal death worldwide with an incidence of 5%-10% of all deliveries. 70% of cases of HPP are caused by atony of the uterus. If HPP is not handled properly, it will cause worsening of the patient's condition which causes various multiorgan complications. Objectives : To discuss the management of HPP cases complicated by DIC, sepsis and AKI. Method : case report. Case : A female patient, 36 years old, was referred from a private hospital to PONEK RSUP Dr. M. Djamil Padang with a diagnosis of decreased consciousness ec suspected sepsis in post SCTPP oi used SC 2x + post relaparotomy oi bleeding subfascia + moderate anemia. After surgery, the patient looked pale and the hemoglobin was 7, then relaparotomy was done and done B-lynch oi uterine hypotony. After relaparotomy, the patient experienced worsening then referred to the hospital. The patient arrives with hipovolemic shock + AKI + Sepsis + DIC , then the condition improvement is carried out in ROI and hysterectomy relaparotomy is performed. The patient has worsened, maximum treatment has been carried out from the intersivist, but the patient's condition continues to worsen and eventually dies.Conclusion : Early diagnosis and rapid treatment through a multidisciplinary team and the availability of an Intensive Care Unit (ICU) can prevent complications and reduce morbidity and mortality.

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