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All Journal The Indonesian Biomedical Journal Jurnal Kesehatan Komunitas Amerta Nutrition Majalah Kedokteran Andalas Jurnal Ilmu dan Teknologi Kesehatan Andalas obstetrics and gynecology journal Best Journal (Biology Education, Sains and Technology)
Karmia, Hudila Rifa
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Perbedaan Kadar 25(OH)D Serum, Asupan Vitamin D, Magnesium dan Zink pada Status Gizi Obesitas dan Normal: Differences in Serum 25(OH)D Levels, Intake of Vitamin D, Magnesium, and Zinc in Obese and Normal Nutritional Status Risanti, Suci Padma; Desmawati, Desmawati; Karmia, Hudila Rifa
Amerta Nutrition Vol. 8 No. 2 (2024): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v8i2.2024.305-311

Abstract

Background: Vitamin D deficiency affects about 50% of people worldwide and 95% of Indonesian women of childbearing age. Micronutrient intake can impact serum 25(OH)D levels. Obesity is linked to serum 25(OH)D levels and micronutrients like zinc, magnesium, and vitamin D consumption. Objectives: This study aims to determine the differences in serum levels of 25(OH)D, vitamin D, magnesium, and zinc intakes in obese and normal students at the Faculty of Medicine, Andalas University, Padang. Methods: This research was observational with a comparative case-control design at the Faculty of Medicine and Biomedical Laboratory, Andalas University, from November 2021 to July 2022. Systematic random sampling was used to select the sample, obtaining 64 female students with obesity and normal nutritional status. Data were collected by blood sampling and questionnaires. Bivariate analysis used an independent t-test. Results: The results showed the mean serum levels of 25(OH)D, vitamin D, magnesium, and zinc intakes in the obese group were 10.98 ± 2,12 ng/mL; 5.07 ± 1,47 mcg; 166.04 ± 65.27 mcg and 6.88 ± 2.73 mcg, while the mean in the standard group were 13.94 ± 4.57 ng/mL; 5.92 ± 1.77 mcg; 205.88 ± 92.84 mcg; and 7.62 ± 2.67 mcg. The mean serum levels were 25(OH)D, vitamin D, magnesium, and zinc intakes were lower in the obese group (p-value = 0.001; 0.040; 0.044; 0.280). Conclusions: There are significant differences in serum levels of 25(OH)D, vitamin D, and magnesium in female students with obese and normal nutritional status. There is no significant difference in zinc intake in female students with obese and normal nutritional status.
Pengetahuan dan Sikap Kesehatan Prakonsepsi Calon Pengantin Wanita dalam Pendidikan Pranikah: Studi Quasi Eksperimental Amizuar, Yulia Fauziah; Serudji, Joserizal; Oktova, Rafika; Semiarty, Rima; Karmia, Hudila Rifa; Rita, Rauza Sukma
Jurnal Ilmu dan Teknologi Kesehatan Vol 12 No 1 (2024): September 2024
Publisher : Poltekkes Kemenkes Jakarta III

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32668/jitek.v12i1.1301

Abstract

Maternal and child health challenges have been seen before the process of pregnancy. Improving education, attitudes and behavior of couples is an important part of preconception health. The aimed of this research was to verify the impact of premarital education on enhanced knowledge and attitudes of preconception health on brides. Research method was quasi-experimental, pretest-posttest control group design. Sampling technique was purposive sampling, based on inclusion and exclusion criteria. Time and location of the study September-November 2022 at three Office of religious (KUA Koto Tangah, KUA Kuranji and KUA Padang Utara). The intervention group were given educational material related to marriage law in Islam and preconception health education using lecture and discussion methods. The control group were given education only related to the law of marriage in Islam (religious sphere) with the lecture method. Questionnaires with tested validity and reliability were used to gather data. The results of knowledge intervention group compared the control group (p = 0.00). Prospective bride’s attitudes were not impacted by premarital education in the intervention group compare the control group (p=0.59). In conclusion, it has been proven that premarital education enhance preconception health knowledge, as opposed to women' preconception health attitudes.
miR-200a as Potential Early-onset Biomarker, while High Nitric Oxide as Potential Late-onset Biomarker in Preeclampsia Karmia, Hudila Rifa; Yusrawati, Yusrawati; Jamsari, Jamsari; Hardisman, Hardisman
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3572

Abstract

BACKGROUND: miR-200a is known to alter trophoblast invasion and spiral artery remodeling, leading to defective placentation that causes placental hypoxia, which is the main pathomechanism in early-onset preeclampsia (EOPE). Hypoxic placentas cause systemic endothelial dysfunction that is characterized by low production of endothelial vasodilator, mainly nitric oxide (NO). On the other hand, defective placentation does not cause late-onset preeclampsia (LOPE), making the role of miR-200a expression and NO level as predictors in LOPE questionable. Therefore, this study was conducted to compare miR-200a expressions and NO levels in EOPE and LOPE to clarify their role in pathomechanism of both types of preeclampsia.METHODS: A cross-sectional comparative study was conducted in 62 preeclamptic patients (31 EOPEs and 31 LOPEs). Subjects were classified into EOPE or LOPE groups based on whether the diagnosis of preeclampsia was made at <34 or ≥34 weeks of pregnancy. miR-200a expression was analyzed using real-time polymerase chain reaction technique, and NO level was analyzed using colorimetric assay method.RESULTS: EOPE and LOPE subjects were equivalent in terms of age and parity (p=0.709 and p=0.066), but significantly difference in gestational age (p=0.000). miR-200a were expressed in 74.2% of EOPE and 41.9% of LOPE subjects (p=0.010). Median NO levels were lower in EOPE compared to LOPE subjects (23.75 vs. 106.00 µmol/L) (p=0.027), and lower in subjects with detected miR-200a compared to subjects with undetected miR-200a (62.75 vs. 132.25 µmol/L) (p=0.032).CONCLUSION: miR-200a was more expressed in EOPE compared to LOPE subjects suggesting that it might be a significant in predicting EOPE. While NO level was significantly lower in EOPE whilst higher in LOPE subjects, hence might be potential as a marker to differentiate EOPE and LOPE.KEYWORDS: miR-200a expression, NO level, early-onset preeclampsia, late-onset preeclampsia
Factors Related to Primary Dysmenorrhoea in Students at The Faculty of Medicine of Andalas University in 2023 Dzaky, Aditya Luthfian; Karmia, Hudila Rifa; Abdiana, Abdiana
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 2 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.2.267-278.2025

Abstract

Introduction: Dysmenorrhoea or menstrual pain is a commonly reported reproductive health issue, particularly affecting those aged 18-25 years. It can significantly disrupt daily activities and reduce productivity. The high prevalence of dysmenorrhoea is attributed to multiple factors, which are multifactorial in nature. The research aims to identify the factors related to incidence of primary dysmenorrhoea among in students of the Bachelor of Medical Education Study Program at the Faculty of Medicine, Andalas University 2023. Method: A cross-sectional study was conducted in October 2023 using a Google form to collect primary data. The sample consisted of 212 female students from the batch of 2020-2022, selected using a simple random sampling technique. Univariate and bivariate analyses were used to analyse the data, with the chi-square test employed in bivariate analysis. Results: The results of the study of the relationship between age of menarche, family history of sleep quality, and duration of menstrual bleeding, the incidence of primary dysmenorrhoea obtained p values of p = 0.538, p = 0.059, p = 0.004, and p = 1.000. Conclusion: There is a significant relationship between sleep quality and the incidence of primary dysmenorrhoea. However, there is no significant relationship between menarche age, family history, and duration of menstrual bleeding with the incidence of primary dysmenorrhoea in students of the Bachelor of Medical Education Study Program at the Faculty of Medicine, Andalas University 2023.It is important for all women of childbearing age to be aware of the risk factors that cause dysmenorrhoea and the measures taken to alleviate menstrual pain.
Correlation of Leukopenia with Vitamin D Levels in Ovarian Cancer Patients Undergoing Platinum-Taxane-Based Chemotherapy Antonius, Puja Agung; Firdawati, Firdawati; Syamel Muhammad; Yusrawati, Yusrawati; Karmia, Hudila Rifa; Wijaya, Caesar Muhammad
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 2 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.2.251-258.2025

Abstract

Introduction: Ovarian cancer is a significant cause of death in women. One of the management of advanced ovarian cancer patients is chemotherapy. The effects of administering Platinum-Taxane-Based chemotherapy to ovarian cancer patients show side effects of myelosuppression, one of which is leukopenia. Methods: This type of study is a correlation analytical study with a cross-sectional design from October 2023 to May 2024 at Dr. M. Djamil Central General Hospital Padang. The patients included were ovarian cancer patients who underwent Platinum-Taxane-Based chemotherapy with laboratory results of leukopenia. Results: From 70 patients, it was found that 37 patients (52.9%) had grade I leukopenia, 27 patients (38.6%) had grade II, and 6 patients (8.6%) had grade III. Based on the results obtained, in grade I leukopenia, the average vitamin D value is 13.162 ng/mL, grade II has an average vitamin D value of 11.851 ng/mL, grade III has an average vitamin D value of 14.333 ng/mL. The study results showed a relationship between leukopenia and vitamin D levels p = 0.034 (p < 0.05). Conclusion: There was a relationship between leukopenia and vitamin D levels in ovarian cancer patients undergoing Platinum-Taxane-Based Chemotherapy at Dr. M. Djamil Central General Hospital Padang.
Asuhan Kebidanan Nifas Pada Ny.”A” Post Op Sc Indikasi Fetal Hipoksida Dengan Absent End Diastolic Dan Intrauterine Growth Retriction Anggraini, Fitri; Basyir, Vaulinne; Karmia, Hudila Rifa
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 2 (2025): September 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i2.11724

Abstract

Angka Kematian Ibu (AKI) merupakan salah satu indikator penting dalam menilai derajat kesehatan masyarakat dan keberhasilan pembangunan sektor kesehatan. Salah satu penyebab utama tingginya AKI adalah perdarahan postpartum, yang banyak terjadi pada masa nifas—periode krusial setelah melahirkan. Seksio sesarea (SC) merupakan metode persalinan yang sering digunakan untuk menangani kasus kehamilan risiko tinggi, termasuk fetal distress dan Intrauterine Growth Restriction (IUGR), yang keduanya merupakan kondisi serius yang berdampak pada kesehatan ibu dan bayi. Studi ini bertujuan untuk mengkaji asuhan kebidanan masa nifas pada Ny. “A” pasca SC dengan indikasi fetal hipoksia dan IUGR di Rumah Sakit Universitas Andalas Padang pada tahun 2025. Pendekatan yang digunakan adalah studi kasus dengan fokus pada identifikasi masalah, penatalaksanaan, serta evaluasi asuhan kebidanan yang diberikan selama masa nifas. Hasil kajian menunjukkan bahwa penatalaksanaan yang tepat dan holistik pada masa nifas, termasuk pemantauan kondisi fisik dan psikologis ibu, mampu mencegah komplikasi lanjutan dan meningkatkan pemulihan pascapersalinan. Peran bidan sangat penting dalam memberikan pelayanan profesional, beretika, dan berbasis kompetensi, terutama dalam masa kritis 24 jam pertama pascapersalinan. Kajian ini menekankan pentingnya optimalisasi asuhan kebidanan masa nifas untuk menurunkan AKI dan meningkatkan kualitas hidup ibu pascapersalinan
Faktor Determinan Perilaku Deteksi Dini Kanker Payudara dengan SADARI pada WUS di Puskesmas Padang Pasir Ginting, Desi Scorpinasari; Asri, Aswiyanti; Karmia, Hudila Rifa; Hilbertina, Noza; Meinapuri, Malinda; Hasmiwati, Hasmiwati
Jurnal Kesehatan Komunitas Vol 11 No 2 (2025): Jurnal Kesehatan Komunitas
Publisher : LPPM Hang Tuah Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25311/keskom.Vol11.Iss2.2267

Abstract

Breast cancer is the most commonly diagnosed cancer globally, accounting for nearly 12% of all cases. One in eight women worldwide is at risk of developing breast cancer. Regular Breast Self-Examination (BSE) is one of the most effective methods for early detection. This study aimed to identify the determinants of early breast cancer detection behavior through BSE among women of reproductive age. The study found significant associations between BSE behavior and several predisposing factors, including education level (p = 0.002), knowledge (p = 0.000), perception (p = 0.009), attitude (p = 0.024), and motivation (p = 0.016); enabling factor, namely information exposure (p = 0.000); and reinforcing factors, including family support (p = 0.001) and support from health workers (p = 0.027). Conversely, there was no significant association between social support and BSE behavior (p = 0.394). The study concludes that predisposing, enabling, and reinforcing factors are significantly associated with BSE behavior. Information exposure is identified as the most influential determinant of BSE behavior among women in the working area of Padang Pasir Public Health Center.
The Role of Endothelial Nitrit Oxide in Preeclampsia Onset Ramya Sausan; Yusrawati, Yusrawati; Karmia, Hudila Rifa
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.41-48.2025

Abstract

Background: Preeclampsia is a pregnancy-specific hypertensive disorder associated with significant maternal and fetal morbidity and mortality. Endothelial dysfunction plays a critical role in the pathogenesis of preeclampsia, with nitric oxide (NO) being a key regulator of vascular tone and endothelial function. This study aims to investigate the relationship between endothelial nitric oxide (eNOS) levels and the onset of preeclampsia. Methods: A cross-sectional study was conducted on pregnant women diagnosed with severe preeclampsia and receive treatment at Dr. M. Djamil Hospital, Padang. After met the inclusion criteria and do not have exclusion criteria, demographic and clinical data was taken. Maternal plasma concentrations of eNOS were determined by ELISA. Non-parametric statistics were used for analysis. Results: The study evaluated the levels of endothelial nitric oxide synthase (eNOS) in two groups of preeclampsia patients: those with Early Onset Preeclampsia (EOP) and Late Onset Preeclampsia (LOPE). The median eNOS levels were 50.43 pg/ml for the EOP group (range: 28.72 - 232.78 pg/ml) and 54.76 pg/ml for the LOPE group (range: 15.39 - 235.70 pg/ml). A Mann-Whitney U test revealed a p-value of 0.303, indicating no statistically significant difference in eNOS levels between the two groups. This suggests that the timing of preeclampsia onset does not significantly influence eNOS levels, providing insights into the disease's mechanisms. Conclusion: eNOS levels in the early preeclampsia (EOP) group were found to be lower compared to the late preeclampsia (LOPE) group. Although there was a difference in eNOS levels between the two groups, the difference was not statistically significant. Keywords: Preeclampsia, endothelial dysfunction, nitric oxide; pregnancy, hypertensive disorders
Pengaruh Pemberian Ekstrak Daun Kelor (Moringa Oleifera) Sebagai Antioksidan Terhadap Kadar Malondialdehyde Pada Tikus Model Hiperglikemia Sari, Asti Marian; Yerizel, Eti -; karmia, Hudila Rifa
Majalah Kedokteran Andalas Vol. 48 No. 1 (2025): MKA January 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i1.p63-70.2025

Abstract

Tujuan: Mengetahui pengaruh pemberiak ekstrak Moringa Oleifera terhadap kadar malondialdehyde pada tikus wistar model hiperglikemia. Metode: Penelitian ini melibatkan 20 ekor tikus strain wistar betina yang berumur 8-12 minggu dengan bobot 200-250 gram yang memenuhi kriteria inklusi maupun ekslusi. Tikus dibagi menjadi kelompok empat, yaitu Kelompok kontrol negatif (K-), Kontrol positif (K+), Perlakuan 1 (P1) dan Perlakuan 2 (P2). Kelompok P1 hanya diberikan makan dan minum standar saja, tanpa perlakuan. Kelompok K+ diinjeksi aloksan secara Intraperotoneal dengan dosis 100 mg/kgBB sehingga tikus menjadi hiperglikemia, P1 diberi injeksi aloksan menjadi hiperglikemia dan diberikan ekstrak moringa oleifera dengan dosis 250 mg/kgBB dan P2 injeksi aloksan menjadi hiperglikemia dan diberikan ekstrak moringa oleifera dengan dosis 500 mg/ kgBB selama 21 hari, Pada hari ke-22 semua kelompok diambil darah untuk dilakukan pemeriksaan kadar malondialdehyde. Hasil: Rerata kadar malondialdehid pada K-, K+, P1 dan P2 berturut-turut, yaitu 1,81±0,06 nmol/mL, 3,81±0,24 nmol/mL, 2,55±0,30 nmol/ mL, 2,09±0,21 nmol/mL, dengan nilai p=0,01. Kesimpulan : Pemberian ekstrak moringa oleifera sebagai antioksidan berpengaruh terhadap penurunan kadar malondialdehid
Co-Authors Abdiana Abdiana, Abdiana Amizuar, Yulia Fauziah Antonius, Puja Agung Aswiyanti Asri Basyir, Vaulinne Desmawati Desmawati Dzaky, Aditya Luthfian Eti Yerizel Firdawati, Firdawati Fitri Anggraini, Fitri Ginting, Desi Scorpinasari Hardisman Hasmiwati Jamsari Jamsari Malinda Meinapuri Noza Hilbertina, Noza Rafika Oktova Ramya Sausan Rauza Sukma Rita Rima Semiarty Risanti, Suci Padma Sari, Asti Marian Syamel Muhammad Wijaya, Caesar Muhammad Yusrawati Yusrawati